Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	25798
Gene name	Brain protein I3
Gene symbol	BRI3
Synonyms (NCBI Gene)	I3
Chromosome	7
Chromosome location	7q21.3

170

Show/Hide all (170)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051569	hsa-let-7e-5p	CLASH	23622248
MIRT042003	hsa-miR-484	CLASH	23622248
MIRT824644	hsa-miR-127-5p	CLIP-seq
MIRT824645	hsa-miR-3163	CLIP-seq
MIRT824646	hsa-miR-323-3p	CLIP-seq
MIRT824647	hsa-miR-3671	CLIP-seq
MIRT824648	hsa-miR-4282	CLIP-seq
MIRT824649	hsa-miR-4311	CLIP-seq
MIRT824650	hsa-miR-4487	CLIP-seq
MIRT824651	hsa-miR-4731-3p	CLIP-seq
MIRT824652	hsa-miR-4801	CLIP-seq
MIRT824653	hsa-miR-944	CLIP-seq
MIRT1545795	hsa-miR-15a	CLIP-seq
MIRT1545796	hsa-miR-15b	CLIP-seq
MIRT1545797	hsa-miR-16	CLIP-seq
MIRT1545798	hsa-miR-195	CLIP-seq
MIRT1545799	hsa-miR-424	CLIP-seq
MIRT1545800	hsa-miR-4750	CLIP-seq
MIRT1545801	hsa-miR-497	CLIP-seq
MIRT1556040	hsa-miR-1224-3p	CLIP-seq
MIRT1556041	hsa-miR-1260	CLIP-seq
MIRT1556042	hsa-miR-1260b	CLIP-seq
MIRT1556043	hsa-miR-1280	CLIP-seq
MIRT1556044	hsa-miR-4315	CLIP-seq
MIRT1556045	hsa-miR-4790-5p	CLIP-seq
MIRT1556046	hsa-miR-520d-5p	CLIP-seq
MIRT1556047	hsa-miR-524-5p	CLIP-seq
MIRT824644	hsa-miR-127-5p	CLIP-seq
MIRT1943793	hsa-miR-132	CLIP-seq
MIRT1545795	hsa-miR-15a	CLIP-seq
MIRT1545796	hsa-miR-15b	CLIP-seq
MIRT1545797	hsa-miR-16	CLIP-seq
MIRT1943794	hsa-miR-1910	CLIP-seq
MIRT1545798	hsa-miR-195	CLIP-seq
MIRT1943795	hsa-miR-212	CLIP-seq
MIRT1943796	hsa-miR-219-1-3p	CLIP-seq
MIRT1943797	hsa-miR-3140-5p	CLIP-seq
MIRT824645	hsa-miR-3163	CLIP-seq
MIRT824647	hsa-miR-3671	CLIP-seq
MIRT1545799	hsa-miR-424	CLIP-seq
MIRT824648	hsa-miR-4282	CLIP-seq
MIRT1556044	hsa-miR-4315	CLIP-seq
MIRT1943798	hsa-miR-4461	CLIP-seq
MIRT1943799	hsa-miR-4519	CLIP-seq
MIRT824651	hsa-miR-4731-3p	CLIP-seq
MIRT1545800	hsa-miR-4750	CLIP-seq
MIRT1556045	hsa-miR-4790-5p	CLIP-seq
MIRT824652	hsa-miR-4801	CLIP-seq
MIRT1545801	hsa-miR-497	CLIP-seq
MIRT1556046	hsa-miR-520d-5p	CLIP-seq
MIRT1943800	hsa-miR-520f	CLIP-seq
MIRT1556047	hsa-miR-524-5p	CLIP-seq
MIRT1943801	hsa-miR-571	CLIP-seq
MIRT824653	hsa-miR-944	CLIP-seq
MIRT2182511	hsa-miR-1207-3p	CLIP-seq
MIRT1556040	hsa-miR-1224-3p	CLIP-seq
MIRT2182512	hsa-miR-1227	CLIP-seq
MIRT1556041	hsa-miR-1260	CLIP-seq
MIRT1556042	hsa-miR-1260b	CLIP-seq
MIRT824644	hsa-miR-127-5p	CLIP-seq
MIRT1556043	hsa-miR-1280	CLIP-seq
MIRT1943793	hsa-miR-132	CLIP-seq
MIRT1545795	hsa-miR-15a	CLIP-seq
