WIPI2 (WD repeat domain, phosphoinositide interacting 2)

Gene

• Entrez ID: 26100
• Gene name: WD repeat domain, phosphoinositide interacting 2
• Gene symbol: WIPI2
• Synonyms (NCBI Gene): ATG18B, Atg21, CGI-50, IDDSSA, WIPI-2
• Chromosome: 7
• Chromosome location: 7p22.1
• Summary: WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI su

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs756429763	G>A	Pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052545	hsa-let-7a-5p	CLASH	23622248
MIRT040290	hsa-miR-615-3p	CLASH	23622248
MIRT037966	hsa-miR-505-5p	CLASH	23622248
MIRT258412	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT258423	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT258415	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT258410	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT258411	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT258413	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT258414	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT541022	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT541021	hsa-miR-376a-3p	PAR-CLIP	21572407
MIRT541020	hsa-miR-376b-3p	PAR-CLIP	21572407
MIRT258421	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT258417	hsa-miR-3908	PAR-CLIP	21572407
MIRT541019	hsa-miR-646	PAR-CLIP	21572407
MIRT542623	hsa-miR-4676-5p	PAR-CLIP	21572407
MIRT542622	hsa-miR-575	PAR-CLIP	21572407
MIRT541018	hsa-miR-103b	PAR-CLIP	21572407
MIRT541017	hsa-miR-4677-3p	PAR-CLIP	21572407
MIRT541016	hsa-miR-4679	PAR-CLIP	21572407
MIRT541015	hsa-miR-4786-3p	PAR-CLIP	21572407
MIRT258418	hsa-miR-3909	PAR-CLIP	21572407
MIRT258424	hsa-miR-6852-3p	PAR-CLIP	21572407
MIRT258419	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT258420	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT258422	hsa-miR-6780a-3p	PAR-CLIP	21572407
MIRT541014	hsa-miR-7843-3p	PAR-CLIP	21572407
MIRT320955	hsa-miR-3611	PAR-CLIP	21572407
MIRT258412	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT258423	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT258415	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT258410	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT258411	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT258413	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT258414	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT541022	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT541021	hsa-miR-376a-3p	PAR-CLIP	21572407
MIRT541020	hsa-miR-376b-3p	PAR-CLIP	21572407
MIRT258421	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT258417	hsa-miR-3908	PAR-CLIP	21572407
MIRT541019	hsa-miR-646	PAR-CLIP	21572407
MIRT541018	hsa-miR-103b	PAR-CLIP	21572407
MIRT541017	hsa-miR-4677-3p	PAR-CLIP	21572407
MIRT541016	hsa-miR-4679	PAR-CLIP	21572407
MIRT541015	hsa-miR-4786-3p	PAR-CLIP	21572407
MIRT258418	hsa-miR-3909	PAR-CLIP	21572407
MIRT258424	hsa-miR-6852-3p	PAR-CLIP	21572407
MIRT258419	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT258420	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT258422	hsa-miR-6780a-3p	PAR-CLIP	21572407
MIRT541014	hsa-miR-7843-3p	PAR-CLIP	21572407
MIRT320955	hsa-miR-3611	PAR-CLIP	21572407
