TRIM58 (tripartite motif containing 58)

Gene

• Entrez ID: 25893
• Gene name: Tripartite motif containing 58
• Gene symbol: TRIM58
• Synonyms (NCBI Gene): BIA2
• Chromosome: 1
• Chromosome location: 1q44

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029012	hsa-miR-26b-5p	Microarray	19088304
MIRT516609	hsa-miR-4438	HITS-CLIP	23313552
MIRT693320	hsa-miR-1295b-5p	HITS-CLIP	23313552
MIRT693319	hsa-miR-1912	HITS-CLIP	23313552
MIRT693318	hsa-miR-3130-5p	HITS-CLIP	23313552
MIRT693317	hsa-miR-4482-5p	HITS-CLIP	23313552
MIRT693316	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT693315	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT693314	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT516604	hsa-miR-4252	HITS-CLIP	23313552
MIRT693313	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT693312	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT516605	hsa-miR-5095	HITS-CLIP	23313552
MIRT516603	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT516602	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT693311	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT516609	hsa-miR-4438	PAR-CLIP	23446348
MIRT516610	hsa-miR-500b-3p	PAR-CLIP	23446348
MIRT516608	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT516607	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT516606	hsa-miR-3130-3p	PAR-CLIP	23446348
MIRT516604	hsa-miR-4252	PAR-CLIP	23446348
MIRT516605	hsa-miR-5095	PAR-CLIP	23446348
MIRT516603	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT516602	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT516609	hsa-miR-4438	HITS-CLIP	23313552
MIRT693320	hsa-miR-1295b-5p	HITS-CLIP	23313552
MIRT693319	hsa-miR-1912	HITS-CLIP	23313552
MIRT693318	hsa-miR-3130-5p	HITS-CLIP	23313552
MIRT693317	hsa-miR-4482-5p	HITS-CLIP	23313552
MIRT693316	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT693315	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT693314	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT516604	hsa-miR-4252	HITS-CLIP	23313552
MIRT693313	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT693312	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT516605	hsa-miR-5095	HITS-CLIP	23313552
MIRT516603	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT516602	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT693311	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT516609	hsa-miR-4438	PAR-CLIP	23446348
MIRT516610	hsa-miR-500b-3p	PAR-CLIP	23446348
MIRT516608	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT516607	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT516606	hsa-miR-3130-3p	PAR-CLIP	23446348
MIRT516604	hsa-miR-4252	PAR-CLIP	23446348
MIRT516605	hsa-miR-5095	PAR-CLIP	23446348
