MYCBP (MYC binding protein)

Gene

• Entrez ID: 26292
• Gene name: MYC binding protein
• Gene symbol: MYCBP
• Synonyms (NCBI Gene): AMY-1
• Chromosome: 1
• Chromosome location: 1p34.3
• Summary: The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus d

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005505	hsa-miR-22-3p	Immunoblot, Luciferase reporter assay, qRT-PCR	20562918
MIRT005505	hsa-miR-22-3p	Immunoblot, Luciferase reporter assay, qRT-PCR	20562918
MIRT023295	hsa-miR-122-5p	Microarray	17612493
MIRT028305	hsa-miR-32-5p	Sequencing	20371350
MIRT032374	hsa-let-7b-5p	Proteomics	18668040
MIRT038801	hsa-miR-93-3p	CLASH	23622248
MIRT674407	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT674406	hsa-miR-5693	HITS-CLIP	23824327
MIRT674405	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT674404	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT674403	hsa-miR-4770	HITS-CLIP	23824327
MIRT674402	hsa-miR-6088	HITS-CLIP	23824327
MIRT674401	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT674400	hsa-miR-1273f	HITS-CLIP	23824327
MIRT674399	hsa-miR-4534	HITS-CLIP	23824327
MIRT674398	hsa-miR-8082	HITS-CLIP	23824327
MIRT674397	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT674396	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674395	hsa-miR-3135b	HITS-CLIP	23824327
MIRT674394	hsa-miR-1289	HITS-CLIP	23824327
MIRT674393	hsa-miR-4294	HITS-CLIP	23824327
MIRT674392	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT023295	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT674391	hsa-miR-4634	HITS-CLIP	23824327
MIRT674390	hsa-miR-3652	HITS-CLIP	23824327
MIRT674389	hsa-miR-4430	HITS-CLIP	23824327
MIRT674388	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT674387	hsa-miR-3198	HITS-CLIP	23824327
MIRT674386	hsa-miR-4309	HITS-CLIP	23824327
MIRT674385	hsa-miR-5698	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT630403	hsa-miR-4521	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT630403	hsa-miR-4521	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT472691	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT472690	hsa-miR-759	PAR-CLIP	21572407
MIRT472689	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT472688	hsa-miR-3689a-5p	PAR-CLIP	21572407
MIRT472687	hsa-miR-3689b-5p	PAR-CLIP	21572407
MIRT472686	hsa-miR-3689e	PAR-CLIP	21572407
MIRT472685	hsa-miR-3689f	PAR-CLIP	21572407
MIRT472683	hsa-miR-6800-5p	PAR-CLIP	21572407
MIRT472684	hsa-miR-183-3p	PAR-CLIP	21572407
MIRT472682	hsa-miR-302c-5p	PAR-CLIP	21572407
MIRT472681	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT472691	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT472690	hsa-miR-759	PAR-CLIP	23592263
MIRT472689	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT472688	hsa-miR-3689a-5p	PAR-CLIP	23592263
MIRT472687	hsa-miR-3689b-5p	PAR-CLIP	23592263
MIRT472686	hsa-miR-3689e	PAR-CLIP	23592263
MIRT472685	hsa-miR-3689f	PAR-CLIP	23592263
MIRT472683	hsa-miR-6800-5p	PAR-CLIP	23592263
MIRT472684	hsa-miR-183-3p	PAR-CLIP	23592263
MIRT472682	hsa-miR-302c-5p	PAR-CLIP	23592263
MIRT472681	hsa-miR-552-5p	PAR-CLIP	23592263