MIRT258410	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT258412	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT258411	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT258413	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT258412	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT258423	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT258415	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT258410	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT258411	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT258413	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT258414	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT541022	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT541021	hsa-miR-376a-3p	PAR-CLIP	21572407
MIRT541020	hsa-miR-376b-3p	PAR-CLIP	21572407
MIRT258421	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT258417	hsa-miR-3908	PAR-CLIP	21572407
MIRT541019	hsa-miR-646	PAR-CLIP	21572407
MIRT542623	hsa-miR-4676-5p	PAR-CLIP	21572407
MIRT542622	hsa-miR-575	PAR-CLIP	21572407
MIRT541018	hsa-miR-103b	PAR-CLIP	21572407
MIRT541017	hsa-miR-4677-3p	PAR-CLIP	21572407
MIRT541016	hsa-miR-4679	PAR-CLIP	21572407
MIRT541015	hsa-miR-4786-3p	PAR-CLIP	21572407
MIRT258418	hsa-miR-3909	PAR-CLIP	21572407
MIRT258424	hsa-miR-6852-3p	PAR-CLIP	21572407
MIRT258419	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT258420	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT258422	hsa-miR-6780a-3p	PAR-CLIP	21572407
MIRT541014	hsa-miR-7843-3p	PAR-CLIP	21572407
MIRT320955	hsa-miR-3611	PAR-CLIP	21572407
MIRT258412	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT258423	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT258415	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT258410	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT258411	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT258413	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT258414	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT541022	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT541021	hsa-miR-376a-3p	PAR-CLIP	21572407
MIRT541020	hsa-miR-376b-3p	PAR-CLIP	21572407
MIRT258421	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT258417	hsa-miR-3908	PAR-CLIP	21572407
MIRT541019	hsa-miR-646	PAR-CLIP	21572407
MIRT541018	hsa-miR-103b	PAR-CLIP	21572407
MIRT541017	hsa-miR-4677-3p	PAR-CLIP	21572407
MIRT541016	hsa-miR-4679	PAR-CLIP	21572407
MIRT541015	hsa-miR-4786-3p	PAR-CLIP	21572407
MIRT258418	hsa-miR-3909	PAR-CLIP	21572407
MIRT258424	hsa-miR-6852-3p	PAR-CLIP	21572407
MIRT258419	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT258420	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT258422	hsa-miR-6780a-3p	PAR-CLIP	21572407
MIRT541014	hsa-miR-7843-3p	PAR-CLIP	21572407
MIRT320955	hsa-miR-3611	PAR-CLIP	21572407
MIRT1493024	hsa-miR-3183	CLIP-seq
MIRT1493025	hsa-miR-4723-3p	CLIP-seq
MIRT1493026	hsa-miR-4727-5p	CLIP-seq
MIRT1493027	hsa-miR-4769-3p	CLIP-seq
MIRT1493028	hsa-miR-593	CLIP-seq
MIRT1493029	hsa-miR-1267	CLIP-seq
MIRT1493030	hsa-miR-1303	CLIP-seq
MIRT1493031	hsa-miR-3133	CLIP-seq
MIRT1493032	hsa-miR-3150a-5p	CLIP-seq
MIRT1493033	hsa-miR-3150b-5p	CLIP-seq
MIRT1493034	hsa-miR-361-5p	CLIP-seq
MIRT1493035	hsa-miR-3616-5p	CLIP-seq
MIRT1493036	hsa-miR-3647-5p	CLIP-seq
MIRT1493037	hsa-miR-4464	CLIP-seq
MIRT1493038	hsa-miR-4670-3p	CLIP-seq
MIRT1493039	hsa-miR-4748	CLIP-seq
MIRT1493040	hsa-miR-548b-3p	CLIP-seq