MIRT516603	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT516602	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT1455238	hsa-miR-106a	CLIP-seq
MIRT1455239	hsa-miR-106b	CLIP-seq
MIRT1455240	hsa-miR-1193	CLIP-seq
MIRT1455241	hsa-miR-1200	CLIP-seq
MIRT1455242	hsa-miR-1208	CLIP-seq
MIRT1455243	hsa-miR-1224-3p	CLIP-seq
MIRT1455244	hsa-miR-128	CLIP-seq
MIRT1455245	hsa-miR-1281	CLIP-seq
MIRT1455246	hsa-miR-1302	CLIP-seq
MIRT1455247	hsa-miR-1304	CLIP-seq
MIRT1455248	hsa-miR-1343	CLIP-seq
MIRT1455249	hsa-miR-150	CLIP-seq
MIRT1455250	hsa-miR-17	CLIP-seq
MIRT1455251	hsa-miR-185	CLIP-seq
MIRT1455252	hsa-miR-1913	CLIP-seq
MIRT1455253	hsa-miR-197	CLIP-seq
MIRT1455254	hsa-miR-1976	CLIP-seq
MIRT1455255	hsa-miR-20a	CLIP-seq
MIRT1455256	hsa-miR-20b	CLIP-seq
MIRT1455257	hsa-miR-224	CLIP-seq
MIRT1455258	hsa-miR-2392	CLIP-seq
MIRT1455259	hsa-miR-302a	CLIP-seq
MIRT1455260	hsa-miR-302b	CLIP-seq
MIRT1455261	hsa-miR-302c	CLIP-seq
MIRT1455262	hsa-miR-302d	CLIP-seq
MIRT1455263	hsa-miR-302e	CLIP-seq
MIRT1455264	hsa-miR-3152-3p	CLIP-seq
MIRT1455265	hsa-miR-3187-3p	CLIP-seq
MIRT1455266	hsa-miR-3199	CLIP-seq
MIRT1455267	hsa-miR-324-3p	CLIP-seq
MIRT1455268	hsa-miR-338-3p	CLIP-seq
MIRT1455269	hsa-miR-3545-3p	CLIP-seq
MIRT1455270	hsa-miR-3663-5p	CLIP-seq
MIRT1455271	hsa-miR-372	CLIP-seq
MIRT1455272	hsa-miR-373	CLIP-seq
MIRT1455273	hsa-miR-3923	CLIP-seq
MIRT1455274	hsa-miR-3974	CLIP-seq
MIRT1455275	hsa-miR-411	CLIP-seq
MIRT1455276	hsa-miR-4270	CLIP-seq
MIRT1455277	hsa-miR-4298	CLIP-seq
MIRT1455278	hsa-miR-4306	CLIP-seq
MIRT1455279	hsa-miR-4311	CLIP-seq
MIRT1455280	hsa-miR-4324	CLIP-seq
MIRT1455281	hsa-miR-4420	CLIP-seq
MIRT1455282	hsa-miR-4435	CLIP-seq
MIRT1455283	hsa-miR-4441	CLIP-seq
MIRT1455284	hsa-miR-4515	CLIP-seq
MIRT1455285	hsa-miR-4517	CLIP-seq
MIRT1455286	hsa-miR-4635	CLIP-seq
MIRT1455287	hsa-miR-4644	CLIP-seq
MIRT1455288	hsa-miR-4662a-5p	CLIP-seq
MIRT1455289	hsa-miR-4676-5p	CLIP-seq
MIRT1455290	hsa-miR-4679	CLIP-seq
MIRT1455291	hsa-miR-4680-5p	CLIP-seq
MIRT1455292	hsa-miR-4685-5p	CLIP-seq
MIRT1455293	hsa-miR-4686	CLIP-seq
MIRT1455294	hsa-miR-4693-3p	CLIP-seq
MIRT1455295	hsa-miR-4701-5p	CLIP-seq
MIRT1455296	hsa-miR-4716-5p	CLIP-seq
MIRT1455297	hsa-miR-4755-3p	CLIP-seq
MIRT1455298	hsa-miR-4772-3p	CLIP-seq
MIRT1455299	hsa-miR-4781-3p	CLIP-seq
MIRT1455300	hsa-miR-4781-5p	CLIP-seq
MIRT1455301	hsa-miR-4795-3p	CLIP-seq
MIRT1455302	hsa-miR-498	CLIP-seq
MIRT1455303	hsa-miR-501-3p	CLIP-seq
MIRT1455304	hsa-miR-502-3p	CLIP-seq
MIRT1455305	hsa-miR-5096	CLIP-seq
MIRT1455306	hsa-miR-512-3p	CLIP-seq
MIRT1455307	hsa-miR-519d	CLIP-seq
MIRT1455308	hsa-miR-520a-3p	CLIP-seq
MIRT1455309	hsa-miR-520b	CLIP-seq
MIRT1455310	hsa-miR-520c-3p	CLIP-seq
MIRT1455311	hsa-miR-520d-3p	CLIP-seq
MIRT1455312	hsa-miR-520d-5p	CLIP-seq
