OLFML2B (olfactomedin like 2B)

Gene

• Entrez ID: 25903
• Gene name: Olfactomedin like 2B
• Gene symbol: OLFML2B
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q23.3
• Summary: This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT046128	hsa-miR-30b-5p	CLASH	23622248
MIRT1203265	hsa-miR-3135b	CLIP-seq
MIRT1203266	hsa-miR-3184	CLIP-seq
MIRT1203267	hsa-miR-423-5p	CLIP-seq
MIRT1203268	hsa-miR-432	CLIP-seq
MIRT1203269	hsa-miR-4487	CLIP-seq
MIRT1203270	hsa-miR-4493	CLIP-seq
MIRT1203271	hsa-miR-4633-3p	CLIP-seq
MIRT1203272	hsa-miR-4656	CLIP-seq
MIRT1203273	hsa-miR-548a-3p	CLIP-seq
MIRT1203274	hsa-miR-548e	CLIP-seq
MIRT1203275	hsa-miR-548f	CLIP-seq
MIRT1203276	hsa-miR-890	CLIP-seq
MIRT2455631	hsa-miR-3152-5p	CLIP-seq
MIRT2455632	hsa-miR-578	CLIP-seq
MIRT2455631	hsa-miR-3152-5p	CLIP-seq
MIRT2455632	hsa-miR-578	CLIP-seq
MIRT1203265	hsa-miR-3135b	CLIP-seq
MIRT1203266	hsa-miR-3184	CLIP-seq
MIRT2585207	hsa-miR-3672	CLIP-seq
MIRT1203267	hsa-miR-423-5p	CLIP-seq
MIRT1203268	hsa-miR-432	CLIP-seq
MIRT1203269	hsa-miR-4487	CLIP-seq
MIRT1203270	hsa-miR-4493	CLIP-seq
MIRT1203271	hsa-miR-4633-3p	CLIP-seq
MIRT2585208	hsa-miR-4635	CLIP-seq
MIRT1203272	hsa-miR-4656	CLIP-seq
MIRT1203276	hsa-miR-890	CLIP-seq
MIRT2686835	hsa-miR-1252	CLIP-seq
MIRT1203265	hsa-miR-3135b	CLIP-seq
MIRT1203266	hsa-miR-3184	CLIP-seq
MIRT2585207	hsa-miR-3672	CLIP-seq
MIRT2686836	hsa-miR-409-5p	CLIP-seq
MIRT1203267	hsa-miR-423-5p	CLIP-seq
MIRT1203268	hsa-miR-432	CLIP-seq
MIRT2686837	hsa-miR-4428	CLIP-seq
MIRT2686838	hsa-miR-4434	CLIP-seq
MIRT2686839	hsa-miR-4476	CLIP-seq
MIRT1203269	hsa-miR-4487	CLIP-seq
MIRT1203270	hsa-miR-4493	CLIP-seq
MIRT2686840	hsa-miR-4516	CLIP-seq
MIRT1203271	hsa-miR-4633-3p	CLIP-seq
MIRT2585208	hsa-miR-4635	CLIP-seq
MIRT1203272	hsa-miR-4656	CLIP-seq
MIRT2686841	hsa-miR-507	CLIP-seq
MIRT2686842	hsa-miR-557	CLIP-seq
MIRT2686843	hsa-miR-579	CLIP-seq
MIRT2686844	hsa-miR-876-3p	CLIP-seq
MIRT1203276	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0007165	Process	Signal transduction	IBA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0050840	Function	Extracellular matrix binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q68BL8
• Protein name: Olfactomedin-like protein 2B (Photomedin-2)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02191	OLF	498 → 748	Olfactomedin-like domain	Family

• Sequence:

  MAKPRLLVLYFALIVVPAWVSSIVLTGTSEPPDAQTVAPAEDETLQNEADNQENVLSQLL
  GDYDKVKAMSEGSDCQCKCVVRPLGRDACQRINAGASRKEDFYTVETITSGSSCKCACVA
  PPSALNPCEGDFRLQKLREADSQDLKLSTIIDMLEGAFYGLDLLKLHSVTTKLVGRVDKL
  EEEVSKNLTKENEQIKEDMEEIRTEMNKRGKENCSENILDSMPDIRSALQRDAAAAYAHP
  EYEERFLQEETVSQQINSIELLQTRPLALPEVVKSQRPLQRQVHLRGRPASQPTVIRGIT
  YYKAKVSEEENDIEEQQDEFFSGDNGVDLLIEDQLLRHNGLMTSVTRRPAATRQGHSTAV
  TSDLNARTAPWSSALPQPSTSDPSIANHASVGPTLQTTSVSPDPTRESVLQPSPQVPATT
  VAHTATQQPAAPAPPAVSPREALMEAMHTVPVPPTTVRTDSLGKDAPAGWGTTPASPTLS
  PEEEDDIRNVIGRCKDTLSTITGPTTQNTYGRNEGAWMKDPLAKDERIYVTNYYYGNTLV
  EFRNLENFKQGRWSNSYKLPYSWIGTGHVVYNGAFYYNRAFTRNIIKYDLKQRYVAAWAM
  LHDVAYEEATPWRWQGHSDVDFAVDENGLWLIYPALDDEGFSQEVIVLSKLNAADLSTQK
  ETTWRTGLRRNFYGNCFVICGVLYAVDSYNQRNANISYAFDTHTNTQIVPRLLFENEYSY
  TTQIDYNPKDRLLYAWDNGHQVTYHVIFAY

• Sequence length: 750

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL LONG QT SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37340445	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30866865, 31370831		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30866865, 31370831		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	30866865, 32908579, 33015704	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	36999020	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	33204728	Associate	★☆☆☆☆ Found in Text Mining only