Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	2671
Gene name	Growth factor, augmenter of liver regeneration
Gene symbol	GFER
Synonyms (NCBI Gene)	ALRERV1HERV1HPOHPO1HPO2HSSMMCHDMPMCD
Chromosome	16
Chromosome location	16p13.3
Summary	The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (H

151

Show/Hide all (151)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040937	hsa-miR-18a-3p	CLASH	23622248
MIRT037615	hsa-miR-744-5p	CLASH	23622248
MIRT495336	hsa-miR-4511	PAR-CLIP	23708386
MIRT495335	hsa-miR-331-3p	PAR-CLIP	23708386
MIRT495334	hsa-miR-4258	PAR-CLIP	23708386
MIRT495333	hsa-miR-519d-5p	PAR-CLIP	23708386
MIRT495332	hsa-miR-149-5p	PAR-CLIP	23708386
MIRT491335	hsa-miR-9500	PAR-CLIP	23592263
MIRT491334	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT491333	hsa-miR-6786-5p	PAR-CLIP	23592263
MIRT491332	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT491331	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT491330	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT491328	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT491329	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT491327	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT491326	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT491325	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT491324	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT491323	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT491322	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT491321	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT491320	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT491319	hsa-miR-4447	PAR-CLIP	23592263
MIRT491318	hsa-miR-4472	PAR-CLIP	23592263
MIRT491316	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT495336	hsa-miR-4511	PAR-CLIP	23708386
MIRT495335	hsa-miR-331-3p	PAR-CLIP	23708386
MIRT495334	hsa-miR-4258	PAR-CLIP	23708386
MIRT495333	hsa-miR-519d-5p	PAR-CLIP	23708386
MIRT495332	hsa-miR-149-5p	PAR-CLIP	23708386
MIRT491335	hsa-miR-9500	PAR-CLIP	23592263
MIRT491334	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT491333	hsa-miR-6786-5p	PAR-CLIP	23592263
MIRT491332	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT491331	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT491330	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT491328	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT491329	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT491327	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT491326	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT491325	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT491324	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT491323	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT491322	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT491321	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT491320	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT491319	hsa-miR-4447	PAR-CLIP	23592263
MIRT491318	hsa-miR-4472	PAR-CLIP	23592263
MIRT491316	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT1016581	hsa-miR-106a	CLIP-seq
MIRT1016582	hsa-miR-106b	CLIP-seq
MIRT1016583	hsa-miR-1225-3p	CLIP-seq
MIRT1016584	hsa-miR-1233	CLIP-seq
MIRT1016585	hsa-miR-124	CLIP-seq
MIRT1016586	hsa-miR-17	CLIP-seq
