Gene Gene information from NCBI Gene database.
Entrez ID 2597
Gene name Glyceraldehyde-3-phosphate dehydrogenase
Gene symbol GAPDH
Synonyms (NCBI Gene)
G3PDGAPDHEL-S-162eP
Chromosome 12
Chromosome location 12p13.31
Summary This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catal
miRNA miRNA information provided by mirtarbase database.
318
miRTarBase ID miRNA Experiments Reference
MIRT001929 hsa-miR-29c-3p Luciferase reporter assay 18390668
MIRT007162 hsa-miR-644a Luciferase reporter assayqRT-PCRWestern blot 23091630
MIRT007162 hsa-miR-644a Luciferase reporter assayqRT-PCRWestern blot 23091630
MIRT052138 hsa-let-7b-5p CLASH 23622248
MIRT052138 hsa-let-7b-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
CEBPA Unknown 12842822
CEBPD Unknown 12842822
HIF1A Unknown 11955624
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
63
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization ISS
GO:0001819 Process Positive regulation of cytokine production IDA 22832495
GO:0002376 Process Immune system process IEA
GO:0004365 Function Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
GO:0004365 Function Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
138400 4141 ENSG00000111640
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P04406
Protein name Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)
Protein function Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in
PDB 1U8F , 1ZNQ , 3GPD , 4WNC , 4WNI , 6ADE , 6IQ6 , 6M61 , 6YND , 6YNE , 6YNF , 6YNH , 8DNS , 8G12 , 8G13 , 8G14 , 8G15 , 8G16 , 8G17 , 8P5F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00044 Gp_dh_N 4 105 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Domain
PF02800 Gp_dh_C 157 314 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Domain
Sequence
Sequence length 335
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glycolysis / Gluconeogenesis
Metabolic pathways
Carbon metabolism
Biosynthesis of amino acids
HIF-1 signaling pathway
Alzheimer disease
Pathogenic Escherichia coli infection
Salmonella infection
Diabetic cardiomyopathy
  Glycolysis
Gluconeogenesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
12
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMERS DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, SQUAMOUS CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acidosis Lactic Lactic acidosis Pubtator 19571378 Associate
★☆☆☆☆
Found in Text Mining only
Acth-Independent Macronodular Adrenal Hyperplasia Cushing`s Syndrome BEFREE 12466375
★☆☆☆☆
Found in Text Mining only
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 10768834, 10902805
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome CTD_human_DG 21751358
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 15293568
★☆☆☆☆
Found in Text Mining only
Acute Megakaryocytic Leukemias Megakaryocytic Leukemia BEFREE 16340238
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 17922974, 20494472, 3180054
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 14963017, 31421831
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma CTD_human_DG 27602772
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 3180054
★☆☆☆☆
Found in Text Mining only