Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	26054
Gene name	SUMO specific peptidase 6
Gene symbol	SENP6
Synonyms (NCBI Gene)	SSP1SUSP1
Chromosome	6
Chromosome location	6q14.1
Summary	Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradati

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Show/Hide all (149)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051074	hsa-miR-16-5p	CLASH	23622248
MIRT528640	hsa-miR-4729	PAR-CLIP	22012620
MIRT528639	hsa-miR-1284	PAR-CLIP	22012620
MIRT528638	hsa-miR-4796-5p	PAR-CLIP	22012620
MIRT528637	hsa-miR-5701	PAR-CLIP	22012620
MIRT528636	hsa-miR-5696	PAR-CLIP	22012620
MIRT528635	hsa-miR-488-3p	PAR-CLIP	22012620
MIRT528634	hsa-miR-510-3p	PAR-CLIP	22012620
MIRT445876	hsa-miR-640	PAR-CLIP	22100165
MIRT445876	hsa-miR-640	PAR-CLIP	22100165
MIRT528640	hsa-miR-4729	PAR-CLIP	22012620
MIRT528639	hsa-miR-1284	PAR-CLIP	22012620
MIRT528638	hsa-miR-4796-5p	PAR-CLIP	22012620
MIRT528637	hsa-miR-5701	PAR-CLIP	22012620
MIRT528636	hsa-miR-5696	PAR-CLIP	22012620
MIRT528635	hsa-miR-488-3p	PAR-CLIP	22012620
MIRT528634	hsa-miR-510-3p	PAR-CLIP	22012620
MIRT445876	hsa-miR-640	PAR-CLIP	22100165
MIRT445876	hsa-miR-640	PAR-CLIP	22100165
MIRT1335990	hsa-miR-127-5p	CLIP-seq
MIRT1335991	hsa-miR-2052	CLIP-seq
MIRT1335992	hsa-miR-25	CLIP-seq
MIRT1335993	hsa-miR-2909	CLIP-seq
MIRT1335994	hsa-miR-3158-5p	CLIP-seq
MIRT1335995	hsa-miR-3174	CLIP-seq
MIRT1335996	hsa-miR-32	CLIP-seq
MIRT1335997	hsa-miR-3202	CLIP-seq
MIRT1335998	hsa-miR-331-5p	CLIP-seq
MIRT1335999	hsa-miR-34b	CLIP-seq
MIRT1336000	hsa-miR-3591-3p	CLIP-seq
MIRT1336001	hsa-miR-3613-3p	CLIP-seq
MIRT1336002	hsa-miR-363	CLIP-seq
MIRT1336003	hsa-miR-3662	CLIP-seq
MIRT1336004	hsa-miR-3663-3p	CLIP-seq
MIRT1336005	hsa-miR-367	CLIP-seq
MIRT1336006	hsa-miR-374c	CLIP-seq
MIRT1336007	hsa-miR-4277	CLIP-seq
MIRT1336008	hsa-miR-4420	CLIP-seq
MIRT1336009	hsa-miR-4475	CLIP-seq
MIRT1336010	hsa-miR-4503	CLIP-seq
MIRT1336011	hsa-miR-4671-5p	CLIP-seq
MIRT1336012	hsa-miR-4681	CLIP-seq
MIRT1336013	hsa-miR-4684-3p	CLIP-seq
MIRT1336014	hsa-miR-4696	CLIP-seq
MIRT1336015	hsa-miR-4699-3p	CLIP-seq
MIRT1336016	hsa-miR-4699-5p	CLIP-seq
MIRT1336017	hsa-miR-4714-3p	CLIP-seq
MIRT1336018	hsa-miR-4731-3p	CLIP-seq
MIRT1336019	hsa-miR-4747-5p	CLIP-seq
MIRT1336020	hsa-miR-4801	CLIP-seq
MIRT1336021	hsa-miR-490-3p	CLIP-seq
MIRT1336022	hsa-miR-495	CLIP-seq
MIRT1336023	hsa-miR-499a-5p	CLIP-seq
MIRT1336024	hsa-miR-561	CLIP-seq
MIRT1336025	hsa-miR-590-3p	CLIP-seq
MIRT1336026	hsa-miR-655	CLIP-seq
MIRT1336027	hsa-miR-668	CLIP-seq
MIRT1336028	hsa-miR-885-3p	CLIP-seq
MIRT1336029	hsa-miR-921	CLIP-seq
MIRT1336030	hsa-miR-92a	CLIP-seq
MIRT1336031	hsa-miR-92b	CLIP-seq
MIRT2099411	hsa-miR-1207-3p	CLIP-seq
MIRT2099412	hsa-miR-219-2-3p	CLIP-seq
MIRT2099413	hsa-miR-2964a-3p	CLIP-seq
MIRT2099414	hsa-miR-3120-5p	CLIP-seq
MIRT1335995	hsa-miR-3174	CLIP-seq
MIRT1336004	hsa-miR-3663-3p	CLIP-seq
MIRT1336006	hsa-miR-374c	CLIP-seq
MIRT2099415	hsa-miR-3978	CLIP-seq
MIRT1336007	hsa-miR-4277	CLIP-seq
MIRT1336008	hsa-miR-4420	CLIP-seq
MIRT1336015	hsa-miR-4699-3p	CLIP-seq
MIRT1336022	hsa-miR-495	CLIP-seq
MIRT1336023	hsa-miR-499a-5p	CLIP-seq
MIRT2099416	hsa-miR-626	CLIP-seq
MIRT1336026	hsa-miR-655	CLIP-seq
