Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	26002
Gene name	Monooxygenase DBH like 1
Gene symbol	MOXD1
Synonyms (NCBI Gene)	MOXPRO5780dJ248E1.1
Chromosome	6
Chromosome location	6q23.2

218

Show/Hide all (218)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030822	hsa-miR-21-5p	Microarray	18591254
MIRT048720	hsa-miR-96-5p	CLASH	23622248
MIRT053409	hsa-miR-591	Microarray	23807165
MIRT1155888	hsa-let-7a	CLIP-seq
MIRT1155889	hsa-let-7b	CLIP-seq
MIRT1155890	hsa-let-7c	CLIP-seq
MIRT1155891	hsa-let-7d	CLIP-seq
MIRT1155892	hsa-let-7e	CLIP-seq
MIRT1155893	hsa-let-7f	CLIP-seq
MIRT1155894	hsa-let-7g	CLIP-seq
MIRT1155895	hsa-let-7i	CLIP-seq
MIRT1155896	hsa-miR-1321	CLIP-seq
MIRT1155897	hsa-miR-202	CLIP-seq
MIRT1155898	hsa-miR-3148	CLIP-seq
MIRT1155899	hsa-miR-3173-3p	CLIP-seq
MIRT1155900	hsa-miR-374c	CLIP-seq
MIRT1155901	hsa-miR-3936	CLIP-seq
MIRT1155902	hsa-miR-4419a	CLIP-seq
MIRT1155903	hsa-miR-4422	CLIP-seq
MIRT1155904	hsa-miR-4458	CLIP-seq
MIRT1155905	hsa-miR-4477a	CLIP-seq
MIRT1155906	hsa-miR-4500	CLIP-seq
MIRT1155907	hsa-miR-4510	CLIP-seq
MIRT1155908	hsa-miR-4668-5p	CLIP-seq
MIRT1155909	hsa-miR-4728-5p	CLIP-seq
MIRT1155910	hsa-miR-4739	CLIP-seq
MIRT1155911	hsa-miR-4756-5p	CLIP-seq
MIRT1155912	hsa-miR-4779	CLIP-seq
MIRT1155913	hsa-miR-655	CLIP-seq
MIRT1155914	hsa-miR-98	CLIP-seq
MIRT2273793	hsa-miR-1234	CLIP-seq
MIRT2273794	hsa-miR-149	CLIP-seq
MIRT2273795	hsa-miR-24	CLIP-seq
MIRT2273796	hsa-miR-342-3p	CLIP-seq
MIRT2273797	hsa-miR-4284	CLIP-seq
MIRT2273798	hsa-miR-4421	CLIP-seq
MIRT2273799	hsa-miR-490-3p	CLIP-seq
MIRT2273800	hsa-miR-511	CLIP-seq
MIRT2273801	hsa-miR-649	CLIP-seq
MIRT2273802	hsa-miR-892b	CLIP-seq
MIRT2431250	hsa-miR-1972	CLIP-seq
MIRT2431251	hsa-miR-224	CLIP-seq
MIRT2431252	hsa-miR-3662	CLIP-seq
MIRT2431253	hsa-miR-4328	CLIP-seq
MIRT2431254	hsa-miR-4650-5p	CLIP-seq
MIRT2431255	hsa-miR-4690-3p	CLIP-seq
MIRT2431256	hsa-miR-522	CLIP-seq
MIRT1155888	hsa-let-7a	CLIP-seq
MIRT1155889	hsa-let-7b	CLIP-seq
MIRT1155890	hsa-let-7c	CLIP-seq
MIRT1155891	hsa-let-7d	CLIP-seq
MIRT1155892	hsa-let-7e	CLIP-seq
MIRT1155893	hsa-let-7f	CLIP-seq
MIRT1155894	hsa-let-7g	CLIP-seq
MIRT1155895	hsa-let-7i	CLIP-seq
MIRT2273793	hsa-miR-1234	CLIP-seq
MIRT2572658	hsa-miR-1253	CLIP-seq
MIRT2572659	hsa-miR-1299	CLIP-seq
MIRT2572660	hsa-miR-1301	CLIP-seq
MIRT2572661	hsa-miR-1305	CLIP-seq
MIRT2572662	hsa-miR-194	CLIP-seq
MIRT2431250	hsa-miR-1972	CLIP-seq
MIRT1155897	hsa-miR-202	CLIP-seq
MIRT2572663	hsa-miR-221	CLIP-seq
MIRT2572664	hsa-miR-222	CLIP-seq
MIRT2431251	hsa-miR-224	CLIP-seq
MIRT2572665	hsa-miR-2277-3p	CLIP-seq
MIRT2572666	hsa-miR-27a	CLIP-seq
MIRT2572667	hsa-miR-27b	CLIP-seq
MIRT2572668	hsa-miR-2964a-5p	CLIP-seq
MIRT2572669	hsa-miR-299-3p	CLIP-seq
MIRT2572670	hsa-miR-3065-5p	CLIP-seq
MIRT2572671	hsa-miR-3129-3p	CLIP-seq
MIRT2572672	hsa-miR-3145-3p	CLIP-seq
MIRT2572673	hsa-miR-338-5p	CLIP-seq
MIRT2572674	hsa-miR-3654	CLIP-seq
MIRT2431252	hsa-miR-3662	CLIP-seq
