Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26259
Gene name	F-box and WD repeat domain containing 8
Gene symbol	FBXW8
Synonyms (NCBI Gene)	FBW6FBW8FBX29FBXO29FBXW6
Chromosome	12
Chromosome location	12q24.22
Summary	This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cul

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miRTarBase ID	miRNA	Experiments	Reference
MIRT643228	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT643227	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT643226	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT643225	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT643224	hsa-miR-604	HITS-CLIP	23824327
MIRT643223	hsa-miR-6762-3p	HITS-CLIP	23824327
MIRT643222	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT643221	hsa-miR-647	HITS-CLIP	23824327
MIRT643220	hsa-miR-6842-3p	HITS-CLIP	23824327
MIRT633402	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT633401	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT633400	hsa-miR-940	HITS-CLIP	23824327
MIRT633399	hsa-miR-3929	HITS-CLIP	23824327
MIRT633398	hsa-miR-4419b	HITS-CLIP	23824327
MIRT633397	hsa-miR-4478	HITS-CLIP	23824327
MIRT633396	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT633395	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT633394	hsa-miR-1827	HITS-CLIP	23824327
MIRT633393	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT633392	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT633391	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT633390	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT633389	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT633388	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT633387	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT633386	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT633385	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT633384	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT633383	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT633382	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT633381	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT633380	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT633379	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT633378	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT633377	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT633376	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT633375	hsa-miR-3689c	HITS-CLIP	23824327
MIRT633374	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT633373	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT633372	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT633371	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT633370	hsa-miR-3122	HITS-CLIP	23824327
MIRT633369	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT633368	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT633367	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT633366	hsa-miR-665	HITS-CLIP	23824327
MIRT633394	hsa-miR-1827	PAR-CLIP	26701625
MIRT633394	hsa-miR-1827	PAR-CLIP	26701625
MIRT643228	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT643227	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT643226	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT643225	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT643224	hsa-miR-604	HITS-CLIP	23824327
MIRT643223	hsa-miR-6762-3p	HITS-CLIP	23824327
MIRT643222	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT643221	hsa-miR-647	HITS-CLIP	23824327
MIRT643220	hsa-miR-6842-3p	HITS-CLIP	23824327
MIRT633402	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT633401	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT633400	hsa-miR-940	HITS-CLIP	23824327
MIRT633399	hsa-miR-3929	HITS-CLIP	23824327
MIRT633398	hsa-miR-4419b	HITS-CLIP	23824327
MIRT633397	hsa-miR-4478	HITS-CLIP	23824327
MIRT633396	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT633395	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT633394	hsa-miR-1827	HITS-CLIP	23824327
MIRT633393	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT633392	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT633391	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT633390	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT633389	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT633388	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT633387	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT633386	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT633385	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT633384	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT633383	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT633382	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT633381	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT633380	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT633379	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT633378	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT633377	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT633376	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT633375	hsa-miR-3689c	HITS-CLIP	23824327
