Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	26034
Gene name	Interaction protein for cytohesin exchange factors 1
Gene symbol	IPCEF1
Synonyms (NCBI Gene)	PIP3-EPIP3E
Chromosome	6
Chromosome location	6q25.2

238

Show/Hide all (238)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022415	hsa-miR-124-3p	Microarray	18668037
MIRT052329	hsa-let-7b-5p	CLASH	23622248
MIRT047560	hsa-miR-10a-5p	CLASH	23622248
MIRT047416	hsa-miR-10b-5p	CLASH	23622248
MIRT667868	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT667867	hsa-miR-6753-5p	HITS-CLIP	23824327
MIRT667866	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT667865	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT667864	hsa-miR-940	HITS-CLIP	23824327
MIRT667863	hsa-miR-3929	HITS-CLIP	23824327
MIRT667862	hsa-miR-4419b	HITS-CLIP	23824327
MIRT667861	hsa-miR-4478	HITS-CLIP	23824327
MIRT667860	hsa-miR-1321	HITS-CLIP	23824327
MIRT667859	hsa-miR-4739	HITS-CLIP	23824327
MIRT667858	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT667857	hsa-miR-5690	HITS-CLIP	23824327
MIRT667856	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT667855	hsa-miR-4270	HITS-CLIP	23824327
MIRT667854	hsa-miR-4441	HITS-CLIP	23824327
MIRT667853	hsa-miR-6754-5p	HITS-CLIP	23824327
MIRT667852	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT667851	hsa-miR-6746-5p	HITS-CLIP	23824327
MIRT667850	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT667849	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT667848	hsa-miR-1827	HITS-CLIP	23824327
MIRT667847	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT667846	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT667845	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT667844	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT667843	hsa-miR-3612	HITS-CLIP	23824327
MIRT667842	hsa-miR-650	HITS-CLIP	23824327
MIRT667841	hsa-miR-6771-5p	HITS-CLIP	23824327
MIRT667840	hsa-miR-665	HITS-CLIP	23824327
MIRT623612	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT623611	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT623610	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT623609	hsa-miR-8064	HITS-CLIP	23824327
MIRT623608	hsa-miR-664b-5p	HITS-CLIP	23824327
MIRT623607	hsa-miR-623	HITS-CLIP	23824327
MIRT623606	hsa-miR-4674	HITS-CLIP	23824327
MIRT623605	hsa-miR-1587	HITS-CLIP	23824327
MIRT623603	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT623604	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT623602	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT623601	hsa-miR-521	HITS-CLIP	23824327
MIRT667868	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT667867	hsa-miR-6753-5p	HITS-CLIP	23824327
MIRT667866	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT667865	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT667864	hsa-miR-940	HITS-CLIP	23824327
MIRT667863	hsa-miR-3929	HITS-CLIP	23824327
MIRT667862	hsa-miR-4419b	HITS-CLIP	23824327
MIRT667861	hsa-miR-4478	HITS-CLIP	23824327
MIRT667860	hsa-miR-1321	HITS-CLIP	23824327
MIRT667859	hsa-miR-4739	HITS-CLIP	23824327
