Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26508
Gene name	Hes related family bHLH transcription factor with YRPW motif like
Gene symbol	HEYL
Synonyms (NCBI Gene)	HESR3HEY3HRT3bHLHb33
Chromosome	1
Chromosome location	1p34.2
Summary	This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverg

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miRTarBase ID	miRNA	Experiments	Reference
MIRT038777	hsa-miR-93-3p	CLASH	23622248
MIRT671673	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT671672	hsa-miR-3655	HITS-CLIP	23824327
MIRT671671	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT671670	hsa-miR-3135b	HITS-CLIP	23824327
MIRT671669	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT671668	hsa-miR-3652	HITS-CLIP	23824327
MIRT671667	hsa-miR-4430	HITS-CLIP	23824327
MIRT671666	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT671665	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT671664	hsa-miR-5698	HITS-CLIP	23824327
MIRT667965	hsa-miR-335-5p	HITS-CLIP	23824327
MIRT667964	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT667963	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT667962	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT667961	hsa-miR-4284	HITS-CLIP	23824327
MIRT667960	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT657453	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT657452	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT657451	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT657450	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT657449	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT640800	hsa-miR-5092	HITS-CLIP	23824327
MIRT657454	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT640799	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT640798	hsa-miR-4469	HITS-CLIP	23824327
MIRT640797	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT640796	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT640795	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT640794	hsa-miR-4279	HITS-CLIP	23824327
MIRT640793	hsa-miR-7641	HITS-CLIP	23824327
MIRT657453	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT657452	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT657451	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT657450	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT657449	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT657448	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT657447	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT657446	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT623708	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT640800	hsa-miR-5092	HITS-CLIP	23824327
MIRT640799	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT640798	hsa-miR-4469	HITS-CLIP	23824327
MIRT640797	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT640796	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT640795	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT640794	hsa-miR-4279	HITS-CLIP	23824327
MIRT640793	hsa-miR-7641	HITS-CLIP	23824327
MIRT623708	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT544171	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT544172	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT544170	hsa-miR-940	PAR-CLIP	21572407
MIRT544169	hsa-miR-3929	PAR-CLIP	21572407
MIRT544168	hsa-miR-4419b	PAR-CLIP	21572407
MIRT544167	hsa-miR-4478	PAR-CLIP	21572407
MIRT544166	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT544165	hsa-miR-135a-5p	PAR-CLIP	21572407
MIRT544164	hsa-miR-135b-5p	PAR-CLIP	21572407
MIRT544163	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT544162	hsa-miR-1827	PAR-CLIP	21572407
MIRT544161	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT544160	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT544159	hsa-miR-1909-3p	PAR-CLIP	21572407
MIRT544158	hsa-miR-6722-3p	PAR-CLIP	21572407
MIRT544157	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT544156	hsa-miR-1207-5p	PAR-CLIP	21572407
MIRT544155	hsa-miR-4763-3p	PAR-CLIP	21572407
MIRT544154	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT544153	hsa-miR-1273e	PAR-CLIP	21572407
MIRT544152	hsa-miR-665	PAR-CLIP	21572407
MIRT495080	hsa-miR-922	PAR-CLIP	23708386
MIRT475711	hsa-miR-214-3p	PAR-CLIP	23708386
MIRT475710	hsa-miR-3619-5p	PAR-CLIP	23708386
MIRT475709	hsa-miR-761	PAR-CLIP	23708386
MIRT495079	hsa-miR-4690-3p	PAR-CLIP	23708386
MIRT495078	hsa-miR-5685	PAR-CLIP	23708386
MIRT495076	hsa-miR-6787-3p	PAR-CLIP	23708386
MIRT495077	hsa-miR-339-3p	PAR-CLIP	23708386
MIRT495075	hsa-miR-668-5p	PAR-CLIP	23708386
MIRT495074	hsa-miR-4291	PAR-CLIP	23708386
MIRT475720	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT475719	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT475718	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT475717	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT475716	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT475715	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT475713	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT475714	hsa-miR-6165	PAR-CLIP	23592263
MIRT475712	hsa-miR-4733-5p	PAR-CLIP	23592263