MIRT1455313	hsa-miR-520e	CLIP-seq
MIRT1455314	hsa-miR-520g	CLIP-seq
MIRT1455315	hsa-miR-520h	CLIP-seq
MIRT1455316	hsa-miR-524-5p	CLIP-seq
MIRT1455317	hsa-miR-542-3p	CLIP-seq
MIRT1455318	hsa-miR-544b	CLIP-seq
MIRT1455319	hsa-miR-548s	CLIP-seq
MIRT1455320	hsa-miR-575	CLIP-seq
MIRT1455321	hsa-miR-588	CLIP-seq
MIRT1455322	hsa-miR-628-3p	CLIP-seq
MIRT1455323	hsa-miR-634	CLIP-seq
MIRT1455324	hsa-miR-640	CLIP-seq
MIRT1455325	hsa-miR-892a	CLIP-seq
MIRT1455326	hsa-miR-93	CLIP-seq
MIRT1455327	hsa-miR-944	CLIP-seq
MIRT1455238	hsa-miR-106a	CLIP-seq
MIRT1455239	hsa-miR-106b	CLIP-seq
MIRT1455240	hsa-miR-1193	CLIP-seq
MIRT2136469	hsa-miR-1206	CLIP-seq
MIRT1455242	hsa-miR-1208	CLIP-seq
MIRT2136470	hsa-miR-122	CLIP-seq
MIRT1455243	hsa-miR-1224-3p	CLIP-seq
MIRT2136471	hsa-miR-1234	CLIP-seq
MIRT2136472	hsa-miR-1252	CLIP-seq
MIRT2136473	hsa-miR-1253	CLIP-seq
MIRT2136474	hsa-miR-1267	CLIP-seq
MIRT2136475	hsa-miR-1273f	CLIP-seq
MIRT1455245	hsa-miR-1281	CLIP-seq
MIRT2136476	hsa-miR-1289	CLIP-seq
MIRT1455246	hsa-miR-1302	CLIP-seq
MIRT2136477	hsa-miR-1307	CLIP-seq
MIRT1455248	hsa-miR-1343	CLIP-seq
MIRT1455249	hsa-miR-150	CLIP-seq
MIRT2136478	hsa-miR-1587	CLIP-seq
MIRT1455250	hsa-miR-17	CLIP-seq
MIRT1455251	hsa-miR-185	CLIP-seq
MIRT1455252	hsa-miR-1913	CLIP-seq
MIRT1455253	hsa-miR-197	CLIP-seq
MIRT1455254	hsa-miR-1976	CLIP-seq
MIRT1455255	hsa-miR-20a	CLIP-seq
MIRT1455256	hsa-miR-20b	CLIP-seq
MIRT1455258	hsa-miR-2392	CLIP-seq
MIRT2136479	hsa-miR-24	CLIP-seq
MIRT1455259	hsa-miR-302a	CLIP-seq
MIRT1455260	hsa-miR-302b	CLIP-seq
MIRT1455261	hsa-miR-302c	CLIP-seq
MIRT1455262	hsa-miR-302d	CLIP-seq
MIRT1455263	hsa-miR-302e	CLIP-seq
MIRT2136480	hsa-miR-3123	CLIP-seq
MIRT2136481	hsa-miR-3135b	CLIP-seq
MIRT1455264	hsa-miR-3152-3p	CLIP-seq
MIRT1455265	hsa-miR-3187-3p	CLIP-seq
MIRT2136482	hsa-miR-3194-3p	CLIP-seq
MIRT2136483	hsa-miR-3198	CLIP-seq
MIRT1455266	hsa-miR-3199	CLIP-seq
MIRT1455267	hsa-miR-324-3p	CLIP-seq
MIRT1455269	hsa-miR-3545-3p	CLIP-seq
MIRT2136484	hsa-miR-3652	CLIP-seq
MIRT1455270	hsa-miR-3663-5p	CLIP-seq
MIRT1455271	hsa-miR-372	CLIP-seq
MIRT1455272	hsa-miR-373	CLIP-seq
MIRT2136485	hsa-miR-378g	CLIP-seq
MIRT1455275	hsa-miR-411	CLIP-seq
MIRT2136486	hsa-miR-4255	CLIP-seq
MIRT2136487	hsa-miR-4257	CLIP-seq
MIRT2136488	hsa-miR-4269	CLIP-seq
MIRT2136489	hsa-miR-4271	CLIP-seq
MIRT2136490	hsa-miR-4279	CLIP-seq
MIRT2136491	hsa-miR-4284	CLIP-seq
MIRT2136492	hsa-miR-4294	CLIP-seq
MIRT1455277	hsa-miR-4298	CLIP-seq
MIRT1455278	hsa-miR-4306	CLIP-seq
MIRT2136493	hsa-miR-4309	CLIP-seq
MIRT2136494	hsa-miR-433	CLIP-seq
MIRT1455281	hsa-miR-4420	CLIP-seq
MIRT2136495	hsa-miR-4421	CLIP-seq
MIRT2136496	hsa-miR-4423-5p	CLIP-seq
MIRT2136497	hsa-miR-4428	CLIP-seq
MIRT2136498	hsa-miR-4430	CLIP-seq
