Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2585
Gene name	Galactokinase 2
Gene symbol	GALK2
Synonyms (NCBI Gene)	GK2
Chromosome	15
Chromosome location	15q21.1-q21.2
Summary	This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. The encoded protein is a member of the GHMP kinase family. Alternative splicing results in multi

174

Show/Hide all (174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038704	hsa-miR-148a-5p	CLASH	23622248
MIRT509609	hsa-miR-548c-3p	HITS-CLIP	19536157
MIRT509608	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT509607	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT509606	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT509605	hsa-miR-4474-5p	HITS-CLIP	19536157
MIRT509609	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT509608	hsa-miR-4668-3p	HITS-CLIP	21572407
MIRT509607	hsa-miR-500a-5p	HITS-CLIP	21572407
MIRT509606	hsa-miR-3613-3p	HITS-CLIP	21572407
MIRT509605	hsa-miR-4474-5p	HITS-CLIP	21572407
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509611	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT509610	hsa-miR-421	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	23446348
MIRT509612	hsa-miR-34c-3p	PAR-CLIP	23446348
MIRT509611	hsa-miR-4709-5p	PAR-CLIP	23446348
MIRT509610	hsa-miR-421	PAR-CLIP	23446348
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	23446348
MIRT509609	hsa-miR-548c-3p	HITS-CLIP	19536157
MIRT509608	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT509607	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT509606	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT509605	hsa-miR-4474-5p	HITS-CLIP	19536157
MIRT509609	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT509608	hsa-miR-4668-3p	HITS-CLIP	21572407
MIRT509607	hsa-miR-500a-5p	HITS-CLIP	21572407
MIRT509606	hsa-miR-3613-3p	HITS-CLIP	21572407
MIRT509605	hsa-miR-4474-5p	HITS-CLIP	21572407
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509611	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT509610	hsa-miR-421	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	20371350
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	23446348
MIRT509612	hsa-miR-34c-3p	PAR-CLIP	23446348
MIRT509611	hsa-miR-4709-5p	PAR-CLIP	23446348
MIRT509610	hsa-miR-421	PAR-CLIP	23446348
MIRT509609	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT509608	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT509607	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT509606	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509605	hsa-miR-4474-5p	PAR-CLIP	23446348
MIRT1010544	hsa-miR-3647-3p	CLIP-seq
MIRT1010545	hsa-miR-369-3p	CLIP-seq
MIRT1010546	hsa-miR-374a	CLIP-seq
MIRT1010547	hsa-miR-374b	CLIP-seq
MIRT1010548	hsa-miR-4676-5p	CLIP-seq
MIRT1010549	hsa-miR-574-5p	CLIP-seq
MIRT1010550	hsa-miR-575	CLIP-seq
MIRT1010551	hsa-miR-579	CLIP-seq
MIRT1010545	hsa-miR-369-3p	CLIP-seq
MIRT1010545	hsa-miR-369-3p	CLIP-seq
MIRT2536667	hsa-miR-1	CLIP-seq
MIRT2536668	hsa-miR-1244	CLIP-seq
MIRT2536669	hsa-miR-1303	CLIP-seq
MIRT2536670	hsa-miR-147	CLIP-seq
MIRT2536671	hsa-miR-202	CLIP-seq
MIRT2536672	hsa-miR-206	CLIP-seq
MIRT2536673	hsa-miR-300	CLIP-seq
MIRT2536674	hsa-miR-302a	CLIP-seq
MIRT2536675	hsa-miR-302b	CLIP-seq
MIRT2536676	hsa-miR-302c	CLIP-seq
MIRT2536677	hsa-miR-302d	CLIP-seq
MIRT2536678	hsa-miR-302e	CLIP-seq
MIRT2536679	hsa-miR-3157-3p	CLIP-seq
MIRT2536680	hsa-miR-3190	CLIP-seq
MIRT2536681	hsa-miR-371b-3p	CLIP-seq
MIRT2536682	hsa-miR-371b-5p	CLIP-seq
MIRT2536683	hsa-miR-372	CLIP-seq
MIRT2536684	hsa-miR-373	CLIP-seq
MIRT2536685	hsa-miR-381	CLIP-seq
MIRT2536686	hsa-miR-3911	CLIP-seq
MIRT2536687	hsa-miR-4305	CLIP-seq
MIRT2536688	hsa-miR-432	CLIP-seq
MIRT2536689	hsa-miR-4666-3p	CLIP-seq
MIRT2536690	hsa-miR-4678	CLIP-seq
MIRT2536691	hsa-miR-4698	CLIP-seq
MIRT2536692	hsa-miR-4722-3p	CLIP-seq
MIRT2536693	hsa-miR-495	CLIP-seq
MIRT2536694	hsa-miR-515-3p	CLIP-seq
MIRT2536695	hsa-miR-519a	CLIP-seq
MIRT2536696	hsa-miR-519b-3p	CLIP-seq
MIRT2536697	hsa-miR-519c-3p	CLIP-seq
MIRT2536698	hsa-miR-519e	CLIP-seq
MIRT2536699	hsa-miR-520a-3p	CLIP-seq
MIRT2536700	hsa-miR-520b	CLIP-seq
MIRT2536701	hsa-miR-520c-3p	CLIP-seq
MIRT2536702	hsa-miR-520d-3p	CLIP-seq
MIRT2536703	hsa-miR-520e	CLIP-seq
MIRT2536704	hsa-miR-539	CLIP-seq
MIRT2536705	hsa-miR-548p	CLIP-seq
MIRT2536706	hsa-miR-562	CLIP-seq
MIRT2536707	hsa-miR-578	CLIP-seq
MIRT2536708	hsa-miR-580	CLIP-seq
MIRT2536709	hsa-miR-613	CLIP-seq
MIRT2536710	hsa-miR-644	CLIP-seq
MIRT2536711	hsa-miR-888	CLIP-seq
MIRT2536667	hsa-miR-1	CLIP-seq
MIRT2536668	hsa-miR-1244	CLIP-seq
MIRT2536669	hsa-miR-1303	CLIP-seq
MIRT2536670	hsa-miR-147	CLIP-seq
MIRT2536672	hsa-miR-206	CLIP-seq
MIRT2536673	hsa-miR-300	CLIP-seq
MIRT2536674	hsa-miR-302a	CLIP-seq
MIRT2536675	hsa-miR-302b	CLIP-seq
MIRT2536676	hsa-miR-302c	CLIP-seq
MIRT2536677	hsa-miR-302d	CLIP-seq
MIRT2536678	hsa-miR-302e	CLIP-seq
MIRT2536679	hsa-miR-3157-3p	CLIP-seq
MIRT2536680	hsa-miR-3190	CLIP-seq
MIRT2536681	hsa-miR-371b-3p	CLIP-seq
MIRT2536683	hsa-miR-372	CLIP-seq
MIRT2536684	hsa-miR-373	CLIP-seq
MIRT2536685	hsa-miR-381	CLIP-seq
MIRT2536686	hsa-miR-3911	CLIP-seq
MIRT2536687	hsa-miR-4305	CLIP-seq
MIRT2536688	hsa-miR-432	CLIP-seq
MIRT2536689	hsa-miR-4666-3p	CLIP-seq
MIRT2536692	hsa-miR-4722-3p	CLIP-seq
MIRT2681335	hsa-miR-4768-5p	CLIP-seq
MIRT2536694	hsa-miR-515-3p	CLIP-seq
MIRT2536695	hsa-miR-519a	CLIP-seq
MIRT2536696	hsa-miR-519b-3p	CLIP-seq
MIRT2536697	hsa-miR-519c-3p	CLIP-seq
MIRT2536698	hsa-miR-519e	CLIP-seq
MIRT2536699	hsa-miR-520a-3p	CLIP-seq
MIRT2536700	hsa-miR-520b	CLIP-seq
MIRT2536701	hsa-miR-520c-3p	CLIP-seq
MIRT2536702	hsa-miR-520d-3p	CLIP-seq
MIRT2536703	hsa-miR-520e	CLIP-seq
MIRT2536705	hsa-miR-548p	CLIP-seq
MIRT2536706	hsa-miR-562	CLIP-seq
MIRT2536707	hsa-miR-578	CLIP-seq
MIRT2536709	hsa-miR-613	CLIP-seq
MIRT2536710	hsa-miR-644	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004335	Function	Galactokinase activity	IBA
GO:0004335	Function	Galactokinase activity	IDA	7542884
GO:0004335	Function	Galactokinase activity	IEA
GO:0004335	Function	Galactokinase activity	TAS	8798585
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005975	Process	Carbohydrate metabolic process	TAS	8798585
GO:0006012	Process	Galactose metabolic process	IBA
GO:0006012	Process	Galactose metabolic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016773	Function	Phosphotransferase activity, alcohol group as acceptor	IEA
GO:0033858	Function	N-acetylgalactosamine kinase activity	IEA
GO:0046835	Process	Carbohydrate phosphorylation	IEA

