Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	25852
Gene name	Armadillo repeat containing 8
Gene symbol	ARMC8
Synonyms (NCBI Gene)	GID5HSPC056S863-2VID28
Chromosome	3
Chromosome location	3q22.3

225

Show/Hide all (225)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030148	hsa-miR-26b-5p	Microarray	19088304
MIRT051825	hsa-let-7c-5p	CLASH	23622248
MIRT051358	hsa-let-7f-5p	CLASH	23622248
MIRT038998	hsa-let-7a-3p	CLASH	23622248
MIRT441182	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT441182	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT728308	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT728307	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT799222	hsa-miR-105	CLIP-seq
MIRT799223	hsa-miR-1252	CLIP-seq
MIRT799224	hsa-miR-1343	CLIP-seq
MIRT799225	hsa-miR-19a	CLIP-seq
MIRT799226	hsa-miR-19b	CLIP-seq
MIRT799227	hsa-miR-204	CLIP-seq
MIRT799228	hsa-miR-211	CLIP-seq
MIRT799229	hsa-miR-219-5p	CLIP-seq
MIRT799230	hsa-miR-2467-5p	CLIP-seq
MIRT799231	hsa-miR-29a	CLIP-seq
MIRT799232	hsa-miR-29b	CLIP-seq
MIRT799233	hsa-miR-29c	CLIP-seq
MIRT799234	hsa-miR-3065-3p	CLIP-seq
MIRT799235	hsa-miR-3120-3p	CLIP-seq
MIRT799236	hsa-miR-3121-3p	CLIP-seq
MIRT799237	hsa-miR-3126-3p	CLIP-seq
MIRT799238	hsa-miR-3137	CLIP-seq
MIRT799239	hsa-miR-3140-3p	CLIP-seq
MIRT799240	hsa-miR-3148	CLIP-seq
MIRT799241	hsa-miR-3150a-3p	CLIP-seq
MIRT799242	hsa-miR-3154	CLIP-seq
MIRT799243	hsa-miR-3164	CLIP-seq
MIRT799244	hsa-miR-3175	CLIP-seq
MIRT799245	hsa-miR-3176	CLIP-seq
MIRT799246	hsa-miR-3183	CLIP-seq
MIRT799247	hsa-miR-3188	CLIP-seq
MIRT799248	hsa-miR-3192	CLIP-seq
MIRT799249	hsa-miR-3662	CLIP-seq
MIRT799250	hsa-miR-3908	CLIP-seq
MIRT799251	hsa-miR-3922-3p	CLIP-seq
MIRT799252	hsa-miR-3938	CLIP-seq
MIRT799253	hsa-miR-3975	CLIP-seq
MIRT799254	hsa-miR-4273	CLIP-seq
MIRT799255	hsa-miR-4308	CLIP-seq
MIRT799256	hsa-miR-4314	CLIP-seq
MIRT799257	hsa-miR-4435	CLIP-seq
MIRT799258	hsa-miR-4445	CLIP-seq
MIRT799259	hsa-miR-450b-5p	CLIP-seq
MIRT799260	hsa-miR-455-3p	CLIP-seq
MIRT799261	hsa-miR-4646-5p	CLIP-seq
MIRT799262	hsa-miR-4652-3p	CLIP-seq
MIRT799263	hsa-miR-4667-5p	CLIP-seq
MIRT799264	hsa-miR-4677-5p	CLIP-seq
MIRT799265	hsa-miR-4678	CLIP-seq
MIRT799266	hsa-miR-4700-5p	CLIP-seq
MIRT799267	hsa-miR-4704-3p	CLIP-seq
MIRT799268	hsa-miR-4720-3p	CLIP-seq
MIRT799269	hsa-miR-4723-3p	CLIP-seq
MIRT799270	hsa-miR-4747-5p	CLIP-seq
MIRT799271	hsa-miR-4749-3p	CLIP-seq
MIRT799272	hsa-miR-4755-5p	CLIP-seq
MIRT799273	hsa-miR-4761-5p	CLIP-seq
MIRT799274	hsa-miR-4778-5p	CLIP-seq
MIRT799275	hsa-miR-4780	CLIP-seq
MIRT799276	hsa-miR-4782-3p	CLIP-seq
MIRT799277	hsa-miR-4789-5p	CLIP-seq
MIRT799278	hsa-miR-4793-5p	CLIP-seq
MIRT799279	hsa-miR-4799-5p	CLIP-seq
MIRT799280	hsa-miR-4804-3p	CLIP-seq
MIRT799281	hsa-miR-485-5p	CLIP-seq
MIRT799282	hsa-miR-507	CLIP-seq
MIRT799283	hsa-miR-508-3p	CLIP-seq
MIRT799284	hsa-miR-518a-5p	CLIP-seq
MIRT799285	hsa-miR-527	CLIP-seq
MIRT799286	hsa-miR-548g	CLIP-seq