MIRT667858	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT667857	hsa-miR-5690	HITS-CLIP	23824327
MIRT667856	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT667855	hsa-miR-4270	HITS-CLIP	23824327
MIRT667854	hsa-miR-4441	HITS-CLIP	23824327
MIRT667853	hsa-miR-6754-5p	HITS-CLIP	23824327
MIRT667852	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT667851	hsa-miR-6746-5p	HITS-CLIP	23824327
MIRT667850	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT667849	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT667848	hsa-miR-1827	HITS-CLIP	23824327
MIRT667847	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT667846	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT667845	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT667844	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT667843	hsa-miR-3612	HITS-CLIP	23824327
MIRT667842	hsa-miR-650	HITS-CLIP	23824327
MIRT667841	hsa-miR-6771-5p	HITS-CLIP	23824327
MIRT667840	hsa-miR-665	HITS-CLIP	23824327
MIRT623612	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT623611	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT623610	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT623609	hsa-miR-8064	HITS-CLIP	23824327
MIRT623608	hsa-miR-664b-5p	HITS-CLIP	23824327
MIRT623607	hsa-miR-623	HITS-CLIP	23824327
MIRT623606	hsa-miR-4674	HITS-CLIP	23824327
MIRT623605	hsa-miR-1587	HITS-CLIP	23824327
MIRT623603	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT623604	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT623602	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT623601	hsa-miR-521	HITS-CLIP	23824327
MIRT1068445	hsa-miR-1228	CLIP-seq
MIRT1068446	hsa-miR-1279	CLIP-seq
MIRT1068447	hsa-miR-1281	CLIP-seq
MIRT1068448	hsa-miR-1285	CLIP-seq
MIRT1068449	hsa-miR-150	CLIP-seq
MIRT1068450	hsa-miR-205	CLIP-seq
MIRT1068451	hsa-miR-24	CLIP-seq
MIRT1068452	hsa-miR-2467-3p	CLIP-seq
MIRT1068453	hsa-miR-3120-5p	CLIP-seq
MIRT1068454	hsa-miR-3187-5p	CLIP-seq
MIRT1068455	hsa-miR-3192	CLIP-seq
MIRT1068456	hsa-miR-326	CLIP-seq
MIRT1068457	hsa-miR-330-5p	CLIP-seq
MIRT1068458	hsa-miR-342-3p	CLIP-seq
MIRT1068459	hsa-miR-3613-5p	CLIP-seq
MIRT1068460	hsa-miR-3664-5p	CLIP-seq
MIRT1068461	hsa-miR-3689a-3p	CLIP-seq
MIRT1068462	hsa-miR-3689c	CLIP-seq
MIRT1068463	hsa-miR-3934	CLIP-seq
MIRT1068464	hsa-miR-4261	CLIP-seq
MIRT1068465	hsa-miR-4284	CLIP-seq
MIRT1068466	hsa-miR-4314	CLIP-seq
MIRT1068467	hsa-miR-4421	CLIP-seq
MIRT1068468	hsa-miR-4432	CLIP-seq
MIRT1068469	hsa-miR-4496	CLIP-seq
MIRT1068470	hsa-miR-451b	CLIP-seq
MIRT1068471	hsa-miR-4522	CLIP-seq
MIRT1068472	hsa-miR-4646-5p	CLIP-seq
MIRT1068473	hsa-miR-4665-3p	CLIP-seq
MIRT1068474	hsa-miR-4684-5p	CLIP-seq
MIRT1068475	hsa-miR-4696	CLIP-seq
MIRT1068476	hsa-miR-4713-5p	CLIP-seq
MIRT1068477	hsa-miR-4728-5p	CLIP-seq
MIRT1068478	hsa-miR-4753-3p	CLIP-seq
MIRT1068479	hsa-miR-4768-5p	CLIP-seq
MIRT1068480	hsa-miR-4796-5p	CLIP-seq
MIRT1068481	hsa-miR-483-3p	CLIP-seq
MIRT1068482	hsa-miR-494	CLIP-seq
MIRT1068483	hsa-miR-532-3p	CLIP-seq
MIRT1068484	hsa-miR-612	CLIP-seq
MIRT1068485	hsa-miR-661	CLIP-seq