MIRT633374	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT633373	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT633372	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT633371	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT633370	hsa-miR-3122	HITS-CLIP	23824327
MIRT633369	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT633368	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT633367	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT633366	hsa-miR-665	HITS-CLIP	23824327
MIRT993580	hsa-miR-1229	CLIP-seq
MIRT993581	hsa-miR-1289	CLIP-seq
MIRT993582	hsa-miR-1304	CLIP-seq
MIRT993583	hsa-miR-3198	CLIP-seq
MIRT993584	hsa-miR-33a	CLIP-seq
MIRT993585	hsa-miR-33b	CLIP-seq
MIRT993586	hsa-miR-4294	CLIP-seq
MIRT993587	hsa-miR-4309	CLIP-seq
MIRT993588	hsa-miR-4778-5p	CLIP-seq
MIRT993589	hsa-miR-544	CLIP-seq
MIRT993590	hsa-miR-579	CLIP-seq
MIRT993591	hsa-miR-653	CLIP-seq
MIRT993592	hsa-miR-1200	CLIP-seq
MIRT993593	hsa-miR-1207-3p	CLIP-seq
MIRT993594	hsa-miR-1207-5p	CLIP-seq
MIRT993580	hsa-miR-1229	CLIP-seq
MIRT993595	hsa-miR-1257	CLIP-seq
MIRT993596	hsa-miR-125a-5p	CLIP-seq
MIRT993597	hsa-miR-125b	CLIP-seq
MIRT993598	hsa-miR-1293	CLIP-seq
MIRT993582	hsa-miR-1304	CLIP-seq
MIRT993599	hsa-miR-2110	CLIP-seq
MIRT993600	hsa-miR-2113	CLIP-seq
MIRT993601	hsa-miR-2116	CLIP-seq
MIRT993602	hsa-miR-218	CLIP-seq
MIRT993603	hsa-miR-223	CLIP-seq
MIRT993604	hsa-miR-2355-5p	CLIP-seq
MIRT993605	hsa-miR-3126-5p	CLIP-seq
MIRT993606	hsa-miR-3140-3p	CLIP-seq
MIRT993607	hsa-miR-3155	CLIP-seq
MIRT993608	hsa-miR-3155b	CLIP-seq
MIRT993609	hsa-miR-3160-3p	CLIP-seq
MIRT993610	hsa-miR-3173-3p	CLIP-seq
MIRT993611	hsa-miR-3184	CLIP-seq
MIRT993612	hsa-miR-3186-5p	CLIP-seq
MIRT993613	hsa-miR-3194-3p	CLIP-seq
MIRT993614	hsa-miR-3197	CLIP-seq
MIRT993615	hsa-miR-3200-5p	CLIP-seq
MIRT993616	hsa-miR-339-5p	CLIP-seq
MIRT993617	hsa-miR-3545-5p	CLIP-seq
MIRT993618	hsa-miR-3650	CLIP-seq
MIRT993619	hsa-miR-3672	CLIP-seq
MIRT993620	hsa-miR-3679-3p	CLIP-seq
MIRT993621	hsa-miR-3975	CLIP-seq
MIRT993622	hsa-miR-423-5p	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT993624	hsa-miR-4300	CLIP-seq
MIRT993625	hsa-miR-4302	CLIP-seq
MIRT993626	hsa-miR-4303	CLIP-seq
MIRT993627	hsa-miR-4319	CLIP-seq
MIRT993628	hsa-miR-4324	CLIP-seq
MIRT993629	hsa-miR-4419a	CLIP-seq
MIRT993630	hsa-miR-4435	CLIP-seq
MIRT993631	hsa-miR-4438	CLIP-seq
MIRT993632	hsa-miR-4446-5p	CLIP-seq
MIRT993633	hsa-miR-4474-3p	CLIP-seq
MIRT993634	hsa-miR-4483	CLIP-seq
MIRT993635	hsa-miR-4487	CLIP-seq
MIRT993636	hsa-miR-4489	CLIP-seq
MIRT993637	hsa-miR-4510	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT993639	hsa-miR-4536	CLIP-seq
MIRT993640	hsa-miR-4662a-5p	CLIP-seq
MIRT993641	hsa-miR-4676-5p	CLIP-seq
MIRT993642	hsa-miR-4677-5p	CLIP-seq
MIRT993643	hsa-miR-4690-3p	CLIP-seq
MIRT993644	hsa-miR-4693-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT993646	hsa-miR-4697-3p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT993648	hsa-miR-4732-3p	CLIP-seq
MIRT993649	hsa-miR-4734	CLIP-seq
MIRT993650	hsa-miR-4736	CLIP-seq
MIRT993651	hsa-miR-4746-3p	CLIP-seq
MIRT993652	hsa-miR-4747-5p	CLIP-seq
MIRT993653	hsa-miR-4755-5p	CLIP-seq
MIRT993654	hsa-miR-4763-3p	CLIP-seq
MIRT993588	hsa-miR-4778-5p	CLIP-seq
MIRT993655	hsa-miR-4786-5p	CLIP-seq
MIRT993656	hsa-miR-484	CLIP-seq
MIRT993657	hsa-miR-491-5p	CLIP-seq
MIRT993658	hsa-miR-518d-5p	CLIP-seq
MIRT993659	hsa-miR-519b-5p	CLIP-seq
MIRT993660	hsa-miR-519c-5p	CLIP-seq
MIRT993661	hsa-miR-520c-5p	CLIP-seq
MIRT993662	hsa-miR-526a	CLIP-seq
MIRT993589	hsa-miR-544	CLIP-seq
MIRT993663	hsa-miR-544b	CLIP-seq
MIRT993664	hsa-miR-548c-3p	CLIP-seq
MIRT993665	hsa-miR-558	CLIP-seq
MIRT993666	hsa-miR-575	CLIP-seq
MIRT993590	hsa-miR-579	CLIP-seq
MIRT993667	hsa-miR-636	CLIP-seq
MIRT993591	hsa-miR-653	CLIP-seq
MIRT993668	hsa-miR-663b	CLIP-seq
MIRT993669	hsa-miR-670	CLIP-seq
MIRT993670	hsa-miR-760	CLIP-seq
MIRT993671	hsa-miR-769-5p	CLIP-seq
MIRT993672	hsa-miR-876-3p	CLIP-seq
MIRT993673	hsa-miR-920	CLIP-seq
MIRT1994694	hsa-miR-1273e	CLIP-seq
MIRT993598	hsa-miR-1293	CLIP-seq
MIRT993599	hsa-miR-2110	CLIP-seq
MIRT1994695	hsa-miR-2964a-3p	CLIP-seq
MIRT1994696	hsa-miR-302f	CLIP-seq
MIRT993610	hsa-miR-3173-3p	CLIP-seq
MIRT1994697	hsa-miR-3545-3p	CLIP-seq
MIRT1994698	hsa-miR-3664-3p	CLIP-seq
MIRT993621	hsa-miR-3975	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT1994699	hsa-miR-4307	CLIP-seq
MIRT1994700	hsa-miR-4433	CLIP-seq
MIRT1994701	hsa-miR-4459	CLIP-seq
