Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26153
Gene name	Kinesin family member 26A
Gene symbol	KIF26A
Synonyms (NCBI Gene)	CDCBM11
Chromosome	14
Chromosome location	14q32.33

Show/Hide all (79)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022436	hsa-miR-124-3p	Microarray	18668037
MIRT611380	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT611379	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT611378	hsa-miR-1470	HITS-CLIP	23824327
MIRT611377	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT614347	hsa-miR-3943	HITS-CLIP	23824327
MIRT611380	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT611379	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT611377	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT614347	hsa-miR-3943	HITS-CLIP	23824327
MIRT611380	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT611378	hsa-miR-1470	HITS-CLIP	23824327
MIRT611377	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611380	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT611379	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT611378	hsa-miR-1470	HITS-CLIP	23824327
MIRT611377	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611380	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT611379	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT611378	hsa-miR-1470	HITS-CLIP	23824327
MIRT611377	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT614347	hsa-miR-3943	HITS-CLIP	23824327
MIRT611380	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT611379	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT611377	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT614347	hsa-miR-3943	HITS-CLIP	23824327
MIRT611380	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT611378	hsa-miR-1470	HITS-CLIP	23824327
MIRT611377	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611380	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT611379	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT611378	hsa-miR-1470	HITS-CLIP	23824327
MIRT611377	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT1094390	hsa-miR-1207-5p	CLIP-seq
MIRT1094391	hsa-miR-1260	CLIP-seq
MIRT1094392	hsa-miR-1260b	CLIP-seq
MIRT1094393	hsa-miR-1273e	CLIP-seq
MIRT1094394	hsa-miR-1273g	CLIP-seq
MIRT1094395	hsa-miR-129-5p	CLIP-seq
MIRT1094396	hsa-miR-188-3p	CLIP-seq
MIRT1094397	hsa-miR-3155	CLIP-seq
MIRT1094398	hsa-miR-3155b	CLIP-seq
MIRT1094399	hsa-miR-3156-3p	CLIP-seq
MIRT1094400	hsa-miR-3671	CLIP-seq
MIRT1094401	hsa-miR-4284	CLIP-seq
MIRT1094402	hsa-miR-4655-3p	CLIP-seq
MIRT1094403	hsa-miR-4736	CLIP-seq
MIRT1094404	hsa-miR-4763-3p	CLIP-seq
MIRT1094405	hsa-miR-484	CLIP-seq
MIRT1094406	hsa-miR-511	CLIP-seq
MIRT1094407	hsa-miR-548al	CLIP-seq
MIRT1094408	hsa-miR-548c-3p	CLIP-seq
MIRT1094409	hsa-miR-579	CLIP-seq
MIRT1094410	hsa-miR-607	CLIP-seq
MIRT1094411	hsa-miR-662	CLIP-seq
MIRT2025277	hsa-miR-3137	CLIP-seq
MIRT2025278	hsa-miR-3146	CLIP-seq
MIRT2025279	hsa-miR-320a	CLIP-seq
MIRT2025280	hsa-miR-320b	CLIP-seq
MIRT2025281	hsa-miR-320c	CLIP-seq
MIRT2025282	hsa-miR-320d	CLIP-seq
MIRT2025283	hsa-miR-3620	CLIP-seq
MIRT2025284	hsa-miR-4429	CLIP-seq
MIRT2025285	hsa-miR-451b	CLIP-seq
MIRT2025286	hsa-miR-4643	CLIP-seq
MIRT2025287	hsa-miR-466	CLIP-seq
MIRT2025288	hsa-miR-4789-3p	CLIP-seq
MIRT2025289	hsa-miR-520d-5p	CLIP-seq
MIRT2025290	hsa-miR-524-5p	CLIP-seq
MIRT2025291	hsa-miR-548ae	CLIP-seq
MIRT2025292	hsa-miR-548aj	CLIP-seq
MIRT2025293	hsa-miR-548am	CLIP-seq
MIRT2025294	hsa-miR-548x	CLIP-seq
MIRT2256563	hsa-miR-138	CLIP-seq
MIRT2256564	hsa-miR-3138	CLIP-seq
MIRT2256565	hsa-miR-4761-5p	CLIP-seq
MIRT2256566	hsa-miR-513c	CLIP-seq
MIRT2256567	hsa-miR-514b-5p	CLIP-seq
MIRT1094399	hsa-miR-3156-3p	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001560	Process	Regulation of cell growth by extracellular stimulus	IEA
GO:0001560	Process	Regulation of cell growth by extracellular stimulus	ISS
GO:0003777	Function	Microtubule motor activity	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007018	Process	Microtubule-based movement	ISS
GO:0008017	Function	Microtubule binding	IEA
GO:0008017	Function	Microtubule binding	ISS
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0009968	Process	Negative regulation of signal transduction	ISS
GO:0010975	Process	Regulation of neuron projection development	IMP	36228617
GO:0016887	Function	ATP hydrolysis activity	ISS
GO:0021987	Process	Cerebral cortex development	IMP	36228617
GO:0048484	Process	Enteric nervous system development	IEA
GO:0048484	Process	Enteric nervous system development	ISS
GO:0048731	Process	System development	IEA
GO:2001222	Process	Regulation of neuron migration	IMP	36228617

MIM	HGNC	e!Ensembl
613231	20226	ENSG00000066735

Q9ULI4

Protein name

Kinesin-like protein KIF26A

Protein function

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00225	Kinesin	403 → 725	Kinesin motor domain	Domain

Tissue specificity

TISSUE SPECIFICITY: In the developing cerebral cortex, preferentially expressed by migrating excitatory neurons. {ECO:0000269|PubMed:36228617}.

