Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	25976
Gene name	TCDD inducible poly(ADP-ribose) polymerase
Gene symbol	TIPARP
Synonyms (NCBI Gene)	ARTD14PARP7pART14
Chromosome	3
Chromosome location	3q25.31
Summary	This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in m

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Show/Hide all (163)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024175	hsa-miR-221-3p	Sequencing	20371350
MIRT029801	hsa-miR-26b-5p	Microarray	19088304
MIRT208842	hsa-miR-142-3p	MicroarrayqRT-PCR	22815788
MIRT437683	hsa-miR-222-3p	MicroarrayqRT-PCR	22815788
MIRT237128	hsa-miR-4311	PAR-CLIP	22012620
MIRT237127	hsa-miR-1276	PAR-CLIP	22012620
MIRT237125	hsa-miR-583	PAR-CLIP	22012620
MIRT090928	hsa-miR-5692a	PAR-CLIP	22012620
MIRT237129	hsa-miR-203b-5p	PAR-CLIP	22012620
MIRT237133	hsa-miR-6718-5p	PAR-CLIP	22012620
MIRT531050	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT531049	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT531048	hsa-miR-4680-5p	PAR-CLIP	22012620
MIRT531047	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT531046	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT531045	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT531044	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT531043	hsa-miR-552-5p	PAR-CLIP	22012620
MIRT237128	hsa-miR-4311	PAR-CLIP	22012620
MIRT237127	hsa-miR-1276	PAR-CLIP	22012620
MIRT237125	hsa-miR-583	PAR-CLIP	22012620
MIRT090928	hsa-miR-5692a	PAR-CLIP	22012620
MIRT237129	hsa-miR-203b-5p	PAR-CLIP	22012620
MIRT237133	hsa-miR-6718-5p	PAR-CLIP	22012620
MIRT531050	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT531049	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT531048	hsa-miR-4680-5p	PAR-CLIP	22012620
MIRT531047	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT531046	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT531045	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT531044	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT531043	hsa-miR-552-5p	PAR-CLIP	22012620
MIRT1425527	hsa-miR-105	CLIP-seq
MIRT1425528	hsa-miR-1200	CLIP-seq
MIRT1425529	hsa-miR-1283	CLIP-seq
MIRT1425530	hsa-miR-1287	CLIP-seq
MIRT1425531	hsa-miR-1323	CLIP-seq
MIRT1425532	hsa-miR-1911	CLIP-seq
MIRT1425533	hsa-miR-194	CLIP-seq
MIRT1425534	hsa-miR-221	CLIP-seq
MIRT1425535	hsa-miR-222	CLIP-seq
MIRT1425536	hsa-miR-23a	CLIP-seq
MIRT1425537	hsa-miR-23b	CLIP-seq
MIRT1425538	hsa-miR-23c	CLIP-seq
MIRT1425539	hsa-miR-3133	CLIP-seq
MIRT1425540	hsa-miR-3135b	CLIP-seq
MIRT1425541	hsa-miR-3140-5p	CLIP-seq
MIRT1425542	hsa-miR-3187-3p	CLIP-seq
MIRT1425543	hsa-miR-320a	CLIP-seq
MIRT1425544	hsa-miR-320b	CLIP-seq
MIRT1425545	hsa-miR-320c	CLIP-seq
MIRT1425546	hsa-miR-320d	CLIP-seq
MIRT1425547	hsa-miR-34c-3p	CLIP-seq
MIRT1425548	hsa-miR-3908	CLIP-seq
MIRT1425549	hsa-miR-3913-3p	CLIP-seq
MIRT1425550	hsa-miR-3942-5p	CLIP-seq
MIRT1425551	hsa-miR-4329	CLIP-seq
MIRT1425552	hsa-miR-4420	CLIP-seq
MIRT1425553	hsa-miR-4429	CLIP-seq
MIRT1425554	hsa-miR-4435	CLIP-seq
MIRT1425555	hsa-miR-4511	CLIP-seq
MIRT1425556	hsa-miR-4529-5p	CLIP-seq
MIRT1425557	hsa-miR-4670-3p	CLIP-seq
MIRT1425558	hsa-miR-4682	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT1425560	hsa-miR-4701-5p	CLIP-seq
MIRT1425561	hsa-miR-4703-5p	CLIP-seq
MIRT1425562	hsa-miR-4704-5p	CLIP-seq
MIRT1425563	hsa-miR-4715-5p	CLIP-seq
MIRT1425564	hsa-miR-4720-3p	CLIP-seq
MIRT1425565	hsa-miR-4766-3p	CLIP-seq
MIRT1425566	hsa-miR-4804-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT1425568	hsa-miR-548c-3p	CLIP-seq
MIRT1425569	hsa-miR-548o	CLIP-seq
MIRT1425570	hsa-miR-548s	CLIP-seq
MIRT1425571	hsa-miR-548v	CLIP-seq
MIRT1425572	hsa-miR-588	CLIP-seq
MIRT1425573	hsa-miR-885-3p	CLIP-seq
MIRT1425533	hsa-miR-194	CLIP-seq
MIRT1425536	hsa-miR-23a	CLIP-seq
