Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	25833
Gene name	POU class 2 homeobox 3
Gene symbol	POU2F3
Synonyms (NCBI Gene)	Epoc-1OCT-11OCT11OTF-11PLA-1PLA1Skn-1a
Chromosome	11
Chromosome location	11q23.3
Summary	This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016830	hsa-miR-335-5p	Microarray	18185580
MIRT028932	hsa-miR-26b-5p	Microarray	19088304
MIRT622661	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT696230	hsa-miR-5694	HITS-CLIP	23313552
MIRT666863	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT622660	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT622659	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT622658	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT666862	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT622657	hsa-miR-378g	HITS-CLIP	23313552
MIRT666861	hsa-miR-4252	HITS-CLIP	23313552
MIRT622656	hsa-miR-661	HITS-CLIP	23313552
MIRT622655	hsa-miR-3135b	HITS-CLIP	23313552
MIRT622654	hsa-miR-6081	HITS-CLIP	23313552
MIRT622653	hsa-miR-3652	HITS-CLIP	23313552
MIRT622652	hsa-miR-4430	HITS-CLIP	23313552
MIRT622651	hsa-miR-4656	HITS-CLIP	23313552
MIRT622650	hsa-miR-6829-5p	HITS-CLIP	23313552
MIRT622649	hsa-miR-4492	HITS-CLIP	23313552
MIRT622648	hsa-miR-4498	HITS-CLIP	23313552
MIRT622647	hsa-miR-5001-5p	HITS-CLIP	23313552
MIRT622646	hsa-miR-762	HITS-CLIP	23313552
MIRT622645	hsa-miR-4675	HITS-CLIP	23313552
MIRT622644	hsa-miR-4741	HITS-CLIP	23313552
MIRT622643	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT622642	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT622641	hsa-miR-7703	HITS-CLIP	23313552
MIRT622640	hsa-miR-1587	HITS-CLIP	23313552
MIRT622639	hsa-miR-3620-5p	HITS-CLIP	23313552
MIRT672462	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT672461	hsa-miR-4690-3p	HITS-CLIP	23824327
MIRT672460	hsa-miR-5685	HITS-CLIP	23824327
MIRT672459	hsa-miR-1972	HITS-CLIP	23824327
MIRT672458	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT672457	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT672456	hsa-miR-4284	HITS-CLIP	23824327
MIRT672455	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672454	hsa-miR-7977	HITS-CLIP	23824327
MIRT622661	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT666863	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622659	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT622658	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT666862	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622657	hsa-miR-378g	HITS-CLIP	23824327
MIRT666861	hsa-miR-4252	HITS-CLIP	23824327
MIRT622656	hsa-miR-661	HITS-CLIP	23824327
MIRT622655	hsa-miR-3135b	HITS-CLIP	23824327
MIRT622654	hsa-miR-6081	HITS-CLIP	23824327
MIRT622653	hsa-miR-3652	HITS-CLIP	23824327
MIRT622652	hsa-miR-4430	HITS-CLIP	23824327
MIRT622651	hsa-miR-4656	HITS-CLIP	23824327
MIRT622650	hsa-miR-6829-5p	HITS-CLIP	23824327
MIRT622649	hsa-miR-4492	HITS-CLIP	23824327
MIRT622648	hsa-miR-4498	HITS-CLIP	23824327
MIRT622647	hsa-miR-5001-5p	HITS-CLIP	23824327
MIRT622646	hsa-miR-762	HITS-CLIP	23824327
MIRT622645	hsa-miR-4675	HITS-CLIP	23824327
MIRT622644	hsa-miR-4741	HITS-CLIP	23824327
MIRT622643	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622642	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622641	hsa-miR-7703	HITS-CLIP	23824327
MIRT622640	hsa-miR-1587	HITS-CLIP	23824327
