Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	27023
Gene name	Forkhead box B1
Gene symbol	FOXB1
Synonyms (NCBI Gene)	FKH5HFKH-5
Chromosome	15
Chromosome location	15q22.2

158

Show/Hide all (158)

miRTarBase ID	miRNA	Experiments	Reference
MIRT527515	hsa-miR-1248	HITS-CLIP	19536157
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT527517	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT483057	hsa-miR-3163	PAR-CLIP	22012620
MIRT483056	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT527516	hsa-miR-1237-3p	PAR-CLIP	22012620
MIRT527515	hsa-miR-1248	PAR-CLIP	22012620
MIRT527514	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT483055	hsa-miR-4446-5p	PAR-CLIP	22012620
MIRT483057	hsa-miR-3163	PAR-CLIP	23592263
MIRT483056	hsa-miR-95-5p	PAR-CLIP	23592263
MIRT483055	hsa-miR-4446-5p	PAR-CLIP	23592263
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	27418678
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	27418678
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	27418678
MIRT483056	hsa-miR-95-5p	HITS-CLIP	27418678
MIRT527515	hsa-miR-1248	HITS-CLIP	19536157
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT483056	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT527516	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT527515	hsa-miR-1248	HITS-CLIP	23824327
MIRT527514	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT483055	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT527517	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT483057	hsa-miR-3163	PAR-CLIP	22012620
MIRT483056	hsa-miR-95-5p	PAR-CLIP	22012620
MIRT527516	hsa-miR-1237-3p	PAR-CLIP	22012620
MIRT527515	hsa-miR-1248	PAR-CLIP	22012620
MIRT527514	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT483055	hsa-miR-4446-5p	PAR-CLIP	22012620
MIRT483057	hsa-miR-3163	PAR-CLIP	23592263
MIRT483056	hsa-miR-95-5p	PAR-CLIP	23592263
MIRT483055	hsa-miR-4446-5p	PAR-CLIP	23592263

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001655	Process	Urogenital system development	IEA
GO:0001756	Process	Somitogenesis	IEA
GO:0001756	Process	Somitogenesis	ISS
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007412	Process	Axon target recognition	IEA
GO:0007412	Process	Axon target recognition	ISS
GO:0007595	Process	Lactation	IEA
GO:0007595	Process	Lactation	ISS
GO:0008542	Process	Visual learning	IEA
GO:0008542	Process	Visual learning	ISS
GO:0009653	Process	Anatomical structure morphogenesis	IBA
GO:0021510	Process	Spinal cord development	IEA
GO:0021767	Process	Mammillary body development	IEA
GO:0021767	Process	Mammillary body development	ISS
GO:0021794	Process	Thalamus development	IEA
GO:0021855	Process	Hypothalamus cell migration	IEA
GO:0021855	Process	Hypothalamus cell migration	ISS
GO:0022029	Process	Telencephalon cell migration	IEA
GO:0022029	Process	Telencephalon cell migration	ISS
GO:0030154	Process	Cell differentiation	IBA
GO:0030901	Process	Midbrain development	IEA
GO:0030901	Process	Midbrain development	ISS
GO:0033504	Process	Floor plate development	IEA
GO:0033504	Process	Floor plate development	ISS
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	ISS
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	ISS
GO:0061030	Process	Epithelial cell differentiation involved in mammary gland alveolus development	IEA
GO:0061030	Process	Epithelial cell differentiation involved in mammary gland alveolus development	ISS
GO:0061374	Process	Mammillothalamic axonal tract development	IEA
GO:0061374	Process	Mammillothalamic axonal tract development	ISS
GO:0061377	Process	Mammary gland lobule development	IEA
GO:0061377	Process	Mammary gland lobule development	ISS
GO:0061379	Process	Inferior colliculus development	IEA
GO:0061379	Process	Inferior colliculus development	ISS
GO:0061381	Process	Cell migration in diencephalon	IEA
GO:0061381	Process	Cell migration in diencephalon	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
619961	3799	ENSG00000171956

Q99853

Protein name

Forkhead box protein B1 (Transcription factor FKH-5)

Protein function

Transcription factor expressed by neural progenitor cells in specific regions of the embryonic neuroepithelium. Essential for the mammillary nuclei maintenance. Negatively regulates the proliferation of oligodendrocyte progenitors and promotes o

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00250	Forkhead	12 → 98	Forkhead domain	Domain

Sequence

MPRPGRNTYSDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQRWQNS
LRHNLSFNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSFLRRRKRFKVLKSDHLAPS
KPADAAQYLQQQAKLRLSALAASGTHLPQMPAAAYNLGGVAQPSGFKHPFAIENIIAREY
KMPGGLAFSAMQPVPAAYPLPNQLTTMGSSLGTGWPHVYGSAGMIDSATPISMASGDYSA
YGVPLKPLCHAAGQTLPAIPVPIKPTPAAVPALPALPAPIPTLLSNSPPSLSPTSSQTAT
SQSSPATPSETLTSPASALHSVAVH

Sequence length

325

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma	Asthma	Pubtator	26635092	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood asthma	Asthma	BEFREE	26635092		★★★★★ ★☆☆☆☆ Found in Text Mining only

FOXB1 (forkhead box B1)