Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	25875
Gene name	LETM1 domain containing 1
Gene symbol	LETMD1
Synonyms (NCBI Gene)	1110019O13RikHCCRHCCR-1HCCR-2HCCR1HCCR2HCRR-2SLC55A3
Chromosome	12
Chromosome location	12q13.12
Summary	This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT037208	hsa-miR-877-5p	CLASH	23622248
MIRT709582	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT709581	hsa-miR-1229-3p	HITS-CLIP	19536157
MIRT709580	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT571010	hsa-miR-4438	HITS-CLIP	23706177
MIRT571008	hsa-miR-6746-3p	HITS-CLIP	23706177
MIRT682855	hsa-miR-6504-3p	HITS-CLIP	23706177
MIRT571009	hsa-miR-1292-3p	HITS-CLIP	23706177
MIRT571006	hsa-miR-4537	HITS-CLIP	23706177
MIRT571005	hsa-miR-6869-3p	HITS-CLIP	23706177
MIRT571004	hsa-miR-5095	HITS-CLIP	23706177
MIRT571003	hsa-miR-7151-3p	HITS-CLIP	23706177
MIRT571010	hsa-miR-4438	PAR-CLIP	20371350
MIRT571008	hsa-miR-6746-3p	PAR-CLIP	20371350
MIRT571009	hsa-miR-1292-3p	PAR-CLIP	20371350
MIRT571007	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT571006	hsa-miR-4537	PAR-CLIP	20371350
MIRT571005	hsa-miR-6869-3p	PAR-CLIP	20371350
MIRT571004	hsa-miR-5095	PAR-CLIP	20371350
MIRT571003	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT474192	hsa-miR-4426	PAR-CLIP	23592263
MIRT474191	hsa-miR-4647	PAR-CLIP	23592263
MIRT474190	hsa-miR-4662b	PAR-CLIP	23592263
MIRT474189	hsa-miR-576-3p	PAR-CLIP	23592263
MIRT474188	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT474187	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT474186	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT474185	hsa-miR-940	PAR-CLIP	23592263
MIRT474183	hsa-miR-1321	PAR-CLIP	23592263
MIRT474184	hsa-miR-4739	PAR-CLIP	23592263
MIRT474182	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT474181	hsa-miR-3922-5p	PAR-CLIP	23592263
MIRT474180	hsa-miR-1253	PAR-CLIP	23592263
MIRT474179	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT474178	hsa-miR-1827	PAR-CLIP	23592263
MIRT474177	hsa-miR-765	PAR-CLIP	23592263
MIRT474176	hsa-miR-3612	PAR-CLIP	23592263
MIRT474175	hsa-miR-650	PAR-CLIP	23592263
MIRT474174	hsa-miR-4736	PAR-CLIP	23592263
MIRT474173	hsa-miR-1538	PAR-CLIP	23592263
MIRT474172	hsa-miR-4745-3p	PAR-CLIP	23592263
MIRT474171	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT709582	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT709581	hsa-miR-1229-3p	HITS-CLIP	19536157
MIRT709580	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT571010	hsa-miR-4438	HITS-CLIP	23706177
MIRT571008	hsa-miR-6746-3p	HITS-CLIP	23706177
MIRT682855	hsa-miR-6504-3p	HITS-CLIP	23706177
MIRT571009	hsa-miR-1292-3p	HITS-CLIP	23706177
MIRT571006	hsa-miR-4537	HITS-CLIP	23706177
MIRT571005	hsa-miR-6869-3p	HITS-CLIP	23706177
MIRT571004	hsa-miR-5095	HITS-CLIP	23706177
MIRT571003	hsa-miR-7151-3p	HITS-CLIP	23706177
MIRT571010	hsa-miR-4438	PAR-CLIP	20371350
MIRT571008	hsa-miR-6746-3p	PAR-CLIP	20371350