MIRT1068448	hsa-miR-1285	CLIP-seq
MIRT1068486	hsa-miR-204	CLIP-seq
MIRT1068487	hsa-miR-211	CLIP-seq
MIRT1068488	hsa-miR-2277-3p	CLIP-seq
MIRT1068452	hsa-miR-2467-3p	CLIP-seq
MIRT1068489	hsa-miR-3122	CLIP-seq
MIRT1068454	hsa-miR-3187-5p	CLIP-seq
MIRT1068490	hsa-miR-3613-3p	CLIP-seq
MIRT1068491	hsa-miR-3622a-3p	CLIP-seq
MIRT1068492	hsa-miR-3622b-3p	CLIP-seq
MIRT1068493	hsa-miR-371b-5p	CLIP-seq
MIRT1068494	hsa-miR-377	CLIP-seq
MIRT1068495	hsa-miR-3913-5p	CLIP-seq
MIRT1068496	hsa-miR-3923	CLIP-seq
MIRT1068497	hsa-miR-3926	CLIP-seq
MIRT1068498	hsa-miR-4257	CLIP-seq
MIRT1068499	hsa-miR-4328	CLIP-seq
MIRT1068500	hsa-miR-4433	CLIP-seq
MIRT1068501	hsa-miR-4446-5p	CLIP-seq
MIRT1068502	hsa-miR-4459	CLIP-seq
MIRT1068503	hsa-miR-4640-5p	CLIP-seq
MIRT1068504	hsa-miR-4704-5p	CLIP-seq
MIRT1068505	hsa-miR-4726-5p	CLIP-seq
MIRT1068506	hsa-miR-4731-5p	CLIP-seq
MIRT1068507	hsa-miR-4778-3p	CLIP-seq
MIRT1068508	hsa-miR-514	CLIP-seq
MIRT1068509	hsa-miR-514b-3p	CLIP-seq
MIRT1068510	hsa-miR-544b	CLIP-seq
MIRT1068511	hsa-miR-587	CLIP-seq
MIRT1068484	hsa-miR-612	CLIP-seq
MIRT1068512	hsa-miR-628-3p	CLIP-seq
MIRT1068485	hsa-miR-661	CLIP-seq
MIRT2248780	hsa-miR-1179	CLIP-seq
MIRT2248781	hsa-miR-4324	CLIP-seq
MIRT1068510	hsa-miR-544b	CLIP-seq
MIRT2451896	hsa-miR-3163	CLIP-seq
MIRT2451897	hsa-miR-3675-5p	CLIP-seq
MIRT2451898	hsa-miR-4656	CLIP-seq
MIRT1068474	hsa-miR-4684-5p	CLIP-seq
MIRT1068477	hsa-miR-4728-5p	CLIP-seq
MIRT2451899	hsa-miR-486-3p	CLIP-seq
MIRT2451900	hsa-miR-548c-3p	CLIP-seq
MIRT2451901	hsa-miR-585	CLIP-seq
MIRT2451902	hsa-miR-885-3p	CLIP-seq
MIRT2451897	hsa-miR-3675-5p	CLIP-seq
MIRT2451898	hsa-miR-4656	CLIP-seq
MIRT1068477	hsa-miR-4728-5p	CLIP-seq
MIRT2451899	hsa-miR-486-3p	CLIP-seq
MIRT2451902	hsa-miR-885-3p	CLIP-seq
MIRT1068445	hsa-miR-1228	CLIP-seq
MIRT1068448	hsa-miR-1285	CLIP-seq
MIRT2552526	hsa-miR-2114	CLIP-seq
MIRT1068452	hsa-miR-2467-3p	CLIP-seq
MIRT1068453	hsa-miR-3120-5p	CLIP-seq
MIRT2451896	hsa-miR-3163	CLIP-seq
MIRT1068454	hsa-miR-3187-5p	CLIP-seq
MIRT1068455	hsa-miR-3192	CLIP-seq
MIRT1068456	hsa-miR-326	CLIP-seq
MIRT1068457	hsa-miR-330-5p	CLIP-seq
MIRT1068491	hsa-miR-3622a-3p	CLIP-seq
MIRT1068492	hsa-miR-3622b-3p	CLIP-seq
MIRT1068460	hsa-miR-3664-5p	CLIP-seq
MIRT1068461	hsa-miR-3689a-3p	CLIP-seq
MIRT1068462	hsa-miR-3689c	CLIP-seq
MIRT1068494	hsa-miR-377	CLIP-seq
MIRT2552527	hsa-miR-3924	CLIP-seq
MIRT2552528	hsa-miR-4252	CLIP-seq
MIRT1068466	hsa-miR-4314	CLIP-seq
MIRT1068468	hsa-miR-4432	CLIP-seq
MIRT1068500	hsa-miR-4433	CLIP-seq
MIRT1068502	hsa-miR-4459	CLIP-seq
MIRT2552529	hsa-miR-4514	CLIP-seq
MIRT1068470	hsa-miR-451b	CLIP-seq
MIRT1068471	hsa-miR-4522	CLIP-seq
MIRT1068472	hsa-miR-4646-5p	CLIP-seq
MIRT1068474	hsa-miR-4684-5p	CLIP-seq
MIRT2552530	hsa-miR-4692	CLIP-seq
MIRT1068475	hsa-miR-4696	CLIP-seq
MIRT1068477	hsa-miR-4728-5p	CLIP-seq
MIRT2552531	hsa-miR-4793-3p	CLIP-seq
MIRT2552532	hsa-miR-508-5p	CLIP-seq
MIRT1068510	hsa-miR-544b	CLIP-seq
MIRT2451900	hsa-miR-548c-3p	CLIP-seq
MIRT2552533	hsa-miR-561	CLIP-seq
MIRT2451901	hsa-miR-585	CLIP-seq
MIRT1068484	hsa-miR-612	CLIP-seq
MIRT2552534	hsa-miR-633	CLIP-seq
