Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	266727
Gene name	MAM domain containing glycosylphosphatidylinositol anchor 1
Gene symbol	MDGA1
Synonyms (NCBI Gene)	GPIMMAMDC3
Chromosome	6
Chromosome location	6p21.2
Summary	This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six I

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003161	hsa-miR-210-3p	immunoprecipitaionMicroarrayqRT-PCR	19826008
MIRT677340	hsa-miR-8485	HITS-CLIP	23313552
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	23313552
MIRT687569	hsa-miR-1913	HITS-CLIP	23313552
MIRT687568	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT623284	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT687567	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT687566	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT687565	hsa-miR-3189-5p	HITS-CLIP	23313552
MIRT677340	hsa-miR-8485	HITS-CLIP	23313552
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	23313552
MIRT687569	hsa-miR-1913	HITS-CLIP	23313552
MIRT687568	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT623284	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT687567	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT687566	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT687565	hsa-miR-3189-5p	HITS-CLIP	23313552
MIRT623283	hsa-miR-4727-5p	HITS-CLIP	23313552
MIRT623282	hsa-miR-5001-3p	HITS-CLIP	23313552
MIRT623281	hsa-miR-6738-3p	HITS-CLIP	23313552
MIRT677340	hsa-miR-8485	HITS-CLIP	23824327
MIRT677339	hsa-miR-8064	HITS-CLIP	23824327
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT623285	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT623284	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT623283	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT623282	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT623281	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT623285	hsa-miR-1237-3p	HITS-CLIP	27418678
MIRT623284	hsa-miR-18a-3p	HITS-CLIP	27418678
MIRT687569	hsa-miR-1913	HITS-CLIP	27418678
MIRT687565	hsa-miR-3189-5p	HITS-CLIP	27418678
MIRT687568	hsa-miR-324-3p	HITS-CLIP	27418678
MIRT623283	hsa-miR-4727-5p	HITS-CLIP	27418678
MIRT687566	hsa-miR-4758-3p	HITS-CLIP	27418678
MIRT623282	hsa-miR-5001-3p	HITS-CLIP	27418678
MIRT687567	hsa-miR-5699-5p	HITS-CLIP	27418678
MIRT623281	hsa-miR-6738-3p	HITS-CLIP	27418678
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	27418678
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	27418678
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	27418678
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	27418678
MIRT677339	hsa-miR-8064	HITS-CLIP	27418678
MIRT677339	hsa-miR-8064	HITS-CLIP	27418678
MIRT677340	hsa-miR-8485	HITS-CLIP	27418678
MIRT677340	hsa-miR-8485	HITS-CLIP	27418678
MIRT677340	hsa-miR-8485	HITS-CLIP	27418678
MIRT677340	hsa-miR-8485	HITS-CLIP	23313552
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	23313552
MIRT687569	hsa-miR-1913	HITS-CLIP	23313552
MIRT687568	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT623284	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT687567	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT687566	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT687565	hsa-miR-3189-5p	HITS-CLIP	23313552