MIRT993634	hsa-miR-4483	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT1994702	hsa-miR-4680-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT1994703	hsa-miR-4722-5p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT993652	hsa-miR-4747-5p	CLIP-seq
MIRT1994704	hsa-miR-4768-3p	CLIP-seq
MIRT993657	hsa-miR-491-5p	CLIP-seq
MIRT1994705	hsa-miR-510	CLIP-seq
MIRT1994706	hsa-miR-512-5p	CLIP-seq
MIRT993663	hsa-miR-544b	CLIP-seq
MIRT2228799	hsa-miR-1246	CLIP-seq
MIRT1994694	hsa-miR-1273e	CLIP-seq
MIRT2228800	hsa-miR-1290	CLIP-seq
MIRT2228801	hsa-miR-1292	CLIP-seq
MIRT2228802	hsa-miR-19a	CLIP-seq
MIRT2228803	hsa-miR-19b	CLIP-seq
MIRT993601	hsa-miR-2116	CLIP-seq
MIRT1994695	hsa-miR-2964a-3p	CLIP-seq
MIRT1994696	hsa-miR-302f	CLIP-seq
MIRT2228804	hsa-miR-31	CLIP-seq
MIRT2228805	hsa-miR-3135b	CLIP-seq
MIRT2228806	hsa-miR-3167	CLIP-seq
MIRT2228807	hsa-miR-3202	CLIP-seq
MIRT1994697	hsa-miR-3545-3p	CLIP-seq
MIRT2228808	hsa-miR-3646	CLIP-seq
MIRT2228809	hsa-miR-3652	CLIP-seq
MIRT2228810	hsa-miR-3662	CLIP-seq
MIRT1994698	hsa-miR-3664-3p	CLIP-seq
MIRT2228811	hsa-miR-3926	CLIP-seq
MIRT2228812	hsa-miR-3936	CLIP-seq
MIRT2228813	hsa-miR-3978	CLIP-seq
MIRT2228814	hsa-miR-4315	CLIP-seq
MIRT2228815	hsa-miR-4328	CLIP-seq
MIRT2228816	hsa-miR-4430	CLIP-seq
MIRT1994700	hsa-miR-4433	CLIP-seq
MIRT1994701	hsa-miR-4459	CLIP-seq
MIRT2228817	hsa-miR-4471	CLIP-seq
MIRT993633	hsa-miR-4474-3p	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT2228818	hsa-miR-4646-5p	CLIP-seq
MIRT2228819	hsa-miR-4660	CLIP-seq
MIRT993642	hsa-miR-4677-5p	CLIP-seq
MIRT1994702	hsa-miR-4680-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT2228820	hsa-miR-4698	CLIP-seq
MIRT1994703	hsa-miR-4722-5p	CLIP-seq
MIRT1994704	hsa-miR-4768-3p	CLIP-seq
MIRT993655	hsa-miR-4786-5p	CLIP-seq
MIRT2228821	hsa-miR-4790-5p	CLIP-seq
MIRT2228822	hsa-miR-493	CLIP-seq
MIRT1994705	hsa-miR-510	CLIP-seq
MIRT1994706	hsa-miR-512-5p	CLIP-seq
MIRT2228823	hsa-miR-548s	CLIP-seq
MIRT2228824	hsa-miR-583	CLIP-seq
MIRT993668	hsa-miR-663b	CLIP-seq
MIRT993671	hsa-miR-769-5p	CLIP-seq
MIRT993672	hsa-miR-876-3p	CLIP-seq
MIRT2228825	hsa-miR-876-5p	CLIP-seq
MIRT2228826	hsa-miR-885-3p	CLIP-seq
MIRT2228827	hsa-miR-891b	CLIP-seq
MIRT993606	hsa-miR-3140-3p	CLIP-seq
MIRT993591	hsa-miR-653	CLIP-seq
MIRT993593	hsa-miR-1207-3p	CLIP-seq
MIRT993598	hsa-miR-1293	CLIP-seq
MIRT993599	hsa-miR-2110	CLIP-seq
MIRT993610	hsa-miR-3173-3p	CLIP-seq
MIRT993621	hsa-miR-3975	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT993634	hsa-miR-4483	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT993652	hsa-miR-4747-5p	CLIP-seq
MIRT993657	hsa-miR-491-5p	CLIP-seq
MIRT993593	hsa-miR-1207-3p	CLIP-seq
MIRT993598	hsa-miR-1293	CLIP-seq
MIRT993599	hsa-miR-2110	CLIP-seq
MIRT993610	hsa-miR-3173-3p	CLIP-seq
MIRT993621	hsa-miR-3975	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT993634	hsa-miR-4483	CLIP-seq
MIRT993638	hsa-miR-4533	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT993652	hsa-miR-4747-5p	CLIP-seq
MIRT993657	hsa-miR-491-5p	CLIP-seq
MIRT1994694	hsa-miR-1273e	CLIP-seq
MIRT1994695	hsa-miR-2964a-3p	CLIP-seq
MIRT1994696	hsa-miR-302f	CLIP-seq
MIRT2532375	hsa-miR-320e	CLIP-seq
MIRT1994697	hsa-miR-3545-3p	CLIP-seq
MIRT1994698	hsa-miR-3664-3p	CLIP-seq
MIRT993623	hsa-miR-4271	CLIP-seq
MIRT1994700	hsa-miR-4433	CLIP-seq
MIRT1994701	hsa-miR-4459	CLIP-seq
MIRT2532376	hsa-miR-4495	CLIP-seq
MIRT993640	hsa-miR-4662a-5p	CLIP-seq
MIRT993641	hsa-miR-4676-5p	CLIP-seq
MIRT1994702	hsa-miR-4680-5p	CLIP-seq
MIRT2532377	hsa-miR-4684-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT1994703	hsa-miR-4722-5p	CLIP-seq
MIRT993647	hsa-miR-4725-3p	CLIP-seq
MIRT1994704	hsa-miR-4768-3p	CLIP-seq
MIRT2532378	hsa-miR-4794	CLIP-seq
MIRT1994705	hsa-miR-510	CLIP-seq
MIRT1994706	hsa-miR-512-5p	CLIP-seq
MIRT993664	hsa-miR-548c-3p	CLIP-seq
MIRT993666	hsa-miR-575	CLIP-seq
MIRT993596	hsa-miR-125a-5p	CLIP-seq
MIRT993597	hsa-miR-125b	CLIP-seq
MIRT1994694	hsa-miR-1273e	CLIP-seq
MIRT1994695	hsa-miR-2964a-3p	CLIP-seq
MIRT1994696	hsa-miR-302f	CLIP-seq
MIRT2532375	hsa-miR-320e	CLIP-seq
MIRT1994697	hsa-miR-3545-3p	CLIP-seq
MIRT1994698	hsa-miR-3664-3p	CLIP-seq
MIRT993627	hsa-miR-4319	CLIP-seq
MIRT1994700	hsa-miR-4433	CLIP-seq
MIRT1994701	hsa-miR-4459	CLIP-seq
MIRT2532376	hsa-miR-4495	CLIP-seq
MIRT993640	hsa-miR-4662a-5p	CLIP-seq
MIRT993641	hsa-miR-4676-5p	CLIP-seq
MIRT1994702	hsa-miR-4680-5p	CLIP-seq
MIRT2532377	hsa-miR-4684-5p	CLIP-seq
MIRT993645	hsa-miR-4695-5p	CLIP-seq
MIRT1994703	hsa-miR-4722-5p	CLIP-seq
MIRT993648	hsa-miR-4732-3p	CLIP-seq
MIRT1994704	hsa-miR-4768-3p	CLIP-seq
MIRT2532378	hsa-miR-4794	CLIP-seq
MIRT1994705	hsa-miR-510	CLIP-seq
MIRT1994706	hsa-miR-512-5p	CLIP-seq
MIRT993663	hsa-miR-544b	CLIP-seq
MIRT993664	hsa-miR-548c-3p	CLIP-seq
MIRT993666	hsa-miR-575	CLIP-seq
MIRT993669	hsa-miR-670	CLIP-seq

