Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26168
Gene name	SUMO specific peptidase 3
Gene symbol	SENP3
Synonyms (NCBI Gene)	SMT3IP1SSP3Ulp1
Chromosome	17
Chromosome location	17p13.1
Summary	The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial pr

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Show/Hide all (193)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048004	hsa-miR-30c-5p	CLASH	23622248
MIRT044811	hsa-miR-320a	CLASH	23622248
MIRT040884	hsa-miR-18a-3p	CLASH	23622248
MIRT038466	hsa-miR-296-3p	CLASH	23622248
MIRT510813	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT510812	hsa-miR-548n	HITS-CLIP	21572407
MIRT510811	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT510810	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT510809	hsa-miR-561-3p	HITS-CLIP	21572407
MIRT510808	hsa-miR-3163	HITS-CLIP	21572407
MIRT510807	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510806	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510805	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510813	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT510812	hsa-miR-548n	HITS-CLIP	21572407
MIRT510811	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT510810	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT510809	hsa-miR-561-3p	HITS-CLIP	21572407
MIRT510808	hsa-miR-3163	HITS-CLIP	21572407
MIRT510807	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510806	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT521153	hsa-miR-6083	HITS-CLIP	21572407
MIRT510805	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510813	hsa-miR-410-3p	HITS-CLIP	22927820
MIRT510812	hsa-miR-548n	HITS-CLIP	22927820
MIRT510811	hsa-miR-548az-5p	HITS-CLIP	22927820
MIRT510810	hsa-miR-548t-5p	HITS-CLIP	22927820
MIRT510809	hsa-miR-561-3p	HITS-CLIP	22927820
MIRT510808	hsa-miR-3163	HITS-CLIP	22927820
MIRT510807	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT510806	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT521153	hsa-miR-6083	HITS-CLIP	22927820
MIRT510805	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT510807	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT510806	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT521153	hsa-miR-6083	HITS-CLIP	23313552
MIRT510805	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT510813	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT510812	hsa-miR-548n	PAR-CLIP	21572407
MIRT510811	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT510810	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT510809	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT510808	hsa-miR-3163	PAR-CLIP	21572407
MIRT510807	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510806	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT521153	hsa-miR-6083	PAR-CLIP	21572407
MIRT510805	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT534396	hsa-miR-4717-5p	PAR-CLIP	22012620
MIRT534397	hsa-miR-500b-3p	PAR-CLIP	22012620
MIRT534395	hsa-miR-1972	PAR-CLIP	22012620
MIRT534394	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT534392	hsa-miR-5002-3p	PAR-CLIP	22012620
MIRT534393	hsa-miR-3605-5p	PAR-CLIP	22012620
MIRT534391	hsa-miR-6894-5p	PAR-CLIP	22012620
MIRT534390	hsa-miR-6744-5p	PAR-CLIP	22012620
MIRT510813	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT510812	hsa-miR-548n	PAR-CLIP	22012620
MIRT510811	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT510810	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT510809	hsa-miR-561-3p	PAR-CLIP	22012620
MIRT510808	hsa-miR-3163	PAR-CLIP	22012620
MIRT510807	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT510806	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT510805	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT510813	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT510812	hsa-miR-548n	PAR-CLIP	23446348
MIRT510811	hsa-miR-548az-5p	PAR-CLIP	23446348
MIRT510810	hsa-miR-548t-5p	PAR-CLIP	23446348
MIRT510809	hsa-miR-561-3p	PAR-CLIP	23446348
MIRT510808	hsa-miR-3163	PAR-CLIP	23446348
MIRT510807	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521156	hsa-miR-4729	PAR-CLIP	23446348
MIRT521155	hsa-miR-1256	PAR-CLIP	23446348
MIRT510806	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521154	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT521153	hsa-miR-6083	PAR-CLIP	23446348
MIRT510805	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510813	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT510812	hsa-miR-548n	PAR-CLIP	23446348
MIRT510811	hsa-miR-548az-5p	PAR-CLIP	23446348
MIRT510810	hsa-miR-548t-5p	PAR-CLIP	23446348
MIRT510809	hsa-miR-561-3p	PAR-CLIP	23446348
MIRT510808	hsa-miR-3163	PAR-CLIP	23446348
MIRT510807	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510806	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510805	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510813	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT510812	hsa-miR-548n	HITS-CLIP	21572407
MIRT510811	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT510810	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT510809	hsa-miR-561-3p	HITS-CLIP	21572407
MIRT510808	hsa-miR-3163	HITS-CLIP	21572407
MIRT510807	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510806	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510805	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510813	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT510812	hsa-miR-548n	HITS-CLIP	21572407
