Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	26262
Gene name	Tetraspanin 17
Gene symbol	TSPAN17
Synonyms (NCBI Gene)	FBX23FBXO23TM4SF17
Chromosome	5
Chromosome location	5q35.2
Summary	This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014]

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Show/Hide all (144)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037387	hsa-miR-744-5p	CLASH	23622248
MIRT1459600	hsa-miR-1184	CLIP-seq
MIRT1459601	hsa-miR-1197	CLIP-seq
MIRT1459602	hsa-miR-1205	CLIP-seq
MIRT1459603	hsa-miR-1207-3p	CLIP-seq
MIRT1459604	hsa-miR-1321	CLIP-seq
MIRT1459605	hsa-miR-134	CLIP-seq
MIRT1459606	hsa-miR-142-3p	CLIP-seq
MIRT1459607	hsa-miR-1538	CLIP-seq
MIRT1459608	hsa-miR-1827	CLIP-seq
MIRT1459609	hsa-miR-1909	CLIP-seq
MIRT1459610	hsa-miR-1915	CLIP-seq
MIRT1459611	hsa-miR-193a-3p	CLIP-seq
MIRT1459612	hsa-miR-193b	CLIP-seq
MIRT1459613	hsa-miR-196a	CLIP-seq
MIRT1459614	hsa-miR-196b	CLIP-seq
MIRT1459615	hsa-miR-2682	CLIP-seq
MIRT1459616	hsa-miR-3064-3p	CLIP-seq
MIRT1459617	hsa-miR-3118	CLIP-seq
MIRT1459618	hsa-miR-3150a-3p	CLIP-seq
MIRT1459619	hsa-miR-3158-5p	CLIP-seq
MIRT1459620	hsa-miR-3175	CLIP-seq
MIRT1459621	hsa-miR-3177-5p	CLIP-seq
MIRT1459622	hsa-miR-3180	CLIP-seq
MIRT1459623	hsa-miR-3180-3p	CLIP-seq
MIRT1459624	hsa-miR-3194-3p	CLIP-seq
MIRT1459625	hsa-miR-3196	CLIP-seq
MIRT1459626	hsa-miR-323-5p	CLIP-seq
MIRT1459627	hsa-miR-328	CLIP-seq
MIRT1459628	hsa-miR-335	CLIP-seq
MIRT1459629	hsa-miR-34a	CLIP-seq
MIRT1459630	hsa-miR-34c-5p	CLIP-seq
MIRT1459631	hsa-miR-3612	CLIP-seq
MIRT1459632	hsa-miR-3657	CLIP-seq
MIRT1459633	hsa-miR-3676	CLIP-seq
MIRT1459634	hsa-miR-4255	CLIP-seq
MIRT1459635	hsa-miR-4267	CLIP-seq
MIRT1459636	hsa-miR-4270	CLIP-seq
MIRT1459637	hsa-miR-4280	CLIP-seq
MIRT1459638	hsa-miR-4423-5p	CLIP-seq
MIRT1459639	hsa-miR-4435	CLIP-seq
MIRT1459640	hsa-miR-4436a	CLIP-seq
MIRT1459641	hsa-miR-4441	CLIP-seq
MIRT1459642	hsa-miR-4488	CLIP-seq
MIRT1459643	hsa-miR-449a	CLIP-seq
MIRT1459644	hsa-miR-449b	CLIP-seq
MIRT1459645	hsa-miR-449c	CLIP-seq
MIRT1459646	hsa-miR-4640-5p	CLIP-seq
MIRT1459647	hsa-miR-4660	CLIP-seq
MIRT1459648	hsa-miR-4667-5p	CLIP-seq
MIRT1459649	hsa-miR-4691-3p	CLIP-seq
MIRT1459650	hsa-miR-4697-5p	CLIP-seq
MIRT1459651	hsa-miR-4699-5p	CLIP-seq
MIRT1459652	hsa-miR-4700-5p	CLIP-seq
MIRT1459653	hsa-miR-4715-3p	CLIP-seq
MIRT1459654	hsa-miR-4726-3p	CLIP-seq
MIRT1459655	hsa-miR-4726-5p	CLIP-seq
MIRT1459656	hsa-miR-4728-5p	CLIP-seq
MIRT1459657	hsa-miR-4731-5p	CLIP-seq
MIRT1459658	hsa-miR-4738-5p	CLIP-seq
MIRT1459659	hsa-miR-4739	CLIP-seq
MIRT1459660	hsa-miR-4745-3p	CLIP-seq
MIRT1459661	hsa-miR-4756-5p	CLIP-seq
MIRT1459662	hsa-miR-4781-5p	CLIP-seq
MIRT1459663	hsa-miR-483-3p	CLIP-seq
MIRT1459664	hsa-miR-508-5p	CLIP-seq
MIRT1459665	hsa-miR-624	CLIP-seq
MIRT1459666	hsa-miR-650	CLIP-seq
MIRT1459667	hsa-miR-744	CLIP-seq
MIRT1459668	hsa-miR-939	CLIP-seq
MIRT2137952	hsa-miR-324-5p	CLIP-seq
MIRT2137953	hsa-miR-338-3p	CLIP-seq
MIRT2358858	hsa-miR-378	CLIP-seq
MIRT2358859	hsa-miR-378b	CLIP-seq
MIRT2358860	hsa-miR-378c	CLIP-seq
MIRT2358861	hsa-miR-378d	CLIP-seq
MIRT2358862	hsa-miR-378e	CLIP-seq
MIRT2358863	hsa-miR-378f	CLIP-seq
MIRT2358864	hsa-miR-378h	CLIP-seq
MIRT2358865	hsa-miR-378i	CLIP-seq
MIRT2358866	hsa-miR-422a	CLIP-seq
MIRT2358867	hsa-miR-2278	CLIP-seq
MIRT1459635	hsa-miR-4267	CLIP-seq
MIRT2652058	hsa-miR-147b	CLIP-seq
MIRT2652059	hsa-miR-210	CLIP-seq
