Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	261729
Gene name	STEAP2 metalloreductase
Gene symbol	STEAP2
Synonyms (NCBI Gene)	IPCA1PCANAP1PUMPCnSTAMP1STMP
Chromosome	7
Chromosome location	7q21.13
Summary	This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase an

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Show/Hide all (230)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031189	hsa-miR-19b-3p	Sequencing	20371350
MIRT048078	hsa-miR-197-3p	CLASH	23622248
MIRT036587	hsa-miR-940	CLASH	23622248
MIRT036587	hsa-miR-940	PAR-CLIP	27292025
MIRT1396787	hsa-miR-1266	CLIP-seq
MIRT1396788	hsa-miR-146a	CLIP-seq
MIRT1396789	hsa-miR-146b-5p	CLIP-seq
MIRT1396790	hsa-miR-1908	CLIP-seq
MIRT1396791	hsa-miR-2114	CLIP-seq
MIRT1396792	hsa-miR-3120-5p	CLIP-seq
MIRT1396793	hsa-miR-3612	CLIP-seq
MIRT1396794	hsa-miR-3664-3p	CLIP-seq
MIRT1396795	hsa-miR-4518	CLIP-seq
MIRT1396796	hsa-miR-4768-3p	CLIP-seq
MIRT1396797	hsa-miR-511	CLIP-seq
MIRT1396798	hsa-miR-650	CLIP-seq
MIRT1396799	hsa-miR-663	CLIP-seq
MIRT1396800	hsa-miR-873	CLIP-seq
MIRT1396801	hsa-miR-1	CLIP-seq
MIRT1396802	hsa-miR-1912	CLIP-seq
MIRT1396803	hsa-miR-194	CLIP-seq
MIRT1396804	hsa-miR-206	CLIP-seq
MIRT1396805	hsa-miR-22	CLIP-seq
MIRT1396806	hsa-miR-2276	CLIP-seq
MIRT1396807	hsa-miR-329	CLIP-seq
MIRT1396808	hsa-miR-362-3p	CLIP-seq
MIRT1396809	hsa-miR-380	CLIP-seq
MIRT1396810	hsa-miR-3915	CLIP-seq
MIRT1396811	hsa-miR-3928	CLIP-seq
MIRT1396812	hsa-miR-4264	CLIP-seq
MIRT1396813	hsa-miR-4506	CLIP-seq
MIRT1396814	hsa-miR-4704-3p	CLIP-seq
MIRT1396815	hsa-miR-4708-3p	CLIP-seq
MIRT1396816	hsa-miR-4717-3p	CLIP-seq
MIRT1396817	hsa-miR-516b	CLIP-seq
MIRT1396818	hsa-miR-613	CLIP-seq
MIRT1396819	hsa-miR-640	CLIP-seq
MIRT1396820	hsa-miR-1185	CLIP-seq
MIRT1396821	hsa-miR-1257	CLIP-seq
MIRT1396822	hsa-miR-128	CLIP-seq
MIRT1396823	hsa-miR-144	CLIP-seq
MIRT1396824	hsa-miR-186	CLIP-seq
MIRT1396790	hsa-miR-1908	CLIP-seq
MIRT1396791	hsa-miR-2114	CLIP-seq
MIRT1396825	hsa-miR-27a	CLIP-seq
MIRT1396826	hsa-miR-27b	CLIP-seq
MIRT1396827	hsa-miR-3179	CLIP-seq
MIRT1396828	hsa-miR-3605-5p	CLIP-seq
MIRT1396829	hsa-miR-3607-5p	CLIP-seq
MIRT1396793	hsa-miR-3612	CLIP-seq
MIRT1396830	hsa-miR-3622b-5p	CLIP-seq
MIRT1396831	hsa-miR-3662	CLIP-seq
MIRT1396832	hsa-miR-3679-5p	CLIP-seq
MIRT1396833	hsa-miR-3921	CLIP-seq
MIRT1396834	hsa-miR-4253	CLIP-seq
MIRT1396835	hsa-miR-4255	CLIP-seq
MIRT1396836	hsa-miR-4276	CLIP-seq
MIRT1396837	hsa-miR-4302	CLIP-seq
MIRT1396838	hsa-miR-4433	CLIP-seq
MIRT1396839	hsa-miR-4436b-3p	CLIP-seq
MIRT1396840	hsa-miR-4443	CLIP-seq
MIRT1396841	hsa-miR-4459	CLIP-seq
MIRT1396842	hsa-miR-4653-5p	CLIP-seq
MIRT1396843	hsa-miR-4683	CLIP-seq
MIRT1396844	hsa-miR-4767	CLIP-seq
MIRT1396796	hsa-miR-4768-3p	CLIP-seq
MIRT1396845	hsa-miR-4775	CLIP-seq
MIRT1396846	hsa-miR-4786-5p	CLIP-seq
MIRT1396847	hsa-miR-4793-5p	CLIP-seq
MIRT1396848	hsa-miR-4794	CLIP-seq
MIRT1396849	hsa-miR-513a-5p	CLIP-seq
MIRT1396850	hsa-miR-555	CLIP-seq
MIRT1396851	hsa-miR-590-3p	CLIP-seq
MIRT1396798	hsa-miR-650	CLIP-seq
MIRT1396799	hsa-miR-663	CLIP-seq
MIRT1554217	hsa-miR-1224-5p	CLIP-seq
MIRT1554218	hsa-miR-1304	CLIP-seq
MIRT1554219	hsa-miR-3121-5p	CLIP-seq
MIRT1554220	hsa-miR-3150b-3p	CLIP-seq
MIRT1554221	hsa-miR-3667-3p	CLIP-seq