MIRT571009	hsa-miR-1292-3p	PAR-CLIP	20371350
MIRT571007	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT571006	hsa-miR-4537	PAR-CLIP	20371350
MIRT571005	hsa-miR-6869-3p	PAR-CLIP	20371350
MIRT571004	hsa-miR-5095	PAR-CLIP	20371350
MIRT571003	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT474192	hsa-miR-4426	PAR-CLIP	23592263
MIRT474191	hsa-miR-4647	PAR-CLIP	23592263
MIRT474190	hsa-miR-4662b	PAR-CLIP	23592263
MIRT474189	hsa-miR-576-3p	PAR-CLIP	23592263
MIRT474188	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT474187	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT474186	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT474185	hsa-miR-940	PAR-CLIP	23592263
MIRT474183	hsa-miR-1321	PAR-CLIP	23592263
MIRT474184	hsa-miR-4739	PAR-CLIP	23592263
MIRT474182	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT474181	hsa-miR-3922-5p	PAR-CLIP	23592263
MIRT474180	hsa-miR-1253	PAR-CLIP	23592263
MIRT474179	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT474178	hsa-miR-1827	PAR-CLIP	23592263
MIRT474177	hsa-miR-765	PAR-CLIP	23592263
MIRT474176	hsa-miR-3612	PAR-CLIP	23592263
MIRT474175	hsa-miR-650	PAR-CLIP	23592263
MIRT474174	hsa-miR-4736	PAR-CLIP	23592263
MIRT474173	hsa-miR-1538	PAR-CLIP	23592263
MIRT474172	hsa-miR-4745-3p	PAR-CLIP	23592263
MIRT474171	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT1108018	hsa-miR-1	CLIP-seq
MIRT1108019	hsa-miR-1184	CLIP-seq
MIRT1108020	hsa-miR-1205	CLIP-seq
MIRT1108021	hsa-miR-1269	CLIP-seq
MIRT1108022	hsa-miR-1269b	CLIP-seq
MIRT1108023	hsa-miR-128	CLIP-seq
MIRT1108024	hsa-miR-1288	CLIP-seq
MIRT1108025	hsa-miR-1910	CLIP-seq
MIRT1108026	hsa-miR-206	CLIP-seq
MIRT1108027	hsa-miR-219-1-3p	CLIP-seq
MIRT1108028	hsa-miR-223	CLIP-seq
MIRT1108029	hsa-miR-27a	CLIP-seq
MIRT1108030	hsa-miR-27b	CLIP-seq
MIRT1108031	hsa-miR-3125	CLIP-seq
MIRT1108032	hsa-miR-3136-3p	CLIP-seq
MIRT1108033	hsa-miR-3158-5p	CLIP-seq
MIRT1108034	hsa-miR-346	CLIP-seq
MIRT1108035	hsa-miR-3681	CLIP-seq
MIRT1108036	hsa-miR-3714	CLIP-seq
MIRT1108037	hsa-miR-3916	CLIP-seq
MIRT1108038	hsa-miR-3919	CLIP-seq
MIRT1108039	hsa-miR-4252	CLIP-seq
MIRT1108040	hsa-miR-4288	CLIP-seq
MIRT1108041	hsa-miR-4443	CLIP-seq
MIRT1108042	hsa-miR-4515	CLIP-seq
MIRT1108043	hsa-miR-4529-3p	CLIP-seq
MIRT1108044	hsa-miR-455-3p	CLIP-seq
MIRT1108045	hsa-miR-4677-3p	CLIP-seq
MIRT1108046	hsa-miR-4691-3p	CLIP-seq
MIRT1108047	hsa-miR-4697-3p	CLIP-seq
MIRT1108048	hsa-miR-4699-5p	CLIP-seq
MIRT1108049	hsa-miR-4709-3p	CLIP-seq
MIRT1108050	hsa-miR-4711-5p	CLIP-seq
MIRT1108051	hsa-miR-4740-5p	CLIP-seq
MIRT1108052	hsa-miR-4795-5p	CLIP-seq
MIRT1108053	hsa-miR-4802-3p	CLIP-seq
MIRT1108054	hsa-miR-582-5p	CLIP-seq
MIRT1108055	hsa-miR-613	CLIP-seq
MIRT1108056	hsa-miR-632	CLIP-seq
MIRT1108057	hsa-miR-654-3p	CLIP-seq
MIRT1108058	hsa-miR-802	CLIP-seq
MIRT1108059	hsa-miR-922	CLIP-seq
MIRT1108060	hsa-miR-935	CLIP-seq
MIRT1108061	hsa-miR-1224-5p	CLIP-seq
MIRT1108021	hsa-miR-1269	CLIP-seq
MIRT1108022	hsa-miR-1269b	CLIP-seq