MIRT2652060	hsa-miR-28-3p	CLIP-seq
MIRT2652061	hsa-miR-3126-5p	CLIP-seq
MIRT2652062	hsa-miR-3130-3p	CLIP-seq
MIRT1459619	hsa-miR-3158-5p	CLIP-seq
MIRT2652063	hsa-miR-320a	CLIP-seq
MIRT2652064	hsa-miR-320b	CLIP-seq
MIRT2652065	hsa-miR-320c	CLIP-seq
MIRT2652066	hsa-miR-320d	CLIP-seq
MIRT2652067	hsa-miR-320e	CLIP-seq
MIRT2137953	hsa-miR-338-3p	CLIP-seq
MIRT2652068	hsa-miR-3622b-5p	CLIP-seq
MIRT2652069	hsa-miR-3649	CLIP-seq
MIRT2652070	hsa-miR-3675-5p	CLIP-seq
MIRT2652071	hsa-miR-3925-3p	CLIP-seq
MIRT2652072	hsa-miR-3926	CLIP-seq
MIRT2652073	hsa-miR-4253	CLIP-seq
MIRT2652074	hsa-miR-4427	CLIP-seq
MIRT2652075	hsa-miR-4429	CLIP-seq
MIRT2652076	hsa-miR-4530	CLIP-seq
MIRT2652077	hsa-miR-4680-3p	CLIP-seq
MIRT2652078	hsa-miR-4688	CLIP-seq
MIRT2652079	hsa-miR-4727-5p	CLIP-seq
MIRT2652080	hsa-miR-4762-3p	CLIP-seq
MIRT2652081	hsa-miR-4768-5p	CLIP-seq
MIRT2652082	hsa-miR-4769-3p	CLIP-seq
MIRT2652083	hsa-miR-4775	CLIP-seq
MIRT2652084	hsa-miR-511	CLIP-seq
MIRT2652085	hsa-miR-544	CLIP-seq
MIRT2652086	hsa-miR-766	CLIP-seq
MIRT2694337	hsa-miR-1294	CLIP-seq
MIRT2652060	hsa-miR-28-3p	CLIP-seq
MIRT2652062	hsa-miR-3130-3p	CLIP-seq
MIRT2694338	hsa-miR-3153	CLIP-seq
MIRT2694339	hsa-miR-3155	CLIP-seq
MIRT2694340	hsa-miR-3155b	CLIP-seq
MIRT1459619	hsa-miR-3158-5p	CLIP-seq
MIRT2137953	hsa-miR-338-3p	CLIP-seq
MIRT2694341	hsa-miR-3609	CLIP-seq
MIRT2652071	hsa-miR-3925-3p	CLIP-seq
MIRT2694342	hsa-miR-3973	CLIP-seq
MIRT2652074	hsa-miR-4427	CLIP-seq
MIRT1459640	hsa-miR-4436a	CLIP-seq
MIRT2694343	hsa-miR-4438	CLIP-seq
MIRT2652076	hsa-miR-4530	CLIP-seq
MIRT2694344	hsa-miR-4668-5p	CLIP-seq
MIRT2652077	hsa-miR-4680-3p	CLIP-seq
MIRT2694345	hsa-miR-4690-5p	CLIP-seq
MIRT2694346	hsa-miR-4709-5p	CLIP-seq
MIRT2652079	hsa-miR-4727-5p	CLIP-seq
MIRT2652080	hsa-miR-4762-3p	CLIP-seq
MIRT2652082	hsa-miR-4769-3p	CLIP-seq
MIRT2652083	hsa-miR-4775	CLIP-seq
MIRT2694347	hsa-miR-484	CLIP-seq
MIRT2694348	hsa-miR-520g	CLIP-seq
MIRT2694349	hsa-miR-520h	CLIP-seq
MIRT2652085	hsa-miR-544	CLIP-seq
MIRT2694350	hsa-miR-548ah	CLIP-seq
MIRT2694351	hsa-miR-548c-3p	CLIP-seq
MIRT2652086	hsa-miR-766	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0008104	Process	Intracellular protein localization	IEA
GO:0016020	Component	Membrane	IEA
GO:0019899	Function	Enzyme binding	IPI	23091066
GO:0051043	Process	Regulation of membrane protein ectodomain proteolysis	IDA	28600292
GO:0072594	Process	Establishment of protein localization to organelle	IDA	23091066

MIM	HGNC	e!Ensembl
620446	13594	ENSG00000048140

Q96FV3

Protein name

Tetraspanin-17 (Tspan-17) (F-box only protein 23) (Tetraspan protein SB134) (Transmembrane 4 superfamily member 17)

Protein function

Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell sur

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00335	Tetraspanin	17 → 262	Tetraspanin family	Family

Sequence

MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGG
LDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDW
IRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRE
RCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAG
VFMGIALLQIFGICLAQNLVSDIKAVKANW

Sequence length

270

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Glioblastoma	Glioblastoma	Pubtator	31432186	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31432186		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31432186		★★★★★ ★☆☆☆☆ Found in Text Mining only

TSPAN17 (tetraspanin 17)