NSL1 (NSL1 component of MIS12 kinetochore complex)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 25936 |
| Gene name | NSL1 component of MIS12 kinetochore complex |
| Gene symbol | NSL1 |
| Synonyms (NCBI Gene) |
C1orf48DC8MIS14
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| Chromosome | 1 |
| Chromosome location | 1q32.3 |
| Summary | This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserv |
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miRNA
miRNA information provided by mirtarbase database.
637
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q96IY1 | ||||||||||
| Protein name | Kinetochore-associated protein NSL1 homolog | ||||||||||
| Protein function | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. | ||||||||||
| PDB | 4NF9 , 5LSI , 5LSJ , 5LSK , 8PPR , 8Q5H | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 281 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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