CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4)

Gene

• Entrez ID: 26504
• Gene name: Cyclin and CBS domain divalent metal cation transport mediator 4
• Gene symbol: CNNM4
• Synonyms (NCBI Gene): ACDP4, SLC70A4
• Chromosome: 2
• Chromosome location: 2q11.2
• Summary: This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Muta

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs74552543	T>C	Pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant
rs75267011	G>A	Pathogenic-likely-pathogenic	Coding sequence variant, genic upstream transcript variant, missense variant
rs75559353	C>T	Pathogenic	Coding sequence variant, stop gained, missense variant, genic downstream transcript variant
rs79424354	C>A	Pathogenic	Coding sequence variant, genic upstream transcript variant, missense variant
rs80100937	C>T	Pathogenic	Coding sequence variant, stop gained, genic downstream transcript variant
rs746879923	C>-,CC	Pathogenic	Coding sequence variant, genic upstream transcript variant, frameshift variant
rs786205530	C>T	Likely-pathogenic	Coding sequence variant, genic upstream transcript variant, missense variant
rs879255500	G>C	Pathogenic	Splice acceptor variant, genic downstream transcript variant
rs1432600424	C>G,T	Pathogenic	Stop gained, synonymous variant, coding sequence variant, genic downstream transcript variant
rs1574047005	T>C	Likely-pathogenic	Coding sequence variant, genic upstream transcript variant, missense variant
rs1574047454	G>T	Pathogenic	Coding sequence variant, genic upstream transcript variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027523	hsa-miR-98-5p	Microarray	19088304
MIRT624318	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT624317	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT624316	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624315	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT624314	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT659442	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT624318	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT624317	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT624316	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624315	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT624314	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT624318	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT624317	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT624316	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624315	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT624314	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT304110	hsa-miR-4476	PAR-CLIP	20371350
MIRT304115	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT479100	hsa-miR-1203	PAR-CLIP	20371350
MIRT479093	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT479074	hsa-miR-765	PAR-CLIP	20371350
MIRT479102	hsa-miR-1306-5p	PAR-CLIP	20371350
MIRT479100	hsa-miR-1203	PAR-CLIP	20371350
MIRT479093	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT479074	hsa-miR-765	PAR-CLIP	20371350
MIRT559906	hsa-miR-128-3p	PAR-CLIP	20371350
MIRT559905	hsa-miR-216a-3p	PAR-CLIP	20371350
MIRT559904	hsa-miR-3681-3p	PAR-CLIP	20371350
MIRT559903	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT559902	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT479075	hsa-miR-6077	PAR-CLIP	20371350
MIRT479073	hsa-miR-4640-5p	PAR-CLIP	20371350
MIRT479072	hsa-miR-4726-5p	PAR-CLIP	20371350
MIRT479070	hsa-miR-6508-3p	PAR-CLIP	20371350
MIRT559901	hsa-miR-363-5p	PAR-CLIP	20371350
MIRT559900	hsa-miR-6745	PAR-CLIP	20371350