MIRT799287	hsa-miR-557	CLIP-seq
MIRT799288	hsa-miR-576-5p	CLIP-seq
MIRT799289	hsa-miR-623	CLIP-seq
MIRT799290	hsa-miR-624	CLIP-seq
MIRT799291	hsa-miR-630	CLIP-seq
MIRT799292	hsa-miR-767-5p	CLIP-seq
MIRT799293	hsa-miR-875-3p	CLIP-seq
MIRT799294	hsa-miR-939	CLIP-seq
MIRT799225	hsa-miR-19a	CLIP-seq
MIRT799226	hsa-miR-19b	CLIP-seq
MIRT799295	hsa-miR-300	CLIP-seq
MIRT799296	hsa-miR-3133	CLIP-seq
MIRT799297	hsa-miR-338-5p	CLIP-seq
MIRT799298	hsa-miR-381	CLIP-seq
MIRT799299	hsa-miR-4312	CLIP-seq
MIRT799300	hsa-miR-4635	CLIP-seq
MIRT799301	hsa-miR-4643	CLIP-seq
MIRT799302	hsa-miR-4666-3p	CLIP-seq
MIRT799303	hsa-miR-4803	CLIP-seq
MIRT799304	hsa-miR-488	CLIP-seq
MIRT799305	hsa-miR-548a-3p	CLIP-seq
MIRT799306	hsa-miR-548e	CLIP-seq
MIRT799307	hsa-miR-548f	CLIP-seq
MIRT799308	hsa-miR-581	CLIP-seq
MIRT799225	hsa-miR-19a	CLIP-seq
MIRT799226	hsa-miR-19b	CLIP-seq
MIRT799243	hsa-miR-3164	CLIP-seq
MIRT799260	hsa-miR-455-3p	CLIP-seq
MIRT799273	hsa-miR-4761-5p	CLIP-seq
MIRT1935996	hsa-miR-1229	CLIP-seq
MIRT1935997	hsa-miR-1298	CLIP-seq
MIRT1935998	hsa-miR-132	CLIP-seq
MIRT1935999	hsa-miR-212	CLIP-seq
MIRT1936000	hsa-miR-377	CLIP-seq
MIRT1936001	hsa-miR-4422	CLIP-seq
MIRT799259	hsa-miR-450b-5p	CLIP-seq
MIRT1936002	hsa-miR-4719	CLIP-seq
MIRT1936003	hsa-miR-4796-3p	CLIP-seq
MIRT1936004	hsa-miR-486-5p	CLIP-seq
MIRT799282	hsa-miR-507	CLIP-seq
MIRT1936005	hsa-miR-520g	CLIP-seq
MIRT1936006	hsa-miR-520h	CLIP-seq
MIRT799287	hsa-miR-557	CLIP-seq
MIRT1936007	hsa-miR-604	CLIP-seq
MIRT1936008	hsa-miR-647	CLIP-seq
MIRT1936009	hsa-miR-664	CLIP-seq
MIRT2176022	hsa-miR-103a	CLIP-seq
MIRT799222	hsa-miR-105	CLIP-seq
MIRT2176023	hsa-miR-107	CLIP-seq
MIRT2176024	hsa-miR-1184	CLIP-seq
MIRT1935996	hsa-miR-1229	CLIP-seq
MIRT799223	hsa-miR-1252	CLIP-seq
MIRT1935997	hsa-miR-1298	CLIP-seq
MIRT2176025	hsa-miR-146a	CLIP-seq
MIRT2176026	hsa-miR-146b-5p	CLIP-seq
MIRT2176027	hsa-miR-188-5p	CLIP-seq
MIRT2176028	hsa-miR-1915	CLIP-seq
MIRT799225	hsa-miR-19a	CLIP-seq
MIRT799226	hsa-miR-19b	CLIP-seq
MIRT2176029	hsa-miR-2053	CLIP-seq
MIRT799230	hsa-miR-2467-5p	CLIP-seq
MIRT799231	hsa-miR-29a	CLIP-seq
MIRT799232	hsa-miR-29b	CLIP-seq
MIRT799233	hsa-miR-29c	CLIP-seq
MIRT799234	hsa-miR-3065-3p	CLIP-seq
MIRT799236	hsa-miR-3121-3p	CLIP-seq
MIRT2176030	hsa-miR-3136-3p	CLIP-seq
MIRT799242	hsa-miR-3154	CLIP-seq
MIRT799243	hsa-miR-3164	CLIP-seq
MIRT2176031	hsa-miR-3173-3p	CLIP-seq
MIRT799245	hsa-miR-3176	CLIP-seq
MIRT799247	hsa-miR-3188	CLIP-seq
MIRT2176032	hsa-miR-342-3p	CLIP-seq
MIRT2176033	hsa-miR-3665	CLIP-seq
MIRT2176034	hsa-miR-3689d	CLIP-seq
MIRT2176035	hsa-miR-371-3p	CLIP-seq
MIRT2176036	hsa-miR-371b-3p	CLIP-seq
MIRT1936000	hsa-miR-377	CLIP-seq
MIRT799251	hsa-miR-3922-3p	CLIP-seq
MIRT799253	hsa-miR-3975	CLIP-seq
MIRT2176037	hsa-miR-4251	CLIP-seq
MIRT2176038	hsa-miR-4293	CLIP-seq
MIRT2176039	hsa-miR-4324	CLIP-seq
MIRT2176040	hsa-miR-4457	CLIP-seq
MIRT2176041	hsa-miR-448	CLIP-seq
MIRT799259	hsa-miR-450b-5p	CLIP-seq
