CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1)

Gene

• Entrez ID: 26507
• Gene name: Cyclin and CBS domain divalent metal cation transport mediator 1
• Gene symbol: CNNM1
• Synonyms (NCBI Gene): ACDP1, CLP-1, SLC70A1
• Chromosome: 10
• Chromosome location: 10q24.2
• Summary: This gene encodes a member of the ancient conserved domain protein family. The encoded protein may bind copper. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT899915	hsa-miR-1237	CLIP-seq
MIRT899916	hsa-miR-1245	CLIP-seq
MIRT899917	hsa-miR-1248	CLIP-seq
MIRT899918	hsa-miR-125a-5p	CLIP-seq
MIRT899919	hsa-miR-125b	CLIP-seq
MIRT899920	hsa-miR-1276	CLIP-seq
MIRT899921	hsa-miR-129-5p	CLIP-seq
MIRT899922	hsa-miR-1297	CLIP-seq
MIRT899923	hsa-miR-132	CLIP-seq
MIRT899924	hsa-miR-146a	CLIP-seq
MIRT899925	hsa-miR-146b-5p	CLIP-seq
MIRT899926	hsa-miR-1915	CLIP-seq
MIRT899927	hsa-miR-197	CLIP-seq
MIRT899928	hsa-miR-212	CLIP-seq
MIRT899929	hsa-miR-26a	CLIP-seq
MIRT899930	hsa-miR-26b	CLIP-seq
MIRT899931	hsa-miR-3065-3p	CLIP-seq
MIRT899932	hsa-miR-3134	CLIP-seq
MIRT899933	hsa-miR-3160-5p	CLIP-seq
MIRT899934	hsa-miR-3170	CLIP-seq
MIRT899935	hsa-miR-3179	CLIP-seq
MIRT899936	hsa-miR-3182	CLIP-seq
MIRT899937	hsa-miR-3187-3p	CLIP-seq
MIRT899938	hsa-miR-3202	CLIP-seq
MIRT899939	hsa-miR-331-3p	CLIP-seq
MIRT899940	hsa-miR-342-5p	CLIP-seq
MIRT899941	hsa-miR-3653	CLIP-seq
MIRT899942	hsa-miR-3658	CLIP-seq
MIRT899943	hsa-miR-3663-5p	CLIP-seq
MIRT899944	hsa-miR-3689d	CLIP-seq
MIRT899945	hsa-miR-371-5p	CLIP-seq
MIRT899946	hsa-miR-371b-5p	CLIP-seq
MIRT899947	hsa-miR-383	CLIP-seq
MIRT899948	hsa-miR-4267	CLIP-seq
MIRT899949	hsa-miR-4291	CLIP-seq
MIRT899950	hsa-miR-4292	CLIP-seq
MIRT899951	hsa-miR-4303	CLIP-seq
MIRT899952	hsa-miR-4311	CLIP-seq
MIRT899953	hsa-miR-4319	CLIP-seq
MIRT899954	hsa-miR-4328	CLIP-seq
MIRT899955	hsa-miR-4329	CLIP-seq
MIRT899956	hsa-miR-4424	CLIP-seq
MIRT899957	hsa-miR-4435	CLIP-seq
MIRT899958	hsa-miR-4443	CLIP-seq
MIRT899959	hsa-miR-4465	CLIP-seq
MIRT899960	hsa-miR-4476	CLIP-seq
MIRT899961	hsa-miR-4509	CLIP-seq
MIRT899962	hsa-miR-4511	CLIP-seq
MIRT899963	hsa-miR-4529-5p	CLIP-seq
MIRT899964	hsa-miR-4534	CLIP-seq
MIRT899965	hsa-miR-4640-3p	CLIP-seq
MIRT899966	hsa-miR-4651	CLIP-seq
MIRT899967	hsa-miR-4652-3p	CLIP-seq
MIRT899968	hsa-miR-4664-5p	CLIP-seq
