Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	266977
Gene name	Adhesion G protein-coupled receptor F1
Gene symbol	ADGRF1
Synonyms (NCBI Gene)	GPR110KPG_012PGR19hGPCR36
Chromosome	6
Chromosome location	6p12.3\|6

Show/Hide all (90)

miRTarBase ID	miRNA	Experiments	Reference
MIRT740325	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT740326	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT740327	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT740328	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT740329	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT740330	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT740331	hsa-miR-5695	HITS-CLIP	19536157
MIRT740332	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT740333	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT740334	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT740335	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT740336	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT740337	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT740338	hsa-miR-642b-5p	HITS-CLIP	19536157
MIRT740325	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT740326	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT740327	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT740328	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT740329	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT740330	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT740331	hsa-miR-5695	HITS-CLIP	19536157
MIRT740332	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT740333	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT740334	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT740335	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT740336	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT740337	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT740338	hsa-miR-642b-5p	HITS-CLIP	19536157
MIRT740325	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT740326	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT740327	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT740328	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT740329	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT740330	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT740331	hsa-miR-5695	HITS-CLIP	19536157
MIRT740332	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT740333	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT740334	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT740335	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT740336	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT740337	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT740338	hsa-miR-642b-5p	HITS-CLIP	19536157
MIRT742039	hsa-miR-8485	HITS-CLIP	23824327
MIRT742040	hsa-miR-4317	HITS-CLIP	23824327
MIRT742041	hsa-miR-7976	HITS-CLIP	23824327
MIRT742042	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT742043	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT742044	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT742045	hsa-miR-4261	HITS-CLIP	23824327
MIRT742046	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT742047	hsa-miR-3153	HITS-CLIP	23824327
MIRT742048	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT742049	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT742050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT742051	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT742039	hsa-miR-8485	HITS-CLIP	23824327
MIRT742040	hsa-miR-4317	HITS-CLIP	23824327
MIRT742042	hsa-miR-3173-5p	HITS-CLIP	23824327
MIRT742043	hsa-miR-6799-3p	HITS-CLIP	23824327
MIRT742044	hsa-miR-146b-3p	HITS-CLIP	23824327
MIRT742045	hsa-miR-4261	HITS-CLIP	23824327
MIRT742046	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT742047	hsa-miR-3153	HITS-CLIP	23824327
MIRT742048	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT742049	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT742050	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT742051	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT740325	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT740326	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT740327	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT740328	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT740329	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT740330	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT740331	hsa-miR-5695	HITS-CLIP	23824327
MIRT740338	hsa-miR-642b-5p	HITS-CLIP	23824327
MIRT740332	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT740333	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT740334	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT740335	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT740336	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT740337	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT754508	hsa-miR-3200-5p	PAR-CLIP	22012620
MIRT754509	hsa-miR-4251	PAR-CLIP	22012620
MIRT754510	hsa-miR-4329	PAR-CLIP	22012620
MIRT754511	hsa-miR-6761-5p	PAR-CLIP	22012620
MIRT754512	hsa-miR-1199-5p	PAR-CLIP	22012620
MIRT754513	hsa-miR-6751-3p	PAR-CLIP	22012620
MIRT754514	hsa-miR-539-5p	PAR-CLIP	22012620
MIRT754515	hsa-miR-610	PAR-CLIP	22012620
MIRT754516	hsa-miR-4303	PAR-CLIP	22012620

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	27759003, 32144388, 35418679, 36127364, 37120430
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	15203201
GO:0005515	Function	Protein binding	IPI	34110646
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	27759003
GO:0005886	Component	Plasma membrane	IEA
GO:0006112	Process	Energy reserve metabolic process	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	15203201
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	17110384
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	35418679
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007416	Process	Synapse assembly	IBA
GO:0007416	Process	Synapse assembly	IEA
GO:0007613	Process	Memory	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	15203201
GO:0019216	Process	Regulation of lipid metabolic process	IBA
GO:0031175	Process	Neuron projection development	IBA
GO:0031175	Process	Neuron projection development	IEA
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0045444	Process	Fat cell differentiation	IBA