MIRT559898	hsa-miR-6756-5p	PAR-CLIP	20371350
MIRT559899	hsa-miR-6766-5p	PAR-CLIP	20371350
MIRT559897	hsa-miR-1293	PAR-CLIP	20371350
MIRT559896	hsa-miR-4483	PAR-CLIP	20371350
MIRT559895	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT559894	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT559893	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT559892	hsa-miR-6748-5p	PAR-CLIP	20371350
MIRT548758	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT548757	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT548756	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT548755	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT548754	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT548753	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT548752	hsa-miR-3914	PAR-CLIP	21572407
MIRT304110	hsa-miR-4476	PAR-CLIP	21572407
MIRT304115	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT304112	hsa-miR-5584-5p	PAR-CLIP	21572407
MIRT304109	hsa-miR-4257	PAR-CLIP	21572407
MIRT304116	hsa-miR-7515	PAR-CLIP	21572407
MIRT304104	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT304113	hsa-miR-6086	PAR-CLIP	21572407
MIRT304107	hsa-miR-3148	PAR-CLIP	21572407
MIRT304108	hsa-miR-3202	PAR-CLIP	21572407
MIRT304111	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT548751	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT548750	hsa-miR-7703	PAR-CLIP	21572407
MIRT548749	hsa-miR-4325	PAR-CLIP	21572407
MIRT304110	hsa-miR-4476	PAR-CLIP	23592263
MIRT304115	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT479103	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT479102	hsa-miR-1306-5p	PAR-CLIP	23592263
MIRT479100	hsa-miR-1203	PAR-CLIP	23592263
MIRT304116	hsa-miR-7515	PAR-CLIP	23592263
MIRT304108	hsa-miR-3202	PAR-CLIP	23592263
MIRT479093	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT479074	hsa-miR-765	PAR-CLIP	23592263
MIRT479091	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT479089	hsa-miR-8085	PAR-CLIP	23592263
MIRT304110	hsa-miR-4476	PAR-CLIP	23592263
MIRT304115	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT479103	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT479102	hsa-miR-1306-5p	PAR-CLIP	23592263
MIRT479101	hsa-miR-1224-3p	PAR-CLIP	23592263
MIRT479100	hsa-miR-1203	PAR-CLIP	23592263
MIRT479099	hsa-miR-326	PAR-CLIP	23592263
MIRT479098	hsa-miR-330-5p	PAR-CLIP	23592263
MIRT479097	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT479096	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT479095	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT479094	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT479093	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT479092	hsa-miR-760	PAR-CLIP	23592263
MIRT479091	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT479089	hsa-miR-8085	PAR-CLIP	23592263
MIRT479090	hsa-miR-4713-3p	PAR-CLIP	23592263
MIRT479088	hsa-miR-638	PAR-CLIP	23592263
MIRT479087	hsa-miR-1260a	PAR-CLIP	23592263
MIRT479086	hsa-miR-1260b	PAR-CLIP	23592263
MIRT479085	hsa-miR-4314	PAR-CLIP	23592263
MIRT479084	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479083	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT479082	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT479081	hsa-miR-575	PAR-CLIP	23592263
MIRT479080	hsa-miR-4779	PAR-CLIP	23592263
MIRT479079	hsa-miR-9500	PAR-CLIP	23592263
MIRT479078	hsa-miR-6895-5p	PAR-CLIP	23592263
MIRT479077	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT479076	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT479075	hsa-miR-6077	PAR-CLIP	23592263
MIRT479074	hsa-miR-765	PAR-CLIP	23592263