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15070733, 17314511, 18498745, 21572988, 24362026, 27705803, 33961781
GO:0005737	Component	Cytoplasm	IDA	17205132, 18498745
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	21572988
GO:0005794	Component	Golgi apparatus	IEA
GO:0005814	Component	Centriole	IBA
GO:0005829	Component	Cytosol	IDA	18498745
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	17636018
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	18498745
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0007030	Process	Golgi organization	IGI	21572988
GO:0007030	Process	Golgi organization	ISS
GO:0008283	Process	Cell population proliferation	IDA	24362026
GO:0008286	Process	Insulin receptor signaling pathway	IDA	38056462
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IDA	24362026
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IEA
GO:0031467	Component	Cul7-RING ubiquitin ligase complex	IBA
GO:0031467	Component	Cul7-RING ubiquitin ligase complex	IDA	17205132, 18498745, 21572988, 24362026
GO:0031467	Component	Cul7-RING ubiquitin ligase complex	IEA
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0036064	Component	Ciliary basal body	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	17205132
GO:0045727	Process	Positive regulation of translation	IMP	28106072
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IDA	18498745
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IDA	18498745
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	21572988
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050775	Process	Positive regulation of dendrite morphogenesis	IDA	21572988
GO:0050775	Process	Positive regulation of dendrite morphogenesis	ISS
GO:0060271	Process	Cilium assembly	IBA
GO:0060716	Process	Labyrinthine layer blood vessel development	IEA
GO:1990393	Component	3M complex	IDA	24793695
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	17205132, 18498745, 24362026
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA
GO:2000059	Process	Negative regulation of ubiquitin-dependent protein catabolic process	IDA	39032648

