Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	25998
Gene name	Inhibitor of Bruton tyrosine kinase
Gene symbol	IBTK
Synonyms (NCBI Gene)	BTBD26BTKI
Chromosome	6
Chromosome location	6q14.1
Summary	Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK`s kinase activity. In addition, the encoded protein disrupts BTK-medi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018477	hsa-miR-335-5p	Microarray	18185580
MIRT051292	hsa-miR-16-5p	CLASH	23622248
MIRT045378	hsa-miR-185-5p	CLASH	23622248
MIRT723786	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT723785	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT723784	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT723783	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT723782	hsa-miR-6083	HITS-CLIP	19536157
MIRT723781	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT723780	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT727478	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727479	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727477	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT723786	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT723785	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT723784	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT723783	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT723782	hsa-miR-6083	HITS-CLIP	19536157
MIRT723781	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT723780	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT1058300	hsa-miR-101	CLIP-seq
MIRT1058301	hsa-miR-137	CLIP-seq
MIRT1058302	hsa-miR-141	CLIP-seq
MIRT1058303	hsa-miR-142-5p	CLIP-seq
MIRT1058304	hsa-miR-144	CLIP-seq
MIRT1058305	hsa-miR-146a	CLIP-seq
MIRT1058306	hsa-miR-146b-5p	CLIP-seq
MIRT1058307	hsa-miR-200a	CLIP-seq
MIRT1058308	hsa-miR-200b	CLIP-seq
MIRT1058309	hsa-miR-200c	CLIP-seq
MIRT1058310	hsa-miR-204	CLIP-seq
MIRT1058311	hsa-miR-211	CLIP-seq
MIRT1058312	hsa-miR-25	CLIP-seq
MIRT1058313	hsa-miR-3140-3p	CLIP-seq
MIRT1058314	hsa-miR-3156-5p	CLIP-seq
MIRT1058315	hsa-miR-32	CLIP-seq
MIRT1058316	hsa-miR-340	CLIP-seq
MIRT1058317	hsa-miR-342-3p	CLIP-seq
MIRT1058318	hsa-miR-346	CLIP-seq
MIRT1058319	hsa-miR-363	CLIP-seq
MIRT1058320	hsa-miR-3653	CLIP-seq
MIRT1058321	hsa-miR-3658	CLIP-seq
MIRT1058322	hsa-miR-367	CLIP-seq
MIRT1058323	hsa-miR-3692	CLIP-seq
MIRT1058324	hsa-miR-374c	CLIP-seq
MIRT1058325	hsa-miR-3919	CLIP-seq
MIRT1058326	hsa-miR-3920	CLIP-seq
MIRT1058327	hsa-miR-3925-5p	CLIP-seq
MIRT1058328	hsa-miR-3938	CLIP-seq
MIRT1058329	hsa-miR-3942-3p	CLIP-seq
MIRT1058330	hsa-miR-4288	CLIP-seq
MIRT1058331	hsa-miR-429	CLIP-seq
MIRT1058332	hsa-miR-4291	CLIP-seq
MIRT1058333	hsa-miR-4423-3p	CLIP-seq
MIRT1058334	hsa-miR-4424	CLIP-seq
MIRT1058335	hsa-miR-4436b-5p	CLIP-seq
MIRT1058336	hsa-miR-4640-3p	CLIP-seq
MIRT1058337	hsa-miR-4666-5p	CLIP-seq
MIRT1058338	hsa-miR-4668-3p	CLIP-seq
MIRT1058339	hsa-miR-4686	CLIP-seq
MIRT1058340	hsa-miR-4694-3p	CLIP-seq
