Gene Gene information from NCBI Gene database.
Entrez ID 25940
Gene name Family with sequence similarity 98 member A
Gene symbol FAM98A
Synonyms (NCBI Gene)
-
Chromosome 2
Chromosome location 2p22.3
miRNA miRNA information provided by mirtarbase database.
429
miRTarBase ID miRNA Experiments Reference
MIRT021611 hsa-miR-142-3p Microarray 17612493
MIRT027055 hsa-miR-103a-3p Sequencing 20371350
MIRT029301 hsa-miR-26b-5p Microarray 19088304
MIRT040392 hsa-miR-615-3p CLASH 23622248
MIRT038831 hsa-miR-93-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 24608264, 25416956, 28040436, 29992460, 31515488, 33961781
GO:0005634 Component Nucleus NAS 21311021
GO:0005737 Component Cytoplasm NAS 21311021
GO:0006388 Process TRNA splicing, via endonucleolytic cleavage and ligation NAS 24870230
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620904 24520 ENSG00000119812
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NCA5
Protein name Protein FAM98A
Protein function Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarit
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10239 DUF2465 11 328 Protein of unknown function (DUF2465) Family
Tissue specificity TISSUE SPECIFICITY: Expressed strongly in colorectal cancer cells (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues
Sequence
Sequence length 518
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MOOD DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SARCOIDOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma of lung Lung carcinoma BEFREE 30100758
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Diabetes mellitus, type 2 Pubtator 27896979 Associate
★☆☆☆☆
Found in Text Mining only
Endometrial Carcinoma Endometrial carcinoma BEFREE 31114934
★☆☆☆☆
Found in Text Mining only
Endometrial Neoplasms Endometrial neoplasm Pubtator 34783205 Associate
★☆☆☆☆
Found in Text Mining only
Ischemic stroke Ischemic Stroke BEFREE 29997237
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 30100758
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 30100758
★☆☆☆☆
Found in Text Mining only
Non-Small Cell Lung Carcinoma Lung carcinoma BEFREE 30100758
★☆☆☆☆
Found in Text Mining only
Parathyroid Neoplasms Parathyroid neoplasm Pubtator 38509667 Associate
★☆☆☆☆
Found in Text Mining only