MIRT899969	hsa-miR-4682	CLIP-seq
MIRT899970	hsa-miR-4701-5p	CLIP-seq
MIRT899971	hsa-miR-4716-5p	CLIP-seq
MIRT899972	hsa-miR-4728-5p	CLIP-seq
MIRT899973	hsa-miR-4740-3p	CLIP-seq
MIRT899974	hsa-miR-4744	CLIP-seq
MIRT899975	hsa-miR-4755-3p	CLIP-seq
MIRT899976	hsa-miR-4761-5p	CLIP-seq
MIRT899977	hsa-miR-4772-3p	CLIP-seq
MIRT899978	hsa-miR-4778-5p	CLIP-seq
MIRT899979	hsa-miR-4781-3p	CLIP-seq
MIRT899980	hsa-miR-4785	CLIP-seq
MIRT899981	hsa-miR-5096	CLIP-seq
MIRT899982	hsa-miR-548b-3p	CLIP-seq
MIRT899983	hsa-miR-548s	CLIP-seq
MIRT899984	hsa-miR-582-5p	CLIP-seq
MIRT899985	hsa-miR-583	CLIP-seq
MIRT899986	hsa-miR-587	CLIP-seq
MIRT899987	hsa-miR-588	CLIP-seq
MIRT899988	hsa-miR-589	CLIP-seq
MIRT899989	hsa-miR-600	CLIP-seq
MIRT899990	hsa-miR-608	CLIP-seq
MIRT899991	hsa-miR-617	CLIP-seq
MIRT899992	hsa-miR-640	CLIP-seq
MIRT899993	hsa-miR-711	CLIP-seq
MIRT899994	hsa-miR-765	CLIP-seq
MIRT1966902	hsa-miR-1245b-3p	CLIP-seq
MIRT1966903	hsa-miR-1245b-5p	CLIP-seq
MIRT1966904	hsa-miR-1265	CLIP-seq
MIRT1966905	hsa-miR-1275	CLIP-seq
MIRT1966906	hsa-miR-1287	CLIP-seq
MIRT899926	hsa-miR-1915	CLIP-seq
MIRT1966907	hsa-miR-1972	CLIP-seq
MIRT1966908	hsa-miR-2392	CLIP-seq
MIRT1966909	hsa-miR-3135	CLIP-seq
MIRT1966910	hsa-miR-3142	CLIP-seq
MIRT1966911	hsa-miR-3151	CLIP-seq
MIRT1966912	hsa-miR-3156-3p	CLIP-seq
MIRT1966913	hsa-miR-3189-3p	CLIP-seq
MIRT1966914	hsa-miR-3199	CLIP-seq
MIRT1966915	hsa-miR-3616-5p	CLIP-seq
MIRT1966916	hsa-miR-3647-5p	CLIP-seq
MIRT1966917	hsa-miR-3650	CLIP-seq
MIRT1966918	hsa-miR-3689a-3p	CLIP-seq
MIRT1966919	hsa-miR-3689c	CLIP-seq
MIRT1966920	hsa-miR-4271	CLIP-seq
MIRT1966921	hsa-miR-4301	CLIP-seq
MIRT899951	hsa-miR-4303	CLIP-seq
MIRT899954	hsa-miR-4328	CLIP-seq
MIRT1966922	hsa-miR-4447	CLIP-seq
MIRT1966923	hsa-miR-4455	CLIP-seq
MIRT1966924	hsa-miR-4472	CLIP-seq
MIRT1966925	hsa-miR-4525	CLIP-seq
MIRT1966926	hsa-miR-4645-5p	CLIP-seq
MIRT1966927	hsa-miR-4665-5p	CLIP-seq
MIRT1966928	hsa-miR-4673	CLIP-seq
MIRT899969	hsa-miR-4682	CLIP-seq
MIRT1966929	hsa-miR-4723-5p	CLIP-seq
MIRT1966930	hsa-miR-4725-3p	CLIP-seq
MIRT899973	hsa-miR-4740-3p	CLIP-seq
MIRT1966931	hsa-miR-4742-5p	CLIP-seq
MIRT899975	hsa-miR-4755-3p	CLIP-seq
MIRT899976	hsa-miR-4761-5p	CLIP-seq
MIRT899980	hsa-miR-4785	CLIP-seq
MIRT1966932	hsa-miR-4795-5p	CLIP-seq
MIRT1966933	hsa-miR-491-5p	CLIP-seq