MIRT1396810	hsa-miR-3915	CLIP-seq
MIRT1554222	hsa-miR-4297	CLIP-seq
MIRT1554223	hsa-miR-4643	CLIP-seq
MIRT1554224	hsa-miR-4689	CLIP-seq
MIRT1554225	hsa-miR-4784	CLIP-seq
MIRT1554226	hsa-miR-642b	CLIP-seq
MIRT1396793	hsa-miR-3612	CLIP-seq
MIRT1396796	hsa-miR-4768-3p	CLIP-seq
MIRT1396798	hsa-miR-650	CLIP-seq
MIRT2341167	hsa-miR-1227	CLIP-seq
MIRT2341168	hsa-miR-1275	CLIP-seq
MIRT2341169	hsa-miR-129-5p	CLIP-seq
MIRT2341170	hsa-miR-193a-3p	CLIP-seq
MIRT2341171	hsa-miR-193b	CLIP-seq
MIRT1396793	hsa-miR-3612	CLIP-seq
MIRT2341172	hsa-miR-3926	CLIP-seq
MIRT2341173	hsa-miR-4260	CLIP-seq
MIRT1396838	hsa-miR-4433	CLIP-seq
MIRT1396840	hsa-miR-4443	CLIP-seq
MIRT1396841	hsa-miR-4459	CLIP-seq
MIRT2341174	hsa-miR-4665-5p	CLIP-seq
MIRT1396843	hsa-miR-4683	CLIP-seq
MIRT2341175	hsa-miR-4738-3p	CLIP-seq
MIRT1396844	hsa-miR-4767	CLIP-seq
MIRT1396796	hsa-miR-4768-3p	CLIP-seq
MIRT1396846	hsa-miR-4786-5p	CLIP-seq
MIRT1396847	hsa-miR-4793-5p	CLIP-seq
MIRT2341176	hsa-miR-548g	CLIP-seq
MIRT2341177	hsa-miR-548s	CLIP-seq
MIRT2341178	hsa-miR-625	CLIP-seq
MIRT1396798	hsa-miR-650	CLIP-seq
MIRT2341179	hsa-miR-766	CLIP-seq
MIRT1554221	hsa-miR-3667-3p	CLIP-seq
MIRT1554222	hsa-miR-4297	CLIP-seq
MIRT1554223	hsa-miR-4643	CLIP-seq
MIRT1554226	hsa-miR-642b	CLIP-seq
MIRT2460653	hsa-miR-15a	CLIP-seq
MIRT2460654	hsa-miR-15b	CLIP-seq
MIRT2460655	hsa-miR-16	CLIP-seq
MIRT2460656	hsa-miR-195	CLIP-seq
MIRT1396827	hsa-miR-3179	CLIP-seq
MIRT2460657	hsa-miR-424	CLIP-seq
MIRT2460658	hsa-miR-4530	CLIP-seq
MIRT2460659	hsa-miR-497	CLIP-seq
MIRT2635011	hsa-miR-1228	CLIP-seq
MIRT2635012	hsa-miR-1229	CLIP-seq
MIRT2635013	hsa-miR-1279	CLIP-seq
MIRT1396822	hsa-miR-128	CLIP-seq
MIRT2635014	hsa-miR-1296	CLIP-seq
MIRT2635015	hsa-miR-1303	CLIP-seq
MIRT2635016	hsa-miR-132	CLIP-seq
MIRT2635017	hsa-miR-140-3p	CLIP-seq
MIRT1396823	hsa-miR-144	CLIP-seq
MIRT2635018	hsa-miR-153	CLIP-seq
MIRT1396790	hsa-miR-1908	CLIP-seq
MIRT2635019	hsa-miR-1910	CLIP-seq
MIRT1396803	hsa-miR-194	CLIP-seq
MIRT2635020	hsa-miR-197	CLIP-seq
MIRT1396791	hsa-miR-2114	CLIP-seq
MIRT2635021	hsa-miR-212	CLIP-seq
MIRT2635022	hsa-miR-2355-3p	CLIP-seq
MIRT2635023	hsa-miR-2682	CLIP-seq
MIRT1396825	hsa-miR-27a	CLIP-seq
MIRT1396826	hsa-miR-27b	CLIP-seq
MIRT2635024	hsa-miR-2909	CLIP-seq
MIRT2635025	hsa-miR-3140-5p	CLIP-seq
MIRT2635026	hsa-miR-3153	CLIP-seq
MIRT2635027	hsa-miR-3158-3p	CLIP-seq
MIRT2635028	hsa-miR-3163	CLIP-seq
MIRT2635029	hsa-miR-3189-5p	CLIP-seq
MIRT2635030	hsa-miR-338-5p	CLIP-seq
MIRT2635031	hsa-miR-340	CLIP-seq
MIRT2635032	hsa-miR-34b	CLIP-seq
MIRT2635033	hsa-miR-3607-3p	CLIP-seq
MIRT1396793	hsa-miR-3612	CLIP-seq
MIRT1396830	hsa-miR-3622b-5p	CLIP-seq
MIRT2635034	hsa-miR-3653	CLIP-seq
MIRT2635035	hsa-miR-3658	CLIP-seq
MIRT2635036	hsa-miR-3674	CLIP-seq
MIRT2635037	hsa-miR-3682-5p	CLIP-seq
MIRT2635038	hsa-miR-3686	CLIP-seq
MIRT2635039	hsa-miR-3714	CLIP-seq
MIRT2635040	hsa-miR-375	CLIP-seq
MIRT2635041	hsa-miR-376c	CLIP-seq
MIRT2635042	hsa-miR-3908	CLIP-seq
MIRT2635043	hsa-miR-3914	CLIP-seq
MIRT2635044	hsa-miR-3923	CLIP-seq
MIRT2635045	hsa-miR-3942-5p	CLIP-seq
MIRT2635046	hsa-miR-411	CLIP-seq
MIRT1396834	hsa-miR-4253	CLIP-seq
MIRT1396835	hsa-miR-4255	CLIP-seq
MIRT2635047	hsa-miR-4263	CLIP-seq
MIRT2635048	hsa-miR-4273	CLIP-seq