MIM	HGNC	e!Ensembl
617430	18990	ENSG00000153292

Q5T601

Protein name

Adhesion G-protein coupled receptor F1 (G protein-coupled receptor 110) (G protein-coupled receptor KPG_012) [Cleaved into: Adhesion G-protein coupled receptor F1, N-terminal fragment (ADGRF1 N-terminal fragment); Adhesion G-protein coupled receptor F1, C

Protein function

Adhesion G-protein coupled receptor (aGPCR) for N-docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain (PubMed:27759003, PubMed:32144388). Ligand binding causes a conformation change that triggers s

PDB

7WU3 , 7WU4 , 7WU5 , 7WXU , 7WXW , 7WY0 , 7WZ7 , 7X2V , 8G2Y , 8HC0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01390	SEA	151 → 241	SEA domain	Family
PF01825	GPS	532 → 572	GPCR proteolysis site, GPS, motif	Motif
PF00002	7tm_2	582 → 834	7 transmembrane receptor (Secretin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in the kidney. Up-regulated in lung adenocarcinomas and prostate cancers. {ECO:0000269|PubMed:20149256}.

Sequence

MKVGVLWLISFFTFTDGHGGFLGKNDGIKTKKELIVNKKKHLGPVEEYQLLLQVTYRDSK
EKRDLRNFLKLLKPPLLWSHGLIRIIRAKATTDCNSLNGVLQCTCEDSYTWFPPSCLDPQ
NCYLHTAGALPSCECHLNNLSQSVNFCERTKIWGTFKINERFTNDLLNSSSAIYSKYANG
IEIQLKKAYERIQGFESVQVTQFRNGSIVAGYEVVGSSSASELLSAIEHVAEKAKTALHK
LFPLEDGSFRVFGKAQCNDIVFGFGSKDDEYTLPCSSGYRGNITAKCESSGWQVIRETCV
LSLLEELNKNFSMIVGNATEAAVSSFVQNLSVIIRQNPSTTVGNLASVVSILSNISSLSL
ASHFRVSNSTMEDVISIADNILNSASVTNWTVLLREEKYASSRLLETLENISTLVPPTAL
PLNFSRKFIDWKGIPVNKSQLKRGYSYQIKMCPQNTSIPIRGRVLIGSDQFQRSLPETII
SMASLTLGNILPVSKNGNAQVNGPVISTVIQNYSINEVFLFFSKIESNLSQPHCVFWDFS
HLQWNDAGCHLVNETQDIVTCQCTHLTSFSILMSPFVPSTIFPVVKWITYVGLGISIGSL
ILCLIIEALFWKQIKKSQTSHTRRICMVNIALSLLIADVWFIVGATVDTTVNPSGVCTAA
VFFTHFFYLSLFFWMLMLGILLAYRIILVFHHMAQHLMMAVGFCLGYGCPLIISVITIAV
TQPSNTYKRKDVCWLNWSNGSKPLLAFVVPALAIVAVNFVVVLLVLTKLWRPTVGERLSR
DDKATIIRVGKSLLILTPLLGLTWGFGIGTIVDSQNLAWHVIFALLNAFQGFFILCFGIL
LDSKLRQLLFNKLSALSSWKQTEKQNSSDLSAKPKFSKPFNPLQNKGHYAFSHTGDSSDN
IMLTQFVSNE

Sequence length

910

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Nonpapillary renal cell carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OROFACIAL CLEFT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cirrhosis	Cirrhosis	BEFREE	28401002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36148682	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30052620, 30638950		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	30052620	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30638950		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	28401002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30638950		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30052620		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29574636, 30052620		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28968839		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	30052620		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	30052620	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30638950		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	25887408	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ADGRF1 (adhesion G protein-coupled receptor F1)