Gene Gene information from NCBI Gene database.
Entrez ID 26156
Gene name Ribosomal L1 domain containing 1
Gene symbol RSL1D1
Synonyms (NCBI Gene)
CSIGL12PBK1UTP30
Chromosome 16
Chromosome location 16p13.13
miRNA miRNA information provided by mirtarbase database.
768
miRTarBase ID miRNA Experiments Reference
MIRT027166 hsa-miR-103a-3p Sequencing 20371350
MIRT051659 hsa-let-7e-5p CLASH 23622248
MIRT051068 hsa-miR-16-5p CLASH 23622248
MIRT041332 hsa-miR-193b-3p CLASH 23622248
MIRT676142 hsa-miR-5571-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0001649 Process Osteoblast differentiation HDA 16210410
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IBA
GO:0003730 Function MRNA 3'-UTR binding IDA 16213212
GO:0005515 Function Protein binding IPI 30021884, 33961781, 36647821
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615874 24534 ENSG00000171490
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O76021
Protein name Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)
Protein function Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
PDB 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL2 , 8FL6 , 8FLA , 8FLD , 8INE , 8INF , 8IPX , 8IPY , 8IR3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00687 Ribosomal_L1 43 259 Ribosomal protein L1p/L10e family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at high intensities in the heart, skeletal muscle, and placenta. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:9859858}.
Sequence
MEDSASASLSSAAATGTSTSTPAAPTARKQLDKEQVRKAVDALLTHCKSRKNNYGLLLNE
NESLFLMVVLWKIPSKELRVRLTLPHSIRSDSEDICLFTKDEPNSTPEKTEQFYRKLLNK
HGIKTVSQIISLQTLKKEYKSYEAKLRLLSSFDFFLTDARIRRLLPSLIGRHFYQRKKVP
VSVNLLSKNLSREINDCIGGTVLNISKSGSCSAIRIGHVGMQIEHIIENIVAVTKGLSEK
LPEKWESVKLLFVKTEKSA
ALPIFSSFVSNWDEATKRSLLNKKKKEARRKRRERNFEKQK
ERKKKRQQARKTASVLSKDDVAPESGDTTVKKPESKKEQTPEHGKKKRGRGKAQVKATNE
SEDEIPQLVPIGKKTPANEKVEIQKHATGKKSPAKSPNPSTPRGKKRKALPASETPKAAE
SETPGKSPEKKPKIKEEAVKEKSPSLGKKDARQTPKKPEAKFFTTPSKSVRKASHTPKKW
PKKPKVPQST
Sequence length 490
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SCOLIOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 11145021 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 38102665 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 15880258
★☆☆☆☆
Found in Text Mining only
Colonic Diseases Colonic disease Pubtator 38102665 Associate
★☆☆☆☆
Found in Text Mining only
Hemophilia A Hemophilia a Pubtator 14610717 Associate
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 25749381
★☆☆☆☆
Found in Text Mining only
Lung Diseases Lung disease Pubtator 38102665 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 15880258
★☆☆☆☆
Found in Text Mining only