CCDC69 (coiled-coil domain containing 69)

Gene

• Entrez ID: 26112
• Gene name: Coiled-coil domain containing 69
• Gene symbol: CCDC69
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q33.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018220	hsa-miR-335-5p	Microarray	18185580
MIRT646681	hsa-miR-892a	HITS-CLIP	23824327
MIRT646680	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT646679	hsa-miR-4676-5p	HITS-CLIP	23824327
MIRT646678	hsa-miR-575	HITS-CLIP	23824327
MIRT646677	hsa-miR-2392	HITS-CLIP	23824327
MIRT646676	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT646675	hsa-miR-1193	HITS-CLIP	23824327
MIRT646674	hsa-miR-3152-3p	HITS-CLIP	23824327
MIRT646673	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT646672	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT646671	hsa-miR-640	HITS-CLIP	23824327
MIRT646670	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT646669	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT646668	hsa-miR-8070	HITS-CLIP	23824327
MIRT646681	hsa-miR-892a	HITS-CLIP	23824327
MIRT646680	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT646679	hsa-miR-4676-5p	HITS-CLIP	23824327
MIRT646678	hsa-miR-575	HITS-CLIP	23824327
MIRT646677	hsa-miR-2392	HITS-CLIP	23824327
MIRT646676	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT646675	hsa-miR-1193	HITS-CLIP	23824327
MIRT646674	hsa-miR-3152-3p	HITS-CLIP	23824327
MIRT646673	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT646672	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT646671	hsa-miR-640	HITS-CLIP	23824327
MIRT646670	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT646669	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT646668	hsa-miR-8070	HITS-CLIP	23824327
MIRT869676	hsa-miR-1200	CLIP-seq
MIRT869677	hsa-miR-122	CLIP-seq
MIRT869678	hsa-miR-1228	CLIP-seq
MIRT869679	hsa-miR-1248	CLIP-seq
MIRT869680	hsa-miR-1253	CLIP-seq
MIRT869681	hsa-miR-127-5p	CLIP-seq
MIRT869682	hsa-miR-1285	CLIP-seq
MIRT869683	hsa-miR-1302	CLIP-seq
MIRT869684	hsa-miR-1343	CLIP-seq
MIRT869685	hsa-miR-136	CLIP-seq
MIRT869686	hsa-miR-150	CLIP-seq
MIRT869687	hsa-miR-2110	CLIP-seq
MIRT869688	hsa-miR-2276	CLIP-seq
MIRT869689	hsa-miR-24	CLIP-seq
MIRT869690	hsa-miR-29a	CLIP-seq
MIRT869691	hsa-miR-29b	CLIP-seq
MIRT869692	hsa-miR-29c	CLIP-seq
MIRT869693	hsa-miR-3064-3p	CLIP-seq
MIRT869694	hsa-miR-3135b	CLIP-seq
MIRT869695	hsa-miR-3187-5p	CLIP-seq
MIRT869696	hsa-miR-329	CLIP-seq
MIRT869697	hsa-miR-34a	CLIP-seq
MIRT869698	hsa-miR-34c-5p	CLIP-seq
MIRT869699	hsa-miR-362-3p	CLIP-seq
MIRT869700	hsa-miR-3652	CLIP-seq
MIRT869701	hsa-miR-3663-3p	CLIP-seq
MIRT869702	hsa-miR-3689a-3p	CLIP-seq
