Gene Gene information from NCBI Gene database.
Entrez ID 26959
Gene name HMG-box transcription factor 1
Gene symbol HBP1
Synonyms (NCBI Gene)
-
Chromosome 7
Chromosome location 7q22.3
miRNA miRNA information provided by mirtarbase database.
648
miRTarBase ID miRNA Experiments Reference
MIRT018624 hsa-miR-335-5p Microarray 18185580
MIRT020927 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT031302 hsa-miR-19b-3p Sequencing 20371350
MIRT031371 hsa-miR-17-5p Reporter assay 20505989
MIRT035539 hsa-miR-29a-3p Luciferase reporter assay 23541945
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
RB1 Unknown 16966377
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0003677 Function DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616714 23200 ENSG00000105856
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60381
Protein name HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1)
Protein function Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter i
PDB 2E6O , 3QVE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08517 AXH 215 339 Ataxin-1 and HBP1 module (AXH) Family
PF00505 HMG_box 434 501 HMG (high mobility group) box Domain
Sequence
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLP
ELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATS
PQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER
ANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARA
EGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDH
PFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGH
PDAINFDDSGVFDTFKSYDFT
PMDSSAVYVLSSMARQRRASLSCGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKN
HSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEER
RMYTLEAKALAEEQKRLNPDC
WKRKRTNSGSQQH
Sequence length 514
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COG5 CONGENITAL DISORDER OF GLYCOSYLATION Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONGENITAL DISORDERS OF GLYCOSYLATION Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arteriosclerosis Arteriosclerosis BEFREE 24675724
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 24675724
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 35795669 Associate
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 28719732
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 17616670, 20505989
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 16495219, 16966377, 20008325, 34990474, 37414199 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 24895061 Inhibit
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 28099936 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 29367693
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 37406020 Associate
★☆☆☆☆
Found in Text Mining only