MIRT1058341	hsa-miR-4755-5p	CLIP-seq
MIRT1058342	hsa-miR-4756-3p	CLIP-seq
MIRT1058343	hsa-miR-4760-3p	CLIP-seq
MIRT1058344	hsa-miR-4762-3p	CLIP-seq
MIRT1058345	hsa-miR-4768-5p	CLIP-seq
MIRT1058346	hsa-miR-4789-3p	CLIP-seq
MIRT1058347	hsa-miR-4789-5p	CLIP-seq
MIRT1058348	hsa-miR-495	CLIP-seq
MIRT1058349	hsa-miR-545	CLIP-seq
MIRT1058350	hsa-miR-548ag	CLIP-seq
MIRT1058351	hsa-miR-548ai	CLIP-seq
MIRT1058352	hsa-miR-548m	CLIP-seq
MIRT1058353	hsa-miR-561	CLIP-seq
MIRT1058354	hsa-miR-590-3p	CLIP-seq
MIRT1058355	hsa-miR-623	CLIP-seq
MIRT1058356	hsa-miR-630	CLIP-seq
MIRT1058357	hsa-miR-632	CLIP-seq
MIRT1058358	hsa-miR-654-3p	CLIP-seq
MIRT1058359	hsa-miR-655	CLIP-seq
MIRT1058360	hsa-miR-890	CLIP-seq
MIRT1058361	hsa-miR-92a	CLIP-seq
MIRT1058362	hsa-miR-92b	CLIP-seq
MIRT1058363	hsa-miR-944	CLIP-seq
MIRT2013476	hsa-miR-1279	CLIP-seq
MIRT1058301	hsa-miR-137	CLIP-seq
MIRT1058302	hsa-miR-141	CLIP-seq
MIRT1058307	hsa-miR-200a	CLIP-seq
MIRT2013477	hsa-miR-219-2-3p	CLIP-seq
MIRT2013478	hsa-miR-223	CLIP-seq
MIRT1058312	hsa-miR-25	CLIP-seq
MIRT2013479	hsa-miR-2964a-3p	CLIP-seq
MIRT2013480	hsa-miR-302f	CLIP-seq
MIRT1058313	hsa-miR-3140-3p	CLIP-seq
MIRT2013481	hsa-miR-3180-5p	CLIP-seq
MIRT1058315	hsa-miR-32	CLIP-seq
MIRT1058317	hsa-miR-342-3p	CLIP-seq
MIRT1058318	hsa-miR-346	CLIP-seq
MIRT2013482	hsa-miR-34b	CLIP-seq
MIRT1058319	hsa-miR-363	CLIP-seq
MIRT1058320	hsa-miR-3653	CLIP-seq
MIRT1058321	hsa-miR-3658	CLIP-seq
MIRT1058322	hsa-miR-367	CLIP-seq
MIRT2013483	hsa-miR-377	CLIP-seq
MIRT2013484	hsa-miR-410	CLIP-seq
MIRT2013485	hsa-miR-4274	CLIP-seq
MIRT1058330	hsa-miR-4288	CLIP-seq
MIRT1058332	hsa-miR-4291	CLIP-seq
MIRT2013486	hsa-miR-4328	CLIP-seq
MIRT1058333	hsa-miR-4423-3p	CLIP-seq
MIRT1058334	hsa-miR-4424	CLIP-seq
MIRT2013487	hsa-miR-4461	CLIP-seq
MIRT2013488	hsa-miR-4519	CLIP-seq
MIRT1058337	hsa-miR-4666-5p	CLIP-seq
MIRT1058338	hsa-miR-4668-3p	CLIP-seq
MIRT1058339	hsa-miR-4686	CLIP-seq
MIRT2013489	hsa-miR-4705	CLIP-seq
MIRT2013490	hsa-miR-4724-3p	CLIP-seq
MIRT1058343	hsa-miR-4760-3p	CLIP-seq
MIRT1058345	hsa-miR-4768-5p	CLIP-seq
MIRT2013491	hsa-miR-4773	CLIP-seq
MIRT1058346	hsa-miR-4789-3p	CLIP-seq
MIRT2013492	hsa-miR-499-3p	CLIP-seq
MIRT2013493	hsa-miR-499a-3p	CLIP-seq
MIRT2013494	hsa-miR-520a-5p	CLIP-seq
MIRT2013495	hsa-miR-525-5p	CLIP-seq
MIRT1058349	hsa-miR-545	CLIP-seq
MIRT2013496	hsa-miR-627	CLIP-seq
MIRT1058357	hsa-miR-632	CLIP-seq
MIRT1058358	hsa-miR-654-3p	CLIP-seq
MIRT1058360	hsa-miR-890	CLIP-seq
MIRT1058361	hsa-miR-92a	CLIP-seq
MIRT1058362	hsa-miR-92b	CLIP-seq
MIRT2013476	hsa-miR-1279	CLIP-seq
MIRT1058301	hsa-miR-137	CLIP-seq
MIRT1058302	hsa-miR-141	CLIP-seq
MIRT1058307	hsa-miR-200a	CLIP-seq
MIRT2013477	hsa-miR-219-2-3p	CLIP-seq
MIRT2013478	hsa-miR-223	CLIP-seq
MIRT1058312	hsa-miR-25	CLIP-seq
MIRT2013479	hsa-miR-2964a-3p	CLIP-seq
MIRT2245653	hsa-miR-300	CLIP-seq
MIRT2013480	hsa-miR-302f	CLIP-seq
MIRT1058315	hsa-miR-32	CLIP-seq
MIRT1058317	hsa-miR-342-3p	CLIP-seq
MIRT1058318	hsa-miR-346	CLIP-seq