MIRT475711	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT475710	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT475709	hsa-miR-761	PAR-CLIP	23592263
MIRT475708	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT475707	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT475706	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT475705	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT475704	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT475703	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT475702	hsa-miR-6081	PAR-CLIP	23592263
MIRT475701	hsa-miR-765	PAR-CLIP	23592263
MIRT671673	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT671672	hsa-miR-3655	HITS-CLIP	23824327
MIRT671671	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT671670	hsa-miR-3135b	HITS-CLIP	23824327
MIRT671669	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT671668	hsa-miR-3652	HITS-CLIP	23824327
MIRT671667	hsa-miR-4430	HITS-CLIP	23824327
MIRT671666	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT671665	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT671664	hsa-miR-5698	HITS-CLIP	23824327
MIRT667965	hsa-miR-335-5p	HITS-CLIP	23824327
MIRT667964	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT667963	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT667962	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT667961	hsa-miR-4284	HITS-CLIP	23824327
MIRT667960	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT657453	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT657452	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT657451	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT657450	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT657449	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT640800	hsa-miR-5092	HITS-CLIP	23824327
MIRT657454	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT640799	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT640798	hsa-miR-4469	HITS-CLIP	23824327
MIRT640797	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT640796	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT640795	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT640794	hsa-miR-4279	HITS-CLIP	23824327
MIRT640793	hsa-miR-7641	HITS-CLIP	23824327
MIRT657453	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT657452	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT657451	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT657450	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT657449	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT657448	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT657447	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT657446	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT623708	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT640800	hsa-miR-5092	HITS-CLIP	23824327
MIRT640799	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT640798	hsa-miR-4469	HITS-CLIP	23824327
MIRT640797	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT640796	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT640795	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT640794	hsa-miR-4279	HITS-CLIP	23824327
MIRT640793	hsa-miR-7641	HITS-CLIP	23824327
MIRT623708	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT544171	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT544172	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT544170	hsa-miR-940	PAR-CLIP	21572407
MIRT544169	hsa-miR-3929	PAR-CLIP	21572407
MIRT544168	hsa-miR-4419b	PAR-CLIP	21572407
MIRT544167	hsa-miR-4478	PAR-CLIP	21572407
MIRT544166	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT544165	hsa-miR-135a-5p	PAR-CLIP	21572407
MIRT544164	hsa-miR-135b-5p	PAR-CLIP	21572407
MIRT544163	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT544162	hsa-miR-1827	PAR-CLIP	21572407
MIRT544161	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT544160	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT544159	hsa-miR-1909-3p	PAR-CLIP	21572407
MIRT544158	hsa-miR-6722-3p	PAR-CLIP	21572407
MIRT544157	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT544156	hsa-miR-1207-5p	PAR-CLIP	21572407
MIRT544155	hsa-miR-4763-3p	PAR-CLIP	21572407
MIRT544154	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT544153	hsa-miR-1273e	PAR-CLIP	21572407
MIRT544152	hsa-miR-665	PAR-CLIP	21572407
MIRT495080	hsa-miR-922	PAR-CLIP	23708386
MIRT475711	hsa-miR-214-3p	PAR-CLIP	23708386
MIRT475710	hsa-miR-3619-5p	PAR-CLIP	23708386
MIRT475709	hsa-miR-761	PAR-CLIP	23708386
MIRT495079	hsa-miR-4690-3p	PAR-CLIP	23708386
MIRT495078	hsa-miR-5685	PAR-CLIP	23708386
MIRT495076	hsa-miR-6787-3p	PAR-CLIP	23708386
MIRT495077	hsa-miR-339-3p	PAR-CLIP	23708386
MIRT495075	hsa-miR-668-5p	PAR-CLIP	23708386
MIRT495074	hsa-miR-4291	PAR-CLIP	23708386
MIRT475720	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT475719	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT475718	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT475717	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT475716	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT475715	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT475713	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT475714	hsa-miR-6165	PAR-CLIP	23592263