MIRT1155900	hsa-miR-374c	CLIP-seq
MIRT2572675	hsa-miR-383	CLIP-seq
MIRT2572676	hsa-miR-3914	CLIP-seq
MIRT2572677	hsa-miR-3925-5p	CLIP-seq
MIRT1155901	hsa-miR-3936	CLIP-seq
MIRT2572678	hsa-miR-3945	CLIP-seq
MIRT2572679	hsa-miR-410	CLIP-seq
MIRT2572680	hsa-miR-4253	CLIP-seq
MIRT2572681	hsa-miR-4263	CLIP-seq
MIRT2572682	hsa-miR-4279	CLIP-seq
MIRT2572683	hsa-miR-4307	CLIP-seq
MIRT2572684	hsa-miR-4311	CLIP-seq
MIRT2431253	hsa-miR-4328	CLIP-seq
MIRT2572685	hsa-miR-4330	CLIP-seq
MIRT2273798	hsa-miR-4421	CLIP-seq
MIRT1155903	hsa-miR-4422	CLIP-seq
MIRT1155904	hsa-miR-4458	CLIP-seq
MIRT1155905	hsa-miR-4477a	CLIP-seq
MIRT2572686	hsa-miR-4481	CLIP-seq
MIRT2572687	hsa-miR-4491	CLIP-seq
MIRT1155906	hsa-miR-4500	CLIP-seq
MIRT2572688	hsa-miR-4504	CLIP-seq
MIRT2572689	hsa-miR-4536	CLIP-seq
MIRT2572690	hsa-miR-4638-3p	CLIP-seq
MIRT2431254	hsa-miR-4650-5p	CLIP-seq
MIRT2572691	hsa-miR-4657	CLIP-seq
MIRT2572692	hsa-miR-4666-5p	CLIP-seq
MIRT2572693	hsa-miR-4676-5p	CLIP-seq
MIRT2431255	hsa-miR-4690-3p	CLIP-seq
MIRT2572694	hsa-miR-4729	CLIP-seq
MIRT2572695	hsa-miR-4745-5p	CLIP-seq
MIRT2572696	hsa-miR-4760-3p	CLIP-seq
MIRT2572697	hsa-miR-4772-5p	CLIP-seq
MIRT2572698	hsa-miR-5047	CLIP-seq
MIRT2273800	hsa-miR-511	CLIP-seq
MIRT2572699	hsa-miR-513a-5p	CLIP-seq
MIRT2431256	hsa-miR-522	CLIP-seq
MIRT2572700	hsa-miR-545	CLIP-seq
MIRT2572701	hsa-miR-548g	CLIP-seq
MIRT2572702	hsa-miR-575	CLIP-seq
MIRT2572703	hsa-miR-576-5p	CLIP-seq
MIRT2572704	hsa-miR-577	CLIP-seq
MIRT2572705	hsa-miR-589	CLIP-seq
MIRT2572706	hsa-miR-592	CLIP-seq
MIRT2572707	hsa-miR-593	CLIP-seq
MIRT2572708	hsa-miR-597	CLIP-seq
MIRT2572709	hsa-miR-629	CLIP-seq
MIRT1155913	hsa-miR-655	CLIP-seq
MIRT2572710	hsa-miR-759	CLIP-seq
MIRT2572711	hsa-miR-875-3p	CLIP-seq
MIRT2572712	hsa-miR-935	CLIP-seq
MIRT1155914	hsa-miR-98	CLIP-seq
MIRT1155888	hsa-let-7a	CLIP-seq
MIRT1155889	hsa-let-7b	CLIP-seq
MIRT1155890	hsa-let-7c	CLIP-seq
MIRT1155891	hsa-let-7d	CLIP-seq
MIRT1155892	hsa-let-7e	CLIP-seq
MIRT1155893	hsa-let-7f	CLIP-seq
MIRT1155894	hsa-let-7g	CLIP-seq
MIRT1155895	hsa-let-7i	CLIP-seq
MIRT2685215	hsa-miR-103b	CLIP-seq
MIRT2273793	hsa-miR-1234	CLIP-seq
MIRT2572658	hsa-miR-1253	CLIP-seq
MIRT2572659	hsa-miR-1299	CLIP-seq
MIRT2572660	hsa-miR-1301	CLIP-seq
MIRT2572661	hsa-miR-1305	CLIP-seq
MIRT2572662	hsa-miR-194	CLIP-seq
MIRT2431250	hsa-miR-1972	CLIP-seq
MIRT1155897	hsa-miR-202	CLIP-seq
MIRT2572663	hsa-miR-221	CLIP-seq
MIRT2572664	hsa-miR-222	CLIP-seq
MIRT2431251	hsa-miR-224	CLIP-seq
MIRT2572665	hsa-miR-2277-3p	CLIP-seq
MIRT2572666	hsa-miR-27a	CLIP-seq
MIRT2572667	hsa-miR-27b	CLIP-seq
MIRT2572668	hsa-miR-2964a-5p	CLIP-seq
MIRT2572669	hsa-miR-299-3p	CLIP-seq
MIRT2572670	hsa-miR-3065-5p	CLIP-seq
MIRT2572671	hsa-miR-3129-3p	CLIP-seq
MIRT2572672	hsa-miR-3145-3p	CLIP-seq
MIRT2685216	hsa-miR-3163	CLIP-seq
MIRT2572673	hsa-miR-338-5p	CLIP-seq
MIRT2572674	hsa-miR-3654	CLIP-seq
MIRT2431252	hsa-miR-3662	CLIP-seq
