CNRIP1 (cannabinoid receptor interacting protein 1)

Gene

• Entrez ID: 25927
• Gene name: Cannabinoid receptor interacting protein 1
• Gene symbol: CNRIP1
• Synonyms (NCBI Gene): C2orf32, CRIP-1, CRIP1
• Chromosome: 2
• Chromosome location: 2p14
• Summary: This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT046968	hsa-miR-221-3p	CLASH	23622248
MIRT901409	hsa-miR-1253	CLIP-seq
MIRT901410	hsa-miR-4290	CLIP-seq
MIRT901411	hsa-miR-4677-3p	CLIP-seq
MIRT901412	hsa-miR-4687-5p	CLIP-seq
MIRT901413	hsa-miR-2276	CLIP-seq
MIRT901414	hsa-miR-4666-5p	CLIP-seq
MIRT1967396	hsa-miR-3149	CLIP-seq
MIRT1967397	hsa-miR-4719	CLIP-seq
MIRT1967398	hsa-miR-5096	CLIP-seq
MIRT1967399	hsa-miR-513b	CLIP-seq
MIRT2506001	hsa-miR-25	CLIP-seq
MIRT2506002	hsa-miR-3120-3p	CLIP-seq
MIRT2506003	hsa-miR-3140-3p	CLIP-seq
MIRT2506004	hsa-miR-32	CLIP-seq
MIRT2506005	hsa-miR-340	CLIP-seq
MIRT2506006	hsa-miR-361-3p	CLIP-seq
MIRT2506007	hsa-miR-363	CLIP-seq
MIRT2506008	hsa-miR-367	CLIP-seq
MIRT2506009	hsa-miR-3679-3p	CLIP-seq
MIRT2506010	hsa-miR-374c	CLIP-seq
MIRT2506011	hsa-miR-3908	CLIP-seq
MIRT2506012	hsa-miR-4446-5p	CLIP-seq
MIRT2506013	hsa-miR-4717-5p	CLIP-seq
MIRT2506014	hsa-miR-645	CLIP-seq
MIRT2506015	hsa-miR-655	CLIP-seq
MIRT2506016	hsa-miR-668	CLIP-seq
MIRT2506017	hsa-miR-92a	CLIP-seq
MIRT2506018	hsa-miR-92b	CLIP-seq
MIRT2506001	hsa-miR-25	CLIP-seq
MIRT2506002	hsa-miR-3120-3p	CLIP-seq
MIRT2506003	hsa-miR-3140-3p	CLIP-seq
MIRT2506004	hsa-miR-32	CLIP-seq
MIRT2506005	hsa-miR-340	CLIP-seq
MIRT2506006	hsa-miR-361-3p	CLIP-seq
MIRT2506007	hsa-miR-363	CLIP-seq
MIRT2506008	hsa-miR-367	CLIP-seq
MIRT2506009	hsa-miR-3679-3p	CLIP-seq
MIRT2506010	hsa-miR-374c	CLIP-seq
MIRT2506011	hsa-miR-3908	CLIP-seq
MIRT2506012	hsa-miR-4446-5p	CLIP-seq
MIRT2506013	hsa-miR-4717-5p	CLIP-seq
MIRT2506014	hsa-miR-645	CLIP-seq
MIRT2506015	hsa-miR-655	CLIP-seq
MIRT2506016	hsa-miR-668	CLIP-seq
MIRT2506017	hsa-miR-92a	CLIP-seq
MIRT2506018	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17895407, 32296183
GO:0005737	Component	Cytoplasm	IDA	17895407
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17895407
GO:0010469	Process	Regulation of signaling receptor activity	IDA	17895407
GO:0031718	Function	Type 1 cannabinoid receptor binding	IBA
GO:0031718	Function	Type 1 cannabinoid receptor binding	IEA
GO:0031718	Function	Type 1 cannabinoid receptor binding	IPI	17895407
GO:0098793	Component	Presynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0150036	Process	Regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IEA
GO:2000272	Process	Negative regulation of signaling receptor activity	IDA	17895407

Other IDs

• MIM: 618538
• HGNC: 24546
• e!Ensembl: ENSG00000119865

Protein

• UniProt ID: Q96F85
• Protein name: CB1 cannabinoid receptor-interacting protein 1 (CRIP-1)
• Protein function: [Isoform 1]: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. ; [Isoform 2]: Does not suppress cannabinoid receptor CNR1-mediated tonic inhibition of voltag
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15043	CNRIP1	4 → 163	CB1 cannabinoid receptor-interacting protein 1	Family

• Sequence:

  MGDLPGLVRLSIALRIQPNDGPVFYKVDGQRFGQNRTIKLLTGSSYKVEVKIKPSTLQVE
  NISIGGVLVPLELKSKEPDGDRVVYTGTYDTEGVTPTKSGERQPIQITMPFTDIGTFETV
  WQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNKESFL

• Sequence length: 164

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DEAFNESS, AUTOSOMAL DOMINANT 58	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	BEFREE	22970180		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	23570421		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22647880, 23570421, 35150481	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34585826	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35775648	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	34413913	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomegaly	Cardiomegaly	Pubtator	28784648	Associate	★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	28784648		★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	29959029		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	29959029		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	25644509	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	29179181		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28940471, 29179181, 29181058, 30850009, 31312368		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21777459, 24362313, 29179181	Associate	★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	28915434		★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	24362313		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	31614728		★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	12498717	Associate	★☆☆☆☆ Found in Text Mining only
Hearing Loss	Hearing loss	Pubtator	37595341	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	28784648	Associate	★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	BEFREE	30624666		★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	21882188		★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	37400623	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	31577790, 35924822	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	31577790		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31141535		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic Metastasis	BEFREE	29059670		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	29059670	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	34413913, 34585826, 37409440	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23570421		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22144904, 29179181		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	29959029		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29179181		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	34261404	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10226527, 23570421, 29059670, 30850009		★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	30522798		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	32788627	Associate	★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	22202598		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	22202598	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34413913, 35140819	Associate	★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	30522798		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	33986404	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	21882188		★☆☆☆☆ Found in Text Mining only
Reactive hypoglycemia	Reactive hypoglycemia	BEFREE	30624666		★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	33316779, 34294833	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	30522798, 31614728		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	22202598, 34262130, 37409440	Associate	★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	28784648	Stimulate	★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	29059670		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	29059670	Stimulate	★☆☆☆☆ Found in Text Mining only
Vesicular Stomatitis	Vesicular Stomatitis	BEFREE	8280795		★☆☆☆☆ Found in Text Mining only