MIRT1336029	hsa-miR-921	CLIP-seq
MIRT2099417	hsa-miR-944	CLIP-seq
MIRT2324096	hsa-miR-1228	CLIP-seq
MIRT2324097	hsa-miR-1275	CLIP-seq
MIRT2324098	hsa-miR-137	CLIP-seq
MIRT1335995	hsa-miR-3174	CLIP-seq
MIRT2324099	hsa-miR-3660	CLIP-seq
MIRT1336004	hsa-miR-3663-3p	CLIP-seq
MIRT2324100	hsa-miR-3915	CLIP-seq
MIRT2324101	hsa-miR-3928	CLIP-seq
MIRT2324102	hsa-miR-3942-3p	CLIP-seq
MIRT2324103	hsa-miR-4256	CLIP-seq
MIRT2324104	hsa-miR-4260	CLIP-seq
MIRT1336007	hsa-miR-4277	CLIP-seq
MIRT1336008	hsa-miR-4420	CLIP-seq
MIRT2324105	hsa-miR-4525	CLIP-seq
MIRT2324106	hsa-miR-4526	CLIP-seq
MIRT2324107	hsa-miR-4665-5p	CLIP-seq
MIRT2324108	hsa-miR-4723-5p	CLIP-seq
MIRT2324109	hsa-miR-4724-3p	CLIP-seq
MIRT2324110	hsa-miR-4789-5p	CLIP-seq
MIRT2324111	hsa-miR-513c	CLIP-seq
MIRT2324112	hsa-miR-514b-5p	CLIP-seq
MIRT2324113	hsa-miR-548a-3p	CLIP-seq
MIRT2324114	hsa-miR-548e	CLIP-seq
MIRT2324115	hsa-miR-548f	CLIP-seq
MIRT2324116	hsa-miR-625	CLIP-seq
MIRT1336029	hsa-miR-921	CLIP-seq
MIRT1335992	hsa-miR-25	CLIP-seq
MIRT2619967	hsa-miR-300	CLIP-seq
MIRT1335995	hsa-miR-3174	CLIP-seq
MIRT1335996	hsa-miR-32	CLIP-seq
MIRT1335999	hsa-miR-34b	CLIP-seq
MIRT1336002	hsa-miR-363	CLIP-seq
MIRT1336004	hsa-miR-3663-3p	CLIP-seq
MIRT1336005	hsa-miR-367	CLIP-seq
MIRT2619968	hsa-miR-381	CLIP-seq
MIRT2324100	hsa-miR-3915	CLIP-seq
MIRT2324101	hsa-miR-3928	CLIP-seq
MIRT1336007	hsa-miR-4277	CLIP-seq
MIRT2619969	hsa-miR-4282	CLIP-seq
MIRT1336008	hsa-miR-4420	CLIP-seq
MIRT2619970	hsa-miR-4666-3p	CLIP-seq
MIRT2619971	hsa-miR-4698	CLIP-seq
MIRT2619972	hsa-miR-4762-3p	CLIP-seq
MIRT2619973	hsa-miR-4766-5p	CLIP-seq
MIRT2324110	hsa-miR-4789-5p	CLIP-seq
MIRT2619974	hsa-miR-488	CLIP-seq
MIRT2619975	hsa-miR-513a-3p	CLIP-seq
MIRT1336027	hsa-miR-668	CLIP-seq
MIRT1336029	hsa-miR-921	CLIP-seq
MIRT1336030	hsa-miR-92a	CLIP-seq
MIRT1336031	hsa-miR-92b	CLIP-seq
MIRT1335992	hsa-miR-25	CLIP-seq
MIRT2619967	hsa-miR-300	CLIP-seq
MIRT1335995	hsa-miR-3174	CLIP-seq
MIRT1335996	hsa-miR-32	CLIP-seq
MIRT1335999	hsa-miR-34b	CLIP-seq
MIRT1336002	hsa-miR-363	CLIP-seq
MIRT1336004	hsa-miR-3663-3p	CLIP-seq
MIRT1336005	hsa-miR-367	CLIP-seq
MIRT2619968	hsa-miR-381	CLIP-seq
MIRT1336007	hsa-miR-4277	CLIP-seq
MIRT2619969	hsa-miR-4282	CLIP-seq
MIRT1336008	hsa-miR-4420	CLIP-seq
MIRT2619970	hsa-miR-4666-3p	CLIP-seq
MIRT2619971	hsa-miR-4698	CLIP-seq
MIRT2324110	hsa-miR-4789-5p	CLIP-seq
MIRT2619975	hsa-miR-513a-3p	CLIP-seq
MIRT1336027	hsa-miR-668	CLIP-seq
MIRT1336029	hsa-miR-921	CLIP-seq
MIRT1336030	hsa-miR-92a	CLIP-seq
MIRT1336031	hsa-miR-92b	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20212317
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016925	Process	Protein sumoylation	IEA
GO:0016926	Process	Protein desumoylation	IBA
GO:0016926	Process	Protein desumoylation	IMP	20212317
GO:0070139	Function	SUMO-specific endopeptidase activity	IBA
GO:0070139	Function	SUMO-specific endopeptidase activity	IMP	20212317
GO:0070646	Process	Protein modification by small protein removal	IDA	20212317
GO:0090169	Process	Regulation of spindle assembly	IBA
GO:0090169	Process	Regulation of spindle assembly	IMP	20212317
GO:0090234	Process	Regulation of kinetochore assembly	IBA
GO:0090234	Process	Regulation of kinetochore assembly	IMP	20212317

