Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26155
Gene name	NOC2 like nucleolar associated transcriptional repressor
Gene symbol	NOC2L
Synonyms (NCBI Gene)	NET15NET7NIRPPP1R112
Chromosome	1
Chromosome location	1p36.33
Summary	Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 200

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Show/Hide all (116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023960	hsa-miR-1-3p	Proteomics	18668040
MIRT050868	hsa-miR-17-5p	CLASH	23622248
MIRT049204	hsa-miR-92a-3p	CLASH	23622248
MIRT049204	hsa-miR-92a-3p	CLASH	23622248
MIRT049204	hsa-miR-92a-3p	CLASH	23622248
MIRT045456	hsa-miR-149-5p	CLASH	23622248
MIRT042192	hsa-miR-484	CLASH	23622248
MIRT040269	hsa-miR-615-3p	CLASH	23622248
MIRT458356	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT458355	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT458354	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT458352	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT458353	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT458351	hsa-miR-4257	PAR-CLIP	23592263
MIRT458350	hsa-miR-3179	PAR-CLIP	23592263
MIRT458349	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT458348	hsa-miR-6134	PAR-CLIP	23592263
MIRT458347	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT458346	hsa-miR-4533	PAR-CLIP	23592263
MIRT458345	hsa-miR-3202	PAR-CLIP	23592263
MIRT458344	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT458343	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT458342	hsa-miR-6762-5p	PAR-CLIP	23592263
MIRT458341	hsa-miR-6845-5p	PAR-CLIP	23592263
MIRT458340	hsa-miR-8071	PAR-CLIP	23592263
MIRT458339	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT458338	hsa-miR-3165	PAR-CLIP	23592263
MIRT458337	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT458347	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT458338	hsa-miR-3165	PAR-CLIP	26701625
MIRT458350	hsa-miR-3179	PAR-CLIP	26701625
MIRT458337	hsa-miR-3190-3p	PAR-CLIP	26701625
MIRT458345	hsa-miR-3202	PAR-CLIP	26701625
MIRT458349	hsa-miR-3616-3p	PAR-CLIP	26701625
MIRT458351	hsa-miR-4257	PAR-CLIP	26701625
MIRT458356	hsa-miR-4436b-3p	PAR-CLIP	26701625
MIRT458346	hsa-miR-4533	PAR-CLIP	26701625
MIRT458355	hsa-miR-4632-5p	PAR-CLIP	26701625
MIRT458344	hsa-miR-4640-5p	PAR-CLIP	26701625
MIRT458343	hsa-miR-4726-5p	PAR-CLIP	26701625
MIRT458348	hsa-miR-6134	PAR-CLIP	26701625
MIRT458354	hsa-miR-6735-5p	PAR-CLIP	26701625
MIRT458342	hsa-miR-6762-5p	PAR-CLIP	26701625
MIRT458341	hsa-miR-6845-5p	PAR-CLIP	26701625
MIRT458352	hsa-miR-6879-5p	PAR-CLIP	26701625
MIRT458339	hsa-miR-6880-5p	PAR-CLIP	26701625
MIRT458353	hsa-miR-7843-5p	PAR-CLIP	26701625
MIRT458340	hsa-miR-8071	PAR-CLIP	26701625
MIRT458356	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT458355	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT458354	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT458352	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT458353	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT458351	hsa-miR-4257	PAR-CLIP	23592263
MIRT458350	hsa-miR-3179	PAR-CLIP	23592263
MIRT458349	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT458348	hsa-miR-6134	PAR-CLIP	23592263
MIRT458347	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT458346	hsa-miR-4533	PAR-CLIP	23592263
MIRT458345	hsa-miR-3202	PAR-CLIP	23592263