MIRT479073	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT479072	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT479070	hsa-miR-6508-3p	PAR-CLIP	23592263
MIRT479071	hsa-miR-323a-5p	PAR-CLIP	23592263
MIRT479069	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT624318	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT624317	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT624316	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624315	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT624314	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT659442	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT624318	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT624317	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT624316	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624315	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT624314	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT624318	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT624317	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT624316	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624315	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT624314	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT304110	hsa-miR-4476	PAR-CLIP	20371350
MIRT304115	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT479100	hsa-miR-1203	PAR-CLIP	20371350
MIRT479093	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT479074	hsa-miR-765	PAR-CLIP	20371350
MIRT479102	hsa-miR-1306-5p	PAR-CLIP	20371350
MIRT479100	hsa-miR-1203	PAR-CLIP	20371350
MIRT479093	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT479074	hsa-miR-765	PAR-CLIP	20371350
MIRT559906	hsa-miR-128-3p	PAR-CLIP	20371350
MIRT559905	hsa-miR-216a-3p	PAR-CLIP	20371350
MIRT559904	hsa-miR-3681-3p	PAR-CLIP	20371350
MIRT559903	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT559902	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT479075	hsa-miR-6077	PAR-CLIP	20371350
MIRT479073	hsa-miR-4640-5p	PAR-CLIP	20371350
MIRT479072	hsa-miR-4726-5p	PAR-CLIP	20371350
MIRT479070	hsa-miR-6508-3p	PAR-CLIP	20371350
MIRT559901	hsa-miR-363-5p	PAR-CLIP	20371350
MIRT559900	hsa-miR-6745	PAR-CLIP	20371350
MIRT559898	hsa-miR-6756-5p	PAR-CLIP	20371350
MIRT559899	hsa-miR-6766-5p	PAR-CLIP	20371350
MIRT559897	hsa-miR-1293	PAR-CLIP	20371350
MIRT559896	hsa-miR-4483	PAR-CLIP	20371350
MIRT559895	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT559894	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT559893	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT559892	hsa-miR-6748-5p	PAR-CLIP	20371350
MIRT548758	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT548757	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT548756	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT548755	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT548754	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT548753	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT548752	hsa-miR-3914	PAR-CLIP	21572407
MIRT304110	hsa-miR-4476	PAR-CLIP	21572407
MIRT304115	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT304112	hsa-miR-5584-5p	PAR-CLIP	21572407
MIRT304109	hsa-miR-4257	PAR-CLIP	21572407
MIRT304116	hsa-miR-7515	PAR-CLIP	21572407
MIRT304104	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT304113	hsa-miR-6086	PAR-CLIP	21572407
MIRT304107	hsa-miR-3148	PAR-CLIP	21572407
MIRT304108	hsa-miR-3202	PAR-CLIP	21572407
MIRT304111	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT548751	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT548750	hsa-miR-7703	PAR-CLIP	21572407
