SEC22A (SEC22 homolog A, vesicle trafficking protein)

Gene

• Entrez ID: 26984
• Gene name: SEC22 homolog A, vesicle trafficking protein
• Gene symbol: SEC22A
• Synonyms (NCBI Gene): SEC22L2
• Chromosome: 3
• Chromosome location: 3q21.1
• Summary: The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029213	hsa-miR-26b-5p	Microarray	19088304
MIRT1332502	hsa-miR-124	CLIP-seq
MIRT1332503	hsa-miR-1245	CLIP-seq
MIRT1332504	hsa-miR-1254	CLIP-seq
MIRT1332505	hsa-miR-1267	CLIP-seq
MIRT1332506	hsa-miR-1276	CLIP-seq
MIRT1332507	hsa-miR-1279	CLIP-seq
MIRT1332508	hsa-miR-129-5p	CLIP-seq
MIRT1332509	hsa-miR-140-3p	CLIP-seq
MIRT1332510	hsa-miR-24	CLIP-seq
MIRT1332511	hsa-miR-3064-3p	CLIP-seq
MIRT1332512	hsa-miR-3116	CLIP-seq
MIRT1332513	hsa-miR-3122	CLIP-seq
MIRT1332514	hsa-miR-3135b	CLIP-seq
MIRT1332515	hsa-miR-3153	CLIP-seq
MIRT1332516	hsa-miR-3187-3p	CLIP-seq
MIRT1332517	hsa-miR-3199	CLIP-seq
MIRT1332518	hsa-miR-337-5p	CLIP-seq
MIRT1332519	hsa-miR-3622a-5p	CLIP-seq
MIRT1332520	hsa-miR-3652	CLIP-seq
MIRT1332521	hsa-miR-3663-5p	CLIP-seq
MIRT1332522	hsa-miR-3672	CLIP-seq
MIRT1332523	hsa-miR-3674	CLIP-seq
MIRT1332524	hsa-miR-371-5p	CLIP-seq
MIRT1332525	hsa-miR-371b-5p	CLIP-seq
MIRT1332526	hsa-miR-3913-5p	CLIP-seq
MIRT1332527	hsa-miR-3939	CLIP-seq
MIRT1332528	hsa-miR-3942-5p	CLIP-seq
MIRT1332529	hsa-miR-4261	CLIP-seq
MIRT1332530	hsa-miR-4284	CLIP-seq
MIRT1332531	hsa-miR-4326	CLIP-seq
MIRT1332532	hsa-miR-4430	CLIP-seq
MIRT1332533	hsa-miR-4435	CLIP-seq
MIRT1332534	hsa-miR-4436a	CLIP-seq
MIRT1332535	hsa-miR-4476	CLIP-seq
MIRT1332536	hsa-miR-4484	CLIP-seq
MIRT1332537	hsa-miR-4509	CLIP-seq
MIRT1332538	hsa-miR-4533	CLIP-seq
MIRT1332539	hsa-miR-4539	CLIP-seq
MIRT1332540	hsa-miR-4668-5p	CLIP-seq
MIRT1332541	hsa-miR-4670-3p	CLIP-seq
MIRT1332542	hsa-miR-4680-5p	CLIP-seq
MIRT1332543	hsa-miR-4691-5p	CLIP-seq
MIRT1332544	hsa-miR-4699-5p	CLIP-seq
MIRT1332545	hsa-miR-4701-5p	CLIP-seq
MIRT1332546	hsa-miR-4703-5p	CLIP-seq
MIRT1332547	hsa-miR-4732-5p	CLIP-seq
MIRT1332548	hsa-miR-4755-3p	CLIP-seq
MIRT1332549	hsa-miR-4797-5p	CLIP-seq
MIRT1332550	hsa-miR-506	CLIP-seq
MIRT1332551	hsa-miR-510	CLIP-seq
MIRT1332552	hsa-miR-513c	CLIP-seq
MIRT1332553	hsa-miR-514b-5p	CLIP-seq
MIRT1332554	hsa-miR-548an	CLIP-seq
MIRT1332555	hsa-miR-548s	CLIP-seq
MIRT1332556	hsa-miR-588	CLIP-seq
MIRT1332557	hsa-miR-606	CLIP-seq
MIRT1332558	hsa-miR-607	CLIP-seq
MIRT1332559	hsa-miR-648	CLIP-seq
MIRT1332560	hsa-miR-661	CLIP-seq
MIRT1332561	hsa-miR-720	CLIP-seq
MIRT1332562	hsa-miR-873	CLIP-seq
MIRT2098371	hsa-miR-1178	CLIP-seq
MIRT2098372	hsa-miR-200b	CLIP-seq
MIRT2098373	hsa-miR-200c	CLIP-seq
MIRT1332514	hsa-miR-3135b	CLIP-seq
