Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	25851
Gene name	Tectonin beta-propeller repeat containing 1
Gene symbol	TECPR1
Synonyms (NCBI Gene)	-
Chromosome	7
Chromosome location	7q21.3
Summary	This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]

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Show/Hide all (122)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018009	hsa-miR-335-5p	Microarray	18185580
MIRT670032	hsa-miR-4418	HITS-CLIP	23824327
MIRT670031	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT670030	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT670029	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT670028	hsa-miR-5693	HITS-CLIP	23824327
MIRT670027	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT670026	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT670025	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT670024	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT670023	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT670022	hsa-miR-1184	HITS-CLIP	23824327
MIRT670021	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT670020	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT670019	hsa-miR-3135b	HITS-CLIP	23824327
MIRT670018	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT670017	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT670016	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT670015	hsa-miR-4284	HITS-CLIP	23824327
MIRT670014	hsa-miR-3652	HITS-CLIP	23824327
MIRT670013	hsa-miR-4430	HITS-CLIP	23824327
MIRT670012	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT670011	hsa-miR-7641	HITS-CLIP	23824327
MIRT670010	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT670009	hsa-miR-5698	HITS-CLIP	23824327
MIRT496199	hsa-miR-105-5p	PAR-CLIP	22291592
MIRT496198	hsa-miR-7853-5p	PAR-CLIP	22291592
MIRT496197	hsa-miR-371b-5p	PAR-CLIP	22291592
MIRT496196	hsa-miR-373-5p	PAR-CLIP	22291592
MIRT496195	hsa-miR-616-5p	PAR-CLIP	22291592
MIRT496194	hsa-miR-371a-5p	PAR-CLIP	22291592
MIRT496193	hsa-miR-372-5p	PAR-CLIP	22291592
MIRT496192	hsa-miR-1180-5p	PAR-CLIP	22291592
MIRT496191	hsa-miR-7114-3p	PAR-CLIP	22291592
MIRT496190	hsa-miR-6822-3p	PAR-CLIP	22291592
MIRT496189	hsa-miR-760	PAR-CLIP	22291592
MIRT496188	hsa-miR-513c-5p	PAR-CLIP	22291592
MIRT496187	hsa-miR-514b-5p	PAR-CLIP	22291592
MIRT496186	hsa-miR-8057	PAR-CLIP	22291592
MIRT670032	hsa-miR-4418	HITS-CLIP	23824327
MIRT670031	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT670030	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT670029	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT670028	hsa-miR-5693	HITS-CLIP	23824327
MIRT670027	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT670026	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT670025	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT670024	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT670023	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT670022	hsa-miR-1184	HITS-CLIP	23824327
MIRT670021	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT670020	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT670019	hsa-miR-3135b	HITS-CLIP	23824327
MIRT670018	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT670017	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT670016	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT670015	hsa-miR-4284	HITS-CLIP	23824327