MIRT1493041	hsa-miR-573	CLIP-seq
MIRT1493042	hsa-miR-574-3p	CLIP-seq
MIRT1493043	hsa-miR-626	CLIP-seq
MIRT1493044	hsa-miR-720	CLIP-seq
MIRT1493045	hsa-let-7a	CLIP-seq
MIRT1493046	hsa-let-7b	CLIP-seq
MIRT1493047	hsa-let-7c	CLIP-seq
MIRT1493048	hsa-let-7d	CLIP-seq
MIRT1493049	hsa-let-7e	CLIP-seq
MIRT1493050	hsa-let-7f	CLIP-seq
MIRT1493051	hsa-let-7g	CLIP-seq
MIRT1493052	hsa-let-7i	CLIP-seq
MIRT1493053	hsa-miR-1	CLIP-seq
MIRT1493054	hsa-miR-1228	CLIP-seq
MIRT1493055	hsa-miR-1238	CLIP-seq
MIRT1493056	hsa-miR-1252	CLIP-seq
MIRT1493057	hsa-miR-151-3p	CLIP-seq
MIRT1493058	hsa-miR-155	CLIP-seq
MIRT1493059	hsa-miR-15a	CLIP-seq
MIRT1493060	hsa-miR-15b	CLIP-seq
MIRT1493061	hsa-miR-16	CLIP-seq
MIRT1493062	hsa-miR-193a-3p	CLIP-seq
MIRT1493063	hsa-miR-193b	CLIP-seq
MIRT1493064	hsa-miR-195	CLIP-seq
MIRT1493065	hsa-miR-202	CLIP-seq
MIRT1493066	hsa-miR-2052	CLIP-seq
MIRT1493067	hsa-miR-206	CLIP-seq
MIRT1493068	hsa-miR-2467-3p	CLIP-seq
MIRT1493069	hsa-miR-2861	CLIP-seq
MIRT1493070	hsa-miR-298	CLIP-seq
MIRT1493071	hsa-miR-3158-5p	CLIP-seq
MIRT1493072	hsa-miR-3171	CLIP-seq
MIRT1493073	hsa-miR-3176	CLIP-seq
MIRT1493024	hsa-miR-3183	CLIP-seq
MIRT1493074	hsa-miR-3186-5p	CLIP-seq
MIRT1493075	hsa-miR-331-3p	CLIP-seq
MIRT1493076	hsa-miR-3607-3p	CLIP-seq
MIRT1493077	hsa-miR-3614-3p	CLIP-seq
MIRT1493035	hsa-miR-3616-5p	CLIP-seq
MIRT1493078	hsa-miR-3647-3p	CLIP-seq
MIRT1493036	hsa-miR-3647-5p	CLIP-seq
MIRT1493079	hsa-miR-365	CLIP-seq
MIRT1493080	hsa-miR-3662	CLIP-seq
MIRT1493081	hsa-miR-3667-3p	CLIP-seq
MIRT1493082	hsa-miR-3673	CLIP-seq
MIRT1493083	hsa-miR-3678-3p	CLIP-seq
MIRT1493084	hsa-miR-3686	CLIP-seq
MIRT1493085	hsa-miR-376a	CLIP-seq
MIRT1493086	hsa-miR-376b	CLIP-seq
MIRT1493087	hsa-miR-3912	CLIP-seq
MIRT1493088	hsa-miR-3922-3p	CLIP-seq
MIRT1493089	hsa-miR-3924	CLIP-seq
MIRT1493090	hsa-miR-3973	CLIP-seq
MIRT1493091	hsa-miR-424	CLIP-seq
MIRT1493092	hsa-miR-4252	CLIP-seq
MIRT1493093	hsa-miR-4292	CLIP-seq
MIRT1493094	hsa-miR-4297	CLIP-seq
MIRT1493095	hsa-miR-4304	CLIP-seq
MIRT1493096	hsa-miR-4418	CLIP-seq
MIRT1493097	hsa-miR-4456	CLIP-seq
MIRT1493098	hsa-miR-4458	CLIP-seq
MIRT1493099	hsa-miR-4500	CLIP-seq
MIRT1493100	hsa-miR-4517	CLIP-seq
MIRT1493101	hsa-miR-4524	CLIP-seq
MIRT1493102	hsa-miR-4649-3p	CLIP-seq
MIRT1493103	hsa-miR-4653-3p	CLIP-seq
MIRT1493104	hsa-miR-4722-3p	CLIP-seq
MIRT1493025	hsa-miR-4723-3p	CLIP-seq
MIRT1493026	hsa-miR-4727-5p	CLIP-seq
MIRT1493027	hsa-miR-4769-3p	CLIP-seq
MIRT1493105	hsa-miR-4778-5p	CLIP-seq
MIRT1493106	hsa-miR-4795-5p	CLIP-seq
MIRT1493107	hsa-miR-4802-5p	CLIP-seq
MIRT1493108	hsa-miR-495	CLIP-seq
MIRT1493109	hsa-miR-497	CLIP-seq
MIRT1493110	hsa-miR-503	CLIP-seq
MIRT1493111	hsa-miR-509-3-5p	CLIP-seq
MIRT1493112	hsa-miR-509-5p	CLIP-seq
MIRT1493113	hsa-miR-510	CLIP-seq
MIRT1493114	hsa-miR-520g	CLIP-seq
MIRT1493115	hsa-miR-520h	CLIP-seq
MIRT1493116	hsa-miR-521	CLIP-seq
MIRT1493117	hsa-miR-541	CLIP-seq
MIRT1493118	hsa-miR-548ac	CLIP-seq
MIRT1493119	hsa-miR-548d-3p	CLIP-seq
MIRT1493120	hsa-miR-548z	CLIP-seq
MIRT1493041	hsa-miR-573	CLIP-seq
MIRT1493121	hsa-miR-613	CLIP-seq
MIRT1493122	hsa-miR-654-5p	CLIP-seq
MIRT1493123	hsa-miR-657	CLIP-seq
MIRT1493124	hsa-miR-668	CLIP-seq
MIRT1493125	hsa-miR-933	CLIP-seq
MIRT1493126	hsa-miR-98	CLIP-seq
MIRT1493053	hsa-miR-1	CLIP-seq
MIRT2148666	hsa-miR-1233	CLIP-seq
MIRT1493055	hsa-miR-1238	CLIP-seq