MIRT674407	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT674406	hsa-miR-5693	HITS-CLIP	23824327
MIRT674405	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT674404	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT674403	hsa-miR-4770	HITS-CLIP	23824327
MIRT674402	hsa-miR-6088	HITS-CLIP	23824327
MIRT674401	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT674400	hsa-miR-1273f	HITS-CLIP	23824327
MIRT674399	hsa-miR-4534	HITS-CLIP	23824327
MIRT674398	hsa-miR-8082	HITS-CLIP	23824327
MIRT674397	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT674396	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674395	hsa-miR-3135b	HITS-CLIP	23824327
MIRT674394	hsa-miR-1289	HITS-CLIP	23824327
MIRT674393	hsa-miR-4294	HITS-CLIP	23824327
MIRT674392	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT023295	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT674391	hsa-miR-4634	HITS-CLIP	23824327
MIRT674390	hsa-miR-3652	HITS-CLIP	23824327
MIRT674389	hsa-miR-4430	HITS-CLIP	23824327
MIRT674388	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT674387	hsa-miR-3198	HITS-CLIP	23824327
MIRT674386	hsa-miR-4309	HITS-CLIP	23824327
MIRT674385	hsa-miR-5698	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT630403	hsa-miR-4521	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT630403	hsa-miR-4521	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT609941	hsa-miR-8485	HITS-CLIP	23824327
MIRT609940	hsa-miR-101-5p	HITS-CLIP	23824327
MIRT472691	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT472690	hsa-miR-759	PAR-CLIP	21572407
MIRT472689	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT472688	hsa-miR-3689a-5p	PAR-CLIP	21572407
MIRT472687	hsa-miR-3689b-5p	PAR-CLIP	21572407
MIRT472686	hsa-miR-3689e	PAR-CLIP	21572407
MIRT472685	hsa-miR-3689f	PAR-CLIP	21572407
MIRT472683	hsa-miR-6800-5p	PAR-CLIP	21572407
MIRT472684	hsa-miR-183-3p	PAR-CLIP	21572407
MIRT472682	hsa-miR-302c-5p	PAR-CLIP	21572407
MIRT472681	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT472691	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT472690	hsa-miR-759	PAR-CLIP	23592263
MIRT472689	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT472688	hsa-miR-3689a-5p	PAR-CLIP	23592263
MIRT472687	hsa-miR-3689b-5p	PAR-CLIP	23592263
MIRT472686	hsa-miR-3689e	PAR-CLIP	23592263
MIRT472685	hsa-miR-3689f	PAR-CLIP	23592263
MIRT472683	hsa-miR-6800-5p	PAR-CLIP	23592263
MIRT472684	hsa-miR-183-3p	PAR-CLIP	23592263
MIRT472682	hsa-miR-302c-5p	PAR-CLIP	23592263
MIRT472681	hsa-miR-552-5p	PAR-CLIP	23592263
MIRT756212	hsa-miR-889-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP), RNA pull down assay	38570856
MIRT1167752	hsa-let-7a	CLIP-seq
MIRT1167753	hsa-let-7b	CLIP-seq
MIRT1167754	hsa-let-7c	CLIP-seq
MIRT1167755	hsa-let-7d	CLIP-seq
MIRT1167756	hsa-let-7e	CLIP-seq
MIRT1167757	hsa-let-7f	CLIP-seq
MIRT1167758	hsa-let-7g	CLIP-seq
MIRT1167759	hsa-let-7i	CLIP-seq
MIRT1167760	hsa-miR-10a	CLIP-seq
MIRT1167761	hsa-miR-10b	CLIP-seq
MIRT1167762	hsa-miR-1206	CLIP-seq
MIRT1167763	hsa-miR-1244	CLIP-seq
MIRT1167764	hsa-miR-1252	CLIP-seq
MIRT1167765	hsa-miR-1284	CLIP-seq