MIRT670014	hsa-miR-3652	HITS-CLIP	23824327
MIRT670013	hsa-miR-4430	HITS-CLIP	23824327
MIRT670012	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT670011	hsa-miR-7641	HITS-CLIP	23824327
MIRT670010	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT670009	hsa-miR-5698	HITS-CLIP	23824327
MIRT496199	hsa-miR-105-5p	PAR-CLIP	22291592
MIRT496198	hsa-miR-7853-5p	PAR-CLIP	22291592
MIRT496197	hsa-miR-371b-5p	PAR-CLIP	22291592
MIRT496196	hsa-miR-373-5p	PAR-CLIP	22291592
MIRT496195	hsa-miR-616-5p	PAR-CLIP	22291592
MIRT496194	hsa-miR-371a-5p	PAR-CLIP	22291592
MIRT496193	hsa-miR-372-5p	PAR-CLIP	22291592
MIRT496192	hsa-miR-1180-5p	PAR-CLIP	22291592
MIRT496191	hsa-miR-7114-3p	PAR-CLIP	22291592
MIRT496190	hsa-miR-6822-3p	PAR-CLIP	22291592
MIRT496189	hsa-miR-760	PAR-CLIP	22291592
MIRT496188	hsa-miR-513c-5p	PAR-CLIP	22291592
MIRT496187	hsa-miR-514b-5p	PAR-CLIP	22291592
MIRT496186	hsa-miR-8057	PAR-CLIP	22291592
MIRT1417629	hsa-miR-122	CLIP-seq
MIRT1417630	hsa-miR-1825	CLIP-seq
MIRT1417631	hsa-miR-3127-5p	CLIP-seq
MIRT1417632	hsa-miR-3157-5p	CLIP-seq
MIRT1417633	hsa-miR-3918	CLIP-seq
MIRT1417634	hsa-miR-4648	CLIP-seq
MIRT1417635	hsa-miR-4654	CLIP-seq
MIRT1417636	hsa-miR-4669	CLIP-seq
MIRT1417637	hsa-miR-4676-5p	CLIP-seq
MIRT1417638	hsa-miR-4691-3p	CLIP-seq
MIRT1417639	hsa-miR-4721	CLIP-seq
MIRT1417640	hsa-miR-4769-5p	CLIP-seq
MIRT1417641	hsa-miR-515-3p	CLIP-seq
MIRT1417642	hsa-miR-519e	CLIP-seq
MIRT1417643	hsa-miR-575	CLIP-seq
MIRT2347595	hsa-miR-106a	CLIP-seq
MIRT2347596	hsa-miR-106b	CLIP-seq
MIRT2347597	hsa-miR-1224-3p	CLIP-seq
MIRT2347598	hsa-miR-150	CLIP-seq
MIRT2347599	hsa-miR-17	CLIP-seq
MIRT2347600	hsa-miR-1913	CLIP-seq
MIRT2347601	hsa-miR-20a	CLIP-seq
MIRT2347602	hsa-miR-20b	CLIP-seq
MIRT2347603	hsa-miR-302a	CLIP-seq
MIRT2347604	hsa-miR-302b	CLIP-seq
MIRT2347605	hsa-miR-302c	CLIP-seq
MIRT2347606	hsa-miR-302d	CLIP-seq
MIRT2347607	hsa-miR-302e	CLIP-seq
MIRT2347608	hsa-miR-324-3p	CLIP-seq
MIRT2347609	hsa-miR-372	CLIP-seq
MIRT2347610	hsa-miR-373	CLIP-seq
MIRT2347611	hsa-miR-4438	CLIP-seq
MIRT2347612	hsa-miR-4731-5p	CLIP-seq
MIRT2347613	hsa-miR-5095	CLIP-seq
MIRT2347614	hsa-miR-512-3p	CLIP-seq
MIRT2347615	hsa-miR-519d	CLIP-seq
MIRT2347616	hsa-miR-520a-3p	CLIP-seq
MIRT2347617	hsa-miR-520b	CLIP-seq
MIRT2347618	hsa-miR-520c-3p	CLIP-seq
MIRT2347619	hsa-miR-520d-3p	CLIP-seq
MIRT2347620	hsa-miR-520e	CLIP-seq
MIRT2347621	hsa-miR-520g	CLIP-seq
MIRT2347622	hsa-miR-520h	CLIP-seq
MIRT2347623	hsa-miR-93	CLIP-seq
MIRT1417633	hsa-miR-3918	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000421	Component	Autophagosome membrane	IBA
GO:0000421	Component	Autophagosome membrane	IDA	21575909, 22342342
GO:0000421	Component	Autophagosome membrane	IEA
GO:0005515	Function	Protein binding	IPI	20562859, 21575909, 22342342, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IDA	22342342
GO:0005765	Component	Lysosomal membrane	IEA
GO:0006914	Process	Autophagy	IDA	21575909
GO:0006914	Process	Autophagy	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	IMP	25484072
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IBA
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IDA	22342342
GO:0032991	Component	Protein-containing complex	NAS	25484072
GO:0097352	Process	Autophagosome maturation	IBA
GO:0097352	Process	Autophagosome maturation	IMP	22342342
GO:0098588	Component	Bounding membrane of organelle	IEA
GO:1901096	Process	Regulation of autophagosome maturation	IMP	22342342

