Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26037
Gene name	Signal induced proliferation associated 1 like 1
Gene symbol	SIPA1L1
Synonyms (NCBI Gene)	E6TP1SPAR1
Chromosome	14
Chromosome location	14q24.2

Show/Hide all (84)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049597	hsa-miR-92a-3p	CLASH	23622248
MIRT715899	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT715898	hsa-miR-4434	HITS-CLIP	19536157
MIRT715897	hsa-miR-4516	HITS-CLIP	19536157
MIRT715896	hsa-miR-5703	HITS-CLIP	19536157
MIRT715895	hsa-miR-5581-3p	HITS-CLIP	19536157
MIRT715894	hsa-miR-4531	HITS-CLIP	19536157
MIRT726571	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT726570	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT726569	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT726568	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT734963	hsa-miR-204-5p	Luciferase reporter assayWestern blottingImmunofluorescenceqRT-PCRIn situ hybridizationFlow cytometry	33138854
MIRT715899	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT715898	hsa-miR-4434	HITS-CLIP	19536157
MIRT715897	hsa-miR-4516	HITS-CLIP	19536157
MIRT715896	hsa-miR-5703	HITS-CLIP	19536157
MIRT715895	hsa-miR-5581-3p	HITS-CLIP	19536157
MIRT715894	hsa-miR-4531	HITS-CLIP	19536157
MIRT1349692	hsa-miR-1185	CLIP-seq
MIRT1349693	hsa-miR-125a-3p	CLIP-seq
MIRT1349694	hsa-miR-1283	CLIP-seq
MIRT1349695	hsa-miR-18a	CLIP-seq
MIRT1349696	hsa-miR-18b	CLIP-seq
MIRT1349697	hsa-miR-219-5p	CLIP-seq
MIRT1349698	hsa-miR-2276	CLIP-seq
MIRT1349699	hsa-miR-3160-5p	CLIP-seq
MIRT1349700	hsa-miR-3194-3p	CLIP-seq
MIRT1349701	hsa-miR-3605-5p	CLIP-seq
MIRT1349702	hsa-miR-3665	CLIP-seq
MIRT1349703	hsa-miR-3679-5p	CLIP-seq
MIRT1349704	hsa-miR-3682-3p	CLIP-seq
MIRT1349705	hsa-miR-3714	CLIP-seq
MIRT1349706	hsa-miR-3907	CLIP-seq
MIRT1349707	hsa-miR-3921	CLIP-seq
MIRT1349708	hsa-miR-4445	CLIP-seq
MIRT1349709	hsa-miR-4476	CLIP-seq
MIRT1349710	hsa-miR-4649-3p	CLIP-seq
MIRT1349711	hsa-miR-4653-5p	CLIP-seq
MIRT1349712	hsa-miR-4735-3p	CLIP-seq
MIRT1349713	hsa-miR-4736	CLIP-seq
MIRT1349714	hsa-miR-4747-5p	CLIP-seq
MIRT1349715	hsa-miR-4772-3p	CLIP-seq
MIRT1349716	hsa-miR-4782-3p	CLIP-seq
MIRT1349717	hsa-miR-4786-3p	CLIP-seq
MIRT1349718	hsa-miR-486-3p	CLIP-seq
MIRT1349719	hsa-miR-508-3p	CLIP-seq
MIRT1349720	hsa-miR-548an	CLIP-seq
MIRT1349721	hsa-miR-653	CLIP-seq
MIRT1349722	hsa-miR-671-5p	CLIP-seq
MIRT1349723	hsa-miR-891b	CLIP-seq
MIRT1349724	hsa-miR-940	CLIP-seq
MIRT1349692	hsa-miR-1185	CLIP-seq
MIRT1349693	hsa-miR-125a-3p	CLIP-seq
MIRT1349694	hsa-miR-1283	CLIP-seq
MIRT1349695	hsa-miR-18a	CLIP-seq
MIRT1349696	hsa-miR-18b	CLIP-seq
MIRT1349697	hsa-miR-219-5p	CLIP-seq
MIRT1349698	hsa-miR-2276	CLIP-seq
MIRT1349699	hsa-miR-3160-5p	CLIP-seq
MIRT1349700	hsa-miR-3194-3p	CLIP-seq
MIRT1349701	hsa-miR-3605-5p	CLIP-seq
MIRT1349702	hsa-miR-3665	CLIP-seq
MIRT1349703	hsa-miR-3679-5p	CLIP-seq
MIRT1349704	hsa-miR-3682-3p	CLIP-seq
MIRT1349705	hsa-miR-3714	CLIP-seq
MIRT1349706	hsa-miR-3907	CLIP-seq
MIRT1349707	hsa-miR-3921	CLIP-seq
MIRT1349708	hsa-miR-4445	CLIP-seq
MIRT1349709	hsa-miR-4476	CLIP-seq
MIRT1349710	hsa-miR-4649-3p	CLIP-seq
MIRT1349711	hsa-miR-4653-5p	CLIP-seq
MIRT1349712	hsa-miR-4735-3p	CLIP-seq
MIRT1349713	hsa-miR-4736	CLIP-seq
MIRT1349714	hsa-miR-4747-5p	CLIP-seq
MIRT1349715	hsa-miR-4772-3p	CLIP-seq
MIRT1349716	hsa-miR-4782-3p	CLIP-seq
MIRT1349717	hsa-miR-4786-3p	CLIP-seq
MIRT1349718	hsa-miR-486-3p	CLIP-seq
MIRT1349719	hsa-miR-508-3p	CLIP-seq
MIRT1349720	hsa-miR-548an	CLIP-seq
MIRT1349721	hsa-miR-653	CLIP-seq
MIRT1349722	hsa-miR-671-5p	CLIP-seq
MIRT1349723	hsa-miR-891b	CLIP-seq
MIRT1349724	hsa-miR-940	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	15778465, 21653829, 22117215, 36931259
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	ISS
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0043005	Component	Neuron projection	IEA
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0043197	Component	Dendritic spine	ISS
GO:0045202	Component	Synapse	IEA
GO:0046875	Function	Ephrin receptor binding	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	ISS
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0050770	Process	Regulation of axonogenesis	IEA
GO:0050770	Process	Regulation of axonogenesis	ISS
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0061001	Process	Regulation of dendritic spine morphogenesis	ISS
GO:0090630	Process	Activation of GTPase activity	ISS