MIRT622639	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT649935	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT649934	hsa-miR-5681b	HITS-CLIP	23824327
MIRT649933	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT622661	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT622660	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT622659	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT622658	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622657	hsa-miR-378g	HITS-CLIP	23824327
MIRT622656	hsa-miR-661	HITS-CLIP	23824327
MIRT622655	hsa-miR-3135b	HITS-CLIP	23824327
MIRT622654	hsa-miR-6081	HITS-CLIP	23824327
MIRT622653	hsa-miR-3652	HITS-CLIP	23824327
MIRT622652	hsa-miR-4430	HITS-CLIP	23824327
MIRT622651	hsa-miR-4656	HITS-CLIP	23824327
MIRT622650	hsa-miR-6829-5p	HITS-CLIP	23824327
MIRT622649	hsa-miR-4492	HITS-CLIP	23824327
MIRT622648	hsa-miR-4498	HITS-CLIP	23824327
MIRT622647	hsa-miR-5001-5p	HITS-CLIP	23824327
MIRT622646	hsa-miR-762	HITS-CLIP	23824327
MIRT622645	hsa-miR-4675	HITS-CLIP	23824327
MIRT622644	hsa-miR-4741	HITS-CLIP	23824327
MIRT622643	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622642	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622641	hsa-miR-7703	HITS-CLIP	23824327
MIRT622640	hsa-miR-1587	HITS-CLIP	23824327
MIRT622639	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT622660	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT622660	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT622661	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT696230	hsa-miR-5694	HITS-CLIP	23313552
MIRT666863	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT622660	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT622659	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT622658	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT666862	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT622657	hsa-miR-378g	HITS-CLIP	23313552
MIRT666861	hsa-miR-4252	HITS-CLIP	23313552
MIRT622656	hsa-miR-661	HITS-CLIP	23313552
MIRT622655	hsa-miR-3135b	HITS-CLIP	23313552
MIRT622654	hsa-miR-6081	HITS-CLIP	23313552
MIRT622653	hsa-miR-3652	HITS-CLIP	23313552
MIRT622652	hsa-miR-4430	HITS-CLIP	23313552
MIRT622651	hsa-miR-4656	HITS-CLIP	23313552
MIRT622650	hsa-miR-6829-5p	HITS-CLIP	23313552
MIRT622649	hsa-miR-4492	HITS-CLIP	23313552
MIRT622648	hsa-miR-4498	HITS-CLIP	23313552
MIRT622647	hsa-miR-5001-5p	HITS-CLIP	23313552
MIRT622646	hsa-miR-762	HITS-CLIP	23313552
MIRT622645	hsa-miR-4675	HITS-CLIP	23313552
MIRT622644	hsa-miR-4741	HITS-CLIP	23313552
MIRT622643	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT622642	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT622641	hsa-miR-7703	HITS-CLIP	23313552
MIRT622640	hsa-miR-1587	HITS-CLIP	23313552
MIRT622639	hsa-miR-3620-5p	HITS-CLIP	23313552
MIRT672462	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT672461	hsa-miR-4690-3p	HITS-CLIP	23824327
MIRT672460	hsa-miR-5685	HITS-CLIP	23824327
MIRT672459	hsa-miR-1972	HITS-CLIP	23824327
MIRT672458	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT672457	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT672456	hsa-miR-4284	HITS-CLIP	23824327
MIRT672455	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT672454	hsa-miR-7977	HITS-CLIP	23824327
MIRT622661	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT666863	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622659	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT622658	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT666862	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622657	hsa-miR-378g	HITS-CLIP	23824327
