Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26528
Gene name	DAZ associated protein 1
Gene symbol	DAZAP1
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19p13.3
Summary	In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster map

164

Show/Hide all (164)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048966	hsa-miR-92a-3p	CLASH	23622248
MIRT048966	hsa-miR-92a-3p	CLASH	23622248
MIRT048966	hsa-miR-92a-3p	CLASH	23622248
MIRT046606	hsa-miR-222-3p	CLASH	23622248
MIRT046606	hsa-miR-222-3p	CLASH	23622248
MIRT045357	hsa-miR-185-5p	CLASH	23622248
MIRT041192	hsa-miR-193b-3p	CLASH	23622248
MIRT039689	hsa-miR-615-3p	CLASH	23622248
MIRT038914	hsa-miR-93-3p	CLASH	23622248
MIRT548625	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT548626	hsa-miR-3123	PAR-CLIP	20371350
MIRT548623	hsa-miR-1303	PAR-CLIP	20371350
MIRT548639	hsa-miR-218-5p	PAR-CLIP	20371350
MIRT548638	hsa-miR-548ac	PAR-CLIP	20371350
MIRT548637	hsa-miR-548bb-3p	PAR-CLIP	20371350
MIRT548636	hsa-miR-548d-3p	PAR-CLIP	20371350
MIRT548635	hsa-miR-548h-3p	PAR-CLIP	20371350
MIRT548634	hsa-miR-548z	PAR-CLIP	20371350
MIRT548633	hsa-miR-548ae-3p	PAR-CLIP	20371350
MIRT548632	hsa-miR-548ah-3p	PAR-CLIP	20371350
MIRT548631	hsa-miR-548aj-3p	PAR-CLIP	20371350
MIRT548630	hsa-miR-548am-3p	PAR-CLIP	20371350
MIRT548629	hsa-miR-548aq-3p	PAR-CLIP	20371350
MIRT548628	hsa-miR-548j-3p	PAR-CLIP	20371350
MIRT548627	hsa-miR-548x-3p	PAR-CLIP	20371350
MIRT548625	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT548626	hsa-miR-3123	PAR-CLIP	20371350
MIRT548624	hsa-miR-8075	PAR-CLIP	20371350
MIRT548623	hsa-miR-1303	PAR-CLIP	20371350
MIRT548639	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT548638	hsa-miR-548ac	PAR-CLIP	21572407
MIRT548637	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT548636	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT548635	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT548634	hsa-miR-548z	PAR-CLIP	21572407
MIRT548633	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT548632	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT548631	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT548630	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT548629	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT548628	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT548627	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT548625	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT548626	hsa-miR-3123	PAR-CLIP	21572407
MIRT548624	hsa-miR-8075	PAR-CLIP	21572407
MIRT548623	hsa-miR-1303	PAR-CLIP	21572407
MIRT497623	hsa-miR-3613-3p	PAR-CLIP	22291592
MIRT497622	hsa-miR-4670-3p	PAR-CLIP	22291592
MIRT548625	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT548626	hsa-miR-3123	PAR-CLIP	20371350
MIRT548623	hsa-miR-1303	PAR-CLIP	20371350
MIRT548639	hsa-miR-218-5p	PAR-CLIP	20371350
MIRT548638	hsa-miR-548ac	PAR-CLIP	20371350
MIRT548637	hsa-miR-548bb-3p	PAR-CLIP	20371350
MIRT548636	hsa-miR-548d-3p	PAR-CLIP	20371350
MIRT548635	hsa-miR-548h-3p	PAR-CLIP	20371350
MIRT548634	hsa-miR-548z	PAR-CLIP	20371350
MIRT548633	hsa-miR-548ae-3p	PAR-CLIP	20371350
MIRT548632	hsa-miR-548ah-3p	PAR-CLIP	20371350
MIRT548631	hsa-miR-548aj-3p	PAR-CLIP	20371350
MIRT548630	hsa-miR-548am-3p	PAR-CLIP	20371350
MIRT548629	hsa-miR-548aq-3p	PAR-CLIP	20371350
MIRT548628	hsa-miR-548j-3p	PAR-CLIP	20371350
MIRT548627	hsa-miR-548x-3p	PAR-CLIP	20371350
MIRT548625	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT548626	hsa-miR-3123	PAR-CLIP	20371350
MIRT548624	hsa-miR-8075	PAR-CLIP	20371350
MIRT548623	hsa-miR-1303	PAR-CLIP	20371350
MIRT548639	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT548638	hsa-miR-548ac	PAR-CLIP	21572407
MIRT548637	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT548636	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT548635	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT548634	hsa-miR-548z	PAR-CLIP	21572407