MIRT1058319	hsa-miR-363	CLIP-seq
MIRT1058320	hsa-miR-3653	CLIP-seq
MIRT1058321	hsa-miR-3658	CLIP-seq
MIRT1058322	hsa-miR-367	CLIP-seq
MIRT1058323	hsa-miR-3692	CLIP-seq
MIRT2245654	hsa-miR-381	CLIP-seq
MIRT1058330	hsa-miR-4288	CLIP-seq
MIRT1058332	hsa-miR-4291	CLIP-seq
MIRT2013486	hsa-miR-4328	CLIP-seq
MIRT2013487	hsa-miR-4461	CLIP-seq
MIRT2245655	hsa-miR-4666-3p	CLIP-seq
MIRT1058337	hsa-miR-4666-5p	CLIP-seq
MIRT1058339	hsa-miR-4686	CLIP-seq
MIRT2245656	hsa-miR-4719	CLIP-seq
MIRT2245657	hsa-miR-4724-5p	CLIP-seq
MIRT1058346	hsa-miR-4789-3p	CLIP-seq
MIRT2013492	hsa-miR-499-3p	CLIP-seq
MIRT2013493	hsa-miR-499a-3p	CLIP-seq
MIRT1058349	hsa-miR-545	CLIP-seq
MIRT1058354	hsa-miR-590-3p	CLIP-seq
MIRT2013496	hsa-miR-627	CLIP-seq
MIRT1058357	hsa-miR-632	CLIP-seq
MIRT2245658	hsa-miR-642b	CLIP-seq
MIRT1058358	hsa-miR-654-3p	CLIP-seq
MIRT1058360	hsa-miR-890	CLIP-seq
MIRT1058361	hsa-miR-92a	CLIP-seq
MIRT1058362	hsa-miR-92b	CLIP-seq
MIRT1058301	hsa-miR-137	CLIP-seq
MIRT1058312	hsa-miR-25	CLIP-seq
MIRT1058315	hsa-miR-32	CLIP-seq
MIRT1058317	hsa-miR-342-3p	CLIP-seq
MIRT1058319	hsa-miR-363	CLIP-seq
MIRT1058321	hsa-miR-3658	CLIP-seq
MIRT1058322	hsa-miR-367	CLIP-seq
MIRT1058337	hsa-miR-4666-5p	CLIP-seq
MIRT1058339	hsa-miR-4686	CLIP-seq
MIRT1058358	hsa-miR-654-3p	CLIP-seq
MIRT1058361	hsa-miR-92a	CLIP-seq
MIRT1058362	hsa-miR-92b	CLIP-seq
MIRT2451539	hsa-miR-1256	CLIP-seq
MIRT2451540	hsa-miR-183	CLIP-seq
MIRT2451541	hsa-miR-3121-3p	CLIP-seq
MIRT2013476	hsa-miR-1279	CLIP-seq
MIRT2548853	hsa-miR-1302	CLIP-seq
MIRT2548854	hsa-miR-150	CLIP-seq
MIRT2548855	hsa-miR-182	CLIP-seq
MIRT2548856	hsa-miR-1915	CLIP-seq
MIRT1058310	hsa-miR-204	CLIP-seq
MIRT1058311	hsa-miR-211	CLIP-seq
MIRT2013477	hsa-miR-219-2-3p	CLIP-seq
MIRT2013478	hsa-miR-223	CLIP-seq
MIRT2013479	hsa-miR-2964a-3p	CLIP-seq
MIRT2548857	hsa-miR-299-3p	CLIP-seq
MIRT2013480	hsa-miR-302f	CLIP-seq
MIRT2548858	hsa-miR-3122	CLIP-seq
MIRT2548859	hsa-miR-3145-5p	CLIP-seq
MIRT2548860	hsa-miR-3176	CLIP-seq
MIRT2548861	hsa-miR-3187-3p	CLIP-seq
MIRT2548862	hsa-miR-3199	CLIP-seq
MIRT1058320	hsa-miR-3653	CLIP-seq
MIRT1058321	hsa-miR-3658	CLIP-seq
MIRT1058323	hsa-miR-3692	CLIP-seq
MIRT2548863	hsa-miR-3913-5p	CLIP-seq
MIRT2548864	hsa-miR-3922-3p	CLIP-seq
MIRT1058328	hsa-miR-3938	CLIP-seq
MIRT2548865	hsa-miR-4268	CLIP-seq
MIRT2013485	hsa-miR-4274	CLIP-seq
MIRT2548866	hsa-miR-4298	CLIP-seq
MIRT2013486	hsa-miR-4328	CLIP-seq
MIRT2548867	hsa-miR-4434	CLIP-seq
MIRT1058335	hsa-miR-4436b-5p	CLIP-seq
MIRT2548868	hsa-miR-4448	CLIP-seq
MIRT2013487	hsa-miR-4461	CLIP-seq
MIRT2548869	hsa-miR-4470	CLIP-seq
MIRT2548870	hsa-miR-4491	CLIP-seq
MIRT2548871	hsa-miR-4516	CLIP-seq
MIRT2013488	hsa-miR-4519	CLIP-seq
MIRT2548872	hsa-miR-4529-5p	CLIP-seq
MIRT2548873	hsa-miR-4531	CLIP-seq
MIRT2548874	hsa-miR-4657	CLIP-seq
MIRT1058340	hsa-miR-4694-3p	CLIP-seq
MIRT2548875	hsa-miR-4698	CLIP-seq
MIRT2548876	hsa-miR-4711-3p	CLIP-seq
MIRT2548877	hsa-miR-4713-5p	CLIP-seq