MIRT1108023	hsa-miR-128	CLIP-seq
MIRT1108024	hsa-miR-1288	CLIP-seq
MIRT1108062	hsa-miR-188-3p	CLIP-seq
MIRT1108028	hsa-miR-223	CLIP-seq
MIRT1108063	hsa-miR-224	CLIP-seq
MIRT1108029	hsa-miR-27a	CLIP-seq
MIRT1108030	hsa-miR-27b	CLIP-seq
MIRT1108064	hsa-miR-302a	CLIP-seq
MIRT1108065	hsa-miR-302b	CLIP-seq
MIRT1108066	hsa-miR-302c	CLIP-seq
MIRT1108067	hsa-miR-302d	CLIP-seq
MIRT1108068	hsa-miR-302e	CLIP-seq
MIRT1108069	hsa-miR-3074-5p	CLIP-seq
MIRT1108070	hsa-miR-31	CLIP-seq
MIRT1108071	hsa-miR-3128	CLIP-seq
MIRT1108072	hsa-miR-3179	CLIP-seq
MIRT1108073	hsa-miR-3202	CLIP-seq
MIRT1108074	hsa-miR-329	CLIP-seq
MIRT1108075	hsa-miR-338-5p	CLIP-seq
MIRT1108076	hsa-miR-3545-3p	CLIP-seq
MIRT1108077	hsa-miR-362-3p	CLIP-seq
MIRT1108078	hsa-miR-372	CLIP-seq
MIRT1108079	hsa-miR-373	CLIP-seq
MIRT1108080	hsa-miR-375	CLIP-seq
MIRT1108081	hsa-miR-3915	CLIP-seq
MIRT1108082	hsa-miR-3928	CLIP-seq
MIRT1108083	hsa-miR-3936	CLIP-seq
MIRT1108084	hsa-miR-3940-5p	CLIP-seq
MIRT1108085	hsa-miR-3941	CLIP-seq
MIRT1108086	hsa-miR-3977	CLIP-seq
MIRT1108039	hsa-miR-4252	CLIP-seq
MIRT1108087	hsa-miR-4267	CLIP-seq
MIRT1108088	hsa-miR-4274	CLIP-seq
MIRT1108089	hsa-miR-4326	CLIP-seq
MIRT1108090	hsa-miR-4418	CLIP-seq
MIRT1108091	hsa-miR-4420	CLIP-seq
MIRT1108092	hsa-miR-4476	CLIP-seq
MIRT1108093	hsa-miR-4507	CLIP-seq
MIRT1108042	hsa-miR-4515	CLIP-seq
MIRT1108043	hsa-miR-4529-3p	CLIP-seq
MIRT1108094	hsa-miR-4680-5p	CLIP-seq
MIRT1108095	hsa-miR-4689	CLIP-seq
MIRT1108046	hsa-miR-4691-3p	CLIP-seq
MIRT1108047	hsa-miR-4697-3p	CLIP-seq
MIRT1108096	hsa-miR-4724-5p	CLIP-seq
MIRT1108051	hsa-miR-4740-5p	CLIP-seq
MIRT1108097	hsa-miR-4793-3p	CLIP-seq
MIRT1108098	hsa-miR-485-5p	CLIP-seq
MIRT1108099	hsa-miR-494	CLIP-seq
MIRT1108100	hsa-miR-498	CLIP-seq
MIRT1108101	hsa-miR-499-3p	CLIP-seq
MIRT1108102	hsa-miR-499a-3p	CLIP-seq
MIRT1108103	hsa-miR-499a-5p	CLIP-seq
MIRT1108104	hsa-miR-509-3-5p	CLIP-seq
MIRT1108105	hsa-miR-509-5p	CLIP-seq
MIRT1108106	hsa-miR-512-3p	CLIP-seq
MIRT1108107	hsa-miR-520a-3p	CLIP-seq
MIRT1108108	hsa-miR-520b	CLIP-seq
MIRT1108109	hsa-miR-520c-3p	CLIP-seq
MIRT1108110	hsa-miR-520d-3p	CLIP-seq
MIRT1108111	hsa-miR-520e	CLIP-seq
MIRT1108112	hsa-miR-520f	CLIP-seq
MIRT1108113	hsa-miR-532-3p	CLIP-seq
MIRT1108114	hsa-miR-548ac	CLIP-seq
MIRT1108115	hsa-miR-548ae	CLIP-seq
MIRT1108116	hsa-miR-548aj	CLIP-seq
MIRT1108117	hsa-miR-548am	CLIP-seq
MIRT1108118	hsa-miR-548d-3p	CLIP-seq
MIRT1108119	hsa-miR-548x	CLIP-seq
MIRT1108120	hsa-miR-548z	CLIP-seq
MIRT1108121	hsa-miR-556-3p	CLIP-seq
MIRT1108054	hsa-miR-582-5p	CLIP-seq
MIRT1108122	hsa-miR-586	CLIP-seq
MIRT1108123	hsa-miR-603	CLIP-seq
MIRT1108124	hsa-miR-618	CLIP-seq
MIRT1108125	hsa-miR-629	CLIP-seq
MIRT1108126	hsa-miR-890	CLIP-seq
MIRT1108060	hsa-miR-935	CLIP-seq
MIRT1108127	hsa-miR-936	CLIP-seq
MIRT1108020	hsa-miR-1205	CLIP-seq
MIRT1108027	hsa-miR-219-1-3p	CLIP-seq
MIRT2029908	hsa-miR-323b-3p	CLIP-seq
MIRT1108041	hsa-miR-4443	CLIP-seq