MIRT510811	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT510810	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT510809	hsa-miR-561-3p	HITS-CLIP	21572407
MIRT510808	hsa-miR-3163	HITS-CLIP	21572407
MIRT510807	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510806	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT521153	hsa-miR-6083	HITS-CLIP	21572407
MIRT510805	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510813	hsa-miR-410-3p	HITS-CLIP	22927820
MIRT510812	hsa-miR-548n	HITS-CLIP	22927820
MIRT510811	hsa-miR-548az-5p	HITS-CLIP	22927820
MIRT510810	hsa-miR-548t-5p	HITS-CLIP	22927820
MIRT510809	hsa-miR-561-3p	HITS-CLIP	22927820
MIRT510808	hsa-miR-3163	HITS-CLIP	22927820
MIRT510807	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT510806	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT521153	hsa-miR-6083	HITS-CLIP	22927820
MIRT510805	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT510807	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT510806	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT521153	hsa-miR-6083	HITS-CLIP	23313552
MIRT510805	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT510813	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT510812	hsa-miR-548n	PAR-CLIP	21572407
MIRT510811	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT510810	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT510809	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT510808	hsa-miR-3163	PAR-CLIP	21572407
MIRT510807	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510806	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT521153	hsa-miR-6083	PAR-CLIP	21572407
MIRT510805	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT534396	hsa-miR-4717-5p	PAR-CLIP	22012620
MIRT534397	hsa-miR-500b-3p	PAR-CLIP	22012620
MIRT534395	hsa-miR-1972	PAR-CLIP	22012620
MIRT534394	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT534392	hsa-miR-5002-3p	PAR-CLIP	22012620
MIRT534393	hsa-miR-3605-5p	PAR-CLIP	22012620
MIRT534391	hsa-miR-6894-5p	PAR-CLIP	22012620
MIRT534390	hsa-miR-6744-5p	PAR-CLIP	22012620
MIRT510813	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT510812	hsa-miR-548n	PAR-CLIP	22012620
MIRT510811	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT510810	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT510809	hsa-miR-561-3p	PAR-CLIP	22012620
MIRT510808	hsa-miR-3163	PAR-CLIP	22012620
MIRT510807	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT510806	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT510805	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT510813	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT510812	hsa-miR-548n	PAR-CLIP	23446348
MIRT510811	hsa-miR-548az-5p	PAR-CLIP	23446348
MIRT510810	hsa-miR-548t-5p	PAR-CLIP	23446348
MIRT510809	hsa-miR-561-3p	PAR-CLIP	23446348
MIRT510808	hsa-miR-3163	PAR-CLIP	23446348
MIRT510807	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521156	hsa-miR-4729	PAR-CLIP	23446348
MIRT521155	hsa-miR-1256	PAR-CLIP	23446348
MIRT510806	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521154	hsa-miR-4709-3p	PAR-CLIP	23446348
MIRT521153	hsa-miR-6083	PAR-CLIP	23446348
MIRT510805	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510813	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT510812	hsa-miR-548n	PAR-CLIP	23446348
MIRT510811	hsa-miR-548az-5p	PAR-CLIP	23446348
MIRT510810	hsa-miR-548t-5p	PAR-CLIP	23446348
MIRT510809	hsa-miR-561-3p	PAR-CLIP	23446348
MIRT510808	hsa-miR-3163	PAR-CLIP	23446348
MIRT510807	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510806	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510805	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1335778	hsa-miR-3174	CLIP-seq
MIRT1335779	hsa-miR-3202	CLIP-seq
MIRT1335780	hsa-miR-4475	CLIP-seq
MIRT1335781	hsa-miR-4481	CLIP-seq
MIRT1335782	hsa-miR-4745-5p	CLIP-seq
MIRT1335783	hsa-miR-4747-5p	CLIP-seq
MIRT1335784	hsa-miR-4758-5p	CLIP-seq
MIRT1335785	hsa-miR-635	CLIP-seq
MIRT2324027	hsa-miR-1207-5p	CLIP-seq
MIRT2324028	hsa-miR-1245	CLIP-seq
MIRT2324029	hsa-miR-2682	CLIP-seq
MIRT2324030	hsa-miR-3126-3p	CLIP-seq
MIRT2324031	hsa-miR-3128	CLIP-seq
MIRT2324032	hsa-miR-3156-5p	CLIP-seq
MIRT2324033	hsa-miR-34a	CLIP-seq
MIRT2324034	hsa-miR-34c-5p	CLIP-seq
MIRT2324035	hsa-miR-449a	CLIP-seq
MIRT2324036	hsa-miR-449b	CLIP-seq
MIRT2324037	hsa-miR-449c	CLIP-seq
MIRT2324038	hsa-miR-4514	CLIP-seq
MIRT2324039	hsa-miR-4692	CLIP-seq
MIRT2324040	hsa-miR-4720-5p	CLIP-seq
MIRT2324041	hsa-miR-4736	CLIP-seq
MIRT2324042	hsa-miR-4763-3p	CLIP-seq
MIRT2324043	hsa-miR-4799-3p	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0005515	Function	Protein binding	IPI	18259216, 19680224, 21326211, 28514442, 32296183, 32814053, 33961781, 34819669, 36351913
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IDA	32832608
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016926	Process	Protein desumoylation	IBA
GO:0016926	Process	Protein desumoylation	IDA	32832608
GO:0016926	Process	Protein desumoylation	IMP	27814492
GO:0016929	Function	DeSUMOylase activity	IBA
GO:0016929	Function	DeSUMOylase activity	IDA	36050397
GO:0016929	Function	DeSUMOylase activity	IMP	27814492
GO:0071339	Component	MLL1 complex	IDA	15960975
GO:2000042	Process	Negative regulation of double-strand break repair via homologous recombination	IDA	32832608