MIRT2548878	hsa-miR-4726-3p	CLIP-seq
MIRT2548879	hsa-miR-4753-3p	CLIP-seq
MIRT1058341	hsa-miR-4755-5p	CLIP-seq
MIRT1058343	hsa-miR-4760-3p	CLIP-seq
MIRT2548880	hsa-miR-4762-5p	CLIP-seq
MIRT1058346	hsa-miR-4789-3p	CLIP-seq
MIRT2013492	hsa-miR-499-3p	CLIP-seq
MIRT2013493	hsa-miR-499a-3p	CLIP-seq
MIRT2548881	hsa-miR-532-3p	CLIP-seq
MIRT2548882	hsa-miR-548ad	CLIP-seq
MIRT2548883	hsa-miR-548g	CLIP-seq
MIRT1058355	hsa-miR-623	CLIP-seq
MIRT2013496	hsa-miR-627	CLIP-seq
MIRT1058356	hsa-miR-630	CLIP-seq
MIRT2548884	hsa-miR-635	CLIP-seq
MIRT2245658	hsa-miR-642b	CLIP-seq
MIRT2548885	hsa-miR-767-3p	CLIP-seq
MIRT1058360	hsa-miR-890	CLIP-seq
MIRT2013476	hsa-miR-1279	CLIP-seq
MIRT2548853	hsa-miR-1302	CLIP-seq
MIRT2548855	hsa-miR-182	CLIP-seq
MIRT1058310	hsa-miR-204	CLIP-seq
MIRT1058311	hsa-miR-211	CLIP-seq
MIRT2013478	hsa-miR-223	CLIP-seq
MIRT2548857	hsa-miR-299-3p	CLIP-seq
MIRT2548858	hsa-miR-3122	CLIP-seq
MIRT2548859	hsa-miR-3145-5p	CLIP-seq
MIRT2548860	hsa-miR-3176	CLIP-seq
MIRT2548861	hsa-miR-3187-3p	CLIP-seq
MIRT2548862	hsa-miR-3199	CLIP-seq
MIRT1058320	hsa-miR-3653	CLIP-seq
MIRT1058321	hsa-miR-3658	CLIP-seq
MIRT1058323	hsa-miR-3692	CLIP-seq
MIRT2548863	hsa-miR-3913-5p	CLIP-seq
MIRT2548864	hsa-miR-3922-3p	CLIP-seq
MIRT1058328	hsa-miR-3938	CLIP-seq
MIRT2548865	hsa-miR-4268	CLIP-seq
MIRT2548866	hsa-miR-4298	CLIP-seq
MIRT2013486	hsa-miR-4328	CLIP-seq
MIRT2548867	hsa-miR-4434	CLIP-seq
MIRT1058335	hsa-miR-4436b-5p	CLIP-seq
MIRT2548868	hsa-miR-4448	CLIP-seq
MIRT2013487	hsa-miR-4461	CLIP-seq
MIRT2548869	hsa-miR-4470	CLIP-seq
MIRT2548870	hsa-miR-4491	CLIP-seq
MIRT2548871	hsa-miR-4516	CLIP-seq
MIRT2548872	hsa-miR-4529-5p	CLIP-seq
MIRT2548873	hsa-miR-4531	CLIP-seq
MIRT2548874	hsa-miR-4657	CLIP-seq
MIRT1058340	hsa-miR-4694-3p	CLIP-seq
MIRT2548875	hsa-miR-4698	CLIP-seq
MIRT2548879	hsa-miR-4753-3p	CLIP-seq
MIRT1058341	hsa-miR-4755-5p	CLIP-seq
MIRT1058343	hsa-miR-4760-3p	CLIP-seq
MIRT2548880	hsa-miR-4762-5p	CLIP-seq
MIRT1058346	hsa-miR-4789-3p	CLIP-seq
MIRT2013492	hsa-miR-499-3p	CLIP-seq
MIRT2013493	hsa-miR-499a-3p	CLIP-seq
MIRT2548882	hsa-miR-548ad	CLIP-seq
MIRT2548883	hsa-miR-548g	CLIP-seq
MIRT1058355	hsa-miR-623	CLIP-seq
MIRT2013496	hsa-miR-627	CLIP-seq
MIRT1058356	hsa-miR-630	CLIP-seq
MIRT2548884	hsa-miR-635	CLIP-seq
MIRT2245658	hsa-miR-642b	CLIP-seq
MIRT1058360	hsa-miR-890	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001933	Process	Negative regulation of protein phosphorylation	IDA	11577348
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	11577348
GO:0005737	Component	Cytoplasm	IEA
GO:0016020	Component	Membrane	IEA
GO:0019901	Function	Protein kinase binding	IBA
GO:0019901	Function	Protein kinase binding	IDA	11577348
GO:0030292	Function	Protein tyrosine kinase inhibitor activity	IBA
GO:0030292	Function	Protein tyrosine kinase inhibitor activity	IDA	11577348
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IBA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IDA	11577348