MIRT1493056	hsa-miR-1252	CLIP-seq
MIRT2148667	hsa-miR-140-3p	CLIP-seq
MIRT2148668	hsa-miR-142-5p	CLIP-seq
MIRT1493057	hsa-miR-151-3p	CLIP-seq
MIRT2148669	hsa-miR-151-5p	CLIP-seq
MIRT2148670	hsa-miR-151b	CLIP-seq
MIRT1493059	hsa-miR-15a	CLIP-seq
MIRT1493060	hsa-miR-15b	CLIP-seq
MIRT1493061	hsa-miR-16	CLIP-seq
MIRT1493064	hsa-miR-195	CLIP-seq
MIRT2148671	hsa-miR-197	CLIP-seq
MIRT1493067	hsa-miR-206	CLIP-seq
MIRT2148672	hsa-miR-3121-5p	CLIP-seq
MIRT2148673	hsa-miR-3124-3p	CLIP-seq
MIRT2148674	hsa-miR-3127-5p	CLIP-seq
MIRT1493072	hsa-miR-3171	CLIP-seq
MIRT1493024	hsa-miR-3183	CLIP-seq
MIRT2148675	hsa-miR-337-3p	CLIP-seq
MIRT1493035	hsa-miR-3616-5p	CLIP-seq
MIRT1493078	hsa-miR-3647-3p	CLIP-seq
MIRT1493036	hsa-miR-3647-5p	CLIP-seq
MIRT1493080	hsa-miR-3662	CLIP-seq
MIRT1493082	hsa-miR-3673	CLIP-seq
MIRT2148676	hsa-miR-3685	CLIP-seq
MIRT1493085	hsa-miR-376a	CLIP-seq
MIRT1493086	hsa-miR-376b	CLIP-seq
MIRT2148677	hsa-miR-383	CLIP-seq
MIRT2148678	hsa-miR-384	CLIP-seq
MIRT1493090	hsa-miR-3973	CLIP-seq
MIRT2148679	hsa-miR-3978	CLIP-seq
MIRT1493091	hsa-miR-424	CLIP-seq
MIRT1493092	hsa-miR-4252	CLIP-seq
MIRT2148680	hsa-miR-4315	CLIP-seq
MIRT2148681	hsa-miR-4436a	CLIP-seq
MIRT2148682	hsa-miR-4505	CLIP-seq
MIRT2148683	hsa-miR-450a	CLIP-seq
MIRT1493101	hsa-miR-4524	CLIP-seq
MIRT2148684	hsa-miR-4645-5p	CLIP-seq
MIRT1493102	hsa-miR-4649-3p	CLIP-seq
MIRT1493103	hsa-miR-4653-3p	CLIP-seq
MIRT2148685	hsa-miR-4673	CLIP-seq
MIRT2148686	hsa-miR-4687-5p	CLIP-seq
MIRT1493025	hsa-miR-4723-3p	CLIP-seq
MIRT1493026	hsa-miR-4727-5p	CLIP-seq
MIRT2148687	hsa-miR-4738-5p	CLIP-seq
MIRT2148688	hsa-miR-4742-5p	CLIP-seq
MIRT1493027	hsa-miR-4769-3p	CLIP-seq
MIRT2148689	hsa-miR-4790-5p	CLIP-seq
MIRT1493106	hsa-miR-4795-5p	CLIP-seq
MIRT1493107	hsa-miR-4802-5p	CLIP-seq
MIRT1493109	hsa-miR-497	CLIP-seq
MIRT1493110	hsa-miR-503	CLIP-seq
MIRT1493113	hsa-miR-510	CLIP-seq
MIRT2148690	hsa-miR-513a-5p	CLIP-seq
MIRT2148691	hsa-miR-518a-5p	CLIP-seq
MIRT1493114	hsa-miR-520g	CLIP-seq
MIRT1493115	hsa-miR-520h	CLIP-seq
MIRT2148692	hsa-miR-527	CLIP-seq
MIRT1493041	hsa-miR-573	CLIP-seq
MIRT1493028	hsa-miR-593	CLIP-seq
MIRT1493121	hsa-miR-613	CLIP-seq
MIRT1493043	hsa-miR-626	CLIP-seq
MIRT2148693	hsa-miR-642a	CLIP-seq
MIRT2148694	hsa-miR-659	CLIP-seq
MIRT2148695	hsa-miR-665	CLIP-seq
MIRT1493124	hsa-miR-668	CLIP-seq
MIRT2148696	hsa-miR-766	CLIP-seq
MIRT2148697	hsa-miR-875-3p	CLIP-seq
MIRT1493053	hsa-miR-1	CLIP-seq
MIRT2369049	hsa-miR-1206	CLIP-seq
MIRT1493054	hsa-miR-1228	CLIP-seq
MIRT2148666	hsa-miR-1233	CLIP-seq
MIRT1493055	hsa-miR-1238	CLIP-seq
MIRT1493056	hsa-miR-1252	CLIP-seq
MIRT2369050	hsa-miR-1271	CLIP-seq
MIRT2369051	hsa-miR-1297	CLIP-seq
MIRT2369052	hsa-miR-1298	CLIP-seq
MIRT1493057	hsa-miR-151-3p	CLIP-seq
MIRT2148669	hsa-miR-151-5p	CLIP-seq
MIRT2148670	hsa-miR-151b	CLIP-seq
MIRT1493059	hsa-miR-15a	CLIP-seq
MIRT1493060	hsa-miR-15b	CLIP-seq
MIRT1493061	hsa-miR-16	CLIP-seq
MIRT1493062	hsa-miR-193a-3p	CLIP-seq
MIRT1493063	hsa-miR-193b	CLIP-seq
MIRT1493064	hsa-miR-195	CLIP-seq
MIRT2148671	hsa-miR-197	CLIP-seq
MIRT2369053	hsa-miR-199a-5p	CLIP-seq
MIRT2369054	hsa-miR-199b-5p	CLIP-seq
MIRT1493065	hsa-miR-202	CLIP-seq
MIRT1493066	hsa-miR-2052	CLIP-seq
MIRT1493067	hsa-miR-206	CLIP-seq
MIRT2369055	hsa-miR-2117	CLIP-seq
MIRT1493068	hsa-miR-2467-3p	CLIP-seq
MIRT2369056	hsa-miR-26a	CLIP-seq