MIM	HGNC	e!Ensembl
617504	20284	ENSG00000197555

O43166

Protein name

Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)

Protein function

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02145	Rap_GAP	628 → 810	Rap/ran-GAP	Family
PF11881	SPAR_C	1504 → 1749	C-terminal domain of SPAR protein	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9858596}.

Sequence

MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAPVGPPRSE
GSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQGS
SVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDITI
SELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSDRGPTP
TKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLR
NAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTT
TGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNE
IGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRY
IVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFR
TSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLM
KLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQ
LDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGA
QPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVF
RDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASK
KKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCS
CRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNG
LGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTV
KVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQ
VPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMA
LARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKS
TPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRL
MRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQ
GTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETE
SHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSA
RSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFM
DTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKF
HALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYP
SLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWS
NLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASK
VDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNT
IDMS

Sequence length

1804

Interactions

View interactions

	KEGG
	Rap1 signaling pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ARTHRITIS, JUVENILE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST BENIGN NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE, DIASTOLIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OTOSCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PULMONARY EDEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Heart Failure, Diastolic	Heart Failure	CTD_human_DG	29556499		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Juvenile arthritis	Arthritis	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile psoriatic arthritis	Juvenile arthritis	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile-Onset Still Disease	Still Disease	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	9858596	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Negative	Seronegative polyarthritis	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Positive	Polyarthritis, Rheumatoid Factor Positive	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only

SIPA1L1 (signal induced proliferation associated 1 like 1)