MIRT1108048	hsa-miR-4699-5p	CLIP-seq
MIRT1108049	hsa-miR-4709-3p	CLIP-seq
MIRT1108106	hsa-miR-512-3p	CLIP-seq
MIRT1108059	hsa-miR-922	CLIP-seq
MIRT2260758	hsa-miR-1197	CLIP-seq
MIRT2260759	hsa-miR-1226	CLIP-seq
MIRT2260760	hsa-miR-1285	CLIP-seq
MIRT2260761	hsa-miR-197	CLIP-seq
MIRT2260762	hsa-miR-1976	CLIP-seq
MIRT1108063	hsa-miR-224	CLIP-seq
MIRT2260763	hsa-miR-2355-5p	CLIP-seq
MIRT2260764	hsa-miR-3166	CLIP-seq
MIRT2260765	hsa-miR-3168	CLIP-seq
MIRT2260766	hsa-miR-3187-5p	CLIP-seq
MIRT1108075	hsa-miR-338-5p	CLIP-seq
MIRT1108076	hsa-miR-3545-3p	CLIP-seq
MIRT2260767	hsa-miR-384	CLIP-seq
MIRT1108086	hsa-miR-3977	CLIP-seq
MIRT2260768	hsa-miR-4277	CLIP-seq
MIRT1108091	hsa-miR-4420	CLIP-seq
MIRT2260769	hsa-miR-4505	CLIP-seq
MIRT2260770	hsa-miR-451b	CLIP-seq
MIRT1108094	hsa-miR-4680-5p	CLIP-seq
MIRT1108046	hsa-miR-4691-3p	CLIP-seq
MIRT2260771	hsa-miR-4695-3p	CLIP-seq
MIRT1108096	hsa-miR-4724-5p	CLIP-seq
MIRT2260772	hsa-miR-4733-3p	CLIP-seq
MIRT2260773	hsa-miR-4771	CLIP-seq
MIRT1108101	hsa-miR-499-3p	CLIP-seq
MIRT1108102	hsa-miR-499a-3p	CLIP-seq
MIRT1108106	hsa-miR-512-3p	CLIP-seq
MIRT1108112	hsa-miR-520f	CLIP-seq
MIRT1108122	hsa-miR-586	CLIP-seq
MIRT2260774	hsa-miR-612	CLIP-seq
MIRT2260775	hsa-miR-617	CLIP-seq
MIRT1108124	hsa-miR-618	CLIP-seq
MIRT1108023	hsa-miR-128	CLIP-seq
MIRT1108027	hsa-miR-219-1-3p	CLIP-seq
MIRT1108041	hsa-miR-4443	CLIP-seq
MIRT1108048	hsa-miR-4699-5p	CLIP-seq
MIRT1108049	hsa-miR-4709-3p	CLIP-seq
MIRT1108059	hsa-miR-922	CLIP-seq
MIRT1108018	hsa-miR-1	CLIP-seq
MIRT1108019	hsa-miR-1184	CLIP-seq
MIRT1108020	hsa-miR-1205	CLIP-seq
MIRT2560758	hsa-miR-1227	CLIP-seq
MIRT2560759	hsa-miR-1260	CLIP-seq
MIRT2560760	hsa-miR-1260b	CLIP-seq
MIRT2260760	hsa-miR-1285	CLIP-seq
MIRT2560761	hsa-miR-132	CLIP-seq
MIRT2560762	hsa-miR-133a	CLIP-seq
MIRT2560763	hsa-miR-133b	CLIP-seq
MIRT1108062	hsa-miR-188-3p	CLIP-seq
MIRT2260762	hsa-miR-1976	CLIP-seq
MIRT1108026	hsa-miR-206	CLIP-seq
MIRT2560764	hsa-miR-212	CLIP-seq
MIRT2260763	hsa-miR-2355-5p	CLIP-seq
MIRT1108031	hsa-miR-3125	CLIP-seq
MIRT2560765	hsa-miR-3156-3p	CLIP-seq
MIRT1108033	hsa-miR-3158-5p	CLIP-seq
MIRT2260764	hsa-miR-3166	CLIP-seq
MIRT2260765	hsa-miR-3168	CLIP-seq
MIRT2560766	hsa-miR-3183	CLIP-seq
MIRT2260766	hsa-miR-3187-5p	CLIP-seq
MIRT1108034	hsa-miR-346	CLIP-seq
MIRT2560767	hsa-miR-3611	CLIP-seq
MIRT2560768	hsa-miR-3613-3p	CLIP-seq
MIRT1108037	hsa-miR-3916	CLIP-seq
MIRT2560769	hsa-miR-4268	CLIP-seq
MIRT2260768	hsa-miR-4277	CLIP-seq
MIRT1108040	hsa-miR-4288	CLIP-seq
MIRT2560770	hsa-miR-4448	CLIP-seq
MIRT2260769	hsa-miR-4505	CLIP-seq
MIRT2260770	hsa-miR-451b	CLIP-seq
MIRT2560771	hsa-miR-4637	CLIP-seq
MIRT2560772	hsa-miR-4641	CLIP-seq
MIRT2560773	hsa-miR-4659a-5p	CLIP-seq
MIRT2560774	hsa-miR-4659b-5p	CLIP-seq
MIRT1108045	hsa-miR-4677-3p	CLIP-seq
MIRT2260771	hsa-miR-4695-3p	CLIP-seq
MIRT2560775	hsa-miR-4723-3p	CLIP-seq
MIRT2260773	hsa-miR-4771	CLIP-seq
MIRT2560776	hsa-miR-4786-3p	CLIP-seq
MIRT1108113	hsa-miR-532-3p	CLIP-seq