MIRT548749	hsa-miR-4325	PAR-CLIP	21572407
MIRT304110	hsa-miR-4476	PAR-CLIP	23592263
MIRT304115	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT479103	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT479102	hsa-miR-1306-5p	PAR-CLIP	23592263
MIRT479100	hsa-miR-1203	PAR-CLIP	23592263
MIRT304116	hsa-miR-7515	PAR-CLIP	23592263
MIRT304108	hsa-miR-3202	PAR-CLIP	23592263
MIRT479093	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT479074	hsa-miR-765	PAR-CLIP	23592263
MIRT479091	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT479089	hsa-miR-8085	PAR-CLIP	23592263
MIRT304110	hsa-miR-4476	PAR-CLIP	23592263
MIRT304115	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT479103	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT479102	hsa-miR-1306-5p	PAR-CLIP	23592263
MIRT479101	hsa-miR-1224-3p	PAR-CLIP	23592263
MIRT479100	hsa-miR-1203	PAR-CLIP	23592263
MIRT479099	hsa-miR-326	PAR-CLIP	23592263
MIRT479098	hsa-miR-330-5p	PAR-CLIP	23592263
MIRT479097	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT479096	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT479095	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT479094	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT479093	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT479092	hsa-miR-760	PAR-CLIP	23592263
MIRT479091	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT479089	hsa-miR-8085	PAR-CLIP	23592263
MIRT479090	hsa-miR-4713-3p	PAR-CLIP	23592263
MIRT479088	hsa-miR-638	PAR-CLIP	23592263
MIRT479087	hsa-miR-1260a	PAR-CLIP	23592263
MIRT479086	hsa-miR-1260b	PAR-CLIP	23592263
MIRT479085	hsa-miR-4314	PAR-CLIP	23592263
MIRT479084	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479083	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT479082	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT479081	hsa-miR-575	PAR-CLIP	23592263
MIRT479080	hsa-miR-4779	PAR-CLIP	23592263
MIRT479079	hsa-miR-9500	PAR-CLIP	23592263
MIRT479078	hsa-miR-6895-5p	PAR-CLIP	23592263
MIRT479077	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT479076	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT479075	hsa-miR-6077	PAR-CLIP	23592263
MIRT479074	hsa-miR-765	PAR-CLIP	23592263
MIRT479073	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT479072	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT479070	hsa-miR-6508-3p	PAR-CLIP	23592263
MIRT479071	hsa-miR-323a-5p	PAR-CLIP	23592263
MIRT479069	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT900136	hsa-miR-1208	CLIP-seq
MIRT900137	hsa-miR-1237	CLIP-seq
MIRT900138	hsa-miR-1248	CLIP-seq
MIRT900139	hsa-miR-128	CLIP-seq
MIRT900140	hsa-miR-1299	CLIP-seq
MIRT900141	hsa-miR-1324	CLIP-seq
MIRT900142	hsa-miR-135a	CLIP-seq
MIRT900143	hsa-miR-135b	CLIP-seq
MIRT900144	hsa-miR-1912	CLIP-seq
MIRT900145	hsa-miR-1915	CLIP-seq
MIRT900146	hsa-miR-203	CLIP-seq
MIRT900147	hsa-miR-2115	CLIP-seq
MIRT900148	hsa-miR-24	CLIP-seq
MIRT900149	hsa-miR-2467-3p	CLIP-seq
MIRT900150	hsa-miR-25	CLIP-seq
MIRT900151	hsa-miR-3125	CLIP-seq
MIRT900152	hsa-miR-3157-5p	CLIP-seq
MIRT900153	hsa-miR-3194-5p	CLIP-seq
MIRT900154	hsa-miR-3197	CLIP-seq
MIRT900155	hsa-miR-32	CLIP-seq
MIRT900156	hsa-miR-323-5p	CLIP-seq
MIRT900157	hsa-miR-338-5p	CLIP-seq
MIRT900158	hsa-miR-361-3p	CLIP-seq
MIRT900159	hsa-miR-363	CLIP-seq
MIRT900160	hsa-miR-3650	CLIP-seq
MIRT900161	hsa-miR-3665	CLIP-seq
MIRT900162	hsa-miR-367	CLIP-seq
MIRT900163	hsa-miR-3679-3p	CLIP-seq
MIRT900164	hsa-miR-3689a-3p	CLIP-seq
MIRT900165	hsa-miR-3689c	CLIP-seq
MIRT900166	hsa-miR-3689d	CLIP-seq
MIRT900167	hsa-miR-3907	CLIP-seq
MIRT900168	hsa-miR-3916	CLIP-seq
