Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	25900
Gene name	Intermediate filament family orphan 1
Gene symbol	IFFO1
Synonyms (NCBI Gene)	HOM-TES-103IFFO
Chromosome	12
Chromosome location	12p13.31
Summary	This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structu

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Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT450840	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT450844	hsa-miR-520f-3p	PAR-CLIP	22100165
MIRT450843	hsa-miR-302b-3p	PAR-CLIP	22100165
MIRT450842	hsa-miR-520e	PAR-CLIP	22100165
MIRT450841	hsa-miR-302a-3p	PAR-CLIP	22100165
MIRT450840	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT450839	hsa-miR-302d-3p	PAR-CLIP	22100165
MIRT450838	hsa-miR-302e	PAR-CLIP	22100165
MIRT450837	hsa-miR-372-3p	PAR-CLIP	22100165
MIRT450835	hsa-miR-373-3p	PAR-CLIP	22100165
MIRT450836	hsa-miR-520b	PAR-CLIP	22100165
MIRT450834	hsa-miR-520a-3p	PAR-CLIP	22100165
MIRT450833	hsa-miR-520d-3p	PAR-CLIP	22100165
MIRT450832	hsa-miR-520c-3p	PAR-CLIP	22100165
MIRT450831	hsa-miR-4476	PAR-CLIP	22100165
MIRT450830	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT450829	hsa-miR-4524a-3p	PAR-CLIP	22100165
MIRT450828	hsa-miR-636	PAR-CLIP	22100165
MIRT450826	hsa-miR-3672	PAR-CLIP	22100165
MIRT450827	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT450825	hsa-miR-1273e	PAR-CLIP	22100165
MIRT450840	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT450844	hsa-miR-520f-3p	PAR-CLIP	22100165
MIRT450843	hsa-miR-302b-3p	PAR-CLIP	22100165
MIRT450842	hsa-miR-520e	PAR-CLIP	22100165
MIRT450841	hsa-miR-302a-3p	PAR-CLIP	22100165
MIRT450840	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT450839	hsa-miR-302d-3p	PAR-CLIP	22100165
MIRT450838	hsa-miR-302e	PAR-CLIP	22100165
MIRT450837	hsa-miR-372-3p	PAR-CLIP	22100165
MIRT450835	hsa-miR-373-3p	PAR-CLIP	22100165
MIRT450836	hsa-miR-520b	PAR-CLIP	22100165
MIRT450834	hsa-miR-520a-3p	PAR-CLIP	22100165
MIRT450833	hsa-miR-520d-3p	PAR-CLIP	22100165
MIRT450832	hsa-miR-520c-3p	PAR-CLIP	22100165
MIRT450831	hsa-miR-4476	PAR-CLIP	22100165
MIRT450830	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT450829	hsa-miR-4524a-3p	PAR-CLIP	22100165
MIRT450828	hsa-miR-636	PAR-CLIP	22100165
MIRT450826	hsa-miR-3672	PAR-CLIP	22100165
MIRT450827	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT450825	hsa-miR-1273e	PAR-CLIP	22100165
MIRT1060013	hsa-miR-103a	CLIP-seq
MIRT1060014	hsa-miR-107	CLIP-seq
MIRT1060015	hsa-miR-1184	CLIP-seq
MIRT1060016	hsa-miR-1205	CLIP-seq
MIRT1060017	hsa-miR-149	CLIP-seq
MIRT1060018	hsa-miR-2110	CLIP-seq
MIRT1060019	hsa-miR-3126-5p	CLIP-seq
MIRT1060020	hsa-miR-3128	CLIP-seq
MIRT1060021	hsa-miR-3158-5p	CLIP-seq
MIRT1060022	hsa-miR-3160-3p	CLIP-seq
MIRT1060023	hsa-miR-3166	CLIP-seq
MIRT1060024	hsa-miR-3687	CLIP-seq
MIRT1060025	hsa-miR-412	CLIP-seq
MIRT1060026	hsa-miR-4254	CLIP-seq
MIRT1060027	hsa-miR-4271	CLIP-seq
MIRT1060028	hsa-miR-4308	CLIP-seq
MIRT1060029	hsa-miR-4310	CLIP-seq
MIRT1060030	hsa-miR-4419a	CLIP-seq
MIRT1060031	hsa-miR-4434	CLIP-seq
MIRT1060032	hsa-miR-4442	CLIP-seq
MIRT1060033	hsa-miR-4487	CLIP-seq
MIRT1060034	hsa-miR-4499	CLIP-seq
MIRT1060035	hsa-miR-4510	CLIP-seq
MIRT1060036	hsa-miR-4516	CLIP-seq
MIRT1060037	hsa-miR-4531	CLIP-seq
MIRT1060038	hsa-miR-4633-3p	CLIP-seq
MIRT1060039	hsa-miR-4643	CLIP-seq
MIRT1060040	hsa-miR-4720-5p	CLIP-seq
MIRT1060041	hsa-miR-4725-3p	CLIP-seq
MIRT1060042	hsa-miR-4786-3p	CLIP-seq
MIRT1060043	hsa-miR-4799-3p	CLIP-seq
MIRT1060044	hsa-miR-544	CLIP-seq
MIRT1060045	hsa-miR-558	CLIP-seq
MIRT1060046	hsa-miR-562	CLIP-seq
MIRT1060047	hsa-miR-616	CLIP-seq
MIRT1060048	hsa-miR-885-3p	CLIP-seq
MIRT1060049	hsa-miR-942	CLIP-seq
MIRT1060050	hsa-miR-1321	CLIP-seq
MIRT1060019	hsa-miR-3126-5p	CLIP-seq
MIRT1060051	hsa-miR-339-3p	CLIP-seq
MIRT1060052	hsa-miR-4293	CLIP-seq
MIRT1060030	hsa-miR-4419a	CLIP-seq
MIRT1060035	hsa-miR-4510	CLIP-seq
MIRT1060053	hsa-miR-4739	CLIP-seq
MIRT1060054	hsa-miR-4756-5p	CLIP-seq
MIRT1060055	hsa-miR-544b	CLIP-seq