MIM	HGNC	e!Ensembl
614781	22214	ENSG00000205356

Q7Z6L1

Protein name

Tectonin beta-propeller repeat-containing protein 1

Protein function

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present a

PDB

4TQ1 , 8P5P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06398	Pex24p	55 → 165	Integral peroxisomal membrane peroxin	Family
PF06462	Hyd_WA	210 → 239	Propeller	Family
PF19193	Tectonin	288 → 392	Tectonin domain	Domain
PF06398	Pex24p	804 → 916	Integral peroxisomal membrane peroxin	Family
PF06462	Hyd_WA	954 → 983	Propeller	Family
PF06462	Hyd_WA	999 → 1028	Propeller	Family
PF06462	Hyd_WA	1045 → 1074	Propeller	Family
PF06462	Hyd_WA	1088 → 1126	Propeller	Family

Sequence

MPNSVLWAVDLFGRVYTLSTAGQYWEMCKDSQLEFKRVSATTQCCWGIACDNQVYVYVCA
SDVPIRRREEAYENQRWNPMGGFCEKLLLSDRWGWSDVSGLQHRPLDRVALPSPHWEWES
DWYVDENFGGEPTEKGGWTYAIDFPATYTKDKKWNSCVRRRKWIRYRRYKSRDIWAKIPS
KDDPKELPDPFNDLSVGGWEITEEPVGRLSVWAVSLQGKVWYREDVSHSNPEGSSWSLLD
TPGEVVQISCGPHDLLWATLWEGQALVREGINRSNPKGSSWSIVEPPGSENGVMHISVGV
SVVWAVTKDWKVWFRRGVNSHNPCGTSWIEMVGEMTMVNVGMNDQVWGIGCEDRAVYFRQ
GVTPSELSGKTWKAIIAARECDRSHSGSSSSLLSAGCFFGDEVRGSGESAPSDTDASSEV
ERPGPGQILPAEPLDDSKNATGNSASGLGAGRTAEDTVEDACPAEGSREARPNTHPGPAP
TPAELPWTNIDLKEAKKVPSHSAAGFPETTSLSSLGLLPLGLEEPYGVDDHPLWAWVSGG
GCVVEACAMPRWFTVQAGLSSSVHMLSLSITPAQTAAWRKQIFQQLTERTKRELENFRHY
EQAVEQSVWVKTGALQWWCDWKPHKWVDVRLALEQFTGHDGVRDSILFIYYVVHEEKKYI
HIFLNEVVALVPVLNETKHSFALYTPERTRQRWPVRLAAATEQDMNDWLALLSLSCCESR
KVQGRPSPQAIWSITCKGDIFVSEPSPDLEAHEHPLPCDQMFWRQMGGHLRMVEANSRGV
VWGIGYDHTAWVYTGGYGGGCFQGLASSTSNIYTQSDVKCVHIYENQRWNPVTGYTSRGL
PTDRYMWSDASGLQECTKAGTKPPSLQWAWVSDWFVDFSVPGGTDQEGWQYASDFPASYH
GSKTMKDFVRRRCWARKCKLVTSGPWLEVPPIALRDVSIIPESPGAEGSGHSIALWAVSD
KGDVLCRLGVSELNPAGSSWLHVGTDQPFASISIGACYQVWAVARDGSAFYRGSVYPSQP
AGDCWYHIPSPPRQRLKQVSAGQTSVYALDENGNLWYRQGITPSYPQGSSWEHVSNNVCR
VSVGPLDQVWVIANKVQGSHSLSRGTVCHRTGVQPHEPKGHGWDYGIGGGWDHISVRANA
TRAPRSSSQEQEPSAPPEAHGPVCC

Sequence length

1165

Interactions

View interactions

	KEGG
	Shigellosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Esophageal atresia/tracheoesophageal fistula	Likely pathogenic	rs767020833	RCV001172303	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Moyamoya angiopathy	Likely pathogenic	rs376512300	RCV004704511	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	28381171	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

TECPR1 (tectonin beta-propeller repeat containing 1)