MIRT677340	hsa-miR-8485	HITS-CLIP	23313552
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	23313552
MIRT687569	hsa-miR-1913	HITS-CLIP	23313552
MIRT687568	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT623284	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT687567	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT687566	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT687565	hsa-miR-3189-5p	HITS-CLIP	23313552
MIRT623283	hsa-miR-4727-5p	HITS-CLIP	23313552
MIRT623282	hsa-miR-5001-3p	HITS-CLIP	23313552
MIRT623281	hsa-miR-6738-3p	HITS-CLIP	23313552
MIRT677340	hsa-miR-8485	HITS-CLIP	23824327
MIRT677339	hsa-miR-8064	HITS-CLIP	23824327
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT623286	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT623285	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT623284	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT623283	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT623282	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT623281	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT1138509	hsa-miR-125a-3p	CLIP-seq
MIRT1138510	hsa-miR-128	CLIP-seq
MIRT1138511	hsa-miR-1324	CLIP-seq
MIRT1138512	hsa-miR-1587	CLIP-seq
MIRT1138513	hsa-miR-1910	CLIP-seq
MIRT1138514	hsa-miR-2110	CLIP-seq
MIRT1138515	hsa-miR-2117	CLIP-seq
MIRT1138516	hsa-miR-24	CLIP-seq
MIRT1138517	hsa-miR-27a	CLIP-seq
MIRT1138518	hsa-miR-27b	CLIP-seq
MIRT1138519	hsa-miR-28-5p	CLIP-seq
MIRT1138520	hsa-miR-2964a-5p	CLIP-seq
MIRT1138521	hsa-miR-3074-5p	CLIP-seq
MIRT1138522	hsa-miR-3120-3p	CLIP-seq
MIRT1138523	hsa-miR-3139	CLIP-seq
MIRT1138524	hsa-miR-3173-3p	CLIP-seq
MIRT1138525	hsa-miR-342-5p	CLIP-seq
MIRT1138526	hsa-miR-3616-3p	CLIP-seq
MIRT1138527	hsa-miR-3670	CLIP-seq
MIRT1138528	hsa-miR-370	CLIP-seq
MIRT1138529	hsa-miR-377	CLIP-seq
MIRT1138530	hsa-miR-3915	CLIP-seq
MIRT1138531	hsa-miR-3928	CLIP-seq
MIRT1138532	hsa-miR-3934	CLIP-seq
MIRT1138533	hsa-miR-4259	CLIP-seq
MIRT1138534	hsa-miR-4260	CLIP-seq
MIRT1138535	hsa-miR-4271	CLIP-seq
MIRT1138536	hsa-miR-4273	CLIP-seq
MIRT1138537	hsa-miR-4283	CLIP-seq
MIRT1138538	hsa-miR-4330	CLIP-seq
MIRT1138539	hsa-miR-4436b-3p	CLIP-seq
MIRT1138540	hsa-miR-4437	CLIP-seq
MIRT1138541	hsa-miR-4476	CLIP-seq
MIRT1138542	hsa-miR-4492	CLIP-seq
MIRT1138543	hsa-miR-4498	CLIP-seq
MIRT1138544	hsa-miR-4505	CLIP-seq
MIRT1138545	hsa-miR-4533	CLIP-seq
MIRT1138546	hsa-miR-4640-5p	CLIP-seq
MIRT1138547	hsa-miR-4651	CLIP-seq
MIRT1138548	hsa-miR-4656	CLIP-seq
MIRT1138549	hsa-miR-4663	CLIP-seq
MIRT1138550	hsa-miR-4664-5p	CLIP-seq
MIRT1138551	hsa-miR-4675	CLIP-seq
MIRT1138552	hsa-miR-4677-5p	CLIP-seq
MIRT1138553	hsa-miR-4701-5p	CLIP-seq
MIRT1138554	hsa-miR-4715-5p	CLIP-seq
MIRT1138555	hsa-miR-4725-3p	CLIP-seq
MIRT1138556	hsa-miR-4726-5p	CLIP-seq
MIRT1138557	hsa-miR-4728-3p	CLIP-seq
MIRT1138558	hsa-miR-4731-5p	CLIP-seq
MIRT1138559	hsa-miR-4741	CLIP-seq
MIRT1138560	hsa-miR-4757-5p	CLIP-seq
MIRT1138561	hsa-miR-4779	CLIP-seq
MIRT1138562	hsa-miR-485-5p	CLIP-seq
MIRT1138563	hsa-miR-499-3p	CLIP-seq
MIRT1138564	hsa-miR-499a-3p	CLIP-seq
MIRT1138565	hsa-miR-588	CLIP-seq
MIRT1138566	hsa-miR-608	CLIP-seq
MIRT1138567	hsa-miR-708	CLIP-seq
MIRT1138568	hsa-miR-762	CLIP-seq
MIRT1138569	hsa-miR-764	CLIP-seq
MIRT1138570	hsa-miR-765	CLIP-seq
MIRT1138571	hsa-miR-767-3p	CLIP-seq