MIRT1396836	hsa-miR-4276	CLIP-seq
MIRT1396837	hsa-miR-4302	CLIP-seq
MIRT2635049	hsa-miR-4303	CLIP-seq
MIRT2635050	hsa-miR-4422	CLIP-seq
MIRT1396838	hsa-miR-4433	CLIP-seq
MIRT1396840	hsa-miR-4443	CLIP-seq
MIRT2635051	hsa-miR-4446-3p	CLIP-seq
MIRT2635052	hsa-miR-4456	CLIP-seq
MIRT2635053	hsa-miR-4457	CLIP-seq
MIRT1396841	hsa-miR-4459	CLIP-seq
MIRT2635054	hsa-miR-4484	CLIP-seq
MIRT2635055	hsa-miR-449c	CLIP-seq
MIRT2635056	hsa-miR-4502	CLIP-seq
MIRT2635057	hsa-miR-4521	CLIP-seq
MIRT2635058	hsa-miR-4646-3p	CLIP-seq
MIRT2635059	hsa-miR-4668-5p	CLIP-seq
MIRT2635060	hsa-miR-4677-5p	CLIP-seq
MIRT1396843	hsa-miR-4683	CLIP-seq
MIRT2635061	hsa-miR-4684-5p	CLIP-seq
MIRT2635062	hsa-miR-4699-3p	CLIP-seq
MIRT2635063	hsa-miR-4703-5p	CLIP-seq
MIRT2635064	hsa-miR-4729	CLIP-seq
MIRT2341175	hsa-miR-4738-3p	CLIP-seq
MIRT2635065	hsa-miR-4766-3p	CLIP-seq
MIRT1396844	hsa-miR-4767	CLIP-seq
MIRT1396796	hsa-miR-4768-3p	CLIP-seq
MIRT1396846	hsa-miR-4786-5p	CLIP-seq
MIRT2635066	hsa-miR-4789-5p	CLIP-seq
MIRT2635067	hsa-miR-4790-3p	CLIP-seq
MIRT1396847	hsa-miR-4793-5p	CLIP-seq
MIRT1396848	hsa-miR-4794	CLIP-seq
MIRT2635068	hsa-miR-493	CLIP-seq
MIRT2635069	hsa-miR-494	CLIP-seq
MIRT2635070	hsa-miR-499-3p	CLIP-seq
MIRT2635071	hsa-miR-499a-3p	CLIP-seq
MIRT2635072	hsa-miR-5096	CLIP-seq
MIRT1396849	hsa-miR-513a-5p	CLIP-seq
MIRT2635073	hsa-miR-513b	CLIP-seq
MIRT2635074	hsa-miR-541	CLIP-seq
MIRT2635075	hsa-miR-548an	CLIP-seq
MIRT2635076	hsa-miR-548c-3p	CLIP-seq
MIRT2635077	hsa-miR-548m	CLIP-seq
MIRT2635078	hsa-miR-556-3p	CLIP-seq
MIRT2635079	hsa-miR-562	CLIP-seq
MIRT2635080	hsa-miR-579	CLIP-seq
MIRT2635081	hsa-miR-582-5p	CLIP-seq
MIRT2635082	hsa-miR-633	CLIP-seq
MIRT1554226	hsa-miR-642b	CLIP-seq
MIRT1396798	hsa-miR-650	CLIP-seq
MIRT2635083	hsa-miR-654-5p	CLIP-seq
MIRT1396799	hsa-miR-663	CLIP-seq
MIRT2635084	hsa-miR-676	CLIP-seq
MIRT2635085	hsa-miR-889	CLIP-seq
MIRT2635086	hsa-miR-944	CLIP-seq
MIRT2692205	hsa-miR-3129-3p	CLIP-seq
MIRT2692206	hsa-miR-3148	CLIP-seq
MIRT2692207	hsa-miR-3688-3p	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	12095985
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	12095985
GO:0005829	Component	Cytosol	IDA	12095985
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12095985
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006826	Process	Iron ion transport	IEA
GO:0006893	Process	Golgi to plasma membrane transport	IDA	12095985
GO:0006897	Process	Endocytosis	IDA	12095985
GO:0008823	Function	Cupric reductase (NADH) activity	IBA
GO:0008823	Function	Cupric reductase (NADH) activity	IEA
GO:0009725	Process	Response to hormone	IDA	12095985
GO:0010008	Component	Endosome membrane	IEA
GO:0015677	Process	Copper ion import	IBA
GO:0015677	Process	Copper ion import	IEA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0030140	Component	Trans-Golgi network transport vesicle	IDA	12095985
GO:0045055	Process	Regulated exocytosis	IDA	12095985
GO:0046872	Function	Metal ion binding	IEA
GO:0052851	Function	Ferric-chelate reductase (NADPH) activity	IBA
GO:0052851	Function	Ferric-chelate reductase (NADPH) activity	IEA
GO:0098705	Process	Copper ion import across plasma membrane	IEA
GO:0098711	Process	Iron ion import across plasma membrane	IEA