MIRT1332516	hsa-miR-3187-3p	CLIP-seq
MIRT1332520	hsa-miR-3652	CLIP-seq
MIRT2098374	hsa-miR-4269	CLIP-seq
MIRT2098375	hsa-miR-429	CLIP-seq
MIRT1332532	hsa-miR-4430	CLIP-seq
MIRT1332533	hsa-miR-4435	CLIP-seq
MIRT1332545	hsa-miR-4701-5p	CLIP-seq
MIRT2098376	hsa-miR-4728-3p	CLIP-seq
MIRT1332548	hsa-miR-4755-3p	CLIP-seq
MIRT2098377	hsa-miR-513a-3p	CLIP-seq
MIRT2098378	hsa-miR-513a-5p	CLIP-seq
MIRT1332555	hsa-miR-548s	CLIP-seq
MIRT1332556	hsa-miR-588	CLIP-seq
MIRT2323010	hsa-miR-106a	CLIP-seq
MIRT2323011	hsa-miR-106b	CLIP-seq
MIRT2323012	hsa-miR-1228	CLIP-seq
MIRT2323013	hsa-miR-1234	CLIP-seq
MIRT1332506	hsa-miR-1276	CLIP-seq
MIRT2323014	hsa-miR-128	CLIP-seq
MIRT2323015	hsa-miR-1288	CLIP-seq
MIRT2323016	hsa-miR-1307	CLIP-seq
MIRT2323017	hsa-miR-1343	CLIP-seq
MIRT2323018	hsa-miR-148a	CLIP-seq
MIRT2323019	hsa-miR-148b	CLIP-seq
MIRT2323020	hsa-miR-150	CLIP-seq
MIRT2323021	hsa-miR-152	CLIP-seq
MIRT2323022	hsa-miR-17	CLIP-seq
MIRT2323023	hsa-miR-190	CLIP-seq
MIRT2323024	hsa-miR-190b	CLIP-seq
MIRT2323025	hsa-miR-19a	CLIP-seq
MIRT2323026	hsa-miR-19b	CLIP-seq
MIRT2323027	hsa-miR-20a	CLIP-seq
MIRT2323028	hsa-miR-20b	CLIP-seq
MIRT2323029	hsa-miR-27a	CLIP-seq
MIRT2323030	hsa-miR-27b	CLIP-seq
MIRT2323031	hsa-miR-302a	CLIP-seq
MIRT2323032	hsa-miR-302b	CLIP-seq
MIRT2323033	hsa-miR-302c	CLIP-seq
MIRT2323034	hsa-miR-302d	CLIP-seq
MIRT2323035	hsa-miR-302e	CLIP-seq
MIRT2323036	hsa-miR-3169	CLIP-seq
MIRT1332517	hsa-miR-3199	CLIP-seq
MIRT2323037	hsa-miR-340	CLIP-seq
MIRT2323038	hsa-miR-372	CLIP-seq
MIRT2323039	hsa-miR-373	CLIP-seq
MIRT2323040	hsa-miR-377	CLIP-seq
MIRT2323041	hsa-miR-3926	CLIP-seq
MIRT2323042	hsa-miR-4421	CLIP-seq
MIRT1332534	hsa-miR-4436a	CLIP-seq
MIRT2323043	hsa-miR-4438	CLIP-seq
MIRT1332536	hsa-miR-4484	CLIP-seq
MIRT1332537	hsa-miR-4509	CLIP-seq
MIRT2323044	hsa-miR-4638-5p	CLIP-seq
MIRT2323045	hsa-miR-4650-5p	CLIP-seq
MIRT2323046	hsa-miR-4731-5p	CLIP-seq
MIRT2323047	hsa-miR-4778-3p	CLIP-seq
MIRT2323048	hsa-miR-498	CLIP-seq
MIRT2323049	hsa-miR-5095	CLIP-seq
MIRT2323050	hsa-miR-512-3p	CLIP-seq
MIRT2323051	hsa-miR-519d	CLIP-seq
MIRT2323052	hsa-miR-520a-3p	CLIP-seq
MIRT2323053	hsa-miR-520a-5p	CLIP-seq
MIRT2323054	hsa-miR-520b	CLIP-seq
MIRT2323055	hsa-miR-520c-3p	CLIP-seq
MIRT2323056	hsa-miR-520d-3p	CLIP-seq
MIRT2323057	hsa-miR-520e	CLIP-seq
MIRT2323058	hsa-miR-520g	CLIP-seq
MIRT2323059	hsa-miR-520h	CLIP-seq
MIRT2323060	hsa-miR-525-5p	CLIP-seq
MIRT1332554	hsa-miR-548an	CLIP-seq
MIRT1332555	hsa-miR-548s	CLIP-seq
MIRT2323061	hsa-miR-587	CLIP-seq
MIRT2323062	hsa-miR-595	CLIP-seq
MIRT2323063	hsa-miR-617	CLIP-seq
MIRT1332559	hsa-miR-648	CLIP-seq
MIRT2323064	hsa-miR-93	CLIP-seq
MIRT2323065	hsa-miR-943	CLIP-seq