MIRT458344	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT458343	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT458342	hsa-miR-6762-5p	PAR-CLIP	23592263
MIRT458341	hsa-miR-6845-5p	PAR-CLIP	23592263
MIRT458340	hsa-miR-8071	PAR-CLIP	23592263
MIRT458339	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT458338	hsa-miR-3165	PAR-CLIP	23592263
MIRT458337	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT1188231	hsa-miR-1305	CLIP-seq
MIRT1188232	hsa-miR-133a	CLIP-seq
MIRT1188233	hsa-miR-133b	CLIP-seq
MIRT1188234	hsa-miR-187	CLIP-seq
MIRT1188235	hsa-miR-3618	CLIP-seq
MIRT1188236	hsa-miR-4449	CLIP-seq
MIRT1188237	hsa-miR-4728-3p	CLIP-seq
MIRT1188238	hsa-miR-607	CLIP-seq
MIRT1188239	hsa-miR-934	CLIP-seq
MIRT2054531	hsa-miR-1224-3p	CLIP-seq
MIRT2054532	hsa-miR-1226	CLIP-seq
MIRT2054533	hsa-miR-1260	CLIP-seq
MIRT2054534	hsa-miR-1260b	CLIP-seq
MIRT2054535	hsa-miR-1280	CLIP-seq
MIRT2054536	hsa-miR-1291	CLIP-seq
MIRT1188232	hsa-miR-133a	CLIP-seq
MIRT1188233	hsa-miR-133b	CLIP-seq
MIRT2054537	hsa-miR-214	CLIP-seq
MIRT2054538	hsa-miR-3173-5p	CLIP-seq
MIRT2054539	hsa-miR-328	CLIP-seq
MIRT2054540	hsa-miR-3619-5p	CLIP-seq
MIRT2054541	hsa-miR-4267	CLIP-seq
MIRT2054542	hsa-miR-4291	CLIP-seq
MIRT2054543	hsa-miR-4690-3p	CLIP-seq
MIRT2054544	hsa-miR-4691-3p	CLIP-seq
MIRT1188237	hsa-miR-4728-3p	CLIP-seq
MIRT2054545	hsa-miR-532-3p	CLIP-seq
MIRT2054546	hsa-miR-761	CLIP-seq
MIRT2054547	hsa-miR-922	CLIP-seq
MIRT2283616	hsa-miR-4438	CLIP-seq
MIRT2283617	hsa-miR-5095	CLIP-seq
MIRT2283618	hsa-miR-548q	CLIP-seq
MIRT2054532	hsa-miR-1226	CLIP-seq
MIRT2686412	hsa-miR-1321	CLIP-seq
MIRT2686413	hsa-miR-141	CLIP-seq
MIRT2686414	hsa-miR-193a-3p	CLIP-seq
MIRT2686415	hsa-miR-193b	CLIP-seq
MIRT2686416	hsa-miR-200a	CLIP-seq
MIRT2686417	hsa-miR-3689d	CLIP-seq
MIRT2686418	hsa-miR-3940-3p	CLIP-seq
MIRT2686419	hsa-miR-4261	CLIP-seq
MIRT2686420	hsa-miR-4270	CLIP-seq
MIRT2686421	hsa-miR-4441	CLIP-seq
MIRT2686422	hsa-miR-4701-5p	CLIP-seq
MIRT2686423	hsa-miR-4739	CLIP-seq
MIRT2686424	hsa-miR-4755-3p	CLIP-seq
MIRT2686425	hsa-miR-4756-5p	CLIP-seq
MIRT2686426	hsa-miR-588	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	20123734, 20959462
GO:0002903	Process	Negative regulation of B cell apoptotic process	IMP	20959462
GO:0003682	Function	Chromatin binding	IDA	16322561, 20123734
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IDA	16322561
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	16322561, 20123734, 20959462, 21078624
GO:0005634	Component	Nucleus	IDA	16322561, 20959462
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA	20123734
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	20123734
GO:0005730	Component	Nucleolus	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006915	Process	Apoptotic process	IEA
GO:0030690	Component	Noc1p-Noc2p complex	IBA
GO:0030691	Component	Noc2p-Noc3p complex	IBA
GO:0031491	Function	Nucleosome binding	IDA	16322561
GO:0034644	Process	Cellular response to UV	IDA	20959462
GO:0042273	Process	Ribosomal large subunit biogenesis	IBA
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IDA	16322561
GO:0045815	Process	Transcription initiation-coupled chromatin remodeling	IDA	16322561
GO:0140297	Function	DNA-binding transcription factor binding	IDA	16322561
GO:2001243	Process	Negative regulation of intrinsic apoptotic signaling pathway	IMP	16322561