MIRT1108123	hsa-miR-603	CLIP-seq
MIRT2260774	hsa-miR-612	CLIP-seq
MIRT1108055	hsa-miR-613	CLIP-seq
MIRT1108056	hsa-miR-632	CLIP-seq
MIRT1108057	hsa-miR-654-3p	CLIP-seq
MIRT2560777	hsa-miR-660	CLIP-seq
MIRT1108018	hsa-miR-1	CLIP-seq
MIRT1108019	hsa-miR-1184	CLIP-seq
MIRT1108020	hsa-miR-1205	CLIP-seq
MIRT2560758	hsa-miR-1227	CLIP-seq
MIRT2560759	hsa-miR-1260	CLIP-seq
MIRT2560760	hsa-miR-1260b	CLIP-seq
MIRT2260760	hsa-miR-1285	CLIP-seq
MIRT1108062	hsa-miR-188-3p	CLIP-seq
MIRT2260762	hsa-miR-1976	CLIP-seq
MIRT1108026	hsa-miR-206	CLIP-seq
MIRT2260763	hsa-miR-2355-5p	CLIP-seq
MIRT1108031	hsa-miR-3125	CLIP-seq
MIRT1108032	hsa-miR-3136-3p	CLIP-seq
MIRT2560765	hsa-miR-3156-3p	CLIP-seq
MIRT1108033	hsa-miR-3158-5p	CLIP-seq
MIRT2260764	hsa-miR-3166	CLIP-seq
MIRT2260765	hsa-miR-3168	CLIP-seq
MIRT2560766	hsa-miR-3183	CLIP-seq
MIRT2260766	hsa-miR-3187-5p	CLIP-seq
MIRT1108034	hsa-miR-346	CLIP-seq
MIRT2560767	hsa-miR-3611	CLIP-seq
MIRT1108037	hsa-miR-3916	CLIP-seq
MIRT1108038	hsa-miR-3919	CLIP-seq
MIRT2683872	hsa-miR-3934	CLIP-seq
MIRT2683873	hsa-miR-4257	CLIP-seq
MIRT2560769	hsa-miR-4268	CLIP-seq
MIRT2260768	hsa-miR-4277	CLIP-seq
MIRT1108040	hsa-miR-4288	CLIP-seq
MIRT2560770	hsa-miR-4448	CLIP-seq
MIRT2260769	hsa-miR-4505	CLIP-seq
MIRT2260770	hsa-miR-451b	CLIP-seq
MIRT2560771	hsa-miR-4637	CLIP-seq
MIRT2560772	hsa-miR-4641	CLIP-seq
MIRT2560773	hsa-miR-4659a-5p	CLIP-seq
MIRT2560774	hsa-miR-4659b-5p	CLIP-seq
MIRT1108045	hsa-miR-4677-3p	CLIP-seq
MIRT2260771	hsa-miR-4695-3p	CLIP-seq
MIRT2560775	hsa-miR-4723-3p	CLIP-seq
MIRT2260773	hsa-miR-4771	CLIP-seq
MIRT2560776	hsa-miR-4786-3p	CLIP-seq
MIRT1108113	hsa-miR-532-3p	CLIP-seq
MIRT2683874	hsa-miR-552	CLIP-seq
MIRT2683875	hsa-miR-600	CLIP-seq
MIRT2260774	hsa-miR-612	CLIP-seq
MIRT1108055	hsa-miR-613	CLIP-seq
MIRT1108056	hsa-miR-632	CLIP-seq
MIRT2683876	hsa-miR-640	CLIP-seq
MIRT1108057	hsa-miR-654-3p	CLIP-seq
MIRT2560777	hsa-miR-660	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16762630, 17943721, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS	34910916
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0006754	Process	ATP biosynthetic process	IEA
GO:0006909	Process	Phagocytosis	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007005	Process	Mitochondrion organization	ISS
GO:0010467	Process	Gene expression	IEA
GO:0016020	Component	Membrane	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IEA
GO:0038061	Process	Non-canonical NF-kappaB signal transduction	IEA
GO:0043022	Function	Ribosome binding	IEA
GO:0050727	Process	Regulation of inflammatory response	IMP	31980577
GO:0050764	Process	Regulation of phagocytosis	IMP	31980577
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IEA
GO:0060090	Function	Molecular adaptor activity	IEA
GO:0060090	Function	Molecular adaptor activity	ISS	34910916
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	34910916
GO:1903409	Process	Reactive oxygen species biosynthetic process	IEA