MIRT1455282	hsa-miR-4435	CLIP-seq
MIRT2136499	hsa-miR-4492	CLIP-seq
MIRT2136500	hsa-miR-4498	CLIP-seq
MIRT1455284	hsa-miR-4515	CLIP-seq
MIRT2136501	hsa-miR-4533	CLIP-seq
MIRT2136502	hsa-miR-4534	CLIP-seq
MIRT2136503	hsa-miR-4634	CLIP-seq
MIRT1455286	hsa-miR-4635	CLIP-seq
MIRT2136504	hsa-miR-4638-5p	CLIP-seq
MIRT1455287	hsa-miR-4644	CLIP-seq
MIRT2136505	hsa-miR-4656	CLIP-seq
MIRT1455288	hsa-miR-4662a-5p	CLIP-seq
MIRT2136506	hsa-miR-4675	CLIP-seq
MIRT1455289	hsa-miR-4676-5p	CLIP-seq
MIRT1455291	hsa-miR-4680-5p	CLIP-seq
MIRT1455292	hsa-miR-4685-5p	CLIP-seq
MIRT1455295	hsa-miR-4701-5p	CLIP-seq
MIRT2136507	hsa-miR-4707-5p	CLIP-seq
MIRT2136508	hsa-miR-4710	CLIP-seq
MIRT1455296	hsa-miR-4716-5p	CLIP-seq
MIRT2136509	hsa-miR-4722-3p	CLIP-seq
MIRT2136510	hsa-miR-4725-3p	CLIP-seq
MIRT2136511	hsa-miR-4741	CLIP-seq
MIRT2136512	hsa-miR-4747-5p	CLIP-seq
MIRT1455297	hsa-miR-4755-3p	CLIP-seq
MIRT2136513	hsa-miR-4768-3p	CLIP-seq
MIRT1455298	hsa-miR-4772-3p	CLIP-seq
MIRT1455299	hsa-miR-4781-3p	CLIP-seq
MIRT2136514	hsa-miR-4792	CLIP-seq
MIRT1455305	hsa-miR-5096	CLIP-seq
MIRT1455306	hsa-miR-512-3p	CLIP-seq
MIRT1455307	hsa-miR-519d	CLIP-seq
MIRT1455308	hsa-miR-520a-3p	CLIP-seq
MIRT1455309	hsa-miR-520b	CLIP-seq
MIRT1455310	hsa-miR-520c-3p	CLIP-seq
MIRT1455311	hsa-miR-520d-3p	CLIP-seq
MIRT1455313	hsa-miR-520e	CLIP-seq
MIRT1455314	hsa-miR-520g	CLIP-seq
MIRT1455315	hsa-miR-520h	CLIP-seq
MIRT1455319	hsa-miR-548s	CLIP-seq
MIRT2136515	hsa-miR-562	CLIP-seq
MIRT1455320	hsa-miR-575	CLIP-seq
MIRT1455321	hsa-miR-588	CLIP-seq
MIRT2136516	hsa-miR-762	CLIP-seq
MIRT1455325	hsa-miR-892a	CLIP-seq
MIRT1455326	hsa-miR-93	CLIP-seq
MIRT1455240	hsa-miR-1193	CLIP-seq
MIRT2136469	hsa-miR-1206	CLIP-seq
MIRT1455242	hsa-miR-1208	CLIP-seq
MIRT2136473	hsa-miR-1253	CLIP-seq
MIRT1455245	hsa-miR-1281	CLIP-seq
MIRT2136476	hsa-miR-1289	CLIP-seq
MIRT2357321	hsa-miR-1296	CLIP-seq
MIRT1455246	hsa-miR-1302	CLIP-seq
MIRT1455248	hsa-miR-1343	CLIP-seq
MIRT1455249	hsa-miR-150	CLIP-seq
MIRT2136478	hsa-miR-1587	CLIP-seq
MIRT1455251	hsa-miR-185	CLIP-seq
MIRT1455252	hsa-miR-1913	CLIP-seq
MIRT1455254	hsa-miR-1976	CLIP-seq
MIRT1455258	hsa-miR-2392	CLIP-seq
MIRT2357322	hsa-miR-23a	CLIP-seq
MIRT2357323	hsa-miR-23b	CLIP-seq
MIRT2357324	hsa-miR-23c	CLIP-seq
MIRT2357325	hsa-miR-2861	CLIP-seq
MIRT2136481	hsa-miR-3135b	CLIP-seq
MIRT1455264	hsa-miR-3152-3p	CLIP-seq
MIRT2357326	hsa-miR-3153	CLIP-seq
MIRT2357327	hsa-miR-3190	CLIP-seq
MIRT2136482	hsa-miR-3194-3p	CLIP-seq
MIRT2136483	hsa-miR-3198	CLIP-seq
MIRT1455267	hsa-miR-324-3p	CLIP-seq
MIRT2357328	hsa-miR-3591-3p	CLIP-seq
MIRT2136484	hsa-miR-3652	CLIP-seq
MIRT2136485	hsa-miR-378g	CLIP-seq
MIRT1455275	hsa-miR-411	CLIP-seq
MIRT2136488	hsa-miR-4269	CLIP-seq
MIRT2136490	hsa-miR-4279	CLIP-seq