MIRT1966934	hsa-miR-519a	CLIP-seq
MIRT1966935	hsa-miR-519b-3p	CLIP-seq
MIRT1966936	hsa-miR-519c-3p	CLIP-seq
MIRT1966937	hsa-miR-532-3p	CLIP-seq
MIRT1966938	hsa-miR-573	CLIP-seq
MIRT899986	hsa-miR-587	CLIP-seq
MIRT1966939	hsa-miR-609	CLIP-seq
MIRT1966940	hsa-miR-625	CLIP-seq
MIRT2202678	hsa-miR-1243	CLIP-seq
MIRT899916	hsa-miR-1245	CLIP-seq
MIRT1966902	hsa-miR-1245b-3p	CLIP-seq
MIRT1966903	hsa-miR-1245b-5p	CLIP-seq
MIRT2202679	hsa-miR-1255a	CLIP-seq
MIRT2202680	hsa-miR-1255b	CLIP-seq
MIRT2202681	hsa-miR-125a-3p	CLIP-seq
MIRT1966905	hsa-miR-1275	CLIP-seq
MIRT899921	hsa-miR-129-5p	CLIP-seq
MIRT899922	hsa-miR-1297	CLIP-seq
MIRT2202682	hsa-miR-1302	CLIP-seq
MIRT899926	hsa-miR-1915	CLIP-seq
MIRT1966907	hsa-miR-1972	CLIP-seq
MIRT2202683	hsa-miR-2110	CLIP-seq
MIRT2202684	hsa-miR-2278	CLIP-seq
MIRT899929	hsa-miR-26a	CLIP-seq
MIRT899930	hsa-miR-26b	CLIP-seq
MIRT2202685	hsa-miR-299-3p	CLIP-seq
MIRT2202686	hsa-miR-31	CLIP-seq
MIRT2202687	hsa-miR-3122	CLIP-seq
MIRT1966910	hsa-miR-3142	CLIP-seq
MIRT2202688	hsa-miR-3147	CLIP-seq
MIRT2202689	hsa-miR-3150a-3p	CLIP-seq
MIRT1966911	hsa-miR-3151	CLIP-seq
MIRT2202690	hsa-miR-3180-5p	CLIP-seq
MIRT1966913	hsa-miR-3189-3p	CLIP-seq
MIRT2202691	hsa-miR-3194-3p	CLIP-seq
MIRT1966914	hsa-miR-3199	CLIP-seq
MIRT2202692	hsa-miR-326	CLIP-seq
MIRT2202693	hsa-miR-330-5p	CLIP-seq
MIRT2202694	hsa-miR-335	CLIP-seq
MIRT2202695	hsa-miR-3611	CLIP-seq
MIRT2202696	hsa-miR-3622a-3p	CLIP-seq
MIRT2202697	hsa-miR-3622b-3p	CLIP-seq
MIRT2202698	hsa-miR-3665	CLIP-seq
MIRT1966918	hsa-miR-3689a-3p	CLIP-seq
MIRT1966919	hsa-miR-3689c	CLIP-seq
MIRT2202699	hsa-miR-3913-5p	CLIP-seq
MIRT2202700	hsa-miR-3934	CLIP-seq
MIRT2202701	hsa-miR-3940-5p	CLIP-seq
MIRT2202702	hsa-miR-4255	CLIP-seq
MIRT1966920	hsa-miR-4271	CLIP-seq
MIRT2202703	hsa-miR-4298	CLIP-seq
MIRT2202704	hsa-miR-4425	CLIP-seq
MIRT1966922	hsa-miR-4447	CLIP-seq
MIRT899959	hsa-miR-4465	CLIP-seq
MIRT1966924	hsa-miR-4472	CLIP-seq
MIRT2202705	hsa-miR-4491	CLIP-seq
MIRT2202706	hsa-miR-4507	CLIP-seq
MIRT2202707	hsa-miR-4515	CLIP-seq
MIRT1966925	hsa-miR-4525	CLIP-seq
MIRT1966926	hsa-miR-4645-5p	CLIP-seq
MIRT2202708	hsa-miR-4648	CLIP-seq
MIRT2202709	hsa-miR-4654	CLIP-seq
MIRT2202710	hsa-miR-4657	CLIP-seq
MIRT1966927	hsa-miR-4665-5p	CLIP-seq
MIRT2202711	hsa-miR-4670-3p	CLIP-seq