MIRT1016587	hsa-miR-20a	CLIP-seq
MIRT1016588	hsa-miR-20b	CLIP-seq
MIRT1016589	hsa-miR-3138	CLIP-seq
MIRT1016590	hsa-miR-3199	CLIP-seq
MIRT1016591	hsa-miR-339-5p	CLIP-seq
MIRT1016592	hsa-miR-3609	CLIP-seq
MIRT1016593	hsa-miR-3714	CLIP-seq
MIRT1016594	hsa-miR-3910	CLIP-seq
MIRT1016595	hsa-miR-3943	CLIP-seq
MIRT1016596	hsa-miR-425	CLIP-seq
MIRT1016597	hsa-miR-4263	CLIP-seq
MIRT1016598	hsa-miR-4313	CLIP-seq
MIRT1016599	hsa-miR-4434	CLIP-seq
MIRT1016600	hsa-miR-4468	CLIP-seq
MIRT1016601	hsa-miR-4516	CLIP-seq
MIRT1016602	hsa-miR-4520a-3p	CLIP-seq
MIRT1016603	hsa-miR-4521	CLIP-seq
MIRT1016604	hsa-miR-4531	CLIP-seq
MIRT1016605	hsa-miR-4670-3p	CLIP-seq
MIRT1016606	hsa-miR-4740-5p	CLIP-seq
MIRT1016607	hsa-miR-4796-3p	CLIP-seq
MIRT1016608	hsa-miR-4800-5p	CLIP-seq
MIRT1016609	hsa-miR-506	CLIP-seq
MIRT1016610	hsa-miR-519d	CLIP-seq
MIRT1016611	hsa-miR-520g	CLIP-seq
MIRT1016612	hsa-miR-520h	CLIP-seq
MIRT1016613	hsa-miR-548ah	CLIP-seq
MIRT1016614	hsa-miR-642b	CLIP-seq
MIRT1016615	hsa-miR-670	CLIP-seq
MIRT1016616	hsa-miR-759	CLIP-seq
MIRT1016617	hsa-miR-93	CLIP-seq
MIRT2000907	hsa-miR-1227	CLIP-seq
MIRT2000908	hsa-miR-146b-3p	CLIP-seq
MIRT2000909	hsa-miR-149	CLIP-seq
MIRT2000910	hsa-miR-1913	CLIP-seq
MIRT2000911	hsa-miR-3064-5p	CLIP-seq
MIRT2000912	hsa-miR-3173-5p	CLIP-seq
MIRT2000913	hsa-miR-3197	CLIP-seq
MIRT2000914	hsa-miR-324-3p	CLIP-seq
MIRT2000915	hsa-miR-371b-3p	CLIP-seq
MIRT2000916	hsa-miR-4270	CLIP-seq
MIRT2000917	hsa-miR-4286	CLIP-seq
MIRT2000918	hsa-miR-4316	CLIP-seq
MIRT2000919	hsa-miR-4325	CLIP-seq
MIRT2000920	hsa-miR-4441	CLIP-seq
MIRT2000921	hsa-miR-4514	CLIP-seq
MIRT2000922	hsa-miR-455-5p	CLIP-seq
MIRT2000923	hsa-miR-4645-5p	CLIP-seq
MIRT2000924	hsa-miR-4673	CLIP-seq
MIRT2000925	hsa-miR-4679	CLIP-seq
MIRT2000926	hsa-miR-4691-5p	CLIP-seq
MIRT2000927	hsa-miR-4692	CLIP-seq
MIRT2000928	hsa-miR-4707-5p	CLIP-seq
MIRT2000929	hsa-miR-4755-3p	CLIP-seq
MIRT2000930	hsa-miR-4794	CLIP-seq
MIRT2000931	hsa-miR-516a-3p	CLIP-seq
MIRT2000932	hsa-miR-541	CLIP-seq
MIRT2000933	hsa-miR-654-5p	CLIP-seq
MIRT2000934	hsa-miR-874	CLIP-seq
MIRT2000935	hsa-miR-940	CLIP-seq
MIRT2234321	hsa-miR-1200	CLIP-seq
MIRT2234322	hsa-miR-1208	CLIP-seq
MIRT2234323	hsa-miR-1225-5p	CLIP-seq
MIRT2000909	hsa-miR-149	CLIP-seq
MIRT2234324	hsa-miR-1587	CLIP-seq
MIRT2234325	hsa-miR-1976	CLIP-seq
MIRT2000911	hsa-miR-3064-5p	CLIP-seq
MIRT2234326	hsa-miR-3150b-3p	CLIP-seq
MIRT2234327	hsa-miR-3194-3p	CLIP-seq
MIRT2234328	hsa-miR-320e	CLIP-seq
MIRT2234329	hsa-miR-3652	CLIP-seq
MIRT2234330	hsa-miR-378g	CLIP-seq
MIRT2234331	hsa-miR-3914	CLIP-seq
MIRT2234332	hsa-miR-3915	CLIP-seq
MIRT2234333	hsa-miR-3928	CLIP-seq
MIRT2234334	hsa-miR-4324	CLIP-seq
MIRT2234335	hsa-miR-4430	CLIP-seq
MIRT2234336	hsa-miR-4492	CLIP-seq
MIRT2234337	hsa-miR-4498	CLIP-seq
MIRT2234338	hsa-miR-4505	CLIP-seq
MIRT2000921	hsa-miR-4514	CLIP-seq
MIRT2234339	hsa-miR-4640-5p	CLIP-seq
MIRT2234340	hsa-miR-4656	CLIP-seq
MIRT2234341	hsa-miR-4675	CLIP-seq
MIRT2234342	hsa-miR-4689	CLIP-seq
MIRT2000927	hsa-miR-4692	CLIP-seq
MIRT2234343	hsa-miR-4726-5p	CLIP-seq
MIRT2234344	hsa-miR-4731-5p	CLIP-seq
MIRT2234345	hsa-miR-4736	CLIP-seq
MIRT2234346	hsa-miR-4741	CLIP-seq
MIRT2234347	hsa-miR-4779	CLIP-seq
MIRT2234348	hsa-miR-4784	CLIP-seq
MIRT2000930	hsa-miR-4794	CLIP-seq
MIRT2234349	hsa-miR-544b	CLIP-seq
MIRT2234350	hsa-miR-762	CLIP-seq

