FGFR1OP2 (FGFR1 oncogene partner 2)

Gene

• Entrez ID: 26127
• Gene name: FGFR1 oncogene partner 2
• Gene symbol: FGFR1OP2
• Synonyms (NCBI Gene): HSPC123-like, WIT3.0
• Chromosome: 12
• Chromosome location: 12p11.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020087	hsa-miR-361-5p	Sequencing	20371350
MIRT712710	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT712709	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT712708	hsa-miR-6859-3p	HITS-CLIP	19536157
MIRT712707	hsa-miR-711	HITS-CLIP	19536157
MIRT642711	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642710	hsa-miR-4301	HITS-CLIP	23824327
MIRT642709	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT642708	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT642707	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT642706	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT642705	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642704	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642703	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT642702	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642701	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT642700	hsa-miR-4284	HITS-CLIP	23824327
MIRT642699	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT633282	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT633281	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT633280	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT633279	hsa-miR-5695	HITS-CLIP	23824327
MIRT633278	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT633277	hsa-miR-6131	HITS-CLIP	23824327
MIRT633276	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT633275	hsa-miR-1200	HITS-CLIP	23824327
MIRT633274	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT633273	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT633272	hsa-miR-548s	HITS-CLIP	23824327
MIRT633271	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT633270	hsa-miR-588	HITS-CLIP	23824327
MIRT633269	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT633268	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT633267	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT712710	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT712709	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT712708	hsa-miR-6859-3p	HITS-CLIP	19536157
MIRT712707	hsa-miR-711	HITS-CLIP	19536157
MIRT642711	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642710	hsa-miR-4301	HITS-CLIP	23824327
MIRT642709	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT642708	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT642707	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT642706	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT642705	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642704	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642703	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT642702	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642701	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT642700	hsa-miR-4284	HITS-CLIP	23824327
MIRT642699	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT633282	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT633281	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT633280	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT633279	hsa-miR-5695	HITS-CLIP	23824327
MIRT633278	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT633277	hsa-miR-6131	HITS-CLIP	23824327
MIRT633276	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT633275	hsa-miR-1200	HITS-CLIP	23824327