MIRT900169	hsa-miR-3978	CLIP-seq
MIRT900170	hsa-miR-4269	CLIP-seq
MIRT900171	hsa-miR-4284	CLIP-seq
MIRT900172	hsa-miR-4286	CLIP-seq
MIRT900173	hsa-miR-4292	CLIP-seq
MIRT900174	hsa-miR-4300	CLIP-seq
MIRT900175	hsa-miR-4301	CLIP-seq
MIRT900176	hsa-miR-4308	CLIP-seq
MIRT900177	hsa-miR-4318	CLIP-seq
MIRT900178	hsa-miR-4323	CLIP-seq
MIRT900179	hsa-miR-4438	CLIP-seq
MIRT900180	hsa-miR-451	CLIP-seq
MIRT900181	hsa-miR-4514	CLIP-seq
MIRT900182	hsa-miR-4645-3p	CLIP-seq
MIRT900183	hsa-miR-4685-5p	CLIP-seq
MIRT900184	hsa-miR-4690-3p	CLIP-seq
MIRT900185	hsa-miR-4692	CLIP-seq
MIRT900186	hsa-miR-4704-3p	CLIP-seq
MIRT900187	hsa-miR-4726-3p	CLIP-seq
MIRT900188	hsa-miR-4742-5p	CLIP-seq
MIRT900189	hsa-miR-4747-5p	CLIP-seq
MIRT900190	hsa-miR-4782-5p	CLIP-seq
MIRT900191	hsa-miR-510	CLIP-seq
MIRT900192	hsa-miR-512-5p	CLIP-seq
MIRT900193	hsa-miR-516b	CLIP-seq
MIRT900194	hsa-miR-541	CLIP-seq
MIRT900195	hsa-miR-548b-3p	CLIP-seq
MIRT900196	hsa-miR-764	CLIP-seq
MIRT900197	hsa-miR-873	CLIP-seq
MIRT900198	hsa-miR-875-3p	CLIP-seq
MIRT900199	hsa-miR-920	CLIP-seq
MIRT900200	hsa-miR-92a	CLIP-seq
MIRT900201	hsa-miR-92b	CLIP-seq
MIRT1966987	hsa-miR-101	CLIP-seq
MIRT1966988	hsa-miR-1204	CLIP-seq
MIRT1966989	hsa-miR-1207-5p	CLIP-seq
MIRT1966990	hsa-miR-125a-5p	CLIP-seq
MIRT1966991	hsa-miR-125b	CLIP-seq
MIRT1966992	hsa-miR-1260	CLIP-seq
MIRT1966993	hsa-miR-1273d	CLIP-seq
MIRT900139	hsa-miR-128	CLIP-seq
MIRT1966994	hsa-miR-1292	CLIP-seq
MIRT1966995	hsa-miR-1323	CLIP-seq
MIRT900142	hsa-miR-135a	CLIP-seq
MIRT900143	hsa-miR-135b	CLIP-seq
MIRT1966996	hsa-miR-144	CLIP-seq
MIRT1966997	hsa-miR-146a	CLIP-seq
MIRT1966998	hsa-miR-146b-5p	CLIP-seq
MIRT1966999	hsa-miR-153	CLIP-seq
MIRT1967000	hsa-miR-1827	CLIP-seq
MIRT1967001	hsa-miR-188-3p	CLIP-seq
MIRT900144	hsa-miR-1912	CLIP-seq
MIRT900145	hsa-miR-1915	CLIP-seq
MIRT1967002	hsa-miR-197	CLIP-seq
MIRT1967003	hsa-miR-1976	CLIP-seq
MIRT900146	hsa-miR-203	CLIP-seq
MIRT900147	hsa-miR-2115	CLIP-seq
MIRT1967004	hsa-miR-23a	CLIP-seq
MIRT1967005	hsa-miR-23b	CLIP-seq
MIRT1967006	hsa-miR-23c	CLIP-seq
MIRT900148	hsa-miR-24	CLIP-seq
MIRT900150	hsa-miR-25	CLIP-seq
MIRT1967007	hsa-miR-2681	CLIP-seq
MIRT1967008	hsa-miR-28-5p	CLIP-seq
MIRT1967009	hsa-miR-3065-5p	CLIP-seq
MIRT1967010	hsa-miR-3121-5p	CLIP-seq
MIRT900151	hsa-miR-3125	CLIP-seq
MIRT1967011	hsa-miR-3130-3p	CLIP-seq
MIRT1967012	hsa-miR-3130-5p	CLIP-seq
MIRT1967013	hsa-miR-3139	CLIP-seq
MIRT1967014	hsa-miR-3150a-3p	CLIP-seq
MIRT1967015	hsa-miR-3156-3p	CLIP-seq
MIRT1967016	hsa-miR-3175	CLIP-seq
MIRT1967017	hsa-miR-3190	CLIP-seq
MIRT900154	hsa-miR-3197	CLIP-seq
MIRT900155	hsa-miR-32	CLIP-seq
MIRT1967018	hsa-miR-320e	CLIP-seq
MIRT1967019	hsa-miR-3612	CLIP-seq
MIRT1967020	hsa-miR-3616-3p	CLIP-seq
MIRT1967021	hsa-miR-3622a-3p	CLIP-seq
MIRT1967022	hsa-miR-3622b-3p	CLIP-seq
MIRT900159	hsa-miR-363	CLIP-seq
MIRT1967023	hsa-miR-3652	CLIP-seq
MIRT1967024	hsa-miR-3655	CLIP-seq
MIRT1967025	hsa-miR-3657	CLIP-seq
MIRT900162	hsa-miR-367	CLIP-seq
MIRT900164	hsa-miR-3689a-3p	CLIP-seq
MIRT900165	hsa-miR-3689c	CLIP-seq
MIRT1967026	hsa-miR-370	CLIP-seq
MIRT1967027	hsa-miR-3909	CLIP-seq
MIRT900168	hsa-miR-3916	CLIP-seq
MIRT1967028	hsa-miR-3925-3p	CLIP-seq
MIRT1967029	hsa-miR-3977	CLIP-seq
MIRT1967030	hsa-miR-4265	CLIP-seq
MIRT1967031	hsa-miR-4268	CLIP-seq
MIRT900171	hsa-miR-4284	CLIP-seq
MIRT1967032	hsa-miR-4287	CLIP-seq
MIRT1967033	hsa-miR-4289	CLIP-seq
MIRT1967034	hsa-miR-4291	CLIP-seq
MIRT1967035	hsa-miR-4296	CLIP-seq
MIRT900175	hsa-miR-4301	CLIP-seq
MIRT1967036	hsa-miR-4319	CLIP-seq
MIRT1967037	hsa-miR-4322	CLIP-seq
MIRT1967038	hsa-miR-4430	CLIP-seq
