Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2686
Gene name	Gamma-glutamyltransferase 7
Gene symbol	GGT7
Synonyms (NCBI Gene)	D20S101GGT4GGTL3GGTL5
Chromosome	20
Chromosome location	20q11.22
Summary	This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the

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Show/Hide all (213)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043545	hsa-miR-331-3p	CLASH	23622248
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT626195	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT626194	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT626195	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT626194	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	28735896
MIRT611133	hsa-miR-197-3p	HITS-CLIP	28735896
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	28735896
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	28735896
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT626195	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT626194	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT626195	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT626194	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT614189	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611136	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT611135	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT611134	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT611133	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT1018337	hsa-miR-1183	CLIP-seq
MIRT1018338	hsa-miR-1254	CLIP-seq
MIRT1018339	hsa-miR-1292	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq
MIRT1018341	hsa-miR-3064-5p	CLIP-seq
MIRT1018342	hsa-miR-3116	CLIP-seq
MIRT1018343	hsa-miR-3117-5p	CLIP-seq
MIRT1018344	hsa-miR-3126-5p	CLIP-seq
MIRT1018345	hsa-miR-3173-3p	CLIP-seq
MIRT1018346	hsa-miR-3192	CLIP-seq
MIRT1018347	hsa-miR-326	CLIP-seq
MIRT1018348	hsa-miR-330-5p	CLIP-seq
MIRT1018349	hsa-miR-3935	CLIP-seq
MIRT1018350	hsa-miR-4314	CLIP-seq
MIRT1018351	hsa-miR-4471	CLIP-seq
MIRT1018352	hsa-miR-4522	CLIP-seq
MIRT1018353	hsa-miR-4646-5p	CLIP-seq
MIRT1018354	hsa-miR-4687-3p	CLIP-seq
MIRT1018355	hsa-miR-4718	CLIP-seq
MIRT1018356	hsa-miR-4728-3p	CLIP-seq
MIRT1018357	hsa-miR-4779	CLIP-seq
MIRT1018358	hsa-miR-628-5p	CLIP-seq
MIRT1018359	hsa-miR-661	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq
MIRT1018346	hsa-miR-3192	CLIP-seq
MIRT1018347	hsa-miR-326	CLIP-seq
MIRT1018348	hsa-miR-330-5p	CLIP-seq
MIRT1018350	hsa-miR-4314	CLIP-seq
MIRT1018353	hsa-miR-4646-5p	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq
MIRT1018340	hsa-miR-197	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12270127, 25416956, 25910212, 31515488, 32296183, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12270127
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0006750	Process	Glutathione biosynthetic process	IEA
GO:0006751	Process	Glutathione catabolic process	IBA
GO:0006751	Process	Glutathione catabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0036374	Function	Glutathione hydrolase activity	IBA
GO:0036374	Function	Glutathione hydrolase activity	IEA
GO:0103068	Function	Leukotriene C4 gamma-glutamyl transferase activity	IEA
GO:1901750	Process	Leukotriene D4 biosynthetic process	ISS
GO:1902883	Process	Negative regulation of response to oxidative stress	IMP	25884624

MIM	HGNC	e!Ensembl
612342	4259	ENSG00000131067

Q9UJ14

Protein name

Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltransferase-like 5) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathion

Protein function

Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01019	G_glu_transpept	154 → 655		Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.

Sequence

MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDS
FLKSARLQRLPSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFATG
VTVALVMQIYFGDPQIFQQGAVVTDAARCTSLGIEVLSKQGSSVDAAVAAALCLGIVAPH
SSGLGGGGVMLVHDIRRNESHLIDFRESAPGALREETLQRSWETKPGLLVGVPGMVKGLH
EAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARALAEQLPPNMSERFRETFLPSGRPPL
PGSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVITEEDFSNYSALVEK
PVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAETLKIALALAS
RLGDPVYDSTITESMDDMLSKVEAAYLRGHINDSQAAPAPLLPVYELDGAPTAAQVLIMG
PDDFIVAMVSSLNQPFGSGLITPSGILLNSQMLDFSWPNRTANHSAPSLENSVQPGKRPL
SFLLPTVVRPAEGLCGTYLALGANGAARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDL
QSNLLQVDSEFTEEEIEFLEARGHHVEKVDVLSWVHGSRRTNNFIIAVKDPRSPDAAGAT
IL

Sequence length

662

Interactions

View interactions

	KEGG		Reactome
	Taurine and hypotaurine metabolism Glutathione metabolism Metabolic pathways		Glutathione synthesis and recycling Aflatoxin activation and detoxification

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	29212778		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma	Glioblastoma	BEFREE	25884624		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	25884624		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25884624		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	27856519	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GGT7 (gamma-glutamyltransferase 7)