MIRT633274	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT633273	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT633272	hsa-miR-548s	HITS-CLIP	23824327
MIRT633271	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT633270	hsa-miR-588	HITS-CLIP	23824327
MIRT633269	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT633268	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT633267	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT996000	hsa-miR-103b	CLIP-seq
MIRT996001	hsa-miR-1208	CLIP-seq
MIRT996002	hsa-miR-129-5p	CLIP-seq
MIRT996003	hsa-miR-1298	CLIP-seq
MIRT996004	hsa-miR-142-5p	CLIP-seq
MIRT996005	hsa-miR-1973	CLIP-seq
MIRT996006	hsa-miR-199a-3p	CLIP-seq
MIRT996007	hsa-miR-199b-3p	CLIP-seq
MIRT996008	hsa-miR-3129-5p	CLIP-seq
MIRT996009	hsa-miR-3651	CLIP-seq
MIRT996010	hsa-miR-3919	CLIP-seq
MIRT996011	hsa-miR-3940-3p	CLIP-seq
MIRT996012	hsa-miR-3973	CLIP-seq
MIRT996013	hsa-miR-4452	CLIP-seq
MIRT996014	hsa-miR-4652-3p	CLIP-seq
MIRT996015	hsa-miR-4699-3p	CLIP-seq
MIRT996016	hsa-miR-4797-5p	CLIP-seq
MIRT996017	hsa-miR-495	CLIP-seq
MIRT996018	hsa-miR-511	CLIP-seq
MIRT996019	hsa-miR-548a-5p	CLIP-seq
MIRT996020	hsa-miR-548ab	CLIP-seq
MIRT996021	hsa-miR-548ak	CLIP-seq
MIRT996022	hsa-miR-548b-5p	CLIP-seq
MIRT996023	hsa-miR-548c-5p	CLIP-seq
MIRT996024	hsa-miR-548d-5p	CLIP-seq
MIRT996025	hsa-miR-548h	CLIP-seq
MIRT996026	hsa-miR-548i	CLIP-seq
MIRT996027	hsa-miR-548j	CLIP-seq
MIRT996028	hsa-miR-548w	CLIP-seq
MIRT996029	hsa-miR-548y	CLIP-seq
MIRT996030	hsa-miR-559	CLIP-seq
MIRT996031	hsa-miR-570	CLIP-seq
MIRT996032	hsa-miR-586	CLIP-seq
MIRT996033	hsa-miR-591	CLIP-seq
MIRT996034	hsa-miR-664	CLIP-seq
MIRT996035	hsa-miR-936	CLIP-seq
MIRT996001	hsa-miR-1208	CLIP-seq
MIRT996036	hsa-miR-129-3p	CLIP-seq
MIRT996037	hsa-miR-1305	CLIP-seq
MIRT996006	hsa-miR-199a-3p	CLIP-seq
MIRT996007	hsa-miR-199b-3p	CLIP-seq
MIRT996008	hsa-miR-3129-5p	CLIP-seq
MIRT996038	hsa-miR-3163	CLIP-seq
MIRT996039	hsa-miR-340	CLIP-seq
MIRT996040	hsa-miR-34b	CLIP-seq
MIRT996041	hsa-miR-34c-3p	CLIP-seq
MIRT996042	hsa-miR-3671	CLIP-seq
MIRT996043	hsa-miR-409-3p	CLIP-seq
MIRT996044	hsa-miR-410	CLIP-seq
MIRT996045	hsa-miR-4422	CLIP-seq
MIRT996046	hsa-miR-4464	CLIP-seq
MIRT996047	hsa-miR-4640-5p	CLIP-seq
MIRT996048	hsa-miR-4687-5p	CLIP-seq
MIRT996049	hsa-miR-4705	CLIP-seq
MIRT996050	hsa-miR-4726-5p	CLIP-seq
MIRT996051	hsa-miR-4729	CLIP-seq
MIRT996052	hsa-miR-4748	CLIP-seq
MIRT996031	hsa-miR-570	CLIP-seq
MIRT996035	hsa-miR-936	CLIP-seq
MIRT996003	hsa-miR-1298	CLIP-seq
MIRT2229428	hsa-miR-197	CLIP-seq
MIRT996005	hsa-miR-1973	CLIP-seq
MIRT2229429	hsa-miR-203	CLIP-seq
MIRT2229430	hsa-miR-24	CLIP-seq
MIRT2229431	hsa-miR-337-3p	CLIP-seq
MIRT996040	hsa-miR-34b	CLIP-seq
MIRT2229432	hsa-miR-3653	CLIP-seq
MIRT2229433	hsa-miR-374c	CLIP-seq
MIRT996012	hsa-miR-3973	CLIP-seq
MIRT2229434	hsa-miR-4328	CLIP-seq
MIRT2229435	hsa-miR-4528	CLIP-seq
MIRT2229436	hsa-miR-4666-3p	CLIP-seq
MIRT996015	hsa-miR-4699-3p	CLIP-seq
MIRT996049	hsa-miR-4705	CLIP-seq
MIRT2229437	hsa-miR-4803	CLIP-seq
MIRT996017	hsa-miR-495	CLIP-seq
MIRT996019	hsa-miR-548a-5p	CLIP-seq
MIRT996020	hsa-miR-548ab	CLIP-seq
MIRT996021	hsa-miR-548ak	CLIP-seq
MIRT996022	hsa-miR-548b-5p	CLIP-seq
MIRT996023	hsa-miR-548c-5p	CLIP-seq
MIRT996024	hsa-miR-548d-5p	CLIP-seq
MIRT996025	hsa-miR-548h	CLIP-seq
MIRT996026	hsa-miR-548i	CLIP-seq
MIRT996027	hsa-miR-548j	CLIP-seq
MIRT996028	hsa-miR-548w	CLIP-seq
MIRT996029	hsa-miR-548y	CLIP-seq
MIRT996030	hsa-miR-559	CLIP-seq
MIRT996033	hsa-miR-591	CLIP-seq
MIRT2229438	hsa-miR-655	CLIP-seq
MIRT996034	hsa-miR-664	CLIP-seq
MIRT2387986	hsa-miR-4775	CLIP-seq
MIRT2387987	hsa-miR-491-3p	CLIP-seq
MIRT996032	hsa-miR-586	CLIP-seq