MIRT2369057	hsa-miR-26b	CLIP-seq
MIRT1493069	hsa-miR-2861	CLIP-seq
MIRT1493070	hsa-miR-298	CLIP-seq
MIRT2369058	hsa-miR-300	CLIP-seq
MIRT1493071	hsa-miR-3158-5p	CLIP-seq
MIRT1493072	hsa-miR-3171	CLIP-seq
MIRT1493073	hsa-miR-3176	CLIP-seq
MIRT1493024	hsa-miR-3183	CLIP-seq
MIRT1493075	hsa-miR-331-3p	CLIP-seq
MIRT1493035	hsa-miR-3616-5p	CLIP-seq
MIRT1493078	hsa-miR-3647-3p	CLIP-seq
MIRT1493036	hsa-miR-3647-5p	CLIP-seq
MIRT2369059	hsa-miR-3652	CLIP-seq
MIRT1493080	hsa-miR-3662	CLIP-seq
MIRT2369060	hsa-miR-3665	CLIP-seq
MIRT1493082	hsa-miR-3673	CLIP-seq
MIRT1493083	hsa-miR-3678-3p	CLIP-seq
MIRT2369061	hsa-miR-3689a-3p	CLIP-seq
MIRT2369062	hsa-miR-3689c	CLIP-seq
MIRT1493085	hsa-miR-376a	CLIP-seq
MIRT1493086	hsa-miR-376b	CLIP-seq
MIRT2369063	hsa-miR-381	CLIP-seq
MIRT2148677	hsa-miR-383	CLIP-seq
MIRT1493088	hsa-miR-3922-3p	CLIP-seq
MIRT1493090	hsa-miR-3973	CLIP-seq
MIRT2148679	hsa-miR-3978	CLIP-seq
MIRT2369064	hsa-miR-412	CLIP-seq
MIRT1493091	hsa-miR-424	CLIP-seq
MIRT1493092	hsa-miR-4252	CLIP-seq
MIRT2369065	hsa-miR-4255	CLIP-seq
MIRT2369066	hsa-miR-4257	CLIP-seq
MIRT2369067	hsa-miR-4273	CLIP-seq
MIRT1493093	hsa-miR-4292	CLIP-seq
MIRT1493096	hsa-miR-4418	CLIP-seq
MIRT2369068	hsa-miR-4430	CLIP-seq
MIRT1493097	hsa-miR-4456	CLIP-seq
MIRT2369069	hsa-miR-4465	CLIP-seq
MIRT2148682	hsa-miR-4505	CLIP-seq
MIRT2148683	hsa-miR-450a	CLIP-seq
MIRT1493101	hsa-miR-4524	CLIP-seq
MIRT2148684	hsa-miR-4645-5p	CLIP-seq
MIRT1493102	hsa-miR-4649-3p	CLIP-seq
MIRT1493103	hsa-miR-4653-3p	CLIP-seq
MIRT2369070	hsa-miR-4666-3p	CLIP-seq
MIRT2369071	hsa-miR-4668-5p	CLIP-seq
MIRT2148685	hsa-miR-4673	CLIP-seq
MIRT2369072	hsa-miR-4707-5p	CLIP-seq
MIRT1493025	hsa-miR-4723-3p	CLIP-seq
MIRT1493026	hsa-miR-4727-5p	CLIP-seq
MIRT2369073	hsa-miR-4728-3p	CLIP-seq
MIRT2369074	hsa-miR-4728-5p	CLIP-seq
MIRT2369075	hsa-miR-4729	CLIP-seq
MIRT2369076	hsa-miR-4733-5p	CLIP-seq
MIRT2369077	hsa-miR-4736	CLIP-seq
MIRT2148687	hsa-miR-4738-5p	CLIP-seq
MIRT2148688	hsa-miR-4742-5p	CLIP-seq
MIRT2369078	hsa-miR-4767	CLIP-seq
MIRT1493027	hsa-miR-4769-3p	CLIP-seq
MIRT2369079	hsa-miR-4773	CLIP-seq
MIRT2369080	hsa-miR-4775	CLIP-seq
MIRT2369081	hsa-miR-4785	CLIP-seq
MIRT2369082	hsa-miR-4789-5p	CLIP-seq
MIRT1493106	hsa-miR-4795-5p	CLIP-seq
MIRT2369083	hsa-miR-4796-3p	CLIP-seq
MIRT1493107	hsa-miR-4802-5p	CLIP-seq
MIRT1493109	hsa-miR-497	CLIP-seq
MIRT2369084	hsa-miR-498	CLIP-seq
MIRT1493110	hsa-miR-503	CLIP-seq
MIRT2369085	hsa-miR-508-5p	CLIP-seq
MIRT1493111	hsa-miR-509-3-5p	CLIP-seq
MIRT1493112	hsa-miR-509-5p	CLIP-seq
MIRT1493113	hsa-miR-510	CLIP-seq
MIRT2148690	hsa-miR-513a-5p	CLIP-seq
MIRT2148691	hsa-miR-518a-5p	CLIP-seq
MIRT1493114	hsa-miR-520g	CLIP-seq
MIRT1493115	hsa-miR-520h	CLIP-seq
MIRT1493116	hsa-miR-521	CLIP-seq
MIRT2148692	hsa-miR-527	CLIP-seq
MIRT1493117	hsa-miR-541	CLIP-seq
MIRT2369086	hsa-miR-545	CLIP-seq
MIRT1493118	hsa-miR-548ac	CLIP-seq
MIRT1493119	hsa-miR-548d-3p	CLIP-seq
MIRT1493120	hsa-miR-548z	CLIP-seq
MIRT2369087	hsa-miR-564	CLIP-seq
MIRT2369088	hsa-miR-570	CLIP-seq
MIRT1493041	hsa-miR-573	CLIP-seq
MIRT2369089	hsa-miR-579	CLIP-seq
MIRT2369090	hsa-miR-590-3p	CLIP-seq
MIRT2369091	hsa-miR-604	CLIP-seq
MIRT1493121	hsa-miR-613	CLIP-seq
MIRT2369092	hsa-miR-647	CLIP-seq
MIRT1493122	hsa-miR-654-5p	CLIP-seq
MIRT1493123	hsa-miR-657	CLIP-seq
MIRT1493124	hsa-miR-668	CLIP-seq
MIRT2369093	hsa-miR-671-5p	CLIP-seq
