Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2635
Gene name	Guanylate binding protein 3
Gene symbol	GBP3
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1p22.2
Summary	This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts wit

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002517	hsa-miR-373-3p	Microarray	15685193
MIRT440585	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440583	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440585	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727601	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727599	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727600	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727598	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT440583	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1013861	hsa-miR-106a	CLIP-seq
MIRT1013862	hsa-miR-106b	CLIP-seq
MIRT1013863	hsa-miR-1238	CLIP-seq
MIRT1013864	hsa-miR-17	CLIP-seq
MIRT1013865	hsa-miR-20a	CLIP-seq
MIRT1013866	hsa-miR-20b	CLIP-seq
MIRT1013867	hsa-miR-3124-3p	CLIP-seq
MIRT1013868	hsa-miR-3609	CLIP-seq
MIRT1013869	hsa-miR-4263	CLIP-seq
MIRT1013870	hsa-miR-4317	CLIP-seq
MIRT1013871	hsa-miR-4432	CLIP-seq
MIRT1013872	hsa-miR-4474-5p	CLIP-seq
MIRT1013873	hsa-miR-4711-5p	CLIP-seq
MIRT1013874	hsa-miR-4796-3p	CLIP-seq
MIRT1013875	hsa-miR-4797-3p	CLIP-seq
MIRT1013876	hsa-miR-4803	CLIP-seq
MIRT1013877	hsa-miR-499-5p	CLIP-seq
MIRT1013878	hsa-miR-519a	CLIP-seq
MIRT1013879	hsa-miR-519b-3p	CLIP-seq
MIRT1013880	hsa-miR-519c-3p	CLIP-seq
MIRT1013881	hsa-miR-519d	CLIP-seq
MIRT1013882	hsa-miR-548ah	CLIP-seq
MIRT1013883	hsa-miR-576-5p	CLIP-seq
MIRT1013884	hsa-miR-93	CLIP-seq
MIRT1013885	hsa-miR-935	CLIP-seq
MIRT1013861	hsa-miR-106a	CLIP-seq
MIRT1013862	hsa-miR-106b	CLIP-seq
MIRT2233745	hsa-miR-125a-3p	CLIP-seq
MIRT2233746	hsa-miR-1265	CLIP-seq
MIRT2233747	hsa-miR-1266	CLIP-seq
MIRT2233748	hsa-miR-128	CLIP-seq
MIRT2233749	hsa-miR-148a	CLIP-seq
MIRT2233750	hsa-miR-148b	CLIP-seq
MIRT2233751	hsa-miR-152	CLIP-seq
MIRT1013864	hsa-miR-17	CLIP-seq
MIRT1013865	hsa-miR-20a	CLIP-seq
MIRT1013866	hsa-miR-20b	CLIP-seq
MIRT2233752	hsa-miR-2392	CLIP-seq
MIRT2233753	hsa-miR-3127-5p	CLIP-seq
MIRT2233754	hsa-miR-323-3p	CLIP-seq
MIRT1013868	hsa-miR-3609	CLIP-seq
MIRT2233755	hsa-miR-3664-3p	CLIP-seq
MIRT2233756	hsa-miR-3934	CLIP-seq
MIRT2233757	hsa-miR-3941	CLIP-seq
MIRT1013869	hsa-miR-4263	CLIP-seq
MIRT2233758	hsa-miR-4282	CLIP-seq
MIRT1013870	hsa-miR-4317	CLIP-seq
MIRT1013872	hsa-miR-4474-5p	CLIP-seq
MIRT2233759	hsa-miR-4509	CLIP-seq
MIRT2233760	hsa-miR-4518	CLIP-seq
MIRT2233761	hsa-miR-466	CLIP-seq
MIRT2233762	hsa-miR-4672	CLIP-seq
MIRT1013873	hsa-miR-4711-5p	CLIP-seq
MIRT2233763	hsa-miR-4744	CLIP-seq
MIRT2233764	hsa-miR-4760-3p	CLIP-seq
MIRT2233765	hsa-miR-4789-5p	CLIP-seq
MIRT1013874	hsa-miR-4796-3p	CLIP-seq
MIRT1013876	hsa-miR-4803	CLIP-seq
MIRT1013878	hsa-miR-519a	CLIP-seq
MIRT1013879	hsa-miR-519b-3p	CLIP-seq
MIRT1013880	hsa-miR-519c-3p	CLIP-seq
MIRT1013881	hsa-miR-519d	CLIP-seq
MIRT1013882	hsa-miR-548ah	CLIP-seq
MIRT2233766	hsa-miR-548m	CLIP-seq
MIRT1013883	hsa-miR-576-5p	CLIP-seq
MIRT2233767	hsa-miR-651	CLIP-seq
MIRT2233768	hsa-miR-764	CLIP-seq
MIRT1013884	hsa-miR-93	CLIP-seq
MIRT1013885	hsa-miR-935	CLIP-seq
MIRT1013861	hsa-miR-106a	CLIP-seq
MIRT1013862	hsa-miR-106b	CLIP-seq
MIRT1013864	hsa-miR-17	CLIP-seq
MIRT1013865	hsa-miR-20a	CLIP-seq
MIRT1013866	hsa-miR-20b	CLIP-seq
MIRT1013868	hsa-miR-3609	CLIP-seq
MIRT1013870	hsa-miR-4317	CLIP-seq
MIRT1013873	hsa-miR-4711-5p	CLIP-seq
MIRT2233765	hsa-miR-4789-5p	CLIP-seq
MIRT1013874	hsa-miR-4796-3p	CLIP-seq
MIRT1013878	hsa-miR-519a	CLIP-seq
MIRT1013879	hsa-miR-519b-3p	CLIP-seq
MIRT1013880	hsa-miR-519c-3p	CLIP-seq