MIRT475712	hsa-miR-4733-5p	PAR-CLIP	23592263
MIRT475711	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT475710	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT475709	hsa-miR-761	PAR-CLIP	23592263
MIRT475708	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT475707	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT475706	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT475705	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT475704	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT475703	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT475702	hsa-miR-6081	PAR-CLIP	23592263
MIRT475701	hsa-miR-765	PAR-CLIP	23592263
MIRT1044812	hsa-miR-1178	CLIP-seq
MIRT1044813	hsa-miR-1182	CLIP-seq
MIRT1044814	hsa-miR-1184	CLIP-seq
MIRT1044815	hsa-miR-1205	CLIP-seq
MIRT1044816	hsa-miR-1231	CLIP-seq
MIRT1044817	hsa-miR-1245	CLIP-seq
MIRT1044818	hsa-miR-1261	CLIP-seq
MIRT1044819	hsa-miR-1275	CLIP-seq
MIRT1044820	hsa-miR-1276	CLIP-seq
MIRT1044821	hsa-miR-1285	CLIP-seq
MIRT1044822	hsa-miR-1287	CLIP-seq
MIRT1044823	hsa-miR-1293	CLIP-seq
MIRT1044824	hsa-miR-136	CLIP-seq
MIRT1044825	hsa-miR-149	CLIP-seq
MIRT1044826	hsa-miR-2467-3p	CLIP-seq
MIRT1044827	hsa-miR-2467-5p	CLIP-seq
MIRT1044828	hsa-miR-2682	CLIP-seq
MIRT1044829	hsa-miR-298	CLIP-seq
MIRT1044830	hsa-miR-31	CLIP-seq
MIRT1044831	hsa-miR-3120-5p	CLIP-seq
MIRT1044832	hsa-miR-3128	CLIP-seq
MIRT1044833	hsa-miR-3135	CLIP-seq
MIRT1044834	hsa-miR-3157-5p	CLIP-seq
MIRT1044835	hsa-miR-3158-5p	CLIP-seq
MIRT1044836	hsa-miR-3165	CLIP-seq
MIRT1044837	hsa-miR-3187-5p	CLIP-seq
MIRT1044838	hsa-miR-3188	CLIP-seq
MIRT1044839	hsa-miR-3192	CLIP-seq
MIRT1044840	hsa-miR-3199	CLIP-seq
MIRT1044841	hsa-miR-320e	CLIP-seq
MIRT1044842	hsa-miR-330-3p	CLIP-seq
MIRT1044843	hsa-miR-34a	CLIP-seq
MIRT1044844	hsa-miR-34c-5p	CLIP-seq
MIRT1044845	hsa-miR-3616-3p	CLIP-seq
MIRT1044846	hsa-miR-3678-3p	CLIP-seq
MIRT1044847	hsa-miR-3689d	CLIP-seq
MIRT1044848	hsa-miR-3714	CLIP-seq
MIRT1044849	hsa-miR-371b-3p	CLIP-seq
MIRT1044850	hsa-miR-378g	CLIP-seq
MIRT1044851	hsa-miR-3975	CLIP-seq
MIRT1044852	hsa-miR-4303	CLIP-seq
MIRT1044853	hsa-miR-4314	CLIP-seq
MIRT1044854	hsa-miR-4421	CLIP-seq
MIRT1044855	hsa-miR-4436b-3p	CLIP-seq
MIRT1044856	hsa-miR-4437	CLIP-seq
MIRT1044857	hsa-miR-4483	CLIP-seq
MIRT1044858	hsa-miR-4486	CLIP-seq
MIRT1044859	hsa-miR-4487	CLIP-seq
MIRT1044860	hsa-miR-4492	CLIP-seq
MIRT1044861	hsa-miR-4498	CLIP-seq
MIRT1044862	hsa-miR-449a	CLIP-seq
MIRT1044863	hsa-miR-449b	CLIP-seq
MIRT1044864	hsa-miR-449c	CLIP-seq
MIRT1044865	hsa-miR-4505	CLIP-seq
MIRT1044866	hsa-miR-4515	CLIP-seq
MIRT1044867	hsa-miR-451b	CLIP-seq
MIRT1044868	hsa-miR-4525	CLIP-seq
MIRT1044869	hsa-miR-4527	CLIP-seq
MIRT1044870	hsa-miR-4646-5p	CLIP-seq
MIRT1044871	hsa-miR-4665-5p	CLIP-seq
MIRT1044872	hsa-miR-4667-5p	CLIP-seq
MIRT1044873	hsa-miR-4674	CLIP-seq
MIRT1044874	hsa-miR-4685-5p	CLIP-seq
MIRT1044875	hsa-miR-4691-3p	CLIP-seq
MIRT1044876	hsa-miR-4700-5p	CLIP-seq
MIRT1044877	hsa-miR-4723-5p	CLIP-seq
MIRT1044878	hsa-miR-4762-3p	CLIP-seq
MIRT1044879	hsa-miR-4773	CLIP-seq
MIRT1044880	hsa-miR-512-5p	CLIP-seq
MIRT1044881	hsa-miR-548an	CLIP-seq
MIRT1044882	hsa-miR-612	CLIP-seq
MIRT1044883	hsa-miR-625	CLIP-seq
MIRT1044884	hsa-miR-637	CLIP-seq
MIRT1044885	hsa-miR-7	CLIP-seq
MIRT1044886	hsa-miR-762	CLIP-seq
MIRT1044887	hsa-miR-875-3p	CLIP-seq
MIRT1044888	hsa-miR-938	CLIP-seq
MIRT1044813	hsa-miR-1182	CLIP-seq
MIRT1044814	hsa-miR-1184	CLIP-seq
MIRT1044815	hsa-miR-1205	CLIP-seq
MIRT2009781	hsa-miR-1289	CLIP-seq
MIRT2009782	hsa-miR-1915	CLIP-seq
MIRT1044829	hsa-miR-298	CLIP-seq
MIRT1044834	hsa-miR-3157-5p	CLIP-seq
MIRT1044835	hsa-miR-3158-5p	CLIP-seq
MIRT2009783	hsa-miR-3179	CLIP-seq
MIRT2009784	hsa-miR-3198	CLIP-seq
MIRT2009785	hsa-miR-4254	CLIP-seq
MIRT2009786	hsa-miR-4294	CLIP-seq
MIRT2009787	hsa-miR-4309	CLIP-seq
MIRT1044869	hsa-miR-4527	CLIP-seq
MIRT1044875	hsa-miR-4691-3p	CLIP-seq
MIRT1044880	hsa-miR-512-5p	CLIP-seq
MIRT2009788	hsa-miR-520a-5p	CLIP-seq
MIRT2009789	hsa-miR-525-5p	CLIP-seq
MIRT1044815	hsa-miR-1205	CLIP-seq
MIRT2242133	hsa-miR-1292	CLIP-seq
MIRT2242134	hsa-miR-151-5p	CLIP-seq
MIRT2242135	hsa-miR-151b	CLIP-seq
MIRT2242136	hsa-miR-3131	CLIP-seq
MIRT1044834	hsa-miR-3157-5p	CLIP-seq
MIRT1044847	hsa-miR-3689d	CLIP-seq
MIRT2242137	hsa-miR-3921	CLIP-seq
MIRT2242138	hsa-miR-4271	CLIP-seq
MIRT2242139	hsa-miR-4471	CLIP-seq
MIRT2242140	hsa-miR-4476	CLIP-seq
MIRT2242141	hsa-miR-4653-5p	CLIP-seq
MIRT2242142	hsa-miR-4687-3p	CLIP-seq
MIRT1044875	hsa-miR-4691-3p	CLIP-seq
MIRT2242143	hsa-miR-4725-3p	CLIP-seq
MIRT2242144	hsa-miR-544b	CLIP-seq
MIRT2242145	hsa-miR-611	CLIP-seq
MIRT1044824	hsa-miR-136	CLIP-seq
MIRT1044850	hsa-miR-378g	CLIP-seq
MIRT1044856	hsa-miR-4437	CLIP-seq
MIRT2545762	hsa-miR-4447	CLIP-seq
MIRT2545763	hsa-miR-4472	CLIP-seq
MIRT2545764	hsa-miR-4488	CLIP-seq
MIRT1044860	hsa-miR-4492	CLIP-seq
MIRT1044861	hsa-miR-4498	CLIP-seq
MIRT1044865	hsa-miR-4505	CLIP-seq
MIRT1044873	hsa-miR-4674	CLIP-seq
MIRT2545765	hsa-miR-4697-5p	CLIP-seq
MIRT1044886	hsa-miR-762	CLIP-seq