MIRT2136492	hsa-miR-4294	CLIP-seq
MIRT1455277	hsa-miR-4298	CLIP-seq
MIRT1455278	hsa-miR-4306	CLIP-seq
MIRT2136493	hsa-miR-4309	CLIP-seq
MIRT1455281	hsa-miR-4420	CLIP-seq
MIRT2136498	hsa-miR-4430	CLIP-seq
MIRT2357329	hsa-miR-4450	CLIP-seq
MIRT2357330	hsa-miR-4482	CLIP-seq
MIRT2136499	hsa-miR-4492	CLIP-seq
MIRT2136500	hsa-miR-4498	CLIP-seq
MIRT2357331	hsa-miR-4512	CLIP-seq
MIRT2136502	hsa-miR-4534	CLIP-seq
MIRT1455287	hsa-miR-4644	CLIP-seq
MIRT2136505	hsa-miR-4656	CLIP-seq
MIRT1455288	hsa-miR-4662a-5p	CLIP-seq
MIRT2357332	hsa-miR-4667-5p	CLIP-seq
MIRT2136506	hsa-miR-4675	CLIP-seq
MIRT1455289	hsa-miR-4676-5p	CLIP-seq
MIRT1455292	hsa-miR-4685-5p	CLIP-seq
MIRT2357333	hsa-miR-4700-5p	CLIP-seq
MIRT2136509	hsa-miR-4722-3p	CLIP-seq
MIRT2136511	hsa-miR-4741	CLIP-seq
MIRT2357334	hsa-miR-483-5p	CLIP-seq
MIRT1455302	hsa-miR-498	CLIP-seq
MIRT2136515	hsa-miR-562	CLIP-seq
MIRT1455320	hsa-miR-575	CLIP-seq
MIRT2357335	hsa-miR-661	CLIP-seq
MIRT2136516	hsa-miR-762	CLIP-seq
MIRT1455325	hsa-miR-892a	CLIP-seq
MIRT1455251	hsa-miR-185	CLIP-seq
MIRT2396370	hsa-miR-3149	CLIP-seq
MIRT1455275	hsa-miR-411	CLIP-seq
MIRT1455278	hsa-miR-4306	CLIP-seq
MIRT1455281	hsa-miR-4420	CLIP-seq
MIRT1455287	hsa-miR-4644	CLIP-seq
MIRT2357334	hsa-miR-483-5p	CLIP-seq
MIRT1455238	hsa-miR-106a	CLIP-seq
MIRT1455239	hsa-miR-106b	CLIP-seq
MIRT1455249	hsa-miR-150	CLIP-seq
MIRT1455250	hsa-miR-17	CLIP-seq
MIRT1455255	hsa-miR-20a	CLIP-seq
MIRT1455256	hsa-miR-20b	CLIP-seq
MIRT1455259	hsa-miR-302a	CLIP-seq
MIRT1455260	hsa-miR-302b	CLIP-seq
MIRT1455261	hsa-miR-302c	CLIP-seq
MIRT1455262	hsa-miR-302d	CLIP-seq
MIRT1455263	hsa-miR-302e	CLIP-seq
MIRT1455271	hsa-miR-372	CLIP-seq
MIRT1455272	hsa-miR-373	CLIP-seq
MIRT2694184	hsa-miR-4715-3p	CLIP-seq
MIRT2694185	hsa-miR-4735-5p	CLIP-seq
MIRT2694186	hsa-miR-4775	CLIP-seq
MIRT1455306	hsa-miR-512-3p	CLIP-seq
MIRT1455307	hsa-miR-519d	CLIP-seq
MIRT1455308	hsa-miR-520a-3p	CLIP-seq
MIRT1455309	hsa-miR-520b	CLIP-seq
MIRT1455310	hsa-miR-520c-3p	CLIP-seq
MIRT1455311	hsa-miR-520d-3p	CLIP-seq
MIRT1455313	hsa-miR-520e	CLIP-seq
MIRT1455314	hsa-miR-520g	CLIP-seq
MIRT1455315	hsa-miR-520h	CLIP-seq
MIRT2694187	hsa-miR-590-3p	CLIP-seq
MIRT1455324	hsa-miR-640	CLIP-seq
MIRT1455326	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0045087	Process	Innate immune response	IBA
GO:0045504	Function	Dynein heavy chain binding	IEA
GO:0045505	Function	Dynein intermediate chain binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051865	Process	Protein autoubiquitination	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061931	Process	Positive regulation of erythrocyte enucleation	IEA
GO:1902838	Process	Regulation of nuclear migration along microtubule	IEA

Other IDs

• MIM: 620527
• HGNC: 24150