MIRT2387988	hsa-miR-590-3p	CLIP-seq
MIRT2449682	hsa-miR-4282	CLIP-seq
MIRT2449683	hsa-miR-4719	CLIP-seq
MIRT2449684	hsa-miR-513b	CLIP-seq
MIRT2533280	hsa-miR-1207-3p	CLIP-seq
MIRT996037	hsa-miR-1305	CLIP-seq
MIRT2533281	hsa-miR-188-5p	CLIP-seq
MIRT2229428	hsa-miR-197	CLIP-seq
MIRT2533282	hsa-miR-204	CLIP-seq
MIRT2533283	hsa-miR-211	CLIP-seq
MIRT2533284	hsa-miR-3117-5p	CLIP-seq
MIRT2533285	hsa-miR-3126-3p	CLIP-seq
MIRT2533286	hsa-miR-3145-5p	CLIP-seq
MIRT2533287	hsa-miR-323-5p	CLIP-seq
MIRT2533288	hsa-miR-3647-3p	CLIP-seq
MIRT2229432	hsa-miR-3653	CLIP-seq
MIRT2533289	hsa-miR-3658	CLIP-seq
MIRT2533290	hsa-miR-3686	CLIP-seq
MIRT2533291	hsa-miR-3688-5p	CLIP-seq
MIRT2533292	hsa-miR-371-5p	CLIP-seq
MIRT2533293	hsa-miR-371b-5p	CLIP-seq
MIRT2229433	hsa-miR-374c	CLIP-seq
MIRT2533294	hsa-miR-4272	CLIP-seq
MIRT2449682	hsa-miR-4282	CLIP-seq
MIRT2533295	hsa-miR-4286	CLIP-seq
MIRT2533296	hsa-miR-4299	CLIP-seq
MIRT996045	hsa-miR-4422	CLIP-seq
MIRT2533297	hsa-miR-4456	CLIP-seq
MIRT996046	hsa-miR-4464	CLIP-seq
MIRT2533298	hsa-miR-4470	CLIP-seq
MIRT2533299	hsa-miR-4534	CLIP-seq
MIRT2533300	hsa-miR-4633-3p	CLIP-seq
MIRT2533301	hsa-miR-4640-3p	CLIP-seq
MIRT2533302	hsa-miR-4646-5p	CLIP-seq
MIRT996014	hsa-miR-4652-3p	CLIP-seq
MIRT2229436	hsa-miR-4666-3p	CLIP-seq
MIRT996015	hsa-miR-4699-3p	CLIP-seq
MIRT996049	hsa-miR-4705	CLIP-seq
MIRT2449683	hsa-miR-4719	CLIP-seq
MIRT2533303	hsa-miR-4742-3p	CLIP-seq
MIRT996052	hsa-miR-4748	CLIP-seq
MIRT2533304	hsa-miR-4766-5p	CLIP-seq
MIRT2387986	hsa-miR-4775	CLIP-seq
MIRT2533305	hsa-miR-4778-3p	CLIP-seq
MIRT2229437	hsa-miR-4803	CLIP-seq
MIRT2533306	hsa-miR-488	CLIP-seq
MIRT2387987	hsa-miR-491-3p	CLIP-seq
MIRT2533307	hsa-miR-508-5p	CLIP-seq
MIRT2449684	hsa-miR-513b	CLIP-seq
MIRT2533308	hsa-miR-513c	CLIP-seq
MIRT2533309	hsa-miR-514b-5p	CLIP-seq
MIRT2533310	hsa-miR-548ac	CLIP-seq
MIRT2533311	hsa-miR-548ae	CLIP-seq
MIRT2533312	hsa-miR-548aj	CLIP-seq
MIRT2533313	hsa-miR-548am	CLIP-seq
MIRT2533314	hsa-miR-548d-3p	CLIP-seq
MIRT2533315	hsa-miR-548q	CLIP-seq
MIRT2533316	hsa-miR-548x	CLIP-seq
MIRT2533317	hsa-miR-548z	CLIP-seq
MIRT996032	hsa-miR-586	CLIP-seq
MIRT2387988	hsa-miR-590-3p	CLIP-seq
MIRT2229438	hsa-miR-655	CLIP-seq
MIRT2533318	hsa-miR-876-3p	CLIP-seq
MIRT2533280	hsa-miR-1207-3p	CLIP-seq
MIRT2680981	hsa-miR-1224-5p	CLIP-seq
MIRT2680982	hsa-miR-154	CLIP-seq
MIRT2533281	hsa-miR-188-5p	CLIP-seq
MIRT2533282	hsa-miR-204	CLIP-seq
MIRT2533283	hsa-miR-211	CLIP-seq
MIRT2533286	hsa-miR-3145-5p	CLIP-seq
MIRT2229432	hsa-miR-3653	CLIP-seq
MIRT2533289	hsa-miR-3658	CLIP-seq
MIRT2680983	hsa-miR-3665	CLIP-seq
MIRT2533291	hsa-miR-3688-5p	CLIP-seq
MIRT2533292	hsa-miR-371-5p	CLIP-seq
MIRT2533293	hsa-miR-371b-5p	CLIP-seq
MIRT2229433	hsa-miR-374c	CLIP-seq
MIRT2449682	hsa-miR-4282	CLIP-seq
MIRT2533295	hsa-miR-4286	CLIP-seq
MIRT2533298	hsa-miR-4470	CLIP-seq
MIRT2533301	hsa-miR-4640-3p	CLIP-seq
MIRT2229436	hsa-miR-4666-3p	CLIP-seq
MIRT2449683	hsa-miR-4719	CLIP-seq
MIRT2680984	hsa-miR-4751	CLIP-seq
MIRT2533304	hsa-miR-4766-5p	CLIP-seq
MIRT2387986	hsa-miR-4775	CLIP-seq
MIRT2533305	hsa-miR-4778-3p	CLIP-seq
MIRT2533306	hsa-miR-488	CLIP-seq
MIRT2387987	hsa-miR-491-3p	CLIP-seq
MIRT2533307	hsa-miR-508-5p	CLIP-seq
MIRT2449684	hsa-miR-513b	CLIP-seq
MIRT2533308	hsa-miR-513c	CLIP-seq
MIRT2533309	hsa-miR-514b-5p	CLIP-seq
MIRT2680985	hsa-miR-548c-3p	CLIP-seq
MIRT996032	hsa-miR-586	CLIP-seq
MIRT2387988	hsa-miR-590-3p	CLIP-seq
MIRT2229438	hsa-miR-655	CLIP-seq
MIRT2680986	hsa-miR-657	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0009611	Process	Response to wounding	IBA
GO:0042060	Process	Wound healing	IEA
GO:0042802	Function	Identical protein binding	IEA