MIM	HGNC	e!Ensembl
612844	17862	ENSG00000161956

Q9H4L4

Protein name

Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3)

Protein function

Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcription

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02902	Peptidase_C48	400 → 572	Ulp1 protease family, C-terminal catalytic domain	Domain

Sequence

MKETIQGTGSWGPEPPGPGIPPAYSSPRRERLRWPPPPKPRLKSGGGFGPDPGSGTTVPA
RRLPVPRPSFDASASEEEEEEEEEEDEDEEEEVAAWRLPPRWSQLGTSQRPRPSRPTHRK
TCSQRRRRAMRAFRMLLYSKSTSLTFHWKLWGRHRGRRRGLAHPKNHLSPQQGGATPQVP
SPCCRFDSPRGPPPPRLGLLGALMAEDGVRGSPPVPSGPPMEEDGLRWTPKSPLDPDSGL
LSCTLPNGFGGQSGPEGERSLAPPDASILISNVCSIGDHVAQELFQGSDLGMAEEAERPG
EKAGQHSPLREEHVTCVQSILDEFLQTYGSLIPLSTDEVVEKLEDIFQQEFSTPSRKGLV
LQLIQSYQRMPGNAMVRGFRVAYKRHVLTMDDLGTLYGQNWLNDQVMNMYGDLVMDTVPE
KVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHLEVHWSLISVDVRRRTITY
FDSQRTLNRRCPKHIAKYLQAEAVKKDRLDFHQGWKGYFKMNVARQNNDSDCGAFVLQYC
KHLALSQPFSFTQQDMPKLRRQIYKELCHCKLTV

Sequence length

574

Interactions

View interactions

	Reactome
			Major pathway of rRNA processing in the nucleolus and cytosol

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	20181954		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of colon	Adenocarcinoma Of Colon	BEFREE	20181954		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	33030103	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33558447, 36748193	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	28351334	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	35484132	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	37188742	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	28351334		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	29576508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	28351334		★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	27181202	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	35484132	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Laryngeal neoplasm	Pubtator	27181202	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	25216525		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29438989		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial Ischemia	BEFREE	29576508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23467634		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	33030103	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	33030103	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	23467634		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	23467634	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	25216525		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	35672711	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	36227136	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SENP3 (SUMO specific peptidase 3)