MIM	HGNC	e!Ensembl
605003	20944	ENSG00000112701

Q9GZR1

Protein name

Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6)

Protein function

Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to tra

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02902	Peptidase_C48	680 → 845	Ulp1 protease family, C-terminal catalytic domain	Domain
PF02902	Peptidase_C48	940 → 1087	Ulp1 protease family, C-terminal catalytic domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in reproductive organs, such as testis, ovary and prostate.

Sequence

MAAGKSGGSAGEITFLEALARSESKRDGGFKNNWSFDHEEESEGDTDKDGTNLLSVDEDE
DSETSKGKKLNRRSEIVANSSGEFILKTYVRRNKSESFKTLKGNPIGLNMLSNNKKLSEN
TQNTSLCSGTVVHGRRFHHAHAQIPVVKTAAQSSLDRKERKEYPPHVQKVEINPVRLSRL
QGVERIMKKTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQ
AITLNESTGPLLRTSIHQNSGGQKSQNTGLTTKKFYGNNVEKVPIDIIVNCDDSKHTYLQ
TNGKVILPGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSAC
SSPAPSTGKVEAALNENTCRAERELRSIPEDSELNTVTLPRKARMKDQFGNSIINTPLKR
RKVFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHD
PVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKGVNKLT
NLEEQYIILIFQNGLDPPANMVFESIINEIGIKNNISNFFAKIPFEEANGRLVACTRTYE
ESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFDEEEETGENHTIFIGPVEKLIVYPPP
PAKGGISVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQ
RERRNHETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPK
YEPNPHYHENAVIQKCSTVEDSCISSSASEMESCSQNSSAKPVIKKMLNKKHCIAVIDSN
PGQEESDPRYKRNICSVKYSVKKINHTASENEEFNKGESTSQKVADRTKSENGLQNESLS
STHHTDGLSKIRLNYSDESPEAGKMLEDELVDFSEDQDNQDDSSDDGFLADDNCSSEIGQ
WHLKPTICKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKRSFSKDVMKGSNPK
VPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQE
DQSKEKRKHKDTYSTEAPLGEGTEQYVNSISD

Sequence length

1112

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CUTANEOUS LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Delayed speech and language development	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epicanthus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High, narrow palate	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Synophrys	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anaplasia	Anaplasia	BEFREE	16414292		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	32827359	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	32764680	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	23461386		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	27696348		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	29662167		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23721519		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	BEFREE	30743953		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	39251997	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	23671648, 26346884	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteoarthritis of hip	Osteoarthritis Of Hip	BEFREE	26346884		★★★★★ ★☆☆☆☆ Found in Text Mining only
Premature aging syndrome	Premature aging	BEFREE	29321472		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	27696348		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	29662167		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	39251997	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	23825957		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	26164001	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	37355885	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SENP6 (SUMO specific peptidase 6)