MIRT1060056	hsa-miR-765	CLIP-seq
MIRT2246157	hsa-miR-1323	CLIP-seq
MIRT2246158	hsa-miR-141	CLIP-seq
MIRT2246159	hsa-miR-200a	CLIP-seq
MIRT2246160	hsa-miR-4287	CLIP-seq
MIRT2246161	hsa-miR-4685-3p	CLIP-seq
MIRT2246162	hsa-miR-548o	CLIP-seq
MIRT1060015	hsa-miR-1184	CLIP-seq
MIRT1060016	hsa-miR-1205	CLIP-seq
MIRT2549294	hsa-miR-125a-5p	CLIP-seq
MIRT2549295	hsa-miR-125b	CLIP-seq
MIRT2549296	hsa-miR-3138	CLIP-seq
MIRT1060021	hsa-miR-3158-5p	CLIP-seq
MIRT2549297	hsa-miR-3184	CLIP-seq
MIRT1060051	hsa-miR-339-3p	CLIP-seq
MIRT2549298	hsa-miR-3714	CLIP-seq
MIRT1060025	hsa-miR-412	CLIP-seq
MIRT2549299	hsa-miR-423-5p	CLIP-seq
MIRT2549300	hsa-miR-4319	CLIP-seq
MIRT2549301	hsa-miR-4462	CLIP-seq
MIRT2549302	hsa-miR-4493	CLIP-seq
MIRT1060038	hsa-miR-4633-3p	CLIP-seq
MIRT1060039	hsa-miR-4643	CLIP-seq
MIRT2549303	hsa-miR-4710	CLIP-seq
MIRT2549304	hsa-miR-4722-5p	CLIP-seq
MIRT2549305	hsa-miR-4725-5p	CLIP-seq
MIRT2549306	hsa-miR-4761-5p	CLIP-seq
MIRT2549307	hsa-miR-4768-3p	CLIP-seq
MIRT2549308	hsa-miR-504	CLIP-seq
MIRT1060044	hsa-miR-544	CLIP-seq
MIRT1060047	hsa-miR-616	CLIP-seq
MIRT2549309	hsa-miR-624	CLIP-seq
MIRT2549310	hsa-miR-940	CLIP-seq
MIRT1060049	hsa-miR-942	CLIP-seq
MIRT1060015	hsa-miR-1184	CLIP-seq
MIRT1060016	hsa-miR-1205	CLIP-seq
MIRT2549294	hsa-miR-125a-5p	CLIP-seq
MIRT2549295	hsa-miR-125b	CLIP-seq
MIRT1060021	hsa-miR-3158-5p	CLIP-seq
MIRT1060051	hsa-miR-339-3p	CLIP-seq
MIRT1060025	hsa-miR-412	CLIP-seq
MIRT2549300	hsa-miR-4319	CLIP-seq
MIRT2549301	hsa-miR-4462	CLIP-seq
MIRT2682589	hsa-miR-451b	CLIP-seq
MIRT1060038	hsa-miR-4633-3p	CLIP-seq
MIRT1060039	hsa-miR-4643	CLIP-seq
MIRT2549305	hsa-miR-4725-5p	CLIP-seq
MIRT2549307	hsa-miR-4768-3p	CLIP-seq
MIRT2549308	hsa-miR-504	CLIP-seq
MIRT1060044	hsa-miR-544	CLIP-seq
MIRT1060047	hsa-miR-616	CLIP-seq
MIRT2682590	hsa-miR-665	CLIP-seq
MIRT1060049	hsa-miR-942	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 31548606, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005637	Component	Nuclear inner membrane	IEA
GO:0005654	Component	Nucleoplasm	IDA	31548606
GO:0005654	Component	Nucleoplasm	IEA
GO:0005882	Component	Intermediate filament	IEA
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	IMP	31548606
GO:0016020	Component	Membrane	IEA
GO:0016363	Component	Nuclear matrix	IDA	31548606
GO:0016363	Component	Nuclear matrix	IEA
GO:0035861	Component	Site of double-strand break	IDA	31548606
GO:1990166	Process	Protein localization to site of double-strand break	IMP	31548606
GO:1990683	Process	DNA double-strand break attachment to nuclear envelope	IDA	31548606

MIM	HGNC	e!Ensembl
610495	24970	ENSG00000010295

Q0D2I5

Protein name

Non-homologous end joining factor IFFO1 (NHEJ factor IFFO1) (Intermediate filament family orphan 1) (Tumor antigen HOM-TES-103)

Protein function

Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the

PDB

6ABO

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:12032826}.

Sequence

MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAP
PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLG
RRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTS
TSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRA
LYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAE
LVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPS
MGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCD
SLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQI
ELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPP
PPSEAEDSDRDVSSDSSMR

Sequence length

559

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	35173266	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	22163280		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	35173266	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	22163280		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	22163280		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	22163280	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

IFFO1 (intermediate filament family orphan 1)