Gene Gene information from NCBI Gene database.
Entrez ID 25996
Gene name RNA exonuclease 2
Gene symbol REXO2
Synonyms (NCBI Gene)
CGI-114REX2RFNSFN
Chromosome 11
Chromosome location 11q23.2
Summary This gene encodes a 3`-to-5` exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradatio
miRNA miRNA information provided by mirtarbase database.
614
miRTarBase ID miRNA Experiments Reference
MIRT047931 hsa-miR-30c-5p CLASH 23622248
MIRT040651 hsa-miR-92b-3p CLASH 23622248
MIRT036305 hsa-miR-1229-3p CLASH 23622248
MIRT542099 hsa-miR-8485 HITS-CLIP 19536157
MIRT542100 hsa-miR-329-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0000175 Function 3'-5'-RNA exonuclease activity IBA
GO:0000175 Function 3'-5'-RNA exonuclease activity IDA 31588022
GO:0000175 Function 3'-5'-RNA exonuclease activity IEA
GO:0000175 Function 3'-5'-RNA exonuclease activity IMP 30926754, 32365187
GO:0000287 Function Magnesium ion binding IDA 30926754, 31588022
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607149 17851 ENSG00000076043
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y3B8
Protein name Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)
Protein function 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:23741365, PubMed:30926754, PubMed:31588022, PubMed:32365187). Binds and degrades longer oligonucleotides with a lower affi
PDB 6J7Y , 6J7Z , 6J80 , 6N6I , 6N6J , 6N6K , 6RCI , 6RCL , 6RCN , 6STY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00929 RNase_T 44 207 Exonuclease Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus. {ECO:0000269|PubMed:10851236}.
Sequence
Sequence length 237
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Ribosome biogenesis in eukaryotes  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANKYLOSING SPONDYLITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTHRITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EYE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma LHGDN 15131044, 16271083, 17786288
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 22310466, 30728155, 30899432
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma CTD_human_DG 19381893
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 22310466, 26223682, 26423071, 29266838, 29880877, 30728155, 30899432, 31144406
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Clear Cell Adenocarcinoma BEFREE 15044106
★☆☆☆☆
Found in Text Mining only
Adenoid Cystic Carcinoma Adenocarcinoma LHGDN 15292943
★☆☆☆☆
Found in Text Mining only
Agenesis of corpus callosum Agenesis Of Corpus Callosum BEFREE 15292943
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 37221295 Associate
★☆☆☆☆
Found in Text Mining only
Aplasia Cutis Congenita Aplasia Cutis Congenita BEFREE 15292943
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus Pubtator 30404157 Associate
★☆☆☆☆
Found in Text Mining only