MIM	HGNC	e!Ensembl
619070	24241	ENSG00000050426

Q6P1Q0

Protein name

LETM1 domain-containing protein 1 (Cervical cancer 1 proto-oncogene protein p40) (Cervical cancer proto-oncogene 2 protein) (HCCR-1) (HCRR-2)

Protein function

Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07766	LETM1	78 → 346	LETM1-like protein	Family

Tissue specificity

TISSUE SPECIFICITY: Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix. {ECO:0000269|PubMed:12879013}.

Sequence

MALSRVCWARSAVWGSAVTPGHFVTRRLQLGRSGLAWGAPRSSKLHLSPKADVKNLMSYV
VTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADAKKARRIKTNMWKHNIKFHQL
PYREMEHLRQFRQDVTKCLFLGIISIPPFANYLVFLLMYLFPRQLLIRHFWTPKQQTDFL
DIYHAFRKQSHPEIISYLEKVIPLISDAGLRWRLTDLCTKIQRGTHPAIHDILALRECFS
NHPLGMNQLQALHVKALSRAMLLTSYLPPPLLRHRLKTHTTVIHQLDKALAKLGIGQLTA
QEVKSACYLRGLNSTHIGEDRCRTWLGEWLQISCSLKEAELSLLLHNVVLLSTNYLGTRR

Sequence length

360

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (33)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute leukemia	Leukemia	BEFREE	24126909, 25034723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	25034723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	25034723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	9065478	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	14691448, 31424657		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19208263	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19208263, 31424657	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	19435525, 22511601	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	26629942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	26629942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	25034723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	16762630		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	22511601, 31856412	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	LHGDN	12061725		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	19208263	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	12879013, 15944950, 24126909, 25034723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	25034723	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	25034723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	21796456		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	22511601	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	14691448, 17943721, 22851403, 31424657		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	21796456		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	20423485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	27052330, 31293658		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12879013, 15944950, 20591135, 21796456, 27052330		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	26629942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	14691448, 16278390		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12879013, 22511601, 22851403, 27036047, 31293658		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	20423485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21703393	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	22511601		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	27052330, 31293658		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	26629942	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

LETMD1 (LETM1 domain containing 1)