MIRT1167766	hsa-miR-1294	CLIP-seq
MIRT1167767	hsa-miR-1297	CLIP-seq
MIRT1167768	hsa-miR-1324	CLIP-seq
MIRT1167769	hsa-miR-139-5p	CLIP-seq
MIRT1167770	hsa-miR-153	CLIP-seq
MIRT1167771	hsa-miR-186	CLIP-seq
MIRT1167772	hsa-miR-199a-5p	CLIP-seq
MIRT1167773	hsa-miR-199b-5p	CLIP-seq
MIRT1167774	hsa-miR-19a	CLIP-seq
MIRT1167775	hsa-miR-19b	CLIP-seq
MIRT1167776	hsa-miR-202	CLIP-seq
MIRT1167777	hsa-miR-216a	CLIP-seq
MIRT1167778	hsa-miR-26a	CLIP-seq
MIRT1167779	hsa-miR-26b	CLIP-seq
MIRT1167780	hsa-miR-300	CLIP-seq
MIRT1167781	hsa-miR-3130-3p	CLIP-seq
MIRT1167782	hsa-miR-3140-5p	CLIP-seq
MIRT1167783	hsa-miR-3154	CLIP-seq
MIRT1167784	hsa-miR-3545-3p	CLIP-seq
MIRT1167785	hsa-miR-361-5p	CLIP-seq
MIRT1167786	hsa-miR-365	CLIP-seq
MIRT1167787	hsa-miR-381	CLIP-seq
MIRT1167788	hsa-miR-4272	CLIP-seq
MIRT1167789	hsa-miR-4301	CLIP-seq
MIRT1167790	hsa-miR-4302	CLIP-seq
MIRT1167791	hsa-miR-4316	CLIP-seq
MIRT1167792	hsa-miR-4330	CLIP-seq
MIRT1167793	hsa-miR-4420	CLIP-seq
MIRT1167794	hsa-miR-4423-3p	CLIP-seq
MIRT1167795	hsa-miR-4458	CLIP-seq
MIRT1167796	hsa-miR-4465	CLIP-seq
MIRT1167797	hsa-miR-448	CLIP-seq
MIRT1167798	hsa-miR-4500	CLIP-seq
MIRT1167799	hsa-miR-4539	CLIP-seq
MIRT1167800	hsa-miR-4645-3p	CLIP-seq
MIRT1167801	hsa-miR-4666-3p	CLIP-seq
MIRT1167802	hsa-miR-4677-3p	CLIP-seq
MIRT1167803	hsa-miR-4753-5p	CLIP-seq
MIRT1167804	hsa-miR-4773	CLIP-seq
MIRT1167805	hsa-miR-4795-3p	CLIP-seq
MIRT1167806	hsa-miR-485-3p	CLIP-seq
MIRT1167807	hsa-miR-548aa	CLIP-seq
MIRT1167808	hsa-miR-561	CLIP-seq
MIRT1167809	hsa-miR-582-5p	CLIP-seq
MIRT1167810	hsa-miR-597	CLIP-seq
MIRT1167811	hsa-miR-648	CLIP-seq
MIRT1167812	hsa-miR-711	CLIP-seq
MIRT1167813	hsa-miR-767-5p	CLIP-seq
MIRT1167814	hsa-miR-891b	CLIP-seq
MIRT1167815	hsa-miR-943	CLIP-seq
MIRT1167816	hsa-miR-98	CLIP-seq
MIRT1167752	hsa-let-7a	CLIP-seq
MIRT1167753	hsa-let-7b	CLIP-seq
MIRT1167754	hsa-let-7c	CLIP-seq
MIRT1167755	hsa-let-7d	CLIP-seq
MIRT1167756	hsa-let-7e	CLIP-seq
MIRT1167757	hsa-let-7f	CLIP-seq
MIRT1167758	hsa-let-7g	CLIP-seq
MIRT1167759	hsa-let-7i	CLIP-seq
MIRT1167760	hsa-miR-10a	CLIP-seq
MIRT1167761	hsa-miR-10b	CLIP-seq
MIRT1167766	hsa-miR-1294	CLIP-seq
MIRT1167776	hsa-miR-202	CLIP-seq
MIRT1167791	hsa-miR-4316	CLIP-seq
MIRT1167795	hsa-miR-4458	CLIP-seq
MIRT1167798	hsa-miR-4500	CLIP-seq
MIRT1167802	hsa-miR-4677-3p	CLIP-seq
MIRT1167816	hsa-miR-98	CLIP-seq
MIRT2048404	hsa-miR-100	CLIP-seq
MIRT1167763	hsa-miR-1244	CLIP-seq
MIRT2048405	hsa-miR-1292	CLIP-seq
MIRT1167769	hsa-miR-139-5p	CLIP-seq
MIRT2048406	hsa-miR-2278	CLIP-seq
MIRT2048407	hsa-miR-27a	CLIP-seq
MIRT2048408	hsa-miR-27b	CLIP-seq
MIRT2048409	hsa-miR-298	CLIP-seq
MIRT2048410	hsa-miR-3074-3p	CLIP-seq
MIRT2048411	hsa-miR-3119	CLIP-seq
MIRT2048412	hsa-miR-3140-3p	CLIP-seq
MIRT2048413	hsa-miR-3174	CLIP-seq
MIRT2048414	hsa-miR-335	CLIP-seq
MIRT2048415	hsa-miR-3606	CLIP-seq
MIRT1167786	hsa-miR-365	CLIP-seq
MIRT2048416	hsa-miR-3678-5p	CLIP-seq
MIRT2048417	hsa-miR-377	CLIP-seq
MIRT2048418	hsa-miR-4291	CLIP-seq
MIRT2048419	hsa-miR-4328	CLIP-seq
MIRT1167793	hsa-miR-4420	CLIP-seq
MIRT2048420	hsa-miR-4422	CLIP-seq
MIRT2048421	hsa-miR-4468	CLIP-seq