MIRT1425537	hsa-miR-23b	CLIP-seq
MIRT1425538	hsa-miR-23c	CLIP-seq
MIRT1425574	hsa-miR-3159	CLIP-seq
MIRT1425542	hsa-miR-3187-3p	CLIP-seq
MIRT1425543	hsa-miR-320a	CLIP-seq
MIRT1425544	hsa-miR-320b	CLIP-seq
MIRT1425545	hsa-miR-320c	CLIP-seq
MIRT1425546	hsa-miR-320d	CLIP-seq
MIRT1425553	hsa-miR-4429	CLIP-seq
MIRT1425554	hsa-miR-4435	CLIP-seq
MIRT1425575	hsa-miR-4436b-3p	CLIP-seq
MIRT1425555	hsa-miR-4511	CLIP-seq
MIRT1425556	hsa-miR-4529-5p	CLIP-seq
MIRT1425557	hsa-miR-4670-3p	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT1425560	hsa-miR-4701-5p	CLIP-seq
MIRT1425563	hsa-miR-4715-5p	CLIP-seq
MIRT1425576	hsa-miR-4761-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT1425568	hsa-miR-548c-3p	CLIP-seq
MIRT1425570	hsa-miR-548s	CLIP-seq
MIRT1425572	hsa-miR-588	CLIP-seq
MIRT1425573	hsa-miR-885-3p	CLIP-seq
MIRT2127525	hsa-miR-3157-5p	CLIP-seq
MIRT1425543	hsa-miR-320a	CLIP-seq
MIRT1425544	hsa-miR-320b	CLIP-seq
MIRT1425545	hsa-miR-320c	CLIP-seq
MIRT1425546	hsa-miR-320d	CLIP-seq
MIRT2127526	hsa-miR-3691-3p	CLIP-seq
MIRT2127527	hsa-miR-4280	CLIP-seq
MIRT1425553	hsa-miR-4429	CLIP-seq
MIRT2127528	hsa-miR-4477a	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT2127529	hsa-miR-4797-5p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT2127530	hsa-miR-548ag	CLIP-seq
MIRT2127531	hsa-miR-548ai	CLIP-seq
MIRT2127532	hsa-miR-562	CLIP-seq
MIRT2127533	hsa-miR-599	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT2127525	hsa-miR-3157-5p	CLIP-seq
MIRT1425559	hsa-miR-4691-3p	CLIP-seq
MIRT2642642	hsa-miR-1278	CLIP-seq
MIRT2642643	hsa-miR-19a	CLIP-seq
MIRT2642644	hsa-miR-19b	CLIP-seq
MIRT2642645	hsa-miR-2113	CLIP-seq
MIRT2642646	hsa-miR-330-3p	CLIP-seq
MIRT2642647	hsa-miR-338-3p	CLIP-seq
MIRT2127526	hsa-miR-3691-3p	CLIP-seq
MIRT1425549	hsa-miR-3913-3p	CLIP-seq
MIRT2127527	hsa-miR-4280	CLIP-seq
MIRT2642648	hsa-miR-4282	CLIP-seq
MIRT2642649	hsa-miR-433	CLIP-seq
MIRT2127528	hsa-miR-4477a	CLIP-seq
MIRT2642650	hsa-miR-4519	CLIP-seq
MIRT2642651	hsa-miR-4530	CLIP-seq
MIRT2642652	hsa-miR-4639-5p	CLIP-seq
MIRT1425564	hsa-miR-4720-3p	CLIP-seq
MIRT2127529	hsa-miR-4797-5p	CLIP-seq
MIRT1425566	hsa-miR-4804-3p	CLIP-seq
MIRT2642653	hsa-miR-513a-3p	CLIP-seq
MIRT1425567	hsa-miR-545	CLIP-seq
MIRT2642654	hsa-miR-548aa	CLIP-seq
MIRT2127530	hsa-miR-548ag	CLIP-seq
MIRT2127531	hsa-miR-548ai	CLIP-seq
MIRT1425568	hsa-miR-548c-3p	CLIP-seq
MIRT2127532	hsa-miR-562	CLIP-seq
MIRT2127533	hsa-miR-599	CLIP-seq
MIRT2693205	hsa-miR-3545-3p	CLIP-seq
MIRT2127526	hsa-miR-3691-3p	CLIP-seq
MIRT1425549	hsa-miR-3913-3p	CLIP-seq
MIRT2693206	hsa-miR-3915	CLIP-seq
MIRT2693207	hsa-miR-3921	CLIP-seq
MIRT2693208	hsa-miR-3928	CLIP-seq
MIRT2693209	hsa-miR-4261	CLIP-seq
MIRT2693210	hsa-miR-4496	CLIP-seq
MIRT2693211	hsa-miR-4539	CLIP-seq
MIRT2693212	hsa-miR-4653-5p	CLIP-seq
MIRT1425564	hsa-miR-4720-3p	CLIP-seq
MIRT1425566	hsa-miR-4804-3p	CLIP-seq
MIRT2127533	hsa-miR-599	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	IDA	23275542
GO:0001570	Process	Vasculogenesis	IEA
GO:0001822	Process	Kidney development	IEA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IDA	23275542
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23275542, 30373764
GO:0005634	Component	Nucleus	IEA
GO:0008209	Process	Androgen metabolic process	IEA
GO:0008210	Process	Estrogen metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008585	Process	Female gonad development	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0010629	Process	Negative regulation of gene expression	IMP	23275542
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0030097	Process	Hemopoiesis	IEA
GO:0045732	Process	Positive regulation of protein catabolic process	IMP	23275542
GO:0046872	Function	Metal ion binding	IEA
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IEA