MIRT869703	hsa-miR-3689c	CLIP-seq
MIRT869704	hsa-miR-377	CLIP-seq
MIRT869705	hsa-miR-4251	CLIP-seq
MIRT869706	hsa-miR-4271	CLIP-seq
MIRT869707	hsa-miR-4287	CLIP-seq
MIRT869708	hsa-miR-4298	CLIP-seq
MIRT869709	hsa-miR-4324	CLIP-seq
MIRT869710	hsa-miR-4418	CLIP-seq
MIRT869711	hsa-miR-4423-5p	CLIP-seq
MIRT869712	hsa-miR-4430	CLIP-seq
MIRT869713	hsa-miR-4437	CLIP-seq
MIRT869714	hsa-miR-4492	CLIP-seq
MIRT869715	hsa-miR-4498	CLIP-seq
MIRT869716	hsa-miR-449a	CLIP-seq
MIRT869717	hsa-miR-449b	CLIP-seq
MIRT869718	hsa-miR-450b-3p	CLIP-seq
MIRT869719	hsa-miR-4634	CLIP-seq
MIRT869720	hsa-miR-4659a-5p	CLIP-seq
MIRT869721	hsa-miR-4659b-5p	CLIP-seq
MIRT869722	hsa-miR-4661-3p	CLIP-seq
MIRT869723	hsa-miR-4663	CLIP-seq
MIRT869724	hsa-miR-4685-3p	CLIP-seq
MIRT869725	hsa-miR-4688	CLIP-seq
MIRT869726	hsa-miR-4713-3p	CLIP-seq
MIRT869727	hsa-miR-4715-3p	CLIP-seq
MIRT869728	hsa-miR-4716-5p	CLIP-seq
MIRT869729	hsa-miR-4725-3p	CLIP-seq
MIRT869730	hsa-miR-4728-5p	CLIP-seq
MIRT869731	hsa-miR-4731-5p	CLIP-seq
MIRT869732	hsa-miR-4733-3p	CLIP-seq
MIRT869733	hsa-miR-4772-5p	CLIP-seq
MIRT869734	hsa-miR-4776-3p	CLIP-seq
MIRT869735	hsa-miR-486-3p	CLIP-seq
MIRT869736	hsa-miR-509-3-5p	CLIP-seq
MIRT869737	hsa-miR-509-5p	CLIP-seq
MIRT869738	hsa-miR-516a-3p	CLIP-seq
MIRT869739	hsa-miR-544b	CLIP-seq
MIRT869740	hsa-miR-578	CLIP-seq
MIRT869741	hsa-miR-612	CLIP-seq
MIRT869742	hsa-miR-638	CLIP-seq
MIRT869743	hsa-miR-643	CLIP-seq
MIRT869744	hsa-miR-762	CLIP-seq
MIRT869745	hsa-miR-765	CLIP-seq
MIRT869746	hsa-miR-769-3p	CLIP-seq
MIRT869677	hsa-miR-122	CLIP-seq
MIRT1958090	hsa-miR-1224-3p	CLIP-seq
MIRT869678	hsa-miR-1228	CLIP-seq
MIRT1958091	hsa-miR-1234	CLIP-seq
MIRT1958092	hsa-miR-1238	CLIP-seq
MIRT869684	hsa-miR-1343	CLIP-seq
MIRT1958093	hsa-miR-1470	CLIP-seq
MIRT869686	hsa-miR-150	CLIP-seq
MIRT869688	hsa-miR-2276	CLIP-seq
MIRT869689	hsa-miR-24	CLIP-seq
MIRT869693	hsa-miR-3064-3p	CLIP-seq
MIRT1958094	hsa-miR-3124-3p	CLIP-seq
MIRT869694	hsa-miR-3135b	CLIP-seq
MIRT1958095	hsa-miR-3158-3p	CLIP-seq
MIRT1958096	hsa-miR-3194-3p	CLIP-seq
MIRT869700	hsa-miR-3652	CLIP-seq
MIRT869704	hsa-miR-377	CLIP-seq
MIRT1958097	hsa-miR-3938	CLIP-seq
MIRT869712	hsa-miR-4430	CLIP-seq
MIRT869714	hsa-miR-4492	CLIP-seq
MIRT869715	hsa-miR-4498	CLIP-seq
MIRT869719	hsa-miR-4634	CLIP-seq
MIRT1958098	hsa-miR-4667-3p	CLIP-seq
MIRT1958099	hsa-miR-4685-5p	CLIP-seq
MIRT869727	hsa-miR-4715-3p	CLIP-seq
MIRT869734	hsa-miR-4776-3p	CLIP-seq
MIRT1958100	hsa-miR-626	CLIP-seq
MIRT1958101	hsa-miR-642a	CLIP-seq
MIRT869744	hsa-miR-762	CLIP-seq
MIRT869677	hsa-miR-122	CLIP-seq
MIRT869678	hsa-miR-1228	CLIP-seq
MIRT2195035	hsa-miR-1296	CLIP-seq