MIRT1967039	hsa-miR-4436b-3p	CLIP-seq
MIRT1967040	hsa-miR-4448	CLIP-seq
MIRT1967041	hsa-miR-4450	CLIP-seq
MIRT1967042	hsa-miR-4455	CLIP-seq
MIRT1967043	hsa-miR-4469	CLIP-seq
MIRT1967044	hsa-miR-4471	CLIP-seq
MIRT1967045	hsa-miR-4482	CLIP-seq
MIRT1967046	hsa-miR-4493	CLIP-seq
MIRT1967047	hsa-miR-4505	CLIP-seq
MIRT1967048	hsa-miR-450b-5p	CLIP-seq
MIRT1967049	hsa-miR-4532	CLIP-seq
MIRT1967050	hsa-miR-4533	CLIP-seq
MIRT1967051	hsa-miR-4637	CLIP-seq
MIRT1967052	hsa-miR-4661-3p	CLIP-seq
MIRT1967053	hsa-miR-4667-5p	CLIP-seq
MIRT1967054	hsa-miR-4669	CLIP-seq
MIRT1967055	hsa-miR-4685-3p	CLIP-seq
MIRT900183	hsa-miR-4685-5p	CLIP-seq
MIRT1967056	hsa-miR-4700-5p	CLIP-seq
MIRT1967057	hsa-miR-4717-3p	CLIP-seq
MIRT1967058	hsa-miR-4721	CLIP-seq
MIRT900187	hsa-miR-4726-3p	CLIP-seq
MIRT1967059	hsa-miR-4728-5p	CLIP-seq
MIRT1967060	hsa-miR-4731-3p	CLIP-seq
MIRT1967061	hsa-miR-4732-3p	CLIP-seq
MIRT1967062	hsa-miR-4740-3p	CLIP-seq
MIRT900189	hsa-miR-4747-5p	CLIP-seq
MIRT1967063	hsa-miR-4753-5p	CLIP-seq
MIRT1967064	hsa-miR-4757-5p	CLIP-seq
MIRT1967065	hsa-miR-4763-3p	CLIP-seq
MIRT1967066	hsa-miR-4764-5p	CLIP-seq
MIRT1967067	hsa-miR-4768-5p	CLIP-seq
MIRT1967068	hsa-miR-4801	CLIP-seq
MIRT1967069	hsa-miR-491-5p	CLIP-seq
MIRT1967070	hsa-miR-516a-3p	CLIP-seq
MIRT1967071	hsa-miR-518a-5p	CLIP-seq
MIRT1967072	hsa-miR-527	CLIP-seq
MIRT900194	hsa-miR-541	CLIP-seq
MIRT1967073	hsa-miR-545	CLIP-seq
MIRT1967074	hsa-miR-548o	CLIP-seq
MIRT1967075	hsa-miR-549	CLIP-seq
MIRT1967076	hsa-miR-576-3p	CLIP-seq
MIRT1967077	hsa-miR-580	CLIP-seq
MIRT1967078	hsa-miR-582-5p	CLIP-seq
MIRT1967079	hsa-miR-587	CLIP-seq
MIRT1967080	hsa-miR-589	CLIP-seq
MIRT1967081	hsa-miR-597	CLIP-seq
MIRT1967082	hsa-miR-600	CLIP-seq
MIRT1967083	hsa-miR-609	CLIP-seq
MIRT1967084	hsa-miR-650	CLIP-seq
MIRT1967085	hsa-miR-660	CLIP-seq
MIRT1967086	hsa-miR-665	CLIP-seq
MIRT1967087	hsa-miR-670	CLIP-seq
MIRT1967088	hsa-miR-708	CLIP-seq
MIRT1967089	hsa-miR-766	CLIP-seq
MIRT900197	hsa-miR-873	CLIP-seq
MIRT900200	hsa-miR-92a	CLIP-seq
MIRT900201	hsa-miR-92b	CLIP-seq
MIRT1967090	hsa-miR-938	CLIP-seq
MIRT1967091	hsa-miR-939	CLIP-seq
MIRT1967092	hsa-miR-940	CLIP-seq
MIRT1967093	hsa-miR-942	CLIP-seq
MIRT900142	hsa-miR-135a	CLIP-seq
MIRT900143	hsa-miR-135b	CLIP-seq
MIRT2202728	hsa-miR-1913	CLIP-seq
MIRT900145	hsa-miR-1915	CLIP-seq
MIRT900146	hsa-miR-203	CLIP-seq
MIRT1967004	hsa-miR-23a	CLIP-seq
MIRT1967005	hsa-miR-23b	CLIP-seq
MIRT1967006	hsa-miR-23c	CLIP-seq
MIRT900148	hsa-miR-24	CLIP-seq
MIRT900150	hsa-miR-25	CLIP-seq
MIRT1967009	hsa-miR-3065-5p	CLIP-seq
MIRT1967010	hsa-miR-3121-5p	CLIP-seq
MIRT900151	hsa-miR-3125	CLIP-seq
MIRT900155	hsa-miR-32	CLIP-seq
MIRT2202729	hsa-miR-324-3p	CLIP-seq
MIRT2202730	hsa-miR-3613-3p	CLIP-seq
MIRT1967021	hsa-miR-3622a-3p	CLIP-seq
MIRT1967022	hsa-miR-3622b-3p	CLIP-seq
MIRT900159	hsa-miR-363	CLIP-seq
MIRT900162	hsa-miR-367	CLIP-seq
MIRT900168	hsa-miR-3916	CLIP-seq
MIRT1967029	hsa-miR-3977	CLIP-seq
MIRT900171	hsa-miR-4284	CLIP-seq
MIRT900183	hsa-miR-4685-5p	CLIP-seq
MIRT900187	hsa-miR-4726-3p	CLIP-seq
MIRT1967060	hsa-miR-4731-3p	CLIP-seq
MIRT900189	hsa-miR-4747-5p	CLIP-seq
MIRT2202731	hsa-miR-4749-3p	CLIP-seq
MIRT1967068	hsa-miR-4801	CLIP-seq
MIRT2202732	hsa-miR-556-3p	CLIP-seq
MIRT1967085	hsa-miR-660	CLIP-seq
MIRT900197	hsa-miR-873	CLIP-seq
MIRT900200	hsa-miR-92a	CLIP-seq
MIRT900201	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15840172
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007601	Process	Visual perception	IEA
GO:0010960	Process	Magnesium ion homeostasis	IBA
GO:0010960	Process	Magnesium ion homeostasis	IEA
GO:0010960	Process	Magnesium ion homeostasis	IEA