MIRT2685217	hsa-miR-3688-3p	CLIP-seq
MIRT1155900	hsa-miR-374c	CLIP-seq
MIRT2572675	hsa-miR-383	CLIP-seq
MIRT2572676	hsa-miR-3914	CLIP-seq
MIRT2572677	hsa-miR-3925-5p	CLIP-seq
MIRT1155901	hsa-miR-3936	CLIP-seq
MIRT2572678	hsa-miR-3945	CLIP-seq
MIRT2685218	hsa-miR-3978	CLIP-seq
MIRT2572679	hsa-miR-410	CLIP-seq
MIRT2572680	hsa-miR-4253	CLIP-seq
MIRT2572681	hsa-miR-4263	CLIP-seq
MIRT2572682	hsa-miR-4279	CLIP-seq
MIRT2572683	hsa-miR-4307	CLIP-seq
MIRT2572684	hsa-miR-4311	CLIP-seq
MIRT2431253	hsa-miR-4328	CLIP-seq
MIRT2572685	hsa-miR-4330	CLIP-seq
MIRT2273798	hsa-miR-4421	CLIP-seq
MIRT1155903	hsa-miR-4422	CLIP-seq
MIRT1155904	hsa-miR-4458	CLIP-seq
MIRT1155905	hsa-miR-4477a	CLIP-seq
MIRT2572686	hsa-miR-4481	CLIP-seq
MIRT2572687	hsa-miR-4491	CLIP-seq
MIRT1155906	hsa-miR-4500	CLIP-seq
MIRT2572688	hsa-miR-4504	CLIP-seq
MIRT2572689	hsa-miR-4536	CLIP-seq
MIRT2572690	hsa-miR-4638-3p	CLIP-seq
MIRT2431254	hsa-miR-4650-5p	CLIP-seq
MIRT2572691	hsa-miR-4657	CLIP-seq
MIRT2572692	hsa-miR-4666-5p	CLIP-seq
MIRT2572693	hsa-miR-4676-5p	CLIP-seq
MIRT2431255	hsa-miR-4690-3p	CLIP-seq
MIRT2572694	hsa-miR-4729	CLIP-seq
MIRT2572695	hsa-miR-4745-5p	CLIP-seq
MIRT2572696	hsa-miR-4760-3p	CLIP-seq
MIRT2572697	hsa-miR-4772-5p	CLIP-seq
MIRT2685219	hsa-miR-4802-3p	CLIP-seq
MIRT2572698	hsa-miR-5047	CLIP-seq
MIRT2273800	hsa-miR-511	CLIP-seq
MIRT2572699	hsa-miR-513a-5p	CLIP-seq
MIRT2431256	hsa-miR-522	CLIP-seq
MIRT2572700	hsa-miR-545	CLIP-seq
MIRT2685220	hsa-miR-548c-3p	CLIP-seq
MIRT2572701	hsa-miR-548g	CLIP-seq
MIRT2572702	hsa-miR-575	CLIP-seq
MIRT2572703	hsa-miR-576-5p	CLIP-seq
MIRT2572704	hsa-miR-577	CLIP-seq
MIRT2572705	hsa-miR-589	CLIP-seq
MIRT2572706	hsa-miR-592	CLIP-seq
MIRT2572707	hsa-miR-593	CLIP-seq
MIRT2572708	hsa-miR-597	CLIP-seq
MIRT2572709	hsa-miR-629	CLIP-seq
MIRT1155913	hsa-miR-655	CLIP-seq
MIRT2572710	hsa-miR-759	CLIP-seq
MIRT2685221	hsa-miR-873	CLIP-seq
MIRT2572711	hsa-miR-875-3p	CLIP-seq
MIRT2572712	hsa-miR-935	CLIP-seq
MIRT1155914	hsa-miR-98	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004497	Function	Monooxygenase activity	IEA
GO:0004500	Function	Dopamine beta-monooxygenase activity	IBA
GO:0004500	Function	Dopamine beta-monooxygenase activity	IEA
GO:0005507	Function	Copper ion binding	IBA
GO:0005507	Function	Copper ion binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 29892012, 32296183, 33961781
GO:0005615	Component	Extracellular space	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	15337741
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006589	Process	Octopamine biosynthetic process	IBA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016715	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	IEA
GO:0030667	Component	Secretory granule membrane	IBA
GO:0042420	Process	Dopamine catabolic process	IBA
GO:0042421	Process	Norepinephrine biosynthetic process	IBA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
609000	21063	ENSG00000079931