MIRT869684	hsa-miR-1343	CLIP-seq
MIRT869686	hsa-miR-150	CLIP-seq
MIRT869688	hsa-miR-2276	CLIP-seq
MIRT869689	hsa-miR-24	CLIP-seq
MIRT2195036	hsa-miR-2909	CLIP-seq
MIRT869694	hsa-miR-3135b	CLIP-seq
MIRT1958096	hsa-miR-3194-3p	CLIP-seq
MIRT869700	hsa-miR-3652	CLIP-seq
MIRT2195037	hsa-miR-3690	CLIP-seq
MIRT869704	hsa-miR-377	CLIP-seq
MIRT2195038	hsa-miR-3925-3p	CLIP-seq
MIRT2195039	hsa-miR-4256	CLIP-seq
MIRT2195040	hsa-miR-4420	CLIP-seq
MIRT869712	hsa-miR-4430	CLIP-seq
MIRT869714	hsa-miR-4492	CLIP-seq
MIRT869715	hsa-miR-4498	CLIP-seq
MIRT2195041	hsa-miR-4512	CLIP-seq
MIRT869719	hsa-miR-4634	CLIP-seq
MIRT869731	hsa-miR-4731-5p	CLIP-seq
MIRT2195042	hsa-miR-515-5p	CLIP-seq
MIRT869744	hsa-miR-762	CLIP-seq
MIRT2195043	hsa-miR-766	CLIP-seq
MIRT869677	hsa-miR-122	CLIP-seq
MIRT869681	hsa-miR-127-5p	CLIP-seq
MIRT2195035	hsa-miR-1296	CLIP-seq
MIRT2195036	hsa-miR-2909	CLIP-seq
MIRT869694	hsa-miR-3135b	CLIP-seq
MIRT1958096	hsa-miR-3194-3p	CLIP-seq
MIRT869700	hsa-miR-3652	CLIP-seq
MIRT2385670	hsa-miR-3714	CLIP-seq
MIRT2195039	hsa-miR-4256	CLIP-seq
MIRT2385671	hsa-miR-431	CLIP-seq
MIRT869712	hsa-miR-4430	CLIP-seq
MIRT869714	hsa-miR-4492	CLIP-seq
MIRT869715	hsa-miR-4498	CLIP-seq
MIRT2195041	hsa-miR-4512	CLIP-seq
MIRT869719	hsa-miR-4634	CLIP-seq
MIRT2385672	hsa-miR-4667-5p	CLIP-seq
MIRT2385673	hsa-miR-4700-5p	CLIP-seq
MIRT869731	hsa-miR-4731-5p	CLIP-seq
MIRT2385674	hsa-miR-661	CLIP-seq
MIRT869744	hsa-miR-762	CLIP-seq
MIRT869677	hsa-miR-122	CLIP-seq
MIRT869694	hsa-miR-3135b	CLIP-seq
MIRT2446422	hsa-miR-3607-5p	CLIP-seq
MIRT869700	hsa-miR-3652	CLIP-seq
MIRT869712	hsa-miR-4430	CLIP-seq
MIRT869714	hsa-miR-4492	CLIP-seq
MIRT869715	hsa-miR-4498	CLIP-seq
MIRT869719	hsa-miR-4634	CLIP-seq
MIRT2446423	hsa-miR-4643	CLIP-seq
MIRT2446424	hsa-miR-466	CLIP-seq
MIRT2446425	hsa-miR-4789-3p	CLIP-seq
MIRT2446426	hsa-miR-548k	CLIP-seq
MIRT2446427	hsa-miR-548n	CLIP-seq
MIRT869744	hsa-miR-762	CLIP-seq
MIRT869677	hsa-miR-122	CLIP-seq
MIRT1958090	hsa-miR-1224-3p	CLIP-seq
MIRT2498305	hsa-miR-1224-5p	CLIP-seq
MIRT869678	hsa-miR-1228	CLIP-seq
MIRT1958091	hsa-miR-1234	CLIP-seq
MIRT869681	hsa-miR-127-5p	CLIP-seq
MIRT2498306	hsa-miR-129-5p	CLIP-seq
MIRT2195035	hsa-miR-1296	CLIP-seq
MIRT2498307	hsa-miR-1321	CLIP-seq
MIRT869684	hsa-miR-1343	CLIP-seq
MIRT869686	hsa-miR-150	CLIP-seq
MIRT2498308	hsa-miR-1914	CLIP-seq
MIRT869688	hsa-miR-2276	CLIP-seq
MIRT869689	hsa-miR-24	CLIP-seq
MIRT2498309	hsa-miR-2861	CLIP-seq
MIRT2195036	hsa-miR-2909	CLIP-seq
MIRT869694	hsa-miR-3135b	CLIP-seq
MIRT2498310	hsa-miR-3144-5p	CLIP-seq
MIRT2498311	hsa-miR-3149	CLIP-seq
MIRT2498312	hsa-miR-3191	CLIP-seq