MIRT666861	hsa-miR-4252	HITS-CLIP	23824327
MIRT622656	hsa-miR-661	HITS-CLIP	23824327
MIRT622655	hsa-miR-3135b	HITS-CLIP	23824327
MIRT622654	hsa-miR-6081	HITS-CLIP	23824327
MIRT622653	hsa-miR-3652	HITS-CLIP	23824327
MIRT622652	hsa-miR-4430	HITS-CLIP	23824327
MIRT622651	hsa-miR-4656	HITS-CLIP	23824327
MIRT622650	hsa-miR-6829-5p	HITS-CLIP	23824327
MIRT622649	hsa-miR-4492	HITS-CLIP	23824327
MIRT622648	hsa-miR-4498	HITS-CLIP	23824327
MIRT622647	hsa-miR-5001-5p	HITS-CLIP	23824327
MIRT622646	hsa-miR-762	HITS-CLIP	23824327
MIRT622645	hsa-miR-4675	HITS-CLIP	23824327
MIRT622644	hsa-miR-4741	HITS-CLIP	23824327
MIRT622643	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622642	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622641	hsa-miR-7703	HITS-CLIP	23824327
MIRT622640	hsa-miR-1587	HITS-CLIP	23824327
MIRT622639	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT649935	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT649934	hsa-miR-5681b	HITS-CLIP	23824327
MIRT649933	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT622661	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT622660	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT622659	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT622658	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622657	hsa-miR-378g	HITS-CLIP	23824327
MIRT622656	hsa-miR-661	HITS-CLIP	23824327
MIRT622655	hsa-miR-3135b	HITS-CLIP	23824327
MIRT622654	hsa-miR-6081	HITS-CLIP	23824327
MIRT622653	hsa-miR-3652	HITS-CLIP	23824327
MIRT622652	hsa-miR-4430	HITS-CLIP	23824327
MIRT622651	hsa-miR-4656	HITS-CLIP	23824327
MIRT622650	hsa-miR-6829-5p	HITS-CLIP	23824327
MIRT622649	hsa-miR-4492	HITS-CLIP	23824327
MIRT622648	hsa-miR-4498	HITS-CLIP	23824327
MIRT622647	hsa-miR-5001-5p	HITS-CLIP	23824327
MIRT622646	hsa-miR-762	HITS-CLIP	23824327
MIRT622645	hsa-miR-4675	HITS-CLIP	23824327
MIRT622644	hsa-miR-4741	HITS-CLIP	23824327
MIRT622643	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622642	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622641	hsa-miR-7703	HITS-CLIP	23824327
MIRT622640	hsa-miR-1587	HITS-CLIP	23824327
MIRT622639	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT1250936	hsa-miR-1228	CLIP-seq
MIRT1250937	hsa-miR-1827	CLIP-seq
MIRT1250938	hsa-miR-24	CLIP-seq
MIRT1250939	hsa-miR-3929	CLIP-seq
MIRT1250940	hsa-miR-4419b	CLIP-seq
MIRT1250941	hsa-miR-4428	CLIP-seq
MIRT1250942	hsa-miR-4478	CLIP-seq
MIRT1250943	hsa-miR-4649-3p	CLIP-seq
MIRT1250944	hsa-miR-4722-5p	CLIP-seq
MIRT1250945	hsa-miR-485-5p	CLIP-seq
MIRT1250946	hsa-miR-665	CLIP-seq
MIRT1250947	hsa-miR-940	CLIP-seq
MIRT2074069	hsa-miR-1207-3p	CLIP-seq
MIRT2074070	hsa-miR-204	CLIP-seq
MIRT2074071	hsa-miR-211	CLIP-seq
MIRT2074072	hsa-miR-27a	CLIP-seq
MIRT2074073	hsa-miR-27b	CLIP-seq
MIRT2074074	hsa-miR-3154	CLIP-seq
MIRT2074075	hsa-miR-3667-3p	CLIP-seq
MIRT2074076	hsa-miR-3910	CLIP-seq
MIRT2074077	hsa-miR-3938	CLIP-seq
MIRT2074078	hsa-miR-4640-5p	CLIP-seq
MIRT2074079	hsa-miR-4726-5p	CLIP-seq
MIRT2074080	hsa-miR-4729	CLIP-seq
MIRT2074081	hsa-miR-4755-5p	CLIP-seq
MIRT2074082	hsa-miR-4779	CLIP-seq
MIRT2074083	hsa-miR-581	CLIP-seq
MIRT2074084	hsa-miR-623	CLIP-seq
MIRT2301031	hsa-miR-1299	CLIP-seq
MIRT2301032	hsa-miR-1321	CLIP-seq
MIRT1250937	hsa-miR-1827	CLIP-seq