MIM	HGNC	e!Ensembl
610770	24517	ENSG00000188976

Q9Y3T9

Protein name

Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)

Protein function

Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as

PDB

8FKV , 8FKW , 8FKX , 8FKY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03715	Noc2	327 → 622	Noc2p family	Family

Sequence

MAAAGSRKRRLAELTVDEFLASGFDSESESESENSPQAETREAREAARSPDKPGGSPSAS
RRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSLLNFSDSDSSEEEEGPFHSLPDVLEEA
SEEEDGAEEGEDGDRVPRGLKGKKNSVPVTVAMVERWKQAAKQRLTPKLFHEVVQAFRAA
VATTRGDQESAEANKFQVTDSAAFNALVTFCIRDLIGCLQKLLFGKVAKDSSRMLQPSSS
PLWGKLRVDIKAYLGSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVI
VWSTGEESLRVLAFLVLSRVCRHKKDTFLGPVLKQMYITYVRNCKFTSPGALPFISFMQW
TLTELLALEPGVAYQHAFLYIRQLAIHLRNAMTTRKKETYQSVYNWQYVHCLFLWCRVLS
TAGPSEALQPLVYPLAQVIIGCIKLIPTARFYPLRMHCIRALTLLSGSSGAFIPVLPFIL
EMFQQVDFNRKPGRMSSKPINFSVILKLSNVNLQEKAYRDGLVEQLYDLTLEYLHSQAHC
IGFPELVLPVVLQLKSFLRECKVANYCRQVQQLLGKVQENSAYICSRRQRVSFGVSEQQA
VEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLEDLNFPEIKRRKMADRKDED
RKQFKDLFDLNSSEEDDTEGFSERGILRPLSTRHGVEDDEEDEEEGEEDSSNSEDGDPDA
EAGLAPGELQQLAQGPEDELEDLQLSEDD

Sequence length

749

Interactions

View interactions

	Reactome
			Regulation of TP53 Activity through Phosphorylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PANCREATIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (54)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Achromatopsia	Achromatopsia	BEFREE	29618791		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma Of Esophagus	Esophageal Cancer	BEFREE	28415738, 31004866		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	29556334		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	31669371		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	30613279		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	BEFREE	28947085, 29847651, 31499530, 31544579		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	30276537	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	30276537		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	30276537	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Biliary Atresia	Biliary Atresia	BEFREE	31575415		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	31649241		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29885900, 31349407, 31641713, 31761243		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28912426	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	31649241		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chorioretinal atrophy	Chorioretinal atrophy	BEFREE	28947085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Choroideremia	Choroideremia	BEFREE	31544579		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	24531912		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital atresia of extrahepatic bile duct	Extrahepatic Biliary Atresia	BEFREE	31575415		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dental Diseases	Dental Diseases	BEFREE	30951208		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	27177031		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelioma	Epithelioma	BEFREE	30677734		★★★★★ ★☆☆☆☆ Found in Text Mining only
Familial multiple trichoepitheliomata	Multiple Trichoepithelioma	BEFREE	28415738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	28825960, 31416250		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31085358		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	36521011	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	28576716, 31085358, 31422171		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30576599, 31217542		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	36521011	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31228075		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29885900, 31349407, 31641713, 31761243		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	29422604, 31237149		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28588059, 29679664, 29959089, 30882834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	31279897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	31649241		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24135866, 27601187, 28029105, 28151706, 28402624, 28590721, 28652729, 28749498, 28944765, 29030300, 29262641, 29413608, 29459928, 29582583, 29631221 View all (21 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	24531912		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	29800756, 30128039		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23811292, 27258483, 27892715, 28059409, 28060726, 28151706, 28165076, 28248076, 28249642, 28402624, 28408528, 28418679, 28456784, 28588059, 28823719 View all (49 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29504754, 30102469		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	29422604, 31237149		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatic carcinoma	Pancreatic carcinoma	GWASCAT_DG	29422604		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	23705014, 30292647		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28588059, 29679664, 29959089, 30882834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa	Retinitis Pigmentosa	BEFREE	30053465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	29568374		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	31517839	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of mouth	Oral cavity carcinoma	BEFREE	28923838		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	27894812		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	31279897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	31279897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	29156817, 31777866		★★★★★ ★☆☆☆☆ Found in Text Mining only
Truncus Arteriosus, Persistent	Persistent truncus arteriosus	BEFREE	31689082		★★★★★ ★☆☆☆☆ Found in Text Mining only
USHER SYNDROME, TYPE IB (disorder)	Usher Syndrome	BEFREE	19324852		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vitelliform Macular Dystrophy	Vitelliform Macular Dystrophy	BEFREE	31070670		★★★★★ ★☆☆☆☆ Found in Text Mining only

NOC2L (NOC2 like nucleolar associated transcriptional repressor)