Other IDs

• MIM: 608858
• HGNC: 23098
• e!Ensembl: ENSG00000111790

Protein

• UniProt ID: Q9NVK5
• Protein name: FGFR1 oncogene partner 2
• Protein function: May be involved in wound healing pathway.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05769	SIKE	2 → 142	SIKE family	Family
  PF05769	SIKE	146 → 221	SIKE family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in bone marrow, spleen and thymus.
• Sequence:

  MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHR
  PRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDP
  GIIMKLKEQHSKIDMVHRNKSEGFFLDASRHILEAPQHGLERRHLEANQNELQAHVDQIT
  EMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKDDASESTSLS
  ALVTNSDLSLRKS

• Sequence length: 253

Pathways

Reactome:

Signaling by cytosolic FGFR1 fusion mutants
Signaling by FGFR1 in disease

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cervical cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYELOPROLIFERATIVE DISORDERS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atrophy	Atrophy	Pubtator	22880093	Associate	★☆☆☆☆ Found in Text Mining only
Chronic myeloproliferative disorder	Myeloproliferative disorder	BEFREE	21745565		★☆☆☆☆ Found in Text Mining only
Myeloproliferative disease	Myeloproliferative disorder	BEFREE	21745565		★☆☆☆☆ Found in Text Mining only
Myeloproliferative disease	Myeloproliferative disorder	CTD_human_DG	22875613		★☆☆☆☆ Found in Text Mining only