GO:0015081	Function	Sodium ion transmembrane transporter activity	IBA
GO:0015081	Function	Sodium ion transmembrane transporter activity	IEA
GO:0015095	Function	Magnesium ion transmembrane transporter activity	IBA
GO:0015095	Function	Magnesium ion transmembrane transporter activity	IEA
GO:0015693	Process	Magnesium ion transport	IBA
GO:0015693	Process	Magnesium ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0030003	Process	Intracellular monoatomic cation homeostasis	IDA	15840172
GO:0031214	Process	Biomineral tissue development	IEA
GO:0032991	Component	Protein-containing complex	IDA	15840172
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0070166	Process	Enamel mineralization	IEA
GO:1903830	Process	Magnesium ion transmembrane transport	IEA

Other IDs

• MIM: 607805
• HGNC: 105
• e!Ensembl: ENSG00000158158

Protein

• UniProt ID: Q6P4Q7
• Protein name: Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)
• Protein function: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269|Pub
• PDB: 6G52, 6RS2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01595	DUF21	187 → 358	Cyclin M transmembrane N-terminal domain	Domain
  PF00571	CBS	441 → 505	CBS domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Highly expressed in heart. {ECO:0000269|PubMed:12657465}.
• Sequence:

  MAPVGGGGRPVGGPARGRLLLAAPVLLVLLWALGARGQGSPQQGTIVGMRLASCNKSCGT
  NPDGIIFVSEGSTVNLRLYGYSLGNISSNLISFTEVDDAETLHKSTSCLELTKDLVVQQL
  VNVSRGNTSGVLVVLTKFLRRSESMKLYALCTRAQPDGPWLKWTDKDSLLFMVEEPGRFL
  PLWLHILLITVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKGN
  YLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGA
  NTILLTKFFMLLTFPLSFPISKLLDFFLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELN
  MIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVD
  ILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNN
  EGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADN
  ELKVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARH
  YLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSDRSPAHPTPLS
  RSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGL
  LASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHENAI

• Sequence length: 775

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
CNNM4-related disorder	Likely pathogenic	rs758866379	RCV003961783	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Jalili syndrome	Pathogenic; Likely pathogenic	rs2153349278, rs2469454032, rs746879923, rs75267011, rs74552543, rs80100937, rs79424354, rs75559353, rs2469450195, rs879255500, rs2469455174, rs1455470131, rs1432600424, rs1574047454, rs1558993255, rs776159012, rs1574047005	RCV001839443 RCV002294586 RCV000002981 RCV000002982 RCV000002983 RCV000002984 RCV000002985 RCV000002986 RCV000002987 RCV000239384 RCV003330189 RCV000499392 RCV000677261 RCV000855673 RCV000786951 RCV000986792 RCV001002983 RCV001029859	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Retinal dystrophy	Likely pathogenic; Pathogenic	rs746879923, rs80100937, rs1455470131, rs2078763986, rs2078764558	RCV004814813 RCV004814814 RCV004817721 RCV001075625 RCV001073840	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMAUROSIS HYPERTRICHOSIS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	-	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Retinitis pigmentosa	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
RETINITIS PIGMENTOSA 1	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Achromatopsia	Achromatopsia	BEFREE	20706282		★☆☆☆☆ Found in Text Mining only
Achromatopsia	Achromatopsia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	25347473		★☆☆☆☆ Found in Text Mining only