MIRT1068485	hsa-miR-661	CLIP-seq
MIRT2552535	hsa-miR-766	CLIP-seq
MIRT2682868	hsa-miR-1227	CLIP-seq
MIRT1068448	hsa-miR-1285	CLIP-seq
MIRT2552526	hsa-miR-2114	CLIP-seq
MIRT1068453	hsa-miR-3120-5p	CLIP-seq
MIRT2451896	hsa-miR-3163	CLIP-seq
MIRT1068454	hsa-miR-3187-5p	CLIP-seq
MIRT1068460	hsa-miR-3664-5p	CLIP-seq
MIRT2552528	hsa-miR-4252	CLIP-seq
MIRT1068468	hsa-miR-4432	CLIP-seq
MIRT1068470	hsa-miR-451b	CLIP-seq
MIRT1068471	hsa-miR-4522	CLIP-seq
MIRT1068474	hsa-miR-4684-5p	CLIP-seq
MIRT1068475	hsa-miR-4696	CLIP-seq
MIRT2552531	hsa-miR-4793-3p	CLIP-seq
MIRT2552532	hsa-miR-508-5p	CLIP-seq
MIRT2451900	hsa-miR-548c-3p	CLIP-seq
MIRT2552533	hsa-miR-561	CLIP-seq
MIRT2451901	hsa-miR-585	CLIP-seq
MIRT1068484	hsa-miR-612	CLIP-seq
MIRT2552534	hsa-miR-633	CLIP-seq
MIRT1068485	hsa-miR-661	CLIP-seq
MIRT2552535	hsa-miR-766	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004601	Function	Peroxidase activity	ISS	11320098
GO:0005344	Function	Oxygen carrier activity	NAS	11919282
GO:0005515	Function	Protein binding	IPI	22085542, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006979	Process	Response to oxidative stress	ISS	11320098
GO:0015671	Process	Oxygen transport	NAS	11919282
GO:0016020	Component	Membrane	IEA
GO:0098869	Process	Cellular oxidant detoxification	IEA

MIM	HGNC	e!Ensembl
619948	21204	ENSG00000074706

Q8WWN9

Protein name

Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E)

Protein function

Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.

PDB

5MR1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	42 → 139	PH domain	Domain

Sequence

MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSN
KWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYF
AAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTA
QQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITF
AVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIM
DKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIR
TLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDT
PQELKKSPSSPSVENSI

Sequence length

437

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHAGAS CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC LYMPHOCYTIC LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DERMATITIS, ALLERGIC CONTACT	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	GWASDB_DG	24292274		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	GWASCAT_DG	24292274		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dermatitis, Allergic Contact	Dermatitis	CTD_human_DG	17374397		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	34545296	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	26305897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	CTD_human_DG	24292274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	35143416	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Lymphocytic Lymphoma	Lymphocytic Leukemia	GWASCAT_DG	24292274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	36465624	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

IPCEF1 (interaction protein for cytohesin exchange factors 1)