MIRT2394150	hsa-miR-125a-3p	CLIP-seq
MIRT2323014	hsa-miR-128	CLIP-seq
MIRT2323029	hsa-miR-27a	CLIP-seq
MIRT2323030	hsa-miR-27b	CLIP-seq
MIRT2394151	hsa-miR-3934	CLIP-seq
MIRT2394152	hsa-miR-4659a-3p	CLIP-seq
MIRT2394153	hsa-miR-4659b-3p	CLIP-seq
MIRT2323047	hsa-miR-4778-3p	CLIP-seq
MIRT2394154	hsa-miR-499-3p	CLIP-seq
MIRT2394155	hsa-miR-499a-3p	CLIP-seq
MIRT2394156	hsa-miR-764	CLIP-seq
MIRT1332505	hsa-miR-1267	CLIP-seq
MIRT2323017	hsa-miR-1343	CLIP-seq
MIRT1332516	hsa-miR-3187-3p	CLIP-seq
MIRT1332520	hsa-miR-3652	CLIP-seq
MIRT1332532	hsa-miR-4430	CLIP-seq
MIRT1332533	hsa-miR-4435	CLIP-seq
MIRT1332545	hsa-miR-4701-5p	CLIP-seq
MIRT1332548	hsa-miR-4755-3p	CLIP-seq
MIRT1332549	hsa-miR-4797-5p	CLIP-seq
MIRT2323048	hsa-miR-498	CLIP-seq
MIRT1332555	hsa-miR-548s	CLIP-seq
MIRT1332556	hsa-miR-588	CLIP-seq
MIRT1332561	hsa-miR-720	CLIP-seq
MIRT2618920	hsa-miR-1270	CLIP-seq
MIRT2323014	hsa-miR-128	CLIP-seq
MIRT2323017	hsa-miR-1343	CLIP-seq
MIRT2618921	hsa-miR-1470	CLIP-seq
MIRT2323018	hsa-miR-148a	CLIP-seq
MIRT2323019	hsa-miR-148b	CLIP-seq
MIRT2323021	hsa-miR-152	CLIP-seq
MIRT2618922	hsa-miR-185	CLIP-seq
MIRT2323023	hsa-miR-190	CLIP-seq
MIRT2323024	hsa-miR-190b	CLIP-seq
MIRT2618923	hsa-miR-2110	CLIP-seq
MIRT1332510	hsa-miR-24	CLIP-seq
MIRT2323029	hsa-miR-27a	CLIP-seq
MIRT2323030	hsa-miR-27b	CLIP-seq
MIRT1332514	hsa-miR-3135b	CLIP-seq
MIRT2618924	hsa-miR-3151	CLIP-seq
MIRT1332516	hsa-miR-3187-3p	CLIP-seq
MIRT1332517	hsa-miR-3199	CLIP-seq
MIRT2618925	hsa-miR-3614-5p	CLIP-seq
MIRT1332520	hsa-miR-3652	CLIP-seq
MIRT2618926	hsa-miR-3692	CLIP-seq
MIRT2618927	hsa-miR-4271	CLIP-seq
MIRT1332530	hsa-miR-4284	CLIP-seq
MIRT2618928	hsa-miR-4306	CLIP-seq
MIRT2618929	hsa-miR-432	CLIP-seq
MIRT1332532	hsa-miR-4430	CLIP-seq
MIRT1332533	hsa-miR-4435	CLIP-seq
MIRT2618930	hsa-miR-4436b-5p	CLIP-seq
MIRT2618931	hsa-miR-4447	CLIP-seq
MIRT2618932	hsa-miR-4472	CLIP-seq
MIRT2618933	hsa-miR-4531	CLIP-seq
MIRT2618934	hsa-miR-4644	CLIP-seq
MIRT2618935	hsa-miR-4667-3p	CLIP-seq
MIRT1332545	hsa-miR-4701-5p	CLIP-seq
MIRT2618936	hsa-miR-4725-3p	CLIP-seq
MIRT2098376	hsa-miR-4728-3p	CLIP-seq
MIRT1332548	hsa-miR-4755-3p	CLIP-seq
MIRT2323047	hsa-miR-4778-3p	CLIP-seq
MIRT2618937	hsa-miR-4786-3p	CLIP-seq
MIRT2618938	hsa-miR-491-5p	CLIP-seq
MIRT2323048	hsa-miR-498	CLIP-seq
MIRT1332555	hsa-miR-548s	CLIP-seq
MIRT2618939	hsa-miR-579	CLIP-seq
MIRT1332556	hsa-miR-588	CLIP-seq
MIRT2618940	hsa-miR-620	CLIP-seq
MIRT2618941	hsa-miR-642a	CLIP-seq
MIRT2618942	hsa-miR-664	CLIP-seq
MIRT2618943	hsa-miR-890	CLIP-seq
MIRT2618920	hsa-miR-1270	CLIP-seq
MIRT2323014	hsa-miR-128	CLIP-seq
MIRT2323017	hsa-miR-1343	CLIP-seq
MIRT2618921	hsa-miR-1470	CLIP-seq