Amaurosis hypertrichosis	Amaurosis hypertrichosis	Pubtator	19200525, 21393841, 24194943, 27419834, 29322253, 29421294, 31347285, 32022389, 34875963, 35150469, 40232358	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Amaurosis hypertrichosis	Amaurosis-hypertrichosis syndrome	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Amelogenesis Imperfecta	Amelogenesis imperfecta	LHGDN	19200525, 19200527		★☆☆☆☆ Found in Text Mining only
Amelogenesis Imperfecta	Amelogenesis imperfecta	Pubtator	19200525, 19200527, 21393841, 24194943, 29421294	Associate	★☆☆☆☆ Found in Text Mining only
Amelogenesis Imperfecta	Amelogenesis imperfecta	BEFREE	19200527, 20706282, 24194943, 29421294		★☆☆☆☆ Found in Text Mining only
Amelogenesis Imperfecta	Amelogenesis imperfecta	HPO_DG			★☆☆☆☆ Found in Text Mining only
Amelogenesis Imperfecta	Amelogenesis imperfecta	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	25347473		★☆☆☆☆ Found in Text Mining only
Cone Dystrophy	Cone dystrophy	Pubtator	34875963	Associate	★☆☆☆☆ Found in Text Mining only
Cone Dystrophy	Cone Dystrophy	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Cone rod dystrophy amelogenesis imperfecta	Cone-rod dystrophy	ORPHANET_DG	19200525, 24194943		★☆☆☆☆ Found in Text Mining only
Cone-Rod Dystrophies	Cone-rod dystrophy	BEFREE	19200527		★☆☆☆☆ Found in Text Mining only
Cone-Rod Dystrophies	Cone-rod dystrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cone-Rod Dystrophy 2	Cone-rod dystrophy	BEFREE	19200525, 19200527, 20706282, 29421294		★☆☆☆☆ Found in Text Mining only
Dental Diseases	Dental Diseases	BEFREE	24194943		★☆☆☆☆ Found in Text Mining only
Disorder of eye	Disorder Of Eye	BEFREE	24194943		★☆☆☆☆ Found in Text Mining only
Disorder of eye	Disorder Of Eye	GENOMICS_ENGLAND_DG	27419834		★☆☆☆☆ Found in Text Mining only
Jalili syndrome	Jalili Syndrome	BEFREE	19200525, 19200527, 20706282, 21728811, 24194943, 27070327, 27419834, 28246031, 29322253, 29421294, 29421602, 31842432		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Jalili syndrome	Jalili Syndrome	ORPHANET_DG	19200525, 24194943		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Jalili syndrome	Jalili Syndrome	UNIPROT_DG	19200525, 19200527		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Jalili syndrome	Jalili Syndrome	Orphanet			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Jalili syndrome	Jalili Syndrome	GENOMICS_ENGLAND_DG	27419834		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Jalili syndrome	Jalili Syndrome	CLINVAR_DG			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Leber Congenital Amaurosis	Leber congenital amaurosis	Pubtator	29322253	Associate	★☆☆☆☆ Found in Text Mining only
Malabsorption Syndrome	Malabsorption Syndrome	BEFREE	24339795		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25347473, 30670776		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	25347473		★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	Pubtator	35567543	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30755730		★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 1	Neurofibromatosis	BEFREE	21728811		★☆☆☆☆ Found in Text Mining only
Nyctalopia	Nyctalopia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	BEFREE	27419834		★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic Atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Rod-Cone Dystrophy	Rod-cone dystrophy	BEFREE	19200527		★☆☆☆☆ Found in Text Mining only
Trichohepatoenteric Syndrome	Trichohepatoenteric Syndrome	BEFREE	27419834		★☆☆☆☆ Found in Text Mining only