MIRT2039295	hsa-miR-1226	CLIP-seq
MIRT2039296	hsa-miR-1237	CLIP-seq
MIRT2039297	hsa-miR-1273f	CLIP-seq
MIRT2039298	hsa-miR-143	CLIP-seq
MIRT2039299	hsa-miR-1538	CLIP-seq
MIRT2039300	hsa-miR-214	CLIP-seq
MIRT1138516	hsa-miR-24	CLIP-seq
MIRT2039301	hsa-miR-3126-5p	CLIP-seq
MIRT2039302	hsa-miR-3166	CLIP-seq
MIRT2039303	hsa-miR-3619-5p	CLIP-seq
MIRT2039304	hsa-miR-3652	CLIP-seq
MIRT2039305	hsa-miR-3914	CLIP-seq
MIRT2039306	hsa-miR-3921	CLIP-seq
MIRT2039307	hsa-miR-4289	CLIP-seq
MIRT2039308	hsa-miR-4291	CLIP-seq
MIRT2039309	hsa-miR-4419a	CLIP-seq
MIRT2039310	hsa-miR-4430	CLIP-seq
MIRT2039311	hsa-miR-4446-3p	CLIP-seq
MIRT1138544	hsa-miR-4505	CLIP-seq
MIRT2039312	hsa-miR-4510	CLIP-seq
MIRT1138545	hsa-miR-4533	CLIP-seq
MIRT2039313	hsa-miR-4649-3p	CLIP-seq
MIRT2039314	hsa-miR-4653-5p	CLIP-seq
MIRT1138551	hsa-miR-4675	CLIP-seq
MIRT2039315	hsa-miR-4690-5p	CLIP-seq
MIRT2039316	hsa-miR-4708-5p	CLIP-seq
MIRT1138559	hsa-miR-4741	CLIP-seq
MIRT2039317	hsa-miR-4745-3p	CLIP-seq
MIRT2039318	hsa-miR-4760-3p	CLIP-seq
MIRT2039319	hsa-miR-4770	CLIP-seq
MIRT1138561	hsa-miR-4779	CLIP-seq
MIRT2039320	hsa-miR-4793-5p	CLIP-seq
MIRT2039321	hsa-miR-513a-5p	CLIP-seq
MIRT2039322	hsa-miR-642b	CLIP-seq
MIRT2039323	hsa-miR-664	CLIP-seq
MIRT2039324	hsa-miR-761	CLIP-seq
MIRT2039325	hsa-miR-873	CLIP-seq
MIRT2039326	hsa-miR-922	CLIP-seq
MIRT2269352	hsa-miR-122	CLIP-seq
MIRT1138509	hsa-miR-125a-3p	CLIP-seq
MIRT1138510	hsa-miR-128	CLIP-seq
MIRT2269353	hsa-miR-140-5p	CLIP-seq
MIRT2269354	hsa-miR-141	CLIP-seq
MIRT2269355	hsa-miR-147	CLIP-seq
MIRT2269356	hsa-miR-15a	CLIP-seq
MIRT2269357	hsa-miR-15b	CLIP-seq
MIRT2269358	hsa-miR-16	CLIP-seq
MIRT2269359	hsa-miR-195	CLIP-seq
MIRT2269360	hsa-miR-200a	CLIP-seq
MIRT1138516	hsa-miR-24	CLIP-seq
MIRT1138517	hsa-miR-27a	CLIP-seq
MIRT1138518	hsa-miR-27b	CLIP-seq
MIRT1138519	hsa-miR-28-5p	CLIP-seq
MIRT1138520	hsa-miR-2964a-5p	CLIP-seq
MIRT1138521	hsa-miR-3074-5p	CLIP-seq
MIRT2269361	hsa-miR-3130-3p	CLIP-seq
MIRT2269362	hsa-miR-3138	CLIP-seq
MIRT1138523	hsa-miR-3139	CLIP-seq
MIRT2269363	hsa-miR-3155	CLIP-seq
MIRT2269364	hsa-miR-3155b	CLIP-seq
MIRT2269365	hsa-miR-3169	CLIP-seq
MIRT1138524	hsa-miR-3173-3p	CLIP-seq
MIRT2269366	hsa-miR-329	CLIP-seq
MIRT2269367	hsa-miR-342-3p	CLIP-seq
MIRT2269368	hsa-miR-362-3p	CLIP-seq
MIRT2269369	hsa-miR-3651	CLIP-seq
MIRT2269370	hsa-miR-3664-3p	CLIP-seq
MIRT1138527	hsa-miR-3670	CLIP-seq
MIRT2269371	hsa-miR-3672	CLIP-seq
MIRT2269372	hsa-miR-3688-5p	CLIP-seq
MIRT2269373	hsa-miR-3689a-3p	CLIP-seq
MIRT2269374	hsa-miR-3689c	CLIP-seq
MIRT2269375	hsa-miR-3692	CLIP-seq
MIRT1138528	hsa-miR-370	CLIP-seq
MIRT2269376	hsa-miR-3911	CLIP-seq
MIRT1138532	hsa-miR-3934	CLIP-seq
MIRT2269377	hsa-miR-424	CLIP-seq
MIRT1138533	hsa-miR-4259	CLIP-seq
MIRT1138534	hsa-miR-4260	CLIP-seq
MIRT1138537	hsa-miR-4283	CLIP-seq
MIRT2039307	hsa-miR-4289	CLIP-seq
MIRT2269378	hsa-miR-4310	CLIP-seq
MIRT2269379	hsa-miR-4318	CLIP-seq
MIRT2269380	hsa-miR-4329	CLIP-seq
MIRT2269381	hsa-miR-4436b-5p	CLIP-seq
MIRT1138540	hsa-miR-4437	CLIP-seq
MIRT2269382	hsa-miR-4447	CLIP-seq
MIRT2269383	hsa-miR-4472	CLIP-seq
MIRT1138541	hsa-miR-4476	CLIP-seq
MIRT2269384	hsa-miR-4488	CLIP-seq
MIRT2269385	hsa-miR-4522	CLIP-seq
MIRT1138546	hsa-miR-4640-5p	CLIP-seq
MIRT2269386	hsa-miR-4697-5p	CLIP-seq
MIRT2269387	hsa-miR-4700-3p	CLIP-seq