MIRT2323018	hsa-miR-148a	CLIP-seq
MIRT2323019	hsa-miR-148b	CLIP-seq
MIRT2323021	hsa-miR-152	CLIP-seq
MIRT2618922	hsa-miR-185	CLIP-seq
MIRT2323023	hsa-miR-190	CLIP-seq
MIRT2323024	hsa-miR-190b	CLIP-seq
MIRT2618923	hsa-miR-2110	CLIP-seq
MIRT1332510	hsa-miR-24	CLIP-seq
MIRT2323029	hsa-miR-27a	CLIP-seq
MIRT2323030	hsa-miR-27b	CLIP-seq
MIRT1332514	hsa-miR-3135b	CLIP-seq
MIRT2618924	hsa-miR-3151	CLIP-seq
MIRT1332516	hsa-miR-3187-3p	CLIP-seq
MIRT2618925	hsa-miR-3614-5p	CLIP-seq
MIRT1332520	hsa-miR-3652	CLIP-seq
MIRT2618926	hsa-miR-3692	CLIP-seq
MIRT2618927	hsa-miR-4271	CLIP-seq
MIRT1332530	hsa-miR-4284	CLIP-seq
MIRT2618928	hsa-miR-4306	CLIP-seq
MIRT2618929	hsa-miR-432	CLIP-seq
MIRT1332532	hsa-miR-4430	CLIP-seq
MIRT1332533	hsa-miR-4435	CLIP-seq
MIRT2618930	hsa-miR-4436b-5p	CLIP-seq
MIRT2618931	hsa-miR-4447	CLIP-seq
MIRT2618932	hsa-miR-4472	CLIP-seq
MIRT2618933	hsa-miR-4531	CLIP-seq
MIRT2618934	hsa-miR-4644	CLIP-seq
MIRT2618935	hsa-miR-4667-3p	CLIP-seq
MIRT1332545	hsa-miR-4701-5p	CLIP-seq
MIRT2618936	hsa-miR-4725-3p	CLIP-seq
MIRT2098376	hsa-miR-4728-3p	CLIP-seq
MIRT1332548	hsa-miR-4755-3p	CLIP-seq
MIRT2323047	hsa-miR-4778-3p	CLIP-seq
MIRT2618938	hsa-miR-491-5p	CLIP-seq
MIRT2323048	hsa-miR-498	CLIP-seq
MIRT1332555	hsa-miR-548s	CLIP-seq
MIRT1332556	hsa-miR-588	CLIP-seq
MIRT2618940	hsa-miR-620	CLIP-seq
MIRT2618941	hsa-miR-642a	CLIP-seq
MIRT2618943	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005484	Function	SNAP receptor activity	ISS
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS	8621431
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS	8621431
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0061025	Process	Membrane fusion	IEA

Other IDs

• MIM: 612442
• HGNC: 20260
• e!Ensembl: ENSG00000121542

Protein

• UniProt ID: Q96IW7
• Protein name: Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2)
• Protein function: May be involved in vesicle transport between the ER and the Golgi complex.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13774	Longin	37 → 117	Regulated-SNARE-like domain	Domain

• Sequence:

  MSMILSASVIRVRDGLPLSASTDYEQSTGMQECRKYFKMLSRKLAQLPDRCTLKTGHYNI
  NFISSLGVSYMMLCTENYPNVLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQ
  RTKQRYNNPRSLSTKINLSDMQTEIKLRPPYQISMCELGSANGVTSAFSVDCKGAGKISS
  AHQRLEPATLSGIVGFILSLLCGALNLIRGFHAIESLLQSDGDDFNYIIAFFLGTAACLY
  QCYLLVYYTGWRNVKSFLTFGLICLCNMYLYELRNLWQLFFHVTVGAFVTLQIWLRQAQG
  KAPDYDV

• Sequence length: 307

Pathways

Reactome:

COPII-mediated vesicle transport

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Parkinson Disease	Parkinson disease	BEFREE	30579794		★☆☆☆☆ Found in Text Mining only