MIRT2148696	hsa-miR-766	CLIP-seq
MIRT2369094	hsa-miR-767-3p	CLIP-seq
MIRT2148697	hsa-miR-875-3p	CLIP-seq
MIRT1493125	hsa-miR-933	CLIP-seq
MIRT2369095	hsa-miR-944	CLIP-seq
MIRT2369096	hsa-miR-96	CLIP-seq
MIRT1493059	hsa-miR-15a	CLIP-seq
MIRT1493060	hsa-miR-15b	CLIP-seq
MIRT1493061	hsa-miR-16	CLIP-seq
MIRT1493064	hsa-miR-195	CLIP-seq
MIRT1493085	hsa-miR-376a	CLIP-seq
MIRT1493086	hsa-miR-376b	CLIP-seq
MIRT1493090	hsa-miR-3973	CLIP-seq
MIRT1493091	hsa-miR-424	CLIP-seq
MIRT1493101	hsa-miR-4524	CLIP-seq
MIRT1493109	hsa-miR-497	CLIP-seq
MIRT1493110	hsa-miR-503	CLIP-seq
MIRT1493114	hsa-miR-520g	CLIP-seq
MIRT1493115	hsa-miR-520h	CLIP-seq
MIRT2148669	hsa-miR-151-5p	CLIP-seq
MIRT2148670	hsa-miR-151b	CLIP-seq
MIRT2148691	hsa-miR-518a-5p	CLIP-seq
MIRT2148692	hsa-miR-527	CLIP-seq
MIRT2369049	hsa-miR-1206	CLIP-seq
MIRT2369050	hsa-miR-1271	CLIP-seq
MIRT2662503	hsa-miR-133a	CLIP-seq
MIRT2662504	hsa-miR-133b	CLIP-seq
MIRT2662505	hsa-miR-141	CLIP-seq
MIRT2148669	hsa-miR-151-5p	CLIP-seq
MIRT2148670	hsa-miR-151b	CLIP-seq
MIRT2662506	hsa-miR-182	CLIP-seq
MIRT1493062	hsa-miR-193a-3p	CLIP-seq
MIRT1493063	hsa-miR-193b	CLIP-seq
MIRT2148671	hsa-miR-197	CLIP-seq
MIRT2662507	hsa-miR-200a	CLIP-seq
MIRT1493070	hsa-miR-298	CLIP-seq
MIRT1493071	hsa-miR-3158-5p	CLIP-seq
MIRT1493073	hsa-miR-3176	CLIP-seq
MIRT2369059	hsa-miR-3652	CLIP-seq
MIRT2369060	hsa-miR-3665	CLIP-seq
MIRT1493088	hsa-miR-3922-3p	CLIP-seq
MIRT1493089	hsa-miR-3924	CLIP-seq
MIRT2148679	hsa-miR-3978	CLIP-seq
MIRT2369064	hsa-miR-412	CLIP-seq
MIRT2662508	hsa-miR-4281	CLIP-seq
MIRT2662509	hsa-miR-4282	CLIP-seq
MIRT1493095	hsa-miR-4304	CLIP-seq
MIRT2662510	hsa-miR-4311	CLIP-seq
MIRT1493096	hsa-miR-4418	CLIP-seq
MIRT2369068	hsa-miR-4430	CLIP-seq
MIRT2662511	hsa-miR-4470	CLIP-seq
MIRT2148682	hsa-miR-4505	CLIP-seq
MIRT2148683	hsa-miR-450a	CLIP-seq
MIRT2369073	hsa-miR-4728-3p	CLIP-seq
MIRT2369077	hsa-miR-4736	CLIP-seq
MIRT2662512	hsa-miR-4760-3p	CLIP-seq
MIRT2369078	hsa-miR-4767	CLIP-seq
MIRT2369080	hsa-miR-4775	CLIP-seq
MIRT2369083	hsa-miR-4796-3p	CLIP-seq
MIRT2662513	hsa-miR-486-3p	CLIP-seq
MIRT1493108	hsa-miR-495	CLIP-seq
MIRT1493111	hsa-miR-509-3-5p	CLIP-seq
MIRT1493112	hsa-miR-509-5p	CLIP-seq
MIRT2662514	hsa-miR-5096	CLIP-seq
MIRT2148691	hsa-miR-518a-5p	CLIP-seq
MIRT1493116	hsa-miR-521	CLIP-seq
MIRT2148692	hsa-miR-527	CLIP-seq
MIRT1493118	hsa-miR-548ac	CLIP-seq
MIRT1493119	hsa-miR-548d-3p	CLIP-seq
MIRT1493120	hsa-miR-548z	CLIP-seq
MIRT2369087	hsa-miR-564	CLIP-seq
MIRT2369088	hsa-miR-570	CLIP-seq
MIRT2369090	hsa-miR-590-3p	CLIP-seq
MIRT1493124	hsa-miR-668	CLIP-seq
MIRT2662515	hsa-miR-873	CLIP-seq
MIRT2148697	hsa-miR-875-3p	CLIP-seq
MIRT1493125	hsa-miR-933	CLIP-seq
MIRT2369096	hsa-miR-96	CLIP-seq
MIRT2369049	hsa-miR-1206	CLIP-seq
MIRT2369050	hsa-miR-1271	CLIP-seq
MIRT2662503	hsa-miR-133a	CLIP-seq
MIRT2662504	hsa-miR-133b	CLIP-seq
MIRT2662505	hsa-miR-141	CLIP-seq
MIRT2148669	hsa-miR-151-5p	CLIP-seq
MIRT2148670	hsa-miR-151b	CLIP-seq
MIRT2662506	hsa-miR-182	CLIP-seq
MIRT1493062	hsa-miR-193a-3p	CLIP-seq
MIRT1493063	hsa-miR-193b	CLIP-seq
MIRT2148671	hsa-miR-197	CLIP-seq
MIRT2662507	hsa-miR-200a	CLIP-seq
MIRT1493070	hsa-miR-298	CLIP-seq
MIRT1493071	hsa-miR-3158-5p	CLIP-seq
MIRT1493073	hsa-miR-3176	CLIP-seq
MIRT2369059	hsa-miR-3652	CLIP-seq
MIRT2369060	hsa-miR-3665	CLIP-seq
MIRT1493088	hsa-miR-3922-3p	CLIP-seq
