Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26086
Gene name	G protein signaling modulator 1
Gene symbol	GPSM1
Synonyms (NCBI Gene)	AGS3
Chromosome	9
Chromosome location	9q34.3
Summary	G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal act

Show/Hide all (53)

miRTarBase ID	miRNA	Experiments	Reference
MIRT039937	hsa-miR-615-3p	CLASH	23622248
MIRT1032372	hsa-miR-1266	CLIP-seq
MIRT1032373	hsa-miR-1307	CLIP-seq
MIRT1032374	hsa-miR-1908	CLIP-seq
MIRT1032375	hsa-miR-3127-5p	CLIP-seq
MIRT1032376	hsa-miR-3918	CLIP-seq
MIRT1032377	hsa-miR-4446-3p	CLIP-seq
MIRT1032378	hsa-miR-4518	CLIP-seq
MIRT1032379	hsa-miR-663	CLIP-seq
MIRT1032380	hsa-miR-3940-5p	CLIP-seq
MIRT1032381	hsa-miR-3978	CLIP-seq
MIRT1032382	hsa-miR-4507	CLIP-seq
MIRT1032383	hsa-miR-635	CLIP-seq
MIRT1032384	hsa-miR-711	CLIP-seq
MIRT1032385	hsa-miR-1275	CLIP-seq
MIRT1032386	hsa-miR-3122	CLIP-seq
MIRT1032387	hsa-miR-3130-3p	CLIP-seq
MIRT1032388	hsa-miR-3689a-3p	CLIP-seq
MIRT1032389	hsa-miR-3689c	CLIP-seq
MIRT1032390	hsa-miR-3913-5p	CLIP-seq
MIRT1032391	hsa-miR-4290	CLIP-seq
MIRT1032392	hsa-miR-4447	CLIP-seq
MIRT1032393	hsa-miR-4472	CLIP-seq
MIRT1032394	hsa-miR-4481	CLIP-seq
MIRT1032395	hsa-miR-4525	CLIP-seq
MIRT1032396	hsa-miR-4643	CLIP-seq
MIRT1032397	hsa-miR-4665-5p	CLIP-seq
MIRT1032398	hsa-miR-4687-5p	CLIP-seq
MIRT1032399	hsa-miR-4717-3p	CLIP-seq
MIRT1032400	hsa-miR-4721	CLIP-seq
MIRT1032401	hsa-miR-4723-5p	CLIP-seq
MIRT1032402	hsa-miR-4745-5p	CLIP-seq
MIRT1032403	hsa-miR-625	CLIP-seq
MIRT1032404	hsa-miR-642b	CLIP-seq
MIRT2006259	hsa-miR-214	CLIP-seq
MIRT2006260	hsa-miR-3619-5p	CLIP-seq
MIRT2006261	hsa-miR-761	CLIP-seq
MIRT2388688	hsa-miR-1291	CLIP-seq
MIRT2542618	hsa-miR-1297	CLIP-seq
MIRT2542619	hsa-miR-181a	CLIP-seq
MIRT2542620	hsa-miR-181b	CLIP-seq
MIRT2542621	hsa-miR-181c	CLIP-seq
MIRT2542622	hsa-miR-181d	CLIP-seq
MIRT2542623	hsa-miR-26a	CLIP-seq
MIRT2542624	hsa-miR-26b	CLIP-seq
MIRT2542625	hsa-miR-3942-5p	CLIP-seq
MIRT2542626	hsa-miR-4262	CLIP-seq
MIRT2542627	hsa-miR-4465	CLIP-seq
MIRT2542628	hsa-miR-4703-5p	CLIP-seq
MIRT2542629	hsa-miR-4706	CLIP-seq
MIRT2542630	hsa-miR-4749-5p	CLIP-seq
MIRT2542631	hsa-miR-521	CLIP-seq
MIRT2542632	hsa-miR-744	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000132	Process	Establishment of mitotic spindle orientation	IBA
GO:0000139	Component	Golgi membrane	IDA	12642577
GO:0000139	Component	Golgi membrane	IEA
GO:0001965	Function	G-protein alpha-subunit binding	IBA
GO:0005092	Function	GDP-dissociation inhibitor activity	IBA
GO:0005092	Function	GDP-dissociation inhibitor activity	IDA	11024022
GO:0005515	Function	Protein binding	IPI	16458856, 18566450, 22074847, 25416956, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	12642577
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IDA	18566450
GO:0005886	Component	Plasma membrane	IEA
GO:0005938	Component	Cell cortex	IDA	18566450
GO:0007399	Process	Nervous system development	IEA
GO:0016020	Component	Membrane	IEA
GO:0016239	Process	Positive regulation of macroautophagy	IDA	12642577
GO:0030154	Process	Cell differentiation	IEA
GO:0030695	Function	GTPase regulator activity	IEA
GO:0032991	Component	Protein-containing complex	IDA	16458856, 22074847
GO:0034260	Process	Negative regulation of GTPase activity	IDA	11024022
GO:1905098	Process	Negative regulation of guanyl-nucleotide exchange factor activity	IDA	11024022

MIM	HGNC	e!Ensembl
609491	17858	ENSG00000160360

Q86YR5

Protein name

G-protein-signaling modulator 1 (Activator of G-protein signaling 3)

Protein function

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13424	TPR_12	104 → 163		Repeat
PF13424	TPR_12	187 → 241		Repeat
PF13424	TPR_12	208 → 281		Repeat
PF13424	TPR_12	247 → 321		Repeat
PF13424	TPR_12	285 → 361		Repeat
PF02188	GoLoco	496 → 517	GoLoco motif	Motif
PF02188	GoLoco	549 → 569	GoLoco motif	Motif
PF02188	GoLoco	597 → 618	GoLoco motif	Motif
PF02188	GoLoco	631 → 652	GoLoco motif	Motif

Tissue specificity

TISSUE SPECIFICITY: Expressed in intestinal cells. {ECO:0000269|PubMed:12642577}.

Sequence

MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE
DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG
RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD
VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK
EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT
LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ
EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLL
RLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRV
HVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQP
SMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFF
NMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGA
GGPPEPQQQCQPGAS

Sequence length

675

Interactions

View interactions

	KEGG		Reactome
	Cocaine addiction		G alpha (i) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC EYE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of prostate	Prostate adenocarcinoma	BEFREE	31215992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	GWASCAT_DG	23749187		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	12642577, 25774687	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic kidney	Cystic Kidney Disease	BEFREE	20488951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic Kidney Diseases	Cystic Kidney Disease	BEFREE	20488951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	29947923	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASDB_DG	23945395		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	23945395, 26818947, 28869590, 29632382, 30595370, 30718926, 31118516		★★★★★ ★☆☆☆☆ Found in Text Mining only
Episodic Kinesigenic Dyskinesia 1	Episodic Kinesigenic Dyskinesia	BEFREE	20488951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31215992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	19940363		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	24307516		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19940363, 25812748, 31215992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31215992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	31215992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	25812748		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	36609218	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Carcinoma Anaplastic	Thyroid cancer	Pubtator	36609218	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPSM1 (G protein signaling modulator 1)