MIRT2498313	hsa-miR-3199	CLIP-seq
MIRT2498314	hsa-miR-320e	CLIP-seq
MIRT2498315	hsa-miR-3649	CLIP-seq
MIRT869700	hsa-miR-3652	CLIP-seq
MIRT869704	hsa-miR-377	CLIP-seq
MIRT2498316	hsa-miR-3914	CLIP-seq
MIRT2498317	hsa-miR-3915	CLIP-seq
MIRT2498318	hsa-miR-3922-5p	CLIP-seq
MIRT2195038	hsa-miR-3925-3p	CLIP-seq
MIRT2498319	hsa-miR-3928	CLIP-seq
MIRT2498320	hsa-miR-3977	CLIP-seq
MIRT2498321	hsa-miR-4283	CLIP-seq
MIRT2498322	hsa-miR-4419a	CLIP-seq
MIRT869711	hsa-miR-4423-5p	CLIP-seq
MIRT869712	hsa-miR-4430	CLIP-seq
MIRT2498323	hsa-miR-4438	CLIP-seq
MIRT2498324	hsa-miR-4489	CLIP-seq
MIRT869714	hsa-miR-4492	CLIP-seq
MIRT869715	hsa-miR-4498	CLIP-seq
MIRT2498325	hsa-miR-4510	CLIP-seq
MIRT2195041	hsa-miR-4512	CLIP-seq
MIRT2498326	hsa-miR-4539	CLIP-seq
MIRT869719	hsa-miR-4634	CLIP-seq
MIRT2498327	hsa-miR-4652-5p	CLIP-seq
MIRT2498328	hsa-miR-4656	CLIP-seq
MIRT869720	hsa-miR-4659a-5p	CLIP-seq
MIRT869721	hsa-miR-4659b-5p	CLIP-seq
MIRT2385672	hsa-miR-4667-5p	CLIP-seq
MIRT2498329	hsa-miR-4679	CLIP-seq
MIRT2385673	hsa-miR-4700-5p	CLIP-seq
MIRT2498330	hsa-miR-4708-3p	CLIP-seq
MIRT869728	hsa-miR-4716-5p	CLIP-seq
MIRT869730	hsa-miR-4728-5p	CLIP-seq
MIRT869731	hsa-miR-4731-5p	CLIP-seq
MIRT2498331	hsa-miR-4735-5p	CLIP-seq
MIRT2498332	hsa-miR-4739	CLIP-seq
MIRT2498333	hsa-miR-4751	CLIP-seq
MIRT2498334	hsa-miR-4756-5p	CLIP-seq
MIRT2498335	hsa-miR-4775	CLIP-seq
MIRT869734	hsa-miR-4776-3p	CLIP-seq
MIRT2498336	hsa-miR-4799-5p	CLIP-seq
MIRT2498337	hsa-miR-5095	CLIP-seq
MIRT2195042	hsa-miR-515-5p	CLIP-seq
MIRT2498338	hsa-miR-590-3p	CLIP-seq
MIRT2385674	hsa-miR-661	CLIP-seq
MIRT869744	hsa-miR-762	CLIP-seq
MIRT2195043	hsa-miR-766	CLIP-seq
MIRT869677	hsa-miR-122	CLIP-seq
MIRT2498305	hsa-miR-1224-5p	CLIP-seq
MIRT869678	hsa-miR-1228	CLIP-seq
MIRT869681	hsa-miR-127-5p	CLIP-seq
MIRT2195035	hsa-miR-1296	CLIP-seq
MIRT2498307	hsa-miR-1321	CLIP-seq
MIRT869684	hsa-miR-1343	CLIP-seq
MIRT869686	hsa-miR-150	CLIP-seq
MIRT2498308	hsa-miR-1914	CLIP-seq
MIRT869688	hsa-miR-2276	CLIP-seq
MIRT869689	hsa-miR-24	CLIP-seq
MIRT2498309	hsa-miR-2861	CLIP-seq
MIRT2195036	hsa-miR-2909	CLIP-seq
MIRT869694	hsa-miR-3135b	CLIP-seq
MIRT2498310	hsa-miR-3144-5p	CLIP-seq
MIRT2498312	hsa-miR-3191	CLIP-seq
MIRT2498314	hsa-miR-320e	CLIP-seq
MIRT2498315	hsa-miR-3649	CLIP-seq
MIRT869700	hsa-miR-3652	CLIP-seq
MIRT2677504	hsa-miR-3688-3p	CLIP-seq
MIRT869704	hsa-miR-377	CLIP-seq
MIRT2498316	hsa-miR-3914	CLIP-seq
MIRT2498317	hsa-miR-3915	CLIP-seq
MIRT2498318	hsa-miR-3922-5p	CLIP-seq
MIRT2195038	hsa-miR-3925-3p	CLIP-seq
MIRT2498319	hsa-miR-3928	CLIP-seq
MIRT2498320	hsa-miR-3977	CLIP-seq
MIRT2677505	hsa-miR-3978	CLIP-seq
MIRT2498321	hsa-miR-4283	CLIP-seq