Show/Hide all (5)

Transcription factor	Regulation	Reference
CEBPB	Repression	20690902
CEBPB	Unknown	20382118
FOXA2	Unknown	20382118
HNF4A	Repression	18513187
SP1	Activation	18513187

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001889	Process	Liver development	IBA
GO:0005515	Function	Protein binding	IPI	12681488, 23676665, 25416956, 32353859, 33060197, 36217030
GO:0005576	Component	Extracellular region	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	23676665
GO:0005739	Component	Mitochondrion	IEA
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0005829	Component	Cytosol	IDA
GO:0007165	Process	Signal transduction	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0015035	Function	Protein-disulfide reductase activity	IDA	22224850
GO:0015035	Function	Protein-disulfide reductase activity	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016971	Function	Flavin-dependent sulfhydryl oxidase activity	IBA
GO:0016971	Function	Flavin-dependent sulfhydryl oxidase activity	IEA
GO:0016972	Function	Thiol oxidase activity	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA
GO:0050660	Function	Flavin adenine dinucleotide binding	IDA	22224850
GO:0160203	Process	Mitochondrial disulfide relay system	IDA	21383138

MIM	HGNC	e!Ensembl
600924	4236	ENSG00000127554

P55789

Protein name

FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) (hERV1) (Hepatopoietin)

Protein function

[Isoform 1]: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of

PDB

3MBG , 3O55 , 3TK0 , 3U2L , 3U2M , 3U5S , 4LDK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04777	Evr1_Alr	104 → 196	Erv1 / Alr family	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. {ECO:0000269|PubMed:19409522}.

Sequence

MAAPGERGRFHGGNLFFLPGGARSEMMDDLATDARGRGAGRRDAAASASTPAQAPTSDSP
VAEDASRRRPCRACVDFKTWMRTQQKRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDL
PTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRACFTQWLCHLHNEVNRK
LGKPDFDCSKVDERWRDGWKDGSCD