MIM	HGNC	e!Ensembl
605094	17885	ENSG00000157214

Q8NFT2

Protein name

Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1)

Protein function

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential tra

PDB

7TAI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03807	F420_oxidored	32 → 119	NADP oxidoreductase coenzyme F420-dependent	Family
PF01794	Ferric_reduct	259 → 406	Ferric reductase like transmembrane component	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary. {ECO:0000269|PubMed:12095985, ECO:0000269|PubMed:12429817, ECO:0000269|PubMed:16609065}.

Sequence

MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGS
RNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNM
RINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIE
LARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYA
RNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQ
CRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMY
ISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFE
EEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIP
HVSPERVTVM

Sequence length

490

Interactions

View interactions

	KEGG		Reactome
	Mineral absorption		Transferrin endocytosis and recycling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STEAP2-related disorder	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	24025158		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31696760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	32802887	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	12429817, 23980595		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	35346237	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23980595		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	32875483	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	35346237	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	35346237	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31696760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	12095985, 12429817, 20587517, 25248617, 29674723, 31393902, 31696760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31696760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	40179430	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	36316642	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32149080	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	12095985, 12429817, 20587517, 25248617, 29674723, 31393902, 31696760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	12095985		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	12095985, 12429817, 15897894		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	29674723, 31393902	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

STEAP2 (STEAP2 metalloreductase)