MIRT799260	hsa-miR-455-3p	CLIP-seq
MIRT2176042	hsa-miR-4641	CLIP-seq
MIRT2176043	hsa-miR-4654	CLIP-seq
MIRT799265	hsa-miR-4678	CLIP-seq
MIRT2176044	hsa-miR-4688	CLIP-seq
MIRT1936002	hsa-miR-4719	CLIP-seq
MIRT2176045	hsa-miR-4728-3p	CLIP-seq
MIRT799273	hsa-miR-4761-5p	CLIP-seq
MIRT2176046	hsa-miR-4769-5p	CLIP-seq
MIRT799274	hsa-miR-4778-5p	CLIP-seq
MIRT1936003	hsa-miR-4796-3p	CLIP-seq
MIRT799281	hsa-miR-485-5p	CLIP-seq
MIRT1936004	hsa-miR-486-5p	CLIP-seq
MIRT799282	hsa-miR-507	CLIP-seq
MIRT2176047	hsa-miR-515-3p	CLIP-seq
MIRT799284	hsa-miR-518a-5p	CLIP-seq
MIRT2176048	hsa-miR-519e	CLIP-seq
MIRT1936005	hsa-miR-520g	CLIP-seq
MIRT1936006	hsa-miR-520h	CLIP-seq
MIRT799285	hsa-miR-527	CLIP-seq
MIRT799286	hsa-miR-548g	CLIP-seq
MIRT2176049	hsa-miR-550a	CLIP-seq
MIRT799287	hsa-miR-557	CLIP-seq
MIRT2176050	hsa-miR-569	CLIP-seq
MIRT2176051	hsa-miR-589	CLIP-seq
MIRT1936007	hsa-miR-604	CLIP-seq
MIRT799290	hsa-miR-624	CLIP-seq
MIRT799291	hsa-miR-630	CLIP-seq
MIRT1936008	hsa-miR-647	CLIP-seq
MIRT1936009	hsa-miR-664	CLIP-seq
MIRT2176052	hsa-miR-671-5p	CLIP-seq
MIRT2176053	hsa-miR-764	CLIP-seq
MIRT799292	hsa-miR-767-5p	CLIP-seq
MIRT2176054	hsa-miR-873	CLIP-seq
MIRT2176055	hsa-miR-890	CLIP-seq
MIRT2479291	hsa-miR-137	CLIP-seq
MIRT2479292	hsa-miR-3177-3p	CLIP-seq
MIRT2479293	hsa-miR-338-3p	CLIP-seq
MIRT2479294	hsa-miR-3613-3p	CLIP-seq
MIRT2479295	hsa-miR-3682-5p	CLIP-seq
MIRT1936000	hsa-miR-377	CLIP-seq
MIRT2479296	hsa-miR-4252	CLIP-seq
MIRT2479297	hsa-miR-4328	CLIP-seq
MIRT2479298	hsa-miR-4530	CLIP-seq
MIRT2479299	hsa-miR-4659a-3p	CLIP-seq
MIRT2479300	hsa-miR-4659b-3p	CLIP-seq
MIRT2479301	hsa-miR-4762-5p	CLIP-seq
MIRT799279	hsa-miR-4799-5p	CLIP-seq
MIRT2479302	hsa-miR-495	CLIP-seq
MIRT2479303	hsa-miR-522	CLIP-seq
MIRT2479304	hsa-miR-548ac	CLIP-seq
MIRT2479305	hsa-miR-548ae	CLIP-seq
MIRT2479306	hsa-miR-548aj	CLIP-seq
MIRT2479307	hsa-miR-548am	CLIP-seq
MIRT2479308	hsa-miR-548d-3p	CLIP-seq
MIRT2479309	hsa-miR-548x	CLIP-seq
MIRT2479310	hsa-miR-548z	CLIP-seq
MIRT2479311	hsa-miR-616	CLIP-seq
MIRT2479312	hsa-miR-642b	CLIP-seq
MIRT2479292	hsa-miR-3177-3p	CLIP-seq
MIRT2479293	hsa-miR-338-3p	CLIP-seq
MIRT2479294	hsa-miR-3613-3p	CLIP-seq
MIRT2479296	hsa-miR-4252	CLIP-seq
MIRT2479298	hsa-miR-4530	CLIP-seq
MIRT2479311	hsa-miR-616	CLIP-seq
MIRT2479312	hsa-miR-642b	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IDA	29911972
GO:0005515	Function	Protein binding	IPI	17467196, 25416956, 27173435, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IDA	17467196
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	17467196
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0034657	Component	GID complex	IBA
GO:0035580	Component	Specific granule lumen	TAS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:1904724	Component	Tertiary granule lumen	TAS

MIM	HGNC	e!Ensembl
618521	24999	ENSG00000114098

Q8IUR7

Protein name

Armadillo repeat-containing protein 8

Protein function

Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.

PDB

7NSC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00514	Arm	50 → 92	Armadillo/beta-catenin-like repeat	Repeat

Sequence

MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVL
GAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLK
FIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDH
QTILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIF
VKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEG
AETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQA
AFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRT
SFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSE
NPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLS
TRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDIL
QKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNL
CDKAKMALQQYLA

Sequence length

673

Interactions

View interactions

	Reactome
			Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DRY EYE SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (26)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	25987023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	30036398	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	28081738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26081621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25119601, 26081621	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	24894675, 28081738	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ductal	Ductal carcinoma	Pubtator	25119601	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	26944057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Lobular	Lobular carcinoma	Pubtator	25119601	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	28081738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	24894675, 25987023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	26081621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26081621	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	25987023	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24894675	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	26081621	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26081621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	24894675, 25987023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	28081738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24894675, 25987023, 30482882		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	26081621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26081621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	24894675, 26081621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	27712595		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polydactyly	Polydactyly	GENOMICS_ENGLAND_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	28081738	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ARMC8 (armadillo repeat containing 8)