GO:0048705	Process	Skeletal system morphogenesis	IEA
GO:0048745	Process	Smooth muscle tissue development	IEA
GO:0060021	Process	Roof of mouth development	IEA
GO:0060325	Process	Face morphogenesis	IEA
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IDA	30373764
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IEA
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA
GO:0140807	Function	NAD+-protein-glutamate ADP-ribosyltransferase activity	IEA
GO:1904612	Process	Response to 2,3,7,8-tetrachlorodibenzodioxine	IEA
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IDA	25043379
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IEA

MIM	HGNC	e!Ensembl
612480	23696	ENSG00000163659

Q7Z3E1

Protein name

Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)

Protein function

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylati

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00644	PARP	471 → 650	Poly(ADP-ribose) polymerase catalytic domain	Family

Sequence

MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL
NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ
IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK
VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI
EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR
MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY
PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG
VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL
FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD
GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS
HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI

Sequence length

657

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (28)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	28505207, 31695491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33799807, 38011562	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	25173882, 27378695	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	28505207		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	28505207		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	28013023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	28013023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	GWASCAT_DG	25581431		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	25975270		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	28784648	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	33799807	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28505207, 31695491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	CTD_human_DG	20852632		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	GWASDB_DG	20852632, 23535730		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28013023, 31695491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	28505207		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	BEFREE	29302888		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	28013023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic syndrome	Pubtator	37486064	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	28013023		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	CTD_human_DG	20852632		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	GWASCAT_DG	20852632, 23535730		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	20852632, 22235027, 22253144, 23133607, 33475085	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	37077937	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	36012391	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	25975270, 29873790		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	37907864	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	34434692	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TIPARP (TCDD inducible poly(ADP-ribose) polymerase)