Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2580
Gene name	Cyclin G associated kinase
Gene symbol	GAK
Synonyms (NCBI Gene)	DNAJ26DNAJC26
Chromosome	4
Chromosome location	4p16.3
Summary	In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Se

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001367	hsa-miR-1-3p	pSILAC	18668040
MIRT001367	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT049506	hsa-miR-92a-3p	CLASH	23622248
MIRT044214	hsa-miR-301a-3p	CLASH	23622248
MIRT037433	hsa-miR-744-5p	CLASH	23622248
MIRT037433	hsa-miR-744-5p	CLASH	23622248
MIRT440592	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440590	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440592	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727611	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727610	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727608	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727609	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT727607	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT727606	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440590	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1010363	hsa-miR-106a	CLIP-seq
MIRT1010364	hsa-miR-106b	CLIP-seq
MIRT1010365	hsa-miR-1225-3p	CLIP-seq
MIRT1010366	hsa-miR-1228	CLIP-seq
MIRT1010367	hsa-miR-17	CLIP-seq
MIRT1010368	hsa-miR-19a	CLIP-seq
MIRT1010369	hsa-miR-19b	CLIP-seq
MIRT1010370	hsa-miR-20a	CLIP-seq
MIRT1010371	hsa-miR-20b	CLIP-seq
MIRT1010372	hsa-miR-3199	CLIP-seq
MIRT1010373	hsa-miR-3620	CLIP-seq
MIRT1010374	hsa-miR-3686	CLIP-seq
MIRT1010375	hsa-miR-3920	CLIP-seq
MIRT1010376	hsa-miR-4283	CLIP-seq
MIRT1010377	hsa-miR-4323	CLIP-seq
MIRT1010378	hsa-miR-4504	CLIP-seq
MIRT1010379	hsa-miR-4508	CLIP-seq
MIRT1010380	hsa-miR-4532	CLIP-seq
MIRT1010381	hsa-miR-4701-5p	CLIP-seq
MIRT1010382	hsa-miR-4740-5p	CLIP-seq
MIRT1010383	hsa-miR-4746-3p	CLIP-seq
MIRT1010384	hsa-miR-4758-3p	CLIP-seq
MIRT1010385	hsa-miR-4778-5p	CLIP-seq
MIRT1010386	hsa-miR-519d	CLIP-seq
MIRT1010387	hsa-miR-520d-5p	CLIP-seq
MIRT1010388	hsa-miR-520g	CLIP-seq
MIRT1010389	hsa-miR-520h	CLIP-seq
MIRT1010390	hsa-miR-524-5p	CLIP-seq
MIRT1010391	hsa-miR-588	CLIP-seq
MIRT1010392	hsa-miR-765	CLIP-seq
MIRT1010393	hsa-miR-93	CLIP-seq
MIRT1999223	hsa-miR-1204	CLIP-seq
MIRT1999224	hsa-miR-3136-3p	CLIP-seq
MIRT1999225	hsa-miR-339-3p	CLIP-seq
MIRT1999226	hsa-miR-3591-3p	CLIP-seq
MIRT1010376	hsa-miR-4283	CLIP-seq
MIRT1010379	hsa-miR-4508	CLIP-seq
MIRT1999227	hsa-miR-4530	CLIP-seq
MIRT1999228	hsa-miR-4717-5p	CLIP-seq
MIRT1999229	hsa-miR-503	CLIP-seq
MIRT1999230	hsa-miR-520a-5p	CLIP-seq
MIRT1999231	hsa-miR-525-5p	CLIP-seq
MIRT1999232	hsa-miR-663b	CLIP-seq
MIRT1010363	hsa-miR-106a	CLIP-seq
MIRT1010364	hsa-miR-106b	CLIP-seq
MIRT2232935	hsa-miR-1207-3p	CLIP-seq
MIRT1010367	hsa-miR-17	CLIP-seq
MIRT1010368	hsa-miR-19a	CLIP-seq
MIRT1010369	hsa-miR-19b	CLIP-seq
MIRT1010370	hsa-miR-20a	CLIP-seq
MIRT1010371	hsa-miR-20b	CLIP-seq
MIRT1010372	hsa-miR-3199	CLIP-seq
MIRT1999226	hsa-miR-3591-3p	CLIP-seq
MIRT1010374	hsa-miR-3686	CLIP-seq
MIRT2232936	hsa-miR-3918	CLIP-seq
MIRT1010375	hsa-miR-3920	CLIP-seq
MIRT2232937	hsa-miR-4641	CLIP-seq
MIRT2232938	hsa-miR-4685-5p	CLIP-seq
MIRT2232939	hsa-miR-4733-3p	CLIP-seq
MIRT1010382	hsa-miR-4740-5p	CLIP-seq
MIRT1010383	hsa-miR-4746-3p	CLIP-seq
MIRT1010385	hsa-miR-4778-5p	CLIP-seq
MIRT1010386	hsa-miR-519d	CLIP-seq
MIRT1010387	hsa-miR-520d-5p	CLIP-seq
MIRT1010388	hsa-miR-520g	CLIP-seq
MIRT1010389	hsa-miR-520h	CLIP-seq
MIRT1010390	hsa-miR-524-5p	CLIP-seq
MIRT1010392	hsa-miR-765	CLIP-seq
MIRT1010393	hsa-miR-93	CLIP-seq
MIRT1010392	hsa-miR-765	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	9299234
GO:0005515	Function	Protein binding	IPI	22645275, 24510904, 24947832, 28514442, 29513927, 29568061, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	16155256
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	IEA
GO:0006457	Process	Protein folding	TAS	26345367
GO:0006898	Process	Receptor-mediated endocytosis	IMP	16155256
GO:0007029	Process	Endoplasmic reticulum organization	ISS
GO:0007030	Process	Golgi organization	IMP	16155256, 24510904
GO:0010977	Process	Negative regulation of neuron projection development	IDA	24510904
GO:0016020	Component	Membrane	HDA	19946888
GO:0016191	Process	Synaptic vesicle uncoating	ISS	20160091
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030136	Component	Clathrin-coated vesicle	IDA	31962345
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0030276	Function	Clathrin binding	IBA
GO:0030332	Function	Cyclin binding	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031982	Component	Vesicle	IBA
GO:0031982	Component	Vesicle	IDA	24510904
GO:0034067	Process	Protein localization to Golgi apparatus	IMP	16155256
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0044183	Function	Protein folding chaperone	TAS	26345367
GO:0046907	Process	Intracellular transport	IMP	18489706
GO:0048268	Process	Clathrin coat assembly	IMP	16155256
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0072318	Process	Clathrin coat disassembly	IBA
GO:0072318	Process	Clathrin coat disassembly	IMP	16155256
GO:0072583	Process	Clathrin-dependent endocytosis	IBA
GO:0072583	Process	Clathrin-dependent endocytosis	IMP	16155256, 18489706
GO:0072659	Process	Protein localization to plasma membrane	IMP	16155256
GO:0090160	Process	Golgi to lysosome transport	IMP	16155256
GO:0098793	Component	Presynapse	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1905443	Process	Regulation of clathrin coat assembly	IEA
GO:1905443	Process	Regulation of clathrin coat assembly	IMP	18489706