MIRT2498322	hsa-miR-4419a	CLIP-seq
MIRT869711	hsa-miR-4423-5p	CLIP-seq
MIRT869712	hsa-miR-4430	CLIP-seq
MIRT2498324	hsa-miR-4489	CLIP-seq
MIRT869714	hsa-miR-4492	CLIP-seq
MIRT869715	hsa-miR-4498	CLIP-seq
MIRT2498325	hsa-miR-4510	CLIP-seq
MIRT2195041	hsa-miR-4512	CLIP-seq
MIRT869719	hsa-miR-4634	CLIP-seq
MIRT2498327	hsa-miR-4652-5p	CLIP-seq
MIRT2498328	hsa-miR-4656	CLIP-seq
MIRT869720	hsa-miR-4659a-5p	CLIP-seq
MIRT869721	hsa-miR-4659b-5p	CLIP-seq
MIRT2385672	hsa-miR-4667-5p	CLIP-seq
MIRT2498329	hsa-miR-4679	CLIP-seq
MIRT2385673	hsa-miR-4700-5p	CLIP-seq
MIRT2498330	hsa-miR-4708-3p	CLIP-seq
MIRT869728	hsa-miR-4716-5p	CLIP-seq
MIRT869730	hsa-miR-4728-5p	CLIP-seq
MIRT869731	hsa-miR-4731-5p	CLIP-seq
MIRT2498332	hsa-miR-4739	CLIP-seq
MIRT2498333	hsa-miR-4751	CLIP-seq
MIRT2498334	hsa-miR-4756-5p	CLIP-seq
MIRT869734	hsa-miR-4776-3p	CLIP-seq
MIRT2195042	hsa-miR-515-5p	CLIP-seq
MIRT2385674	hsa-miR-661	CLIP-seq
MIRT869744	hsa-miR-762	CLIP-seq
MIRT2195043	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0030496	Component	Midbody	IEA
GO:0051233	Component	Spindle midzone	IDA	20962590
GO:0051255	Process	Spindle midzone assembly	IMP	20962590

Other IDs

• MIM: 619288
• HGNC: 24487
• e!Ensembl: ENSG00000198624

Protein

• UniProt ID: A6NI79
• Protein name: Coiled-coil domain-containing protein 69
• Protein function: May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.
• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in duodenum, esophagus, pancreas, prostate, salivary gland, thymus and urinary bladder. {ECO:0000269|PubMed:20962590}.
• Sequence:

  MGCRHSRLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDI
  TRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALT
  HSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELES
  LHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQL
  SEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTPTEVSFLAT

• Sequence length: 296

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BULIMIA NERVOSA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	33634680	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	37828454	Inhibit	★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	30804561		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32859214	Associate	★☆☆☆☆ Found in Text Mining only
Glomerulonephritis IGA	Iga nephropathy	Pubtator	36793719	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	30651135	Associate	★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	Pubtator	36793719	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	33634680	Inhibit	★☆☆☆☆ Found in Text Mining only