MIRT2048422	hsa-miR-4471	CLIP-seq
MIRT2048423	hsa-miR-4699-5p	CLIP-seq
MIRT2048424	hsa-miR-4716-5p	CLIP-seq
MIRT2048425	hsa-miR-548c-3p	CLIP-seq
MIRT1167809	hsa-miR-582-5p	CLIP-seq
MIRT2048426	hsa-miR-889	CLIP-seq
MIRT2048427	hsa-miR-921	CLIP-seq
MIRT2048428	hsa-miR-99a	CLIP-seq
MIRT2048429	hsa-miR-99b	CLIP-seq
MIRT2048404	hsa-miR-100	CLIP-seq
MIRT2277231	hsa-miR-1236	CLIP-seq
MIRT2277232	hsa-miR-124	CLIP-seq
MIRT1167763	hsa-miR-1244	CLIP-seq
MIRT2048405	hsa-miR-1292	CLIP-seq
MIRT1167769	hsa-miR-139-5p	CLIP-seq
MIRT2277233	hsa-miR-147	CLIP-seq
MIRT2277234	hsa-miR-181a	CLIP-seq
MIRT2277235	hsa-miR-181b	CLIP-seq
MIRT2277236	hsa-miR-181c	CLIP-seq
MIRT2277237	hsa-miR-181d	CLIP-seq
MIRT1167771	hsa-miR-186	CLIP-seq
MIRT2277238	hsa-miR-1912	CLIP-seq
MIRT2277239	hsa-miR-22	CLIP-seq
MIRT2277240	hsa-miR-23a	CLIP-seq
MIRT2277241	hsa-miR-23b	CLIP-seq
MIRT2277242	hsa-miR-23c	CLIP-seq
MIRT2048410	hsa-miR-3074-3p	CLIP-seq
MIRT2277243	hsa-miR-3149	CLIP-seq
MIRT2048413	hsa-miR-3174	CLIP-seq
MIRT2048415	hsa-miR-3606	CLIP-seq
MIRT1167786	hsa-miR-365	CLIP-seq
MIRT2048416	hsa-miR-3678-5p	CLIP-seq
MIRT2277244	hsa-miR-3714	CLIP-seq
MIRT2048417	hsa-miR-377	CLIP-seq
MIRT2277245	hsa-miR-3910	CLIP-seq
MIRT2277246	hsa-miR-3925-3p	CLIP-seq
MIRT2277247	hsa-miR-4262	CLIP-seq
MIRT2277248	hsa-miR-4267	CLIP-seq
MIRT1167793	hsa-miR-4420	CLIP-seq
MIRT2048420	hsa-miR-4422	CLIP-seq
MIRT2048422	hsa-miR-4471	CLIP-seq
MIRT2277249	hsa-miR-4725-5p	CLIP-seq
MIRT2277250	hsa-miR-4762-5p	CLIP-seq
MIRT2277251	hsa-miR-4765	CLIP-seq
MIRT1167804	hsa-miR-4773	CLIP-seq
MIRT2277252	hsa-miR-504	CLIP-seq
MIRT2277253	hsa-miR-506	CLIP-seq
MIRT2277254	hsa-miR-511	CLIP-seq
MIRT2277255	hsa-miR-579	CLIP-seq
MIRT2277256	hsa-miR-581	CLIP-seq
MIRT1167809	hsa-miR-582-5p	CLIP-seq
MIRT1167810	hsa-miR-597	CLIP-seq
MIRT1167812	hsa-miR-711	CLIP-seq
MIRT2277257	hsa-miR-766	CLIP-seq
MIRT2048426	hsa-miR-889	CLIP-seq
MIRT2048427	hsa-miR-921	CLIP-seq
MIRT1167815	hsa-miR-943	CLIP-seq
MIRT2048428	hsa-miR-99a	CLIP-seq
MIRT2048429	hsa-miR-99b	CLIP-seq
MIRT2277239	hsa-miR-22	CLIP-seq
MIRT2277246	hsa-miR-3925-3p	CLIP-seq
MIRT2277248	hsa-miR-4267	CLIP-seq
MIRT2277257	hsa-miR-766	CLIP-seq
MIRT2454657	hsa-miR-4474-5p	CLIP-seq
MIRT2454658	hsa-miR-4480	CLIP-seq
MIRT2454659	hsa-miR-515-5p	CLIP-seq
MIRT2454660	hsa-miR-552	CLIP-seq
MIRT2454661	hsa-miR-764	CLIP-seq
MIRT1167786	hsa-miR-365	CLIP-seq
MIRT2576129	hsa-miR-4266	CLIP-seq
MIRT2576130	hsa-miR-4446-3p	CLIP-seq
MIRT2576131	hsa-miR-4540	CLIP-seq
MIRT2576132	hsa-miR-4641	CLIP-seq
MIRT2576133	hsa-miR-4656	CLIP-seq
MIRT2576134	hsa-miR-4695-5p	CLIP-seq
MIRT2576135	hsa-miR-4779	CLIP-seq
MIRT2576136	hsa-miR-938	CLIP-seq
MIRT2685620	hsa-miR-1273d	CLIP-seq
MIRT2685621	hsa-miR-185	CLIP-seq
MIRT2685622	hsa-miR-3123	CLIP-seq
MIRT2576129	hsa-miR-4266	CLIP-seq
MIRT2685623	hsa-miR-4306	CLIP-seq
MIRT2576131	hsa-miR-4540	CLIP-seq
MIRT2576132	hsa-miR-4641	CLIP-seq
MIRT2685624	hsa-miR-4644	CLIP-seq
MIRT2576134	hsa-miR-4695-5p	CLIP-seq
MIRT2685625	hsa-miR-4742-3p	CLIP-seq
MIRT2576135	hsa-miR-4779	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
LEF1	Activation	15979100