MIM	HGNC	e!Ensembl
602052	4113	ENSG00000178950

O14976

Protein name

Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26)

Protein function

Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625

PDB

4C57 , 4C58 , 4C59 , 4O38 , 4Y8D , 5Y7Z , 5Y80

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	40 → 313	Protein kinase domain	Domain
PF10409	PTEN_C2	570 → 709	C2 domain of PTEN tumour-suppressor protein	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highest in testis.

Sequence

MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDV
GSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFL
LLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL
LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPI
GEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNP
EERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSG
GLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVM
SFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAP
HLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFS
MKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCE
VYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMA
SMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAP
PWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDS
PPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEG
QEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQA
CKAPSSNTDLLSCLLGPPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADP
FGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGE
PSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNP
DPFADLGDLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPPQAKPPPK
ACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKT
IAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAP
EQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF

Sequence length

1311

Interactions

View interactions

	Reactome
			Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BEHCET'S SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VASCULITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (22)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	37328865	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	28586827	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	33115496	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	28586827	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	29209123	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	34980126	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	28586827	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	28586827	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	36329257	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	20881269		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	24971999	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	GWASCAT_DG	18985386, 20711177, 27182965		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	Pubtator	18985386, 21044948, 21058943, 21812969, 22786590, 23071545, 23826309, 24510904, 24514572, 26601739, 27508417, 28586827, 37328865	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	BEFREE	19772629, 21058943, 21248740, 21258085, 22198721, 23618683, 23826309, 24039160, 24373818, 26601739, 27508417, 28147270, 29241837, 31658403		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	CTD_human_DG	20711177		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	GWASDB_DG	20711177, 21258085, 22438815		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	Pubtator	21248740	Stimulate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinsonian Disorders	Parkinson Disease	BEFREE	31120186		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinsonian Disorders	Parkinson disease	Pubtator	32472658	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	24971999	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	26318431	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tremor	Tremor	Pubtator	24514572	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GAK (cyclin G associated kinase)