MIRT1493089	hsa-miR-3924	CLIP-seq
MIRT2148679	hsa-miR-3978	CLIP-seq
MIRT2369064	hsa-miR-412	CLIP-seq
MIRT2695241	hsa-miR-4267	CLIP-seq
MIRT2695242	hsa-miR-4277	CLIP-seq
MIRT2662508	hsa-miR-4281	CLIP-seq
MIRT2662509	hsa-miR-4282	CLIP-seq
MIRT1493095	hsa-miR-4304	CLIP-seq
MIRT2662510	hsa-miR-4311	CLIP-seq
MIRT1493096	hsa-miR-4418	CLIP-seq
MIRT2369068	hsa-miR-4430	CLIP-seq
MIRT2662511	hsa-miR-4470	CLIP-seq
MIRT2148682	hsa-miR-4505	CLIP-seq
MIRT2148683	hsa-miR-450a	CLIP-seq
MIRT2369073	hsa-miR-4728-3p	CLIP-seq
MIRT2369077	hsa-miR-4736	CLIP-seq
MIRT2662512	hsa-miR-4760-3p	CLIP-seq
MIRT2369078	hsa-miR-4767	CLIP-seq
MIRT2369080	hsa-miR-4775	CLIP-seq
MIRT2369083	hsa-miR-4796-3p	CLIP-seq
MIRT2662513	hsa-miR-486-3p	CLIP-seq
MIRT1493108	hsa-miR-495	CLIP-seq
MIRT2369085	hsa-miR-508-5p	CLIP-seq
MIRT1493111	hsa-miR-509-3-5p	CLIP-seq
MIRT1493112	hsa-miR-509-5p	CLIP-seq
MIRT2662514	hsa-miR-5096	CLIP-seq
MIRT2148691	hsa-miR-518a-5p	CLIP-seq
MIRT1493116	hsa-miR-521	CLIP-seq
MIRT2148692	hsa-miR-527	CLIP-seq
MIRT1493118	hsa-miR-548ac	CLIP-seq
MIRT1493119	hsa-miR-548d-3p	CLIP-seq
MIRT1493120	hsa-miR-548z	CLIP-seq
MIRT2369087	hsa-miR-564	CLIP-seq
MIRT2369088	hsa-miR-570	CLIP-seq
MIRT2369090	hsa-miR-590-3p	CLIP-seq
MIRT1493124	hsa-miR-668	CLIP-seq
MIRT2662515	hsa-miR-873	CLIP-seq
MIRT2148697	hsa-miR-875-3p	CLIP-seq
MIRT1493125	hsa-miR-933	CLIP-seq
MIRT2369096	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000045	Process	Autophagosome assembly	IDA	28890335
GO:0000045	Process	Autophagosome assembly	IMP	20505359, 28561066
GO:0000407	Component	Phagophore assembly site	IDA	22456507, 28561066, 33499712
GO:0000407	Component	Phagophore assembly site	IEA
GO:0000422	Process	Autophagy of mitochondrion	IBA
GO:0000425	Process	Pexophagy	IBA
GO:0005515	Function	Protein binding	IPI	21044950, 21575909, 25416956, 28561066, 28890335, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005776	Component	Autophagosome	IDA	20505359
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	20505359
GO:0005829	Component	Cytosol	TAS
GO:0006914	Process	Autophagy	IEA
GO:0006950	Process	Response to stress	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0009267	Process	Cellular response to starvation	IDA	28561066
GO:0010314	Function	Phosphatidylinositol-5-phosphate binding	IDA	25578879
GO:0016020	Component	Membrane	IDA	25578879
GO:0016020	Component	Membrane	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IBA
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IDA	20505359, 25578879, 28561066
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IEA
GO:0032991	Component	Protein-containing complex	IDA
GO:0034045	Component	Phagophore assembly site membrane	IBA
GO:0034045	Component	Phagophore assembly site membrane	IDA	20505359
GO:0034045	Component	Phagophore assembly site membrane	IEA
GO:0034497	Process	Protein localization to phagophore assembly site	IBA
GO:0034497	Process	Protein localization to phagophore assembly site	IEA
GO:0034497	Process	Protein localization to phagophore assembly site	IMP	28561066
GO:0044804	Process	Nucleophagy	IBA
GO:0061723	Process	Glycophagy	IBA
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IBA
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IDA	20505359, 28561066
GO:0097352	Process	Autophagosome maturation	IMP	20505359