Sequence length

205

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome	Pathogenic; Likely pathogenic	rs1363034255, rs121908192, rs373135339, rs1555486560, rs1597063051, rs1597063303	RCV001542783 RCV000009228 RCV003479177 RCV000679993 RCV000824904 RCV000824905 View all (1 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CONGENITAL CATARACT, PROGRESSIVE MUSCULAR HYPOTONIA, HEARING LOSS, DEVELOPMENTAL DELAY SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GFER-related disorder	Conflicting classifications of pathogenicity; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY FAILURE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY FAILURE, ACUTE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER FAILURE, ACUTE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial disease	Conflicting classifications of pathogenicity; Uncertain significance	ClinVar ClinGen, GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
MITOCHONDRIAL DISEASES	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (99)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Kidney Insufficiency	Acute Kidney Insufficiency	CTD_human_DG	20030531		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	29048676		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute pancreatitis	Pancreatitis	BEFREE	29511434		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Hodgkin Lymphoma	Hodgkin Lymphoma	BEFREE	30764825		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	32779864	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	30031384		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anorexia Nervosa	Anorexia	BEFREE	29261731		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	29739755		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	3515562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	29739755		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	28679751		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blepharoptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	18227151, 21878642	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	30296076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	28701670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	19409522	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	15982324		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cirrhosis	Cirrhosis	BEFREE	15982324		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	25778301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36181326	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome	Congenital Cataract-Progressive Muscular Hypotonia-Hearing Loss-Developmental Delay Syndrome	Orphanet			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Congenital diaphragmatic hernia	Congenital diaphragmatic hernia	BEFREE	31345115		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cytochrome c Oxidase Deficiency	Cytochrome c oxidase deficiency	Pubtator	19409522	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	28258830, 30031384, 30081183, 30234618		★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	19409522	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	19120287, 27705028, 27835059		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	19120287, 25722213, 27705028, 27835059		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	27994073	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	19120287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	27705028, 28495421		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Ketoacidosis	Diabetic Ketoacidosis	BEFREE	30026816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	20424224, 25722213, 26580232, 27835059, 31777552		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eosinophilic esophagitis	Eosinophilia	BEFREE	31498177		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	31427480		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	28704337, 29323715, 30540918		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	28877220		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	22033404, 30251695, 31166951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	28876364		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic neoplasm	Pubtator	30408048	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hermaphroditism	Hermaphroditism	BEFREE	29950505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	30764825		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	28993702		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	28155230		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kearns-Sayre syndrome	Kearns Sayre Syndrome	BEFREE	30280217		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure, Acute	Kidney Failure	CTD_human_DG	20030531		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Kidney Failure, Acute	Kidney Failure	BEFREE	20332418, 25633409, 30680481, 30993878, 31822044		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Kidney Neoplasms	Kidney neoplasm	Pubtator	32025001	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	32416059	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	15982324, 19502170, 20943458, 21152698, 25778301, 28825695, 29633440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	15982324, 25778301, 28061452		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	LHGDN	15982324		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	BEFREE	20943458, 29633440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure, Acute	Liver failure	CTD_human_DG	15968720		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Liver Failure, Acute	Liver failure	BEFREE	20332418, 28061452		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung diseases	Lung Diseases	BEFREE	3515562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	BEFREE	29048676		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	30618870		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	30296076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15982324, 25778301, 26552699, 28668825, 28698145, 28825695, 31526056		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	25778301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial Diseases	BEFREE	19409522, 26018198		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial Diseases	Mitochondrial disease	Pubtator	19409522	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial Diseases	Mitochondrial Diseases	CLINVAR_DG	28812649		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial Encephalomyopathies	Mitochondrial encephalomyopathy	BEFREE	26018198		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Respiratory Chain Deficiencies	Mitochondrial Respiratory Chain Deficiencies	BEFREE	28155230		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	28876364		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy	Myopathy	BEFREE	20593814, 25269795		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy	Myopathy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay	Myopathy, Mitochondrial With Congenital Cataract, Hearing Loss, And Developmental Delay	BEFREE	19409522		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay	Myopathy, Mitochondrial With Congenital Cataract, Hearing Loss, And Developmental Delay	ORPHANET_DG	19409522		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay	Myopathy, Mitochondrial With Congenital Cataract, Hearing Loss, And Developmental Delay	GENOMICS_ENGLAND_DG	19409522, 27604308, 28155230		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay	Myopathy, Mitochondrial With Congenital Cataract, Hearing Loss, And Developmental Delay	CLINVAR_DG	19409522, 20593814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay	Myopathy, Mitochondrial With Congenital Cataract, Hearing Loss, And Developmental Delay	UNIPROT_DG	19409522, 20593814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay	Myopathy, Mitochondrial With Congenital Cataract, Hearing Loss, And Developmental Delay	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21152698, 25778301, 28668825		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegeneration with brain iron accumulation (NBIA)	Nephropathy with Pretibial Epidermolysis Bullosa and Deafness	BEFREE	21816641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	21816641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	27705028, 28993702		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29250102		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Nervous System Diseases	Nervous System Diseases	BEFREE	15277434, 28495421		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Neuropathy	Peripheral Neuropathy	BEFREE	15277434, 28495421		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peritoneal Fibrosis	Peritoneal Fibrosis	BEFREE	9845827		★★★★★ ★☆☆☆☆ Found in Text Mining only
POLYCYSTIC KIDNEY DISEASE 1	Polycystic kidney disease	BEFREE	8575761		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	29048676		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	29048676		★★★★★ ★☆☆☆☆ Found in Text Mining only
Progressive cataract	Cataract	BEFREE	20593814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Proliferative diabetic retinopathy	Proliferative Diabetic Retinopathy	BEFREE	25722213		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Rotary Nystagmus	Rotary nystagmus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Schwartz-Jampel Syndrome	Schwartz-Jampel Syndrome	BEFREE	31314143		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	BEFREE	21185929		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Spastic paraplegia 15 autosomal recessive	Spastic paraplegia	Pubtator	30081747	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	28704337, 29323715, 30540918		★★★★★ ★☆☆☆☆ Found in Text Mining only
Toxic Epidermal Necrolysis	Stevens-Johnson Syndrome	BEFREE	31314143		★★★★★ ★☆☆☆☆ Found in Text Mining only
Visceral myopathy familial external ophthalmoplegia	Visceral neuropathy	Pubtator	19772189	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GFER (growth factor, augmenter of liver regeneration)