Show/Hide all (67)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	21290414
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	21454491
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003151	Process	Outflow tract morphogenesis	IEA
GO:0003151	Process	Outflow tract morphogenesis	ISS
GO:0003180	Process	Aortic valve morphogenesis	TAS	20951801
GO:0003181	Process	Atrioventricular valve morphogenesis	IEA
GO:0003181	Process	Atrioventricular valve morphogenesis	ISS
GO:0003184	Process	Pulmonary valve morphogenesis	IEA
GO:0003184	Process	Pulmonary valve morphogenesis	ISS
GO:0003198	Process	Epithelial to mesenchymal transition involved in endocardial cushion formation	IEA
GO:0003198	Process	Epithelial to mesenchymal transition involved in endocardial cushion formation	ISS
GO:0003198	Process	Epithelial to mesenchymal transition involved in endocardial cushion formation	TAS	20951801
GO:0003203	Process	Endocardial cushion morphogenesis	IEA
GO:0003203	Process	Endocardial cushion morphogenesis	ISS
GO:0003208	Process	Cardiac ventricle morphogenesis	IEA
GO:0003208	Process	Cardiac ventricle morphogenesis	ISS
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	15485867
GO:0005515	Function	Protein binding	IPI	15485867, 16189514, 21454491, 21516116, 25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	21454491
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007219	Process	Notch signaling pathway	IDA	10964718
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007219	Process	Notch signaling pathway	TAS	20951801
GO:0009653	Process	Anatomical structure morphogenesis	IEA
GO:0009952	Process	Anterior/posterior pattern specification	IBA
GO:0010629	Process	Negative regulation of gene expression	IEA
GO:0014031	Process	Mesenchymal cell development	IEA
GO:0014031	Process	Mesenchymal cell development	ISS
GO:0032835	Process	Glomerulus development	IEA
GO:0035914	Process	Skeletal muscle cell differentiation	IEA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0043433	Process	Negative regulation of DNA-binding transcription factor activity	IDA	21454491
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	15485867, 21454491
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	21290414
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0050683	Function	AF-1 domain binding	IPI	21454491
GO:0050767	Process	Regulation of neurogenesis	IBA
GO:0060317	Process	Cardiac epithelial to mesenchymal transition	IEA
GO:0060317	Process	Cardiac epithelial to mesenchymal transition	ISS
GO:0060412	Process	Ventricular septum morphogenesis	IEA
GO:0060412	Process	Ventricular septum morphogenesis	ISS
GO:0060766	Process	Negative regulation of androgen receptor signaling pathway	IDA	21454491
GO:0071773	Process	Cellular response to BMP stimulus	IEA
GO:0072014	Process	Proximal tubule development	IEA
GO:0072359	Process	Circulatory system development	IEA