MIRT1966928	hsa-miR-4673	CLIP-seq
MIRT899969	hsa-miR-4682	CLIP-seq
MIRT1966929	hsa-miR-4723-5p	CLIP-seq
MIRT1966930	hsa-miR-4725-3p	CLIP-seq
MIRT899972	hsa-miR-4728-5p	CLIP-seq
MIRT899973	hsa-miR-4740-3p	CLIP-seq
MIRT1966931	hsa-miR-4742-5p	CLIP-seq
MIRT899975	hsa-miR-4755-3p	CLIP-seq
MIRT2202712	hsa-miR-4757-5p	CLIP-seq
MIRT2202713	hsa-miR-4769-5p	CLIP-seq
MIRT1966933	hsa-miR-491-5p	CLIP-seq
MIRT1966939	hsa-miR-609	CLIP-seq
MIRT899991	hsa-miR-617	CLIP-seq
MIRT1966940	hsa-miR-625	CLIP-seq
MIRT899992	hsa-miR-640	CLIP-seq
MIRT2202714	hsa-miR-764	CLIP-seq
MIRT2202715	hsa-miR-943	CLIP-seq
MIRT899915	hsa-miR-1237	CLIP-seq
MIRT899921	hsa-miR-129-5p	CLIP-seq
MIRT2202684	hsa-miR-2278	CLIP-seq
MIRT1966914	hsa-miR-3199	CLIP-seq
MIRT899951	hsa-miR-4303	CLIP-seq
MIRT899926	hsa-miR-1915	CLIP-seq
MIRT899973	hsa-miR-4740-3p	CLIP-seq
MIRT2202678	hsa-miR-1243	CLIP-seq
MIRT2202679	hsa-miR-1255a	CLIP-seq
MIRT2202680	hsa-miR-1255b	CLIP-seq
MIRT2202682	hsa-miR-1302	CLIP-seq
MIRT899926	hsa-miR-1915	CLIP-seq
MIRT1966907	hsa-miR-1972	CLIP-seq
MIRT2202684	hsa-miR-2278	CLIP-seq
MIRT2202686	hsa-miR-31	CLIP-seq
MIRT2505650	hsa-miR-3117-5p	CLIP-seq
MIRT2202687	hsa-miR-3122	CLIP-seq
MIRT2202688	hsa-miR-3147	CLIP-seq
MIRT1966914	hsa-miR-3199	CLIP-seq
MIRT2202694	hsa-miR-335	CLIP-seq
MIRT2202695	hsa-miR-3611	CLIP-seq
MIRT2202698	hsa-miR-3665	CLIP-seq
MIRT2505651	hsa-miR-3685	CLIP-seq
MIRT2202699	hsa-miR-3913-5p	CLIP-seq
MIRT2202700	hsa-miR-3934	CLIP-seq
MIRT2202703	hsa-miR-4298	CLIP-seq
MIRT2505652	hsa-miR-4326	CLIP-seq
MIRT2202704	hsa-miR-4425	CLIP-seq
MIRT2202707	hsa-miR-4515	CLIP-seq
MIRT1966926	hsa-miR-4645-5p	CLIP-seq
MIRT2202711	hsa-miR-4670-3p	CLIP-seq
MIRT1966928	hsa-miR-4673	CLIP-seq
MIRT899973	hsa-miR-4740-3p	CLIP-seq
MIRT1966931	hsa-miR-4742-5p	CLIP-seq
MIRT2202715	hsa-miR-943	CLIP-seq
MIRT899926	hsa-miR-1915	CLIP-seq
MIRT899973	hsa-miR-4740-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	27880917, 28330616, 32296183, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0010960	Process	Magnesium ion homeostasis	IBA
GO:0010960	Process	Magnesium ion homeostasis	IEA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IBA
GO:0030425	Component	Dendrite	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0055085	Process	Transmembrane transport	IEA