MIRT2074072	hsa-miR-27a	CLIP-seq
MIRT2074073	hsa-miR-27b	CLIP-seq
MIRT2301033	hsa-miR-3065-5p	CLIP-seq
MIRT2301034	hsa-miR-3074-3p	CLIP-seq
MIRT2301035	hsa-miR-3122	CLIP-seq
MIRT2301036	hsa-miR-3133	CLIP-seq
MIRT2301037	hsa-miR-3153	CLIP-seq
MIRT2301038	hsa-miR-3202	CLIP-seq
MIRT2301039	hsa-miR-361-5p	CLIP-seq
MIRT2301040	hsa-miR-3647-3p	CLIP-seq
MIRT2301041	hsa-miR-3671	CLIP-seq
MIRT2301042	hsa-miR-3913-5p	CLIP-seq
MIRT2301043	hsa-miR-3919	CLIP-seq
MIRT1250939	hsa-miR-3929	CLIP-seq
MIRT2301044	hsa-miR-3945	CLIP-seq
MIRT2301045	hsa-miR-409-3p	CLIP-seq
MIRT2301046	hsa-miR-4266	CLIP-seq
MIRT2301047	hsa-miR-4270	CLIP-seq
MIRT1250940	hsa-miR-4419b	CLIP-seq
MIRT2301048	hsa-miR-4424	CLIP-seq
MIRT1250941	hsa-miR-4428	CLIP-seq
MIRT2301049	hsa-miR-4433	CLIP-seq
MIRT2301050	hsa-miR-4441	CLIP-seq
MIRT2301051	hsa-miR-4476	CLIP-seq
MIRT1250942	hsa-miR-4478	CLIP-seq
MIRT2301052	hsa-miR-450b-3p	CLIP-seq
MIRT1250943	hsa-miR-4649-3p	CLIP-seq
MIRT2301053	hsa-miR-4713-3p	CLIP-seq
MIRT2301054	hsa-miR-4718	CLIP-seq
MIRT1250944	hsa-miR-4722-5p	CLIP-seq
MIRT2301055	hsa-miR-4739	CLIP-seq
MIRT2301056	hsa-miR-4756-5p	CLIP-seq
MIRT2301057	hsa-miR-4761-3p	CLIP-seq
MIRT2301058	hsa-miR-4762-5p	CLIP-seq
MIRT2301059	hsa-miR-4772-5p	CLIP-seq
MIRT2301060	hsa-miR-4797-5p	CLIP-seq
MIRT1250945	hsa-miR-485-5p	CLIP-seq
MIRT2301061	hsa-miR-505	CLIP-seq
MIRT2301062	hsa-miR-5096	CLIP-seq
MIRT2301063	hsa-miR-513a-5p	CLIP-seq
MIRT2301064	hsa-miR-607	CLIP-seq
MIRT2301065	hsa-miR-638	CLIP-seq
MIRT2301066	hsa-miR-766	CLIP-seq
MIRT2301067	hsa-miR-769-3p	CLIP-seq
MIRT2301068	hsa-miR-875-3p	CLIP-seq
MIRT1250947	hsa-miR-940	CLIP-seq
MIRT2074072	hsa-miR-27a	CLIP-seq
MIRT2074073	hsa-miR-27b	CLIP-seq
MIRT2301035	hsa-miR-3122	CLIP-seq
MIRT2392859	hsa-miR-3127-5p	CLIP-seq
MIRT2301042	hsa-miR-3913-5p	CLIP-seq
MIRT2392860	hsa-miR-4277	CLIP-seq
MIRT2301052	hsa-miR-450b-3p	CLIP-seq
MIRT2301053	hsa-miR-4713-3p	CLIP-seq
MIRT2301065	hsa-miR-638	CLIP-seq
MIRT2301067	hsa-miR-769-3p	CLIP-seq
MIRT2456930	hsa-miR-3173-3p	CLIP-seq
MIRT2456931	hsa-miR-3613-3p	CLIP-seq
MIRT2456932	hsa-miR-3653	CLIP-seq
MIRT2456933	hsa-miR-3658	CLIP-seq
MIRT2301048	hsa-miR-4424	CLIP-seq
MIRT1250941	hsa-miR-4428	CLIP-seq
MIRT2456934	hsa-miR-4511	CLIP-seq
MIRT2456935	hsa-miR-4653-3p	CLIP-seq
MIRT2456936	hsa-miR-4803	CLIP-seq
MIRT2456937	hsa-miR-548b-3p	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	12624109
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12624109
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	12624109
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	12624109, 35576971
GO:0005634	Component	Nucleus	IDA	9242494
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	10473598
GO:0008544	Process	Epidermis development	IEA
GO:0008544	Process	Epidermis development	IEA
GO:0008544	Process	Epidermis development	TAS	10473598
GO:0016604	Component	Nuclear body	IDA
GO:0030154	Process	Cell differentiation	IEA
GO:0030216	Process	Keratinocyte differentiation	IDA	11329378
GO:0030216	Process	Keratinocyte differentiation	IEA
GO:0042060	Process	Wound healing	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	9242494
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0043922	Process	Host-mediated suppression of viral transcription	IDA	14645924
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12624109
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
607394	19864	ENSG00000137709

