Gene Gene information from NCBI Gene database.
Entrez ID 26065
Gene name LSM14A mRNA processing body assembly factor
Gene symbol LSM14A
Synonyms (NCBI Gene)
C19orf13FAM61ARAP55RAP55A
Chromosome 19
Chromosome location 19q13.11
Summary Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length tha
miRNA miRNA information provided by mirtarbase database.
955
miRTarBase ID miRNA Experiments Reference
MIRT050982 hsa-miR-17-5p CLASH 23622248
MIRT050982 hsa-miR-17-5p CLASH 23622248
MIRT050086 hsa-miR-26a-5p CLASH 23622248
MIRT048221 hsa-miR-196a-5p CLASH 23622248
MIRT048221 hsa-miR-196a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0000932 Component P-body IBA
GO:0000932 Component P-body IDA 16484376, 17074753
GO:0000932 Component P-body IEA
GO:0003690 Function Double-stranded DNA binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610677 24489 ENSG00000257103
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8ND56
Protein name Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A)
Protein function Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translat
PDB 6F9W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12701 LSM14 6 80 Scd6-like Sm domain Domain
PF09532 FDF 290 400 FDF domain Domain
Sequence
MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDE
VFEYIIFRGSDIKDLTVCEP
PKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTY
SQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQDTRSLKTQLSQG
RSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAE
VHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFES
ANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPN
CYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPL
RPNRGRGGYRGRGGLGFRGG
RGRGGGRGGTFTAPRGFRGGFRGGRGGREFADFEYRKTTAFGP
Sequence length 463
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANKYLOSING SPONDYLITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PSORIASIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Autoimmune Diseases Autoimmune disease Pubtator 16484376 Associate
★☆☆☆☆
Found in Text Mining only
Liver Cirrhosis Biliary Liver cirrhosis Pubtator 16484376 Associate
★☆☆☆☆
Found in Text Mining only