Q6UVY6

Protein name

DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03351	DOMON	33 → 148	DOMON domain	Domain
PF01082	Cu2_monooxygen	187 → 315	Copper type II ascorbate-dependent monooxygenase, N-terminal domain	Domain
PF03712	Cu2_monoox_C	334 → 491	Copper type II ascorbate-dependent monooxygenase, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in lung, kidney, brain and spinal cord. {ECO:0000269|PubMed:15337741, ECO:0000269|PubMed:9751809}.

Sequence

MCCWPLLLLWGLLPGTAAGGSGRTYPHRTLLDSEGKYWLGWSQRGSQIAFRLQVRTAGYV
GFGFSPTGAMASADIVVGGVAHGRPYLQDYFTNANRELKKDAQQDYHLEYAMENSTHTII
EFTRELHTCDINDKSITDSTVRVIWAYHHEDAGEAGPKYHDSNRGTKSLRLLNPEKTSVL
STALPYFDLVNQDVPIPNKDTTYWCQMFKIPVFQEKHHVIKVEPVIQRGHESLVHHILLY
QCSNNFNDSVLESGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPH
YVLLEVHYDNPTYEEGLIDNSGLRLFYTMDIRKYDAGVIEAGLWVSLFHTIPPGMPEFQS
EGHCTLECLEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGKEMKLLAYDDDFDFN
FQEFQYLKEEQTILPGDNLITECRYNTKDRAEMTWGGLSTRSEMCLSYLLYYPRINLTRC
ASIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYKNLSFMDAMNKFKWTKKEGLSFNKL
VLSLPVNVRCSKTDNAEWSIQGMTALPPDIERPYKAEPLVCGTSSSSSLHRDFSINLLVC
LLLLSCTLSTKSL

Sequence length

613

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma	Asthma	BEFREE	30986547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Excessive tearing	Excessive Tearing	BEFREE	31751751		★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	37085855	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteomyelitis	Osteomyelitis	BEFREE	30892092		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	15329799		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	15329799	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	38200441	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MOXD1 (monooxygenase DBH like 1)