Other IDs

• MIM: 607802
• HGNC: 102
• e!Ensembl: ENSG00000119946

Protein

• UniProt ID: Q9NRU3
• Protein name: Metal transporter CNNM1 (Ancient conserved domain-containing protein 1) (Cyclin-M1)
• Protein function: Probable metal transporter.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01595	DUF21	227 → 414	Cyclin M transmembrane N-terminal domain	Domain
  PF00571	CBS	498 → 562	CBS domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Restricted to brain and testis. {ECO:0000269|PubMed:12657465}.
• Sequence:

  MAAAAAAAAAVGVRLRDCCSRGAVLLLFFSLSPRPPAAAAWLLGLRPEDTAGGRVSLEGG
  TLRAAEGTSFLLRVYFQPGPPATAAPVPSPTLNSGENGTGDWAPRLVFIEEPPGGGGVAP
  SAVPTRPPGPQRCREQSDWASDVEVLGPLRPGGVAGSALVQVRVRELRKGEAERGGAGGG
  GKLFSLCAWDGRAWHHHGAAGGFLLRVRPRLYGPGGDLLPPAWLRALGALLLLALSALFS
  GLRLSLLSLDPVELRVLRNSGSAAEQEQARRVQAVRGRGTHLLCTLLLGQAGANAALAGW
  LYTSLPPGFGGTGEDYSEEGIHFPWLPALVCTGAVFLGAEICPYSVCSRHGLAIASHSVC
  LTRLLMAAAFPVCYPLGRLLDWALRQEISTFYTREKLLETLRAADPYSDLVKEELNIIQG
  ALELRTKVVEEVLTPLGDCFMLRSDAVLDFATVSEILRSGYTRIPVYEGDQRHNIVDILF
  VKDLAFVDPDDCTPLLTVTRFYNRPLHCVFNDTRLDTVLEEFKKGKSHLAIVQRVNNEGE
  GDPFYEVMGIVTLEDIIEEIIKSEILDETDLYTDNRKKQRVPQRERKRHDFSLFKLSDTE
  MRVKISPQLLLATHRFMATEVEPFKSLYLSEKILLRLLKHPNVIQELKFDEKNKKAPEHY
  LYQRNRPVDYFVLLLQGKVEVEVGKEGLRFENGAFTYYGVPAIMTTACSDNDVRKVGSLA
  GSSVFLNRSPSRCSGLNRSESPNRERSDFGGSNTQLYSSSNNLYMPDYSVHILSDVQFVK
  ITRQQYQNALTACHMDSSPQSPDMEAFTDGDSTKAPTTRGTPQTPKDDPAITLLNNRNSL
  PCSRSDGLRSPSEVVYLRMEELAFTQEEMTDFEEHSTQQLTLSPAAVPTRAASDSECCNI
  NLDTETSPCSSDFEENVGKKLLRTLSGQKRKRSPEGERTSEDNSNLTPLIT

• Sequence length: 951

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Breast ductal adenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL ARTERIAL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOOTH DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	25733456	Inhibit	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	25733456	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	25733456		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	37192718	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37192718	Associate	★☆☆☆☆ Found in Text Mining only
Infertility Male	Male infertility	Pubtator	36446526	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30486934		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	CTD_human_DG	16778180		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myopathy	Myopathy	BEFREE	22479198		★☆☆☆☆ Found in Text Mining only
Ochoa syndrome	Ochoa Syndrome	BEFREE	12707951		★☆☆☆☆ Found in Text Mining only
Peripheral Arterial Diseases	Vascular Diseases	GWASCAT_DG	27082954		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30486934		★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	29351916		★☆☆☆☆ Found in Text Mining only
Urofacial syndrome	Urofacial syndrome	Pubtator	15498024, 21393841	Associate	★☆☆☆☆ Found in Text Mining only