MIM	HGNC	e!Ensembl
609034	4882	ENSG00000163909

Q9NQ87

Protein name

Hairy/enhancer-of-split related with YRPW motif-like protein (hHeyL) (Class B basic helix-loop-helix protein 33) (bHLHb33) (Hairy-related transcription factor 3) (HRT-3) (hHRT3)

Protein function

Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcripti

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	44 → 99	Helix-loop-helix DNA-binding domain	Domain
PF07527	Hairy_orange	116 → 158	Hairy Orange	Domain

Sequence

MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKHRGIIEKRRRDRIN
SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIG
FRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFF
HSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSR
GASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNS
SSPGPAGRPAGAMLYHSWVSEITEIGAF

Sequence length

328

Interactions

View interactions

	KEGG		Reactome
	Notch signaling pathway Human papillomavirus infection Pathways in cancer Breast cancer		Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Intracellular Domain Regulates Transcription

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	21036696		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30588893		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	38025763	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31796022		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32957968	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cough	Cough	Pubtator	35655915	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	27743158, 29944673		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma, Primary Open Angle	Glaucoma	BEFREE	27487343		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma, Suspect	Glaucoma	BEFREE	27480527		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Septal Defects Ventricular	Congenital heart septal defect	Pubtator	30897084	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	21036696		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30588893		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	21454491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	21036696		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	15520192		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	21036696		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	21036696		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31796022		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28766235		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	21454491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21454491	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	34831437	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	32463580	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HEYL (hes related family bHLH transcription factor with YRPW motif like)