MIRT548633	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT548632	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT548631	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT548630	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT548629	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT548628	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT548627	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT548625	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT548626	hsa-miR-3123	PAR-CLIP	21572407
MIRT548624	hsa-miR-8075	PAR-CLIP	21572407
MIRT548623	hsa-miR-1303	PAR-CLIP	21572407
MIRT497623	hsa-miR-3613-3p	PAR-CLIP	22291592
MIRT497622	hsa-miR-4670-3p	PAR-CLIP	22291592
MIRT923465	hsa-miR-10a	CLIP-seq
MIRT923466	hsa-miR-10b	CLIP-seq
MIRT923467	hsa-miR-1299	CLIP-seq
MIRT923468	hsa-miR-1910	CLIP-seq
MIRT923469	hsa-miR-198	CLIP-seq
MIRT923470	hsa-miR-2052	CLIP-seq
MIRT923471	hsa-miR-218	CLIP-seq
MIRT923472	hsa-miR-320a	CLIP-seq
MIRT923473	hsa-miR-320b	CLIP-seq
MIRT923474	hsa-miR-320c	CLIP-seq
MIRT923475	hsa-miR-320d	CLIP-seq
MIRT923476	hsa-miR-3619-3p	CLIP-seq
MIRT923477	hsa-miR-3691-3p	CLIP-seq
MIRT923478	hsa-miR-378	CLIP-seq
MIRT923479	hsa-miR-378b	CLIP-seq
MIRT923480	hsa-miR-378c	CLIP-seq
MIRT923481	hsa-miR-378d	CLIP-seq
MIRT923482	hsa-miR-378e	CLIP-seq
MIRT923483	hsa-miR-378f	CLIP-seq
MIRT923484	hsa-miR-378h	CLIP-seq
MIRT923485	hsa-miR-378i	CLIP-seq
MIRT923486	hsa-miR-422a	CLIP-seq
MIRT923487	hsa-miR-4264	CLIP-seq
MIRT923488	hsa-miR-4290	CLIP-seq
MIRT923489	hsa-miR-4429	CLIP-seq
MIRT923490	hsa-miR-4452	CLIP-seq
MIRT923491	hsa-miR-455-3p	CLIP-seq
MIRT923492	hsa-miR-4638-3p	CLIP-seq
MIRT923493	hsa-miR-4776-5p	CLIP-seq
MIRT923494	hsa-miR-4782-5p	CLIP-seq
MIRT923495	hsa-miR-516b	CLIP-seq
MIRT923496	hsa-miR-548ae	CLIP-seq
MIRT923497	hsa-miR-548aj	CLIP-seq
MIRT923498	hsa-miR-548am	CLIP-seq
MIRT923499	hsa-miR-548x	CLIP-seq
MIRT923500	hsa-miR-653	CLIP-seq
MIRT923465	hsa-miR-10a	CLIP-seq
MIRT923466	hsa-miR-10b	CLIP-seq
MIRT923500	hsa-miR-653	CLIP-seq
MIRT923465	hsa-miR-10a	CLIP-seq
MIRT923466	hsa-miR-10b	CLIP-seq
MIRT923500	hsa-miR-653	CLIP-seq
MIRT1973558	hsa-miR-199a-3p	CLIP-seq
MIRT1973559	hsa-miR-199b-3p	CLIP-seq
MIRT923471	hsa-miR-218	CLIP-seq
MIRT1973560	hsa-miR-219-5p	CLIP-seq
MIRT1973561	hsa-miR-3117-5p	CLIP-seq
MIRT1973562	hsa-miR-3129-5p	CLIP-seq
MIRT1973563	hsa-miR-3164	CLIP-seq
MIRT1973564	hsa-miR-3617	CLIP-seq
MIRT1973565	hsa-miR-3673	CLIP-seq
MIRT1973566	hsa-miR-4445	CLIP-seq
MIRT1973567	hsa-miR-4480	CLIP-seq
MIRT1973568	hsa-miR-4782-3p	CLIP-seq
MIRT1973569	hsa-miR-4797-3p	CLIP-seq
MIRT1973570	hsa-miR-508-3p	CLIP-seq
MIRT1973571	hsa-miR-513b	CLIP-seq
MIRT1973572	hsa-miR-641	CLIP-seq
MIRT923500	hsa-miR-653	CLIP-seq
MIRT1973573	hsa-miR-758	CLIP-seq
MIRT1973574	hsa-miR-936	CLIP-seq
MIRT923465	hsa-miR-10a	CLIP-seq
MIRT923466	hsa-miR-10b	CLIP-seq
MIRT1973563	hsa-miR-3164	CLIP-seq
MIRT923488	hsa-miR-4290	CLIP-seq
MIRT923500	hsa-miR-653	CLIP-seq
MIRT2386724	hsa-miR-3064-5p	CLIP-seq
MIRT2386725	hsa-miR-3186-3p	CLIP-seq
MIRT2386726	hsa-miR-450b-3p	CLIP-seq
MIRT2386727	hsa-miR-4654	CLIP-seq
MIRT2386728	hsa-miR-4687-3p	CLIP-seq
MIRT2386729	hsa-miR-4713-3p	CLIP-seq
MIRT2386730	hsa-miR-4769-5p	CLIP-seq
MIRT2386731	hsa-miR-638	CLIP-seq
MIRT2386732	hsa-miR-769-3p	CLIP-seq
MIRT923477	hsa-miR-3691-3p	CLIP-seq
MIRT2679014	hsa-miR-665	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0001893	Process	Maternal placenta development	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003730	Function	MRNA 3'-UTR binding	IBA
GO:0005515	Function	Protein binding	IPI	10857750, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0007283	Process	Spermatogenesis	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0008266	Function	Poly(U) RNA binding	IMP	10857750
GO:0030154	Process	Cell differentiation	IEA
GO:0032991	Component	Protein-containing complex	IDA	10857750
GO:0034046	Function	Poly(G) binding	IBA
GO:0034046	Function	Poly(G) binding	IMP	10857750
GO:0035613	Function	RNA stem-loop binding	IEA
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IBA
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IEA
GO:0048144	Process	Fibroblast proliferation	IEA
GO:1990904	Component	Ribonucleoprotein complex	IMP	10857750

