Gene Gene information from NCBI Gene database.
Entrez ID 26973
Gene name Cysteine and histidine rich domain containing 1
Gene symbol CHORDC1
Synonyms (NCBI Gene)
CHP1
Chromosome 11
Chromosome location 11q14.3
miRNA miRNA information provided by mirtarbase database.
513
miRTarBase ID miRNA Experiments Reference
MIRT001472 hsa-miR-16-5p pSILAC 18668040
MIRT029651 hsa-miR-26b-5p Microarray 19088304
MIRT001472 hsa-miR-16-5p Proteomics;Other 18668040
MIRT029651 hsa-miR-26b-5p ImmunoblotLuciferase reporter assayqRT-PCR 25342750
MIRT029651 hsa-miR-26b-5p ImmunoblotLuciferase reporter assayqRT-PCR 25342750
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19875381, 20230755, 23414517, 25036637, 26496610, 32296183
GO:0005524 Function ATP binding IEA
GO:0006457 Process Protein folding ISS
GO:0008270 Function Zinc ion binding IBA
GO:0008270 Function Zinc ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604353 14525 ENSG00000110172
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UHD1
Protein name Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)
Protein function Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed
PDB 2YRT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04968 CHORD 3 64 CHORD Family
PF04968 CHORD 155 216 CHORD Family
PF04969 CS 230 306 CS domain Domain
Tissue specificity TISSUE SPECIFICITY: Underexpressed in many breast and lung cancers. {ECO:0000269|PubMed:20230755}.
Sequence
Sequence length 332
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute monocytic leukemia Monocytic Leukemia BEFREE 28871137
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 6090008, 6331549
★☆☆☆☆
Found in Text Mining only
Alport Syndrome Alport Syndrome BEFREE 12819239
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 32397415 Inhibit
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 8027338
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 10700443 Associate
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism BEFREE 3864386
★☆☆☆☆
Found in Text Mining only
Biliary Atresia Biliary Atresia BEFREE 26379158
★☆☆☆☆
Found in Text Mining only
Bone Marrow Diseases Bone Marrow Diseases BEFREE 1537894
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 29158506
★☆☆☆☆
Found in Text Mining only