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	9797456
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0005515	Function	Protein binding	IPI	12151104, 12223483, 12740381, 16866877, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9797456
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	9797456, 12151104
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IDA	9797456
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007283	Process	Spermatogenesis	IEP	12151104
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA

Other IDs

• MIM: 606535
• HGNC: 7554
• e!Ensembl: ENSG00000214114

Protein

• UniProt ID: Q99417
• Protein name: c-Myc-binding protein (Associate of Myc 1) (AMY-1)
• Protein function: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
• PDB: 2YY0
• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.
• Sequence:

  MAHYKAADSKREQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENP
  EIELLRLELAEMKEKYEAIVEENKKLKAKLAQYEPPQEEKRAE

• Sequence length: 103

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, ADENOID CYSTIC	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	7507116		★☆☆☆☆ Found in Text Mining only
Adenoid Cystic Carcinoma	Adenocarcinoma	CTD_human_DG	23685749		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	29986195		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36407085	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31385398	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	15979100, 29552163		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31094023		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31094023	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	30982860		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29552163, 29986195		★☆☆☆☆ Found in Text Mining only
Hyperinsulinism	Hyperinsulinism	BEFREE	25996848		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	11567024		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	36581344	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	12104089, 31385398		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	12104089		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	11567024		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	7507116		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29552163		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of tongue	Malignant Neoplasm Of Tongue	BEFREE	11567024		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29552163, 7507116		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29552163		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	25330074	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	26341959		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11567024, 20562918, 20966545, 21625997, 30951707		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29507657		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	24686848, 25394825, 25788522, 26098870, 26132294, 27068483, 27149670, 28101908, 28228143, 30200782, 31056302, 31248128		★☆☆☆☆ Found in Text Mining only
Pediatric Obesity	Childhood obesity	BEFREE	26132294		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29552163		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	30736840		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	34895159	Associate	★☆☆☆☆ Found in Text Mining only