MIM	HGNC	e!Ensembl
606457	17853	ENSG00000005700

Q9P2D0

Protein name

Inhibitor of Bruton tyrosine kinase (IBtk)

Protein function

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	22 → 116	Ankyrin repeats (3 copies)	Repeat
PF00415	RCC1	143 → 192	Regulator of chromosome condensation (RCC1) repeat	Repeat
PF00415	RCC1	195 → 244	Regulator of chromosome condensation (RCC1) repeat	Repeat
PF00415	RCC1	247 → 299	Regulator of chromosome condensation (RCC1) repeat	Repeat
PF00651	BTB	554 → 653	BTB/POZ domain	Domain
PF00651	BTB	758 → 871	BTB/POZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver

Sequence

MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP
LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL
VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Sequence length

1353

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	32365786	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	28105602, 31141631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	24869598, 28373262, 28972595, 29317636, 29891001, 30421802, 30530801, 30785921, 30842083, 30975981, 31141631, 31142233, 31287200, 31512258, 31732977		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	27276707, 28864640		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	31216242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	31142233		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	28105602		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Hairy Cell	Hairy cell leukemia	Pubtator	38440808	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	31310800		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	29884225	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	30975981		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoproliferative Disorders	Lymphoproliferative Disorder	BEFREE	28182323, 29475534		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	BEFREE	30421802, 30785921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28760303, 28775119, 30090839, 30760494, 31230047, 31646085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	30061088, 30421802, 30785921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	29320977		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25669675, 28348046, 30373751, 30975981		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastoma	Nephroblastoma	BEFREE	24503937		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	BEFREE	28710282		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary central nervous system lymphoma	Central Nervous System Lymphoma	BEFREE	28864640		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	31371481		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Lymphocytic Lymphoma	Lymphocytic Leukemia	BEFREE	28373262, 31512258		★★★★★ ★☆☆☆☆ Found in Text Mining only
Waldenstrom Macroglobulinemia	Waldenstrom`s Macroglobulinemia	BEFREE	30785921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Waldenstrom Macroglobulinemia	Waldenstrom macroglobulinemia	Pubtator	35607995	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

IBTK (inhibitor of Bruton tyrosine kinase)