MIM	HGNC	e!Ensembl
137028	4119	ENSG00000156958

Q01415

Protein name

N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2)

Protein function

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. {ECO:0000269|PubMed:1

PDB

2A2C , 2A2D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10509	GalKase_gal_bdg	24 → 73	Galactokinase galactose-binding signature	Domain
PF00288	GHMP_kinases_N	131 → 198	GHMP kinases N terminal domain	Family
PF08544	GHMP_kinases_C	345 → 430	GHMP kinases C terminal	Family

Sequence

MATESPATRRVQVAEHPRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLP
MAVEQDVLIAVEPVKTYALQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGLKGIQE
HFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER
YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHF
NIRVMECRLAAKLLAKYKSLQWDKVLRLEEVQAKLGISLEEMLLVTEDALHPEPYNPEEI
CRCLGISLEELRTQILSPNTQDVLIFKLYQRAKHVYSEAARVLQFKKICEEAPENMVQLL
GELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSF
LANVHKAYYQRSDGSLAPEKQSLFATKPGGGALVLLEA

Sequence length

458

Interactions

View interactions

	KEGG
	Amino sugar and nucleotide sugar metabolism Metabolic pathways Biosynthesis of nucleotide sugars

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	GWASCAT_DG	28604730		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	30503783	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	GWASCAT_DG	28604730		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dental Caries	Dental caries	Pubtator	31148553	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glomerulonephritis IGA	Iga nephropathy	Pubtator	22318827	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	22761715	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GALK2 (galactokinase 2)