MIRT1138553	hsa-miR-4701-5p	CLIP-seq
MIRT1138554	hsa-miR-4715-5p	CLIP-seq
MIRT1138556	hsa-miR-4726-5p	CLIP-seq
MIRT2269388	hsa-miR-4728-5p	CLIP-seq
MIRT2269389	hsa-miR-4733-3p	CLIP-seq
MIRT2269390	hsa-miR-4749-3p	CLIP-seq
MIRT2039318	hsa-miR-4760-3p	CLIP-seq
MIRT2269391	hsa-miR-4786-5p	CLIP-seq
MIRT2269392	hsa-miR-4793-3p	CLIP-seq
MIRT2269393	hsa-miR-484	CLIP-seq
MIRT2269394	hsa-miR-486-3p	CLIP-seq
MIRT2269395	hsa-miR-497	CLIP-seq
MIRT2269396	hsa-miR-5096	CLIP-seq
MIRT2039321	hsa-miR-513a-5p	CLIP-seq
MIRT2269397	hsa-miR-541	CLIP-seq
MIRT2269398	hsa-miR-587	CLIP-seq
MIRT1138565	hsa-miR-588	CLIP-seq
MIRT2269399	hsa-miR-617	CLIP-seq
MIRT2039322	hsa-miR-642b	CLIP-seq
MIRT2269400	hsa-miR-644	CLIP-seq
MIRT2269401	hsa-miR-652	CLIP-seq
MIRT2269402	hsa-miR-654-5p	CLIP-seq
MIRT2039323	hsa-miR-664	CLIP-seq
MIRT1138567	hsa-miR-708	CLIP-seq
MIRT1138569	hsa-miR-764	CLIP-seq
MIRT1138570	hsa-miR-765	CLIP-seq
MIRT2039325	hsa-miR-873	CLIP-seq
MIRT1138511	hsa-miR-1324	CLIP-seq
MIRT2390750	hsa-miR-150	CLIP-seq
MIRT2039300	hsa-miR-214	CLIP-seq
MIRT2390751	hsa-miR-224	CLIP-seq
MIRT2039302	hsa-miR-3166	CLIP-seq
MIRT1138525	hsa-miR-342-5p	CLIP-seq
MIRT2039303	hsa-miR-3619-5p	CLIP-seq
MIRT2039308	hsa-miR-4291	CLIP-seq
MIRT2269378	hsa-miR-4310	CLIP-seq
MIRT1138544	hsa-miR-4505	CLIP-seq
MIRT1138547	hsa-miR-4651	CLIP-seq
MIRT1138550	hsa-miR-4664-5p	CLIP-seq
MIRT2390752	hsa-miR-4667-5p	CLIP-seq
MIRT2390753	hsa-miR-4700-5p	CLIP-seq
MIRT2390754	hsa-miR-4713-5p	CLIP-seq
MIRT1138558	hsa-miR-4731-5p	CLIP-seq
MIRT1138562	hsa-miR-485-5p	CLIP-seq
MIRT2390755	hsa-miR-532-3p	CLIP-seq
MIRT1138566	hsa-miR-608	CLIP-seq
MIRT2039322	hsa-miR-642b	CLIP-seq
MIRT2039324	hsa-miR-761	CLIP-seq
MIRT2039326	hsa-miR-922	CLIP-seq
MIRT2453849	hsa-miR-3189-3p	CLIP-seq
MIRT1138546	hsa-miR-4640-5p	CLIP-seq
MIRT2453850	hsa-miR-4661-5p	CLIP-seq
MIRT1138556	hsa-miR-4726-5p	CLIP-seq
MIRT2453851	hsa-miR-635	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IEA
GO:0001764	Process	Neuron migration	ISS
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005886	Component	Plasma membrane	IDA	15922729
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS	15019943
GO:0005886	Component	Plasma membrane	TAS
GO:0007399	Process	Nervous system development	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0007420	Process	Brain development	ISS	15019943
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0021527	Process	Spinal cord association neuron differentiation	ISS	15019943
GO:0021799	Process	Cerebral cortex radially oriented cell migration	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0042417	Process	Dopamine metabolic process	IEA
GO:0042428	Process	Serotonin metabolic process	IEA
GO:0060134	Process	Prepulse inhibition	IEA
GO:0098552	Component	Side of membrane	IEA
GO:0098982	Component	GABA-ergic synapse	IDA	28641112
GO:0098982	Component	GABA-ergic synapse	IMP	28641112
GO:0099054	Process	Presynapse assembly	IEA
GO:0099179	Process	Regulation of synaptic membrane adhesion	IDA	28641112
GO:0099179	Process	Regulation of synaptic membrane adhesion	IMP	28641112
GO:1904862	Process	Inhibitory synapse assembly	IEA
GO:1905606	Process	Regulation of presynapse assembly	IDA	28641112
GO:1905606	Process	Regulation of presynapse assembly	IMP	28641112

