Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	25878
Gene name	Matrix remodeling associated 5
Gene symbol	MXRA5
Synonyms (NCBI Gene)	-
Chromosome	X
Chromosome location	Xp22.33
Summary	This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010]

Show/Hide all (99)

miRTarBase ID	miRNA	Experiments
MIRT1551464	hsa-miR-4680-3p	CLIP-seq
MIRT2277187	hsa-miR-144	CLIP-seq
MIRT2277188	hsa-miR-2110	CLIP-seq
MIRT2277189	hsa-miR-3185	CLIP-seq
MIRT2277190	hsa-miR-345	CLIP-seq
MIRT2277191	hsa-miR-3652	CLIP-seq
MIRT2277192	hsa-miR-3684	CLIP-seq
MIRT2277193	hsa-miR-4271	CLIP-seq
MIRT2277194	hsa-miR-4430	CLIP-seq
MIRT2277195	hsa-miR-4505	CLIP-seq
MIRT2277196	hsa-miR-4667-5p	CLIP-seq
MIRT2277197	hsa-miR-4691-3p	CLIP-seq
MIRT2277198	hsa-miR-4700-5p	CLIP-seq
MIRT2277199	hsa-miR-4725-3p	CLIP-seq
MIRT2277200	hsa-miR-4731-5p	CLIP-seq
MIRT2576027	hsa-miR-1225-3p	CLIP-seq
MIRT2576028	hsa-miR-1233	CLIP-seq
MIRT2576029	hsa-miR-1237	CLIP-seq
MIRT2576030	hsa-miR-1248	CLIP-seq
MIRT2277188	hsa-miR-2110	CLIP-seq
MIRT2576031	hsa-miR-2355-5p	CLIP-seq
MIRT2576032	hsa-miR-30a	CLIP-seq
MIRT2576033	hsa-miR-30b	CLIP-seq
MIRT2576034	hsa-miR-30c	CLIP-seq
MIRT2576035	hsa-miR-30d	CLIP-seq
MIRT2576036	hsa-miR-30e	CLIP-seq
MIRT2576037	hsa-miR-3140-5p	CLIP-seq
MIRT2576038	hsa-miR-3171	CLIP-seq
MIRT2277189	hsa-miR-3185	CLIP-seq
MIRT2576039	hsa-miR-331-3p	CLIP-seq
MIRT2576040	hsa-miR-3620	CLIP-seq
MIRT2576041	hsa-miR-3622b-5p	CLIP-seq
MIRT2277191	hsa-miR-3652	CLIP-seq
MIRT2576042	hsa-miR-3658	CLIP-seq
MIRT2277192	hsa-miR-3684	CLIP-seq
MIRT2576043	hsa-miR-3929	CLIP-seq
MIRT2576044	hsa-miR-3938	CLIP-seq
MIRT2277193	hsa-miR-4271	CLIP-seq
MIRT2576045	hsa-miR-4290	CLIP-seq
MIRT2576046	hsa-miR-4419b	CLIP-seq
MIRT2277194	hsa-miR-4430	CLIP-seq
MIRT2576047	hsa-miR-4478	CLIP-seq
MIRT2576048	hsa-miR-4495	CLIP-seq
MIRT2277195	hsa-miR-4505	CLIP-seq
MIRT2576049	hsa-miR-4663	CLIP-seq
MIRT2576050	hsa-miR-4667-3p	CLIP-seq
MIRT2277196	hsa-miR-4667-5p	CLIP-seq
MIRT2576051	hsa-miR-4687-5p	CLIP-seq
MIRT2277197	hsa-miR-4691-3p	CLIP-seq
MIRT2277198	hsa-miR-4700-5p	CLIP-seq
MIRT2576052	hsa-miR-4708-3p	CLIP-seq
MIRT2576053	hsa-miR-4720-5p	CLIP-seq
MIRT2277199	hsa-miR-4725-3p	CLIP-seq
MIRT2277200	hsa-miR-4731-5p	CLIP-seq
MIRT2576054	hsa-miR-4786-3p	CLIP-seq
MIRT2576055	hsa-miR-4799-3p	CLIP-seq
MIRT2576056	hsa-miR-545	CLIP-seq
MIRT2576057	hsa-miR-642b	CLIP-seq
MIRT2685600	hsa-miR-1206	CLIP-seq
MIRT2685601	hsa-miR-1294	CLIP-seq
MIRT2685602	hsa-miR-204	CLIP-seq
MIRT2685603	hsa-miR-211	CLIP-seq
MIRT2277188	hsa-miR-2110	CLIP-seq
MIRT2576031	hsa-miR-2355-5p	CLIP-seq
MIRT2576032	hsa-miR-30a	CLIP-seq
MIRT2576033	hsa-miR-30b	CLIP-seq
MIRT2576034	hsa-miR-30c	CLIP-seq
MIRT2576035	hsa-miR-30d	CLIP-seq
MIRT2576036	hsa-miR-30e	CLIP-seq
MIRT2576037	hsa-miR-3140-5p	CLIP-seq
MIRT2576038	hsa-miR-3171	CLIP-seq
MIRT2685604	hsa-miR-3174	CLIP-seq
MIRT2277189	hsa-miR-3185	CLIP-seq
MIRT2576039	hsa-miR-331-3p	CLIP-seq
MIRT2576040	hsa-miR-3620	CLIP-seq
MIRT2576041	hsa-miR-3622b-5p	CLIP-seq
MIRT2277191	hsa-miR-3652	CLIP-seq
MIRT2576042	hsa-miR-3658	CLIP-seq
MIRT2277192	hsa-miR-3684	CLIP-seq
MIRT2277193	hsa-miR-4271	CLIP-seq
MIRT2277194	hsa-miR-4430	CLIP-seq
MIRT2576048	hsa-miR-4495	CLIP-seq
MIRT2277195	hsa-miR-4505	CLIP-seq
MIRT2277196	hsa-miR-4667-5p	CLIP-seq
MIRT2277197	hsa-miR-4691-3p	CLIP-seq
MIRT2277198	hsa-miR-4700-5p	CLIP-seq
MIRT2576053	hsa-miR-4720-5p	CLIP-seq
MIRT2277199	hsa-miR-4725-3p	CLIP-seq
MIRT2277200	hsa-miR-4731-5p	CLIP-seq
MIRT2685605	hsa-miR-4755-5p	CLIP-seq
MIRT2576054	hsa-miR-4786-3p	CLIP-seq
MIRT2685606	hsa-miR-4796-5p	CLIP-seq
MIRT2576055	hsa-miR-4799-3p	CLIP-seq
MIRT2685607	hsa-miR-490-3p	CLIP-seq
MIRT2685608	hsa-miR-520d-5p	CLIP-seq
MIRT2685609	hsa-miR-524-5p	CLIP-seq
MIRT2685610	hsa-miR-623	CLIP-seq
MIRT2576057	hsa-miR-642b	CLIP-seq
MIRT2685611	hsa-miR-921	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005201	Function	Extracellular matrix structural constituent	HDA	28344315
GO:0005201	Function	Extracellular matrix structural constituent	RCA	28327460
GO:0005576	Component	Extracellular region	IEA
GO:0031012	Component	Extracellular matrix	HDA	28327460, 28344315
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071559	Process	Response to transforming growth factor beta	IBA
GO:0071559	Process	Response to transforming growth factor beta	IMP	27599751