• e!Ensembl: ENSG00000162722

Protein

• UniProt ID: Q8NG06
• Protein name: E3 ubiquitin-protein ligase TRIM58 (EC 2.3.2.27) (Protein BIA2) (RING-type E3 ubiquitin transferase TRIM58) (Tripartite motif-containing protein 58)
• Protein function: E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate i
• PDB: 8PD4, 8PD6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15227	zf-C3HC4_4	16 → 60		Domain
  PF00643	zf-B_box	91 → 132	B-box zinc finger	Domain
  PF13765	PRY	293 → 341	SPRY-associated domain	Family
  PF00622	SPRY	345 → 454	SPRY domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in erythroblasts. {ECO:0000269|PubMed:25241935}.
• Sequence:

  MAWAPPGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQC
  RGPFRPSGFRPNRQLAGLVESVRRLGLGAGPGARRCARHGEDLSRFCEEDEAALCWVCDA
  GPEHRTHRTAPLQEAAGSYQVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQ
  RFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELADELQERC
  QRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVDVKLDPATA
  HPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGL
  GVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAG
  EISFYNVTDGSYIYTFNQLFSGLLRPYFFICDATPLILPPTTIAGSGNWASRDHLDPASD
  VRDDHL

• Sequence length: 486

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MYELOPROLIFERATIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	27926516		★☆☆☆☆ Found in Text Mining only
Arthritis Juvenile	Juvenile arthritis	Pubtator	34435051	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	29749538, 29956813		★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	29749538, 32218699	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29956813		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29956813	Inhibit	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37158531	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27373520		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	26842235, 29749538, 29956813	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	29749538, 29956813		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	31747856		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29956813		★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	35445910	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	36534449	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27926516, 29956813, 31747856		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	32219144	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	BEFREE	29749538, 31105813		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	31747856		★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	17914110	Associate	★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	31383741		★☆☆☆☆ Found in Text Mining only