MIM	HGNC	e!Ensembl
609626	19267	ENSG00000112139

Q8NFP4

Protein name

MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3)

Protein function

Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. {ECO:0000250, ECO

PDB

5V5V , 5V5W , 5XEQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13927	Ig_3	40 → 112		Domain
PF13927	Ig_3	131 → 217		Domain
PF13927	Ig_3	239 → 312		Domain
PF13927	Ig_3	335 → 418		Domain
PF13927	Ig_3	439 → 517		Domain
PF13927	Ig_3	538 → 619		Domain
PF00629	MAM	753 → 917	MAM domain, meprin/A5/mu	Domain

Tissue specificity

TISSUE SPECIFICITY: Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.

Sequence

MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQC
LVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIK
SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ
DNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPP
ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQA
RDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVD
AVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP
GAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK
EAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE
VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL
RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL
QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR
LTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALT
QNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHM
YGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGY
LGDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR

Sequence length

955

Interactions

View interactions

	Reactome
			Post-translational modification: synthesis of GPI-anchored proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute megakaryoblastic leukemia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONOTRUNCAL HEART MALFORMATIONS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ANEURYSM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mediastinal germ cell tumor	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bipolar Disorder	Bipolar Disorder	BEFREE	21146959, 31812551	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	21146959	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Aneurysm	Coronary Aneurysm	GWASCAT_DG	27171184	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder	Mental Depression	BEFREE	21146959	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	GWASCAT_DG	27171184	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12082541	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	18384059, 21146959, 31812551	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	18384059, 21146959	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Unipolar Depression	Mental Depression	BEFREE	21146959	★★★★★ ★☆☆☆☆ Found in Text Mining only

MDGA1 (MAM domain containing glycosylphosphatidylinositol anchor 1)