MIRT1013881	hsa-miR-519d	CLIP-seq
MIRT1013882	hsa-miR-548ah	CLIP-seq
MIRT1013884	hsa-miR-93	CLIP-seq
MIRT1013885	hsa-miR-935	CLIP-seq
MIRT2450132	hsa-miR-2116	CLIP-seq
MIRT2450133	hsa-miR-217	CLIP-seq
MIRT2450134	hsa-miR-3545-3p	CLIP-seq
MIRT2450135	hsa-miR-4677-5p	CLIP-seq
MIRT2537644	hsa-miR-154	CLIP-seq
MIRT2537645	hsa-miR-219-2-3p	CLIP-seq
MIRT2537646	hsa-miR-23a	CLIP-seq
MIRT2537647	hsa-miR-23b	CLIP-seq
MIRT2537648	hsa-miR-23c	CLIP-seq
MIRT2537649	hsa-miR-2964a-3p	CLIP-seq
MIRT2537650	hsa-miR-3117-5p	CLIP-seq
MIRT2537651	hsa-miR-3189-3p	CLIP-seq
MIRT2537652	hsa-miR-374a	CLIP-seq
MIRT2537653	hsa-miR-374b	CLIP-seq
MIRT2537654	hsa-miR-4257	CLIP-seq
MIRT2233758	hsa-miR-4282	CLIP-seq
MIRT2537655	hsa-miR-4312	CLIP-seq
MIRT2537656	hsa-miR-4633-5p	CLIP-seq
MIRT2537657	hsa-miR-4684-3p	CLIP-seq
MIRT2537658	hsa-miR-4777-5p	CLIP-seq
MIRT2537659	hsa-miR-4797-5p	CLIP-seq
MIRT2537660	hsa-miR-4799-5p	CLIP-seq
MIRT2537661	hsa-miR-532-5p	CLIP-seq
MIRT1013885	hsa-miR-935	CLIP-seq
MIRT2537650	hsa-miR-3117-5p	CLIP-seq
MIRT2537651	hsa-miR-3189-3p	CLIP-seq
MIRT2681469	hsa-miR-3940-5p	CLIP-seq
MIRT2537654	hsa-miR-4257	CLIP-seq
MIRT2233758	hsa-miR-4282	CLIP-seq
MIRT2537655	hsa-miR-4312	CLIP-seq
MIRT2681470	hsa-miR-4507	CLIP-seq
MIRT2537656	hsa-miR-4633-5p	CLIP-seq
MIRT2537657	hsa-miR-4684-3p	CLIP-seq
MIRT2537659	hsa-miR-4797-5p	CLIP-seq
MIRT2537660	hsa-miR-4799-5p	CLIP-seq
MIRT2537661	hsa-miR-532-5p	CLIP-seq
MIRT1013885	hsa-miR-935	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	12387898, 21151871, 28514442, 33961781
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	17266443
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IDA	21151871
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0042742	Process	Defense response to bacterium	ISS
GO:0042802	Function	Identical protein binding	IPI	21151871
GO:0042803	Function	Protein homodimerization activity	IDA	21151871
GO:0045087	Process	Innate immune response	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051607	Process	Defense response to virus	IEA
GO:0051715	Process	Cytolysis in another organism	ISS
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071346	Process	Cellular response to type II interferon	IBA
GO:0071347	Process	Cellular response to interleukin-1	IEP	17266443
GO:0071356	Process	Cellular response to tumor necrosis factor	IEP	17266443
GO:0140639	Process	Positive regulation of pyroptotic inflammatory response	ISS

MIM	HGNC	e!Ensembl
600413	4184	ENSG00000117226

Q9H0R5

Protein name

Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3)

Protein function

Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:22106366). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction pro

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02263	GBP	18 → 280	Guanylate-binding protein, N-terminal domain	Domain
PF02841	GBP_C	282 → 578	Guanylate-binding protein, C-terminal domain	Domain

Sequence

MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV
LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL
RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI
HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYIN
AISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER
EATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEV
KAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL
TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQL
LEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI

Sequence length

595

Interactions

View interactions

	KEGG		Reactome
	NOD-like receptor signaling pathway		Interferon gamma signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATHEROSCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

GBP3 (guanylate binding protein 3)