Sequence

MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQ
GHSAGGGGWCRHCHTKLVELKRQAWKLVSGPGTTLRDPCLSALLLDKLPAPGALPACRPE
AERRCDVCATHLQQLTREAMHLLQAPASHEDLDAPHGGPSLAPPSTTTSSRDTPGPAGPA
GRQPGRAGPDRTKGLAWSPGPSVQVSVAPAGLGGALSTVTIQAQQCLEGMWSVSRVNSFL
PPACLAEAAVAAVAVADTVRECPPVAGPDGLSKAWGRGGVCTSALVTPTPGSVGGSTGPS
AAASFFIRAMQKLSLASKRKKPHPPPPPATRGTSTYPTDFSGVLQLWPPPAPPCLLRAAS
KTKDNPGSIGKVKVMLRIWPAQGAQRSAEAMSFLKVDPRKKQVILYDPAAGPPGSAGPRR
AATAAVPKMFAFDAVFPQDSEQAEVCSGTVADVLQSVVSGADGCIFSFGHMSLGKSYTMI
GKDSSPQSLGIVPCAISWLFRLIEERRERTGTRFSVRVSAVEVCGRDQSLRDLLAEVAPG
SLQDTQSPGVYLREDPVCGAQLQNQSELRAPTAEKAAFYLDAALAARSTSRAGCGEDARR
SSHMLFTLHVYQYRMEKCGRGGMSGGRSRLHLIDLGSCEAAAGRAGEAAGGPLCLSLSAL
GSVILALVNGAKHVPYRDHRLTMLLRESLATAGCRTTMIAHVSDAPAQHAETLSTVQLAA
RIHRLRRKKAKYASSSSGGESSCEEGRARRPPHLRPFHPRTVALDPDRTPPCLPGDPDYS
SSSEQSCDTVIYVGPGGAALSDRELTDNEGPPDFVPIIPALSRHRPSKGPRDADHFRCST
FAELQERLECMDGNEGPSGGPGGTDGAQASPARGGRKPSPPEAASPRKAVGTPMAASTPR
GSSGPDTHQGTPEPCKAIVWGDQREDSSAWPELLVPEKAAVSGGRRPLPSPAPPPPQLLE
ACRAPEEPGGGGTDGVARTPPVGMSGQVAGSPMLPGATCPRLAAGSRCPERGLLTTTVTL
QRPVELNGEDELVFTVVEELSLGALAGAGRPTSLASFDSDCSLRALASGSRPVSIISSIN
DEFDAYTSQAPEGGPLEGAAWAGSSHGSSISSWLSEVSVCTADSRDPTPQPRFSPDSLAG
LDPGGPPALDGSLGDGSSGFLGPDRPDSPGPTWGPCPGEVAAVAPSRPGREPQAGPSRWA
SAAQTIHSSLPRKPRTASATTRVGCARLGQSPPGRGGLFEDPWLLRVGECDTQAASAGRA
PSPTLGSPRLPEAQVMLACAQRVVDGCEVAARAARRPEAVARIPPLRRGATTLGVTTPAV
SWGDAPTEVVACSGSLKASPTSKKGLAPKAGFLPRPSGAAPPAPPTRKSSLEQRSSPASA
PPHAVNPARVGAAAVLRGEEEPRPSSRADHSVPRATSSLKARASKVEAAHRLAGHASLER
YEGLAHSSSKGREAPGRPPRAVPKLGVPPSSPTHGPAPACRSGAAKAVGAPKPPVGGGKG
RGLVAGGSRALGPSVKLSTASVTGRSPGGPVAGPRAAPRAGPSVGAKAGRGTVMGTKQAL
RAAHSRVHELSASGAPGRGGSSWGSADSDSGHDSGVNVGEERPPTGPALPSPYSKVTAPR
RPQRYSSGHGSDNSSVLSGELPPAMGRTALFHHSGGSSGYESLRRDSEATGSASSAPDSM
SESGAASPGARTRSLKSPKKRATGLQRRRLIPAPLPDTTALGRKPSLPGQWVDLPPPLAG
SLKEPFEIKVYEIDDVERLQRPRPTPREAPTQGLACVSTRLRLAERRQQRLREVQAKHKH
LCEELAETQGRLMLEPGRWLEQFEVDPELEPESAEYLAALERATAALEQCVNLCKAHVMM
VTCFDISVAASAAIPGPQEVDV

Sequence length

1882

Interactions

View interactions

	KEGG		Reactome
	Motor proteins		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Cortical dysplasia, complex, with other brain malformations 11	Pathogenic; Likely pathogenic	rs1003059932, rs746572271, rs771825279, rs2511491044, rs776136395, rs2511493694, rs2511492071	RCV002465481 RCV002465482 RCV002465484 RCV003388303 RCV003482491 RCV003989972 RCV004526512 View all (2 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX CORTICAL DYSPLASIA WITH OTHER BRAIN MALFORMATIONS	—	ClinGen, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 1	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Glioma	Glioma	Pubtator	36837615	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polymicrogyria	Polymicrogyria	Pubtator	37486637	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

KIF26A (kinesin family member 26A)