MIM	HGNC	e!Ensembl
607430	2683	ENSG00000071626

Q96EP5

Protein name

DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1)

Protein function

RNA-binding protein, which may be required during spermatogenesis.

PDB

2DGS , 2DH8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	12 → 81	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	115 → 184	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10857750}.

Sequence

MNNSGADEIGKLFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKD
PNCVGTVLASRPHTLDGRNIDPKPCTPRGMQPERTRPKEGWQKGPRSDNSKSNKIFVGGI
PHNCGETELREYFKKFGVVTEVVMIYDAEKQRPRGFGFITFEDEQSVDQAVNMHFHDIMG
KKVEVKRAEPRDSKSQAPGQPGASQWGSRVVPNAANGWAGQPPPTWQQGYGPQGMWVPAG
QAIGGYGPPPAGRGAPPPPPPFTSYIVSTPPGGFPPPQGFPQGYGAPPQFSFGYGPPPPP
PDQFAPPGVPPPPATPGAAPLAFPPPPSQAAPDMSKPPTAQPDFPYGQYAGYGQDLSGFG
QGFSDPSQQPPSYGGPSVPGSGGPPAGGSGFGRGQNHNVQGFHPYRR

Sequence length

407

Interactions

View interactions

	KEGG
	mRNA surveillance pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC PULMONARY FIBROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Monoclonal B-Cell Lymphocytosis	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	15744350, 17898785		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	23451123		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	32308763	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15744350		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	36242590	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy Duchenne	Duchenne muscular dystrophy	Pubtator	25662218	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	37507717	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	15744350, 17898785		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	Pubtator	33525094	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	PSYGENET_DG	23451123		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Synovitis	Synovitis	Pubtator	29968759	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tourette Syndrome	Tourette syndrome	Pubtator	15182431	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DAZAP1 (DAZ associated protein 1)