Other IDs

• MIM: 609225
• HGNC: 32225
• e!Ensembl: ENSG00000157954

Protein

• UniProt ID: Q9Y4P8
• Protein name: WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2)
• Protein function: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involve
• PDB: 7F69, 7MU2, 7XFR
• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. {ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20505359}.
• Sequence:

  MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS
  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL
  AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT
  IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE
  FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM
  ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD
  PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT
  DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD

• Sequence length: 454

Pathways

KEGG:

Autophagy - other
Autophagy - animal
Alzheimer disease
Amyotrophic lateral sclerosis
Huntington disease
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
Shigellosis

Reactome:

Macroautophagy

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Intellectual developmental disorder with short stature and variable skeletal anomalies	Pathogenic	rs2115280647, rs756429763	RCV001774826 RCV000782105	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Familial cancer of breast	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WIPI2-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	24991767		★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	37639066	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	24991767	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32323845	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral atrophy	Cerebral Atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebral Palsy	Cerebral palsy	BEFREE	25666757		★☆☆☆☆ Found in Text Mining only
Clinodactyly of the 5th finger	Camptodactyly of fingers	HPO_DG			★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32468035, 33357130	Associate	★☆☆☆☆ Found in Text Mining only
Congenital Camptodactyly	Congenital Camptodactyly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	30968111	Associate	★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dysarthria	Dysarthria	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dyskinetic syndrome	Dyskinetic Syndrome	HPO_DG			★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	30968111	Associate	★☆☆☆☆ Found in Text Mining only
Hypoplasia of thumb	Hypoplasia Of Thumb	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	24991767	Inhibit	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	24991767		★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	11167802		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	35199935	Associate	★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	28381171	Associate	★☆☆☆☆ Found in Text Mining only