Q9UKI9

Protein name

POU domain, class 2, transcription factor 3 (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (Transcription factor PLA-1) (Transcription factor Skn-1)

Protein function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex dr

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00157	Pou	186 → 257	Pou domain - N-terminal to homeobox domain	Domain
PF00046	Homeodomain	282 → 338	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Specifically expressed in epidermis and cultured keratinocytes. {ECO:0000269|PubMed:10473598}.

Sequence

MVNLESMHTDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLSDSLQQTLSH
RPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQFLLSQTQPGQQ
GLQPNLLPFPQQQSGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEASQHLPVPKHLPSSG
GADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFK
NMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTSIETNIRLTLEKRF
QDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPIKPPVYNSRLVSPS
GSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQNNSKAAVNSASSF
NSSGSWYRWNHSTYLH

Sequence length

436

Interactions

View interactions

	KEGG
	Herpes simplex virus 1 infection Lipid and atherosclerosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CUTANEOUS MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERNICIOUS ANEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEBORRHEIC KERATOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (67)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Coronary Syndrome	Coronary Syndrome	BEFREE	15840736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alloimmunisation	Alloimmunisation	BEFREE	9746765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	11257275, 14614355		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	11257275, 14614355		★★★★★ ★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet Syndrome	BEFREE	21813062		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood coagulation disorder	Pubtator	16244763	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Platelet Disorders	Platelet disorder	Pubtator	18396070	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	10077160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	35690220, 37179317	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	36253891	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	37179317	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Large Cell	Large cell carcinoma	Pubtator	38168015	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Small Cell	Small cell carcinoma	Pubtator	32721553, 33248321, 34534680, 36716535	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	34301206, 34988657, 39283755	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	18429969		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	24988537, 29526315		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	15672406, 16607278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	15672406, 16607278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholestasis of pregnancy	Cholestasis of pregnancy	BEFREE	29927323		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic kidney disease stage 5	Kidney Disease	BEFREE	19368146		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	14614355, 16675000, 16702043, 9716139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	14614355, 16675000, 16702043, 23184042, 24586027, 25167197, 31511539, 9716139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	14614355, 16675000, 16702043, 9716139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Deep Vein Thrombosis	Thrombosis	BEFREE	11533523, 21813062		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	15565371, 22452684, 23184042		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	10809411		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	22452684, 24979111		★★★★★ ★☆☆☆☆ Found in Text Mining only
Giant Cell Arteritis	Giant Cell Arteritis	BEFREE	17907177		★★★★★ ★☆☆☆☆ Found in Text Mining only
Giant Cell Arteritis	Giant cell arteritis	Pubtator	17907177	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemorrhage	Hemorrhage	Pubtator	19959486, 37203300	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Henoch-Schoenlein Purpura	Henoch-Schonlein Nephritis	BEFREE	23176823		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	19368146	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	19368146, 29526315		★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	28456479		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intermittent Claudication	Claudication	Pubtator	18396070	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	12586134, 24988537		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	19368146	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure, Chronic	Kidney Failure	BEFREE	19368146		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	10077160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29945888		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	15672406, 16607278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	10898417, 11053714, 11812069, 14614355, 15565371, 20739877, 23184042, 24988220, 9241754, 9716139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	10898417	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial ischemia	Pubtator	17907177	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neonatal Alloimmune Thrombocytopenia	Alloimmune Thrombocytopenia	BEFREE	1520609, 7519475, 7912098, 8140066, 8165025		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15672406, 16607278, 29945888		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	36121500	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Optic Neuritis	Optic Neuritis	BEFREE	17907177		★★★★★ ★☆☆☆☆ Found in Text Mining only
Optic Neuritis	Optic neuritis	Pubtator	17907177	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Arterial Disease	Peripheral arterial disease	Pubtator	18396070	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	29945888, 30926931		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	33011388, 33086069, 34653364, 35220975, 35440124, 35489038, 35789143, 36149789, 36197978, 36253891, 36378541, 36399951, 37382635, 39210380, 40649874	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
SMALL PATELLA SYNDROME	SMALL PATELLA SYNDROME	BEFREE	22751911		★★★★★ ★☆☆☆☆ Found in Text Mining only
SPASTIC PARAPLEGIA 54, AUTOSOMAL RECESSIVE	Spastic Paraplegia	BEFREE	23176823		★★★★★ ★☆☆☆☆ Found in Text Mining only
Spastic Paraplegia Hereditary	Hereditary spastic paraplegia	Pubtator	34089703	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stiff-Person Syndrome	Stiff-Person Syndrome	BEFREE	22751911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tachycardia, Ventricular	Ventricular tachycardia	BEFREE	28715142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombasthenia	Thrombasthenia	BEFREE	19245802, 7193688		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombasthenia	Thrombasthenia	Pubtator	566280	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombocytopenia Neonatal Alloimmune	Thrombocytopenia	Pubtator	7519475	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombophilia	Thrombophilia	Pubtator	16244763, 17456620, 34360543	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombophilia, hereditary	Thrombophilia	BEFREE	22751911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	37179317	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular Diseases	BEFREE	11341496		★★★★★ ★☆☆☆☆ Found in Text Mining only
Venous Thrombosis	Venous thrombosis	Pubtator	28081621	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vision Disorders	Visual disorder	Pubtator	17907177	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
von Willebrand Disease	von Willebrand disorder	BEFREE	19959486		★★★★★ ★☆☆☆☆ Found in Text Mining only

POU2F3 (POU class 2 homeobox 3)