MIM	HGNC	e!Ensembl
300938	7539	ENSG00000101825

Q9NR99

Protein name

Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican)

Protein function

In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	55 → 115	Leucine rich repeat	Repeat
PF13855	LRR_8	80 → 130	Leucine rich repeat	Repeat
PF13855	LRR_8	103 → 163	Leucine rich repeat	Repeat
PF13855	LRR_8	127 → 184	Leucine rich repeat	Repeat
PF13927	Ig_3	480 → 558		Domain
PF13927	Ig_3	575 → 655		Domain
PF13927	Ig_3	1852 → 1932		Domain
PF07679	I-set	1950 → 2042	Immunoglobulin I-set domain	Domain
PF07679	I-set	2047 → 2139	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	2147 → 2225		Domain
PF07679	I-set	2244 → 2341	Immunoglobulin I-set domain	Domain
PF07679	I-set	2348 → 2435	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	2439 → 2522		Domain
PF07679	I-set	2542 → 2633	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	2732 → 2814		Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in placenta (at protein level) (PubMed:32337544). Detected in cerebrospinal fluid and fibroblasts (at protein level) (PubMed:25326458, PubMed:36213313). Highly expressed in kidney, also detected on liver and spleen (PubMed:275

Sequence

MPKRAHWGALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERI
NLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITG
QTLQGLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYF
RLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILK
CKKDKAYEGGQLCAMCFSPKKLYKHEIHKLKDMTCLKPSIESPLRQNRSRSIEEEQEQEE
DGGSQLILEKFQLPQWSISLNMTDEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINAT
VALDFECPMTRENYEKLWKLIAYYSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTG
VRAQILAEPEWVMQPSIDIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIE
PSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL
RIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCN
ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD
HFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQ
EVFLKTKDDAINGDKKAKKGRRKLKLWKHSEKEPETNVAEGRRVFESRRRINMANKQINP
ERWADILAKVRGKNLPKGTEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEE
SSADVPLLGEEEHVLGTISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITS
TEGDLKGTAAPTLISEPYEPSPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEY
EPPLDAVSLAESEPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFED
STIGEPGVPGQSHLQGLTDNIHLVKSSLSTQDTLLIKKGMKEMSQTLQGGNMLEGDPTHS
RSSESEGQESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTTATTTPRQKVAPSS
TMSTHPSRRRPNGRRRLRPNKFRHRHKQTPPTTFAPSETFSTQPTQAPDIKISSQVESSL
VPTAWVDNTVNTPKQLEMEKNAEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPS
PENKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPT
SDGKEIKDDVATNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGTPTW
NPSRTAQPGRLQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEEAGSS
TTLSSIKVEVASSQAETTTLDQDHLETTVAILLSETRPQNHTPTAARMKEPASSSPSTIL
MSLGQTTTTKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNELST
PSSDQDAFNLSTKLELEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPAKPILPTATVR
LPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHMSK
PSIPSKFTDRRTDQFNGYSKVFGNNNIPEARNPVGKPPSPRIPHYSNGRLPFFTNKTLSF
PQLGVTRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPS
TNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSP
QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV
QDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAP
QISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL
HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF
VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY
GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL
CVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP
DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVK
VVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD
GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGS
RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMA
RNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN
GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN
KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVRE
ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI
PKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS
KTTYIHVF

Sequence length

2828

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, NON-SMALL-CELL LUNG	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MXRA5-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nephrotic syndrome	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Short stature	Uncertain significance; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorder	Autism	Pubtator	28720891	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	UNIPROT_DG	22696596		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	27599751	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	27599751		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24621823	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic fibrosis	Pubtator	30598261	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	34211612, 40429753	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	34211612	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	40429753	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	32620106, 36254001, 37390254	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	37180146	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	28720891		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	27599751	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	26406953	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26406953		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22696596, 29877573		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	22696596, 26406953		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	CTD_human_DG	22696596		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	37390254	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis Knee	Osteoarthritis	Pubtator	37024074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic hyperplasia	Pubtator	32392178	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	27599751		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	28720891		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37180146	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MXRA5 (matrix remodeling associated 5)