MIM	HGNC	e!Ensembl
609073	13597	ENSG00000174989

Q8N3Y1

Protein name

F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)

Protein function

Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17205132, PubMed:18498745, PubMed:21572988, PubMed:24362026, Pu

PDB

7Z8B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00646	F-box	117 → 161	F-box domain	Domain

Sequence

MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSGRGEQASGDPALAQRLL
EGAGRPPAARATRAEGQDVASRSRSPLAREGAGGGEQLVDQLIRDLNEMNDVPFFDIQLP
YELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLI
FQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTW
DYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDA
RIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVA
VAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLE
AGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSA
VQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRN
ADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV

Sequence length

598

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis		Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY BLADDER NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bladder Neoplasm	Bladder Neoplasm	CTD_human_DG	26039340		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29310837		★★★★★ ★☆☆☆☆ Found in Text Mining only
Choriocarcinoma	Choriocarcinoma	BEFREE	20878477, 24973709, 29096355		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	22504421	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	22504421		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	22504421	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	22504421		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29310837		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	29805667		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	CTD_human_DG	26039340		★★★★★ ★☆☆☆☆ Found in Text Mining only
Marginal Zone B-Cell Lymphoma	B-Cell Lymphoma	GWASCAT_DG	31407831		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastoma	Nephroblastoma	BEFREE	29040381		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	24362026	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	22504421		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	29805667		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	GWASCAT_DG	31407831		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

FBXW8 (F-box and WD repeat domain containing 8)