MIRT1545796	hsa-miR-15b	CLIP-seq
MIRT1545797	hsa-miR-16	CLIP-seq
MIRT1943794	hsa-miR-1910	CLIP-seq
MIRT1545798	hsa-miR-195	CLIP-seq
MIRT1943795	hsa-miR-212	CLIP-seq
MIRT1943796	hsa-miR-219-1-3p	CLIP-seq
MIRT2182513	hsa-miR-3064-3p	CLIP-seq
MIRT1943797	hsa-miR-3140-5p	CLIP-seq
MIRT824645	hsa-miR-3163	CLIP-seq
MIRT824646	hsa-miR-323-3p	CLIP-seq
MIRT824647	hsa-miR-3671	CLIP-seq
MIRT1545799	hsa-miR-424	CLIP-seq
MIRT824648	hsa-miR-4282	CLIP-seq
MIRT1556044	hsa-miR-4315	CLIP-seq
MIRT1943798	hsa-miR-4461	CLIP-seq
MIRT2182514	hsa-miR-4497	CLIP-seq
MIRT824651	hsa-miR-4731-3p	CLIP-seq
MIRT2182515	hsa-miR-4746-5p	CLIP-seq
MIRT1545800	hsa-miR-4750	CLIP-seq
MIRT1556045	hsa-miR-4790-5p	CLIP-seq
MIRT824652	hsa-miR-4801	CLIP-seq
MIRT1545801	hsa-miR-497	CLIP-seq
MIRT1556046	hsa-miR-520d-5p	CLIP-seq
MIRT1943800	hsa-miR-520f	CLIP-seq
MIRT1556047	hsa-miR-524-5p	CLIP-seq
MIRT1943801	hsa-miR-571	CLIP-seq
MIRT824653	hsa-miR-944	CLIP-seq
MIRT1556040	hsa-miR-1224-3p	CLIP-seq
MIRT1556041	hsa-miR-1260	CLIP-seq
MIRT1556042	hsa-miR-1260b	CLIP-seq
MIRT824644	hsa-miR-127-5p	CLIP-seq
MIRT1556043	hsa-miR-1280	CLIP-seq
MIRT1943793	hsa-miR-132	CLIP-seq
MIRT1943794	hsa-miR-1910	CLIP-seq
MIRT1943795	hsa-miR-212	CLIP-seq
MIRT2182513	hsa-miR-3064-3p	CLIP-seq
MIRT1943797	hsa-miR-3140-5p	CLIP-seq
MIRT1556044	hsa-miR-4315	CLIP-seq
MIRT2182515	hsa-miR-4746-5p	CLIP-seq
MIRT1556045	hsa-miR-4790-5p	CLIP-seq
MIRT1556046	hsa-miR-520d-5p	CLIP-seq
MIRT1556047	hsa-miR-524-5p	CLIP-seq
MIRT1556040	hsa-miR-1224-3p	CLIP-seq
MIRT1556041	hsa-miR-1260	CLIP-seq
MIRT1556042	hsa-miR-1260b	CLIP-seq
MIRT824644	hsa-miR-127-5p	CLIP-seq
MIRT1556043	hsa-miR-1280	CLIP-seq
MIRT1943793	hsa-miR-132	CLIP-seq
MIRT1943794	hsa-miR-1910	CLIP-seq
MIRT1943795	hsa-miR-212	CLIP-seq
MIRT2182513	hsa-miR-3064-3p	CLIP-seq
MIRT1943797	hsa-miR-3140-5p	CLIP-seq
MIRT824645	hsa-miR-3163	CLIP-seq
MIRT824647	hsa-miR-3671	CLIP-seq
MIRT1556044	hsa-miR-4315	CLIP-seq
MIRT2182515	hsa-miR-4746-5p	CLIP-seq
MIRT1556045	hsa-miR-4790-5p	CLIP-seq
MIRT1556046	hsa-miR-520d-5p	CLIP-seq
MIRT1556047	hsa-miR-524-5p	CLIP-seq
MIRT1556040	hsa-miR-1224-3p	CLIP-seq
MIRT1556041	hsa-miR-1260	CLIP-seq
MIRT1556042	hsa-miR-1260b	CLIP-seq
MIRT1556043	hsa-miR-1280	CLIP-seq
MIRT2182513	hsa-miR-3064-3p	CLIP-seq
MIRT1556044	hsa-miR-4315	CLIP-seq
MIRT2182515	hsa-miR-4746-5p	CLIP-seq
MIRT1556045	hsa-miR-4790-5p	CLIP-seq
MIRT1556046	hsa-miR-520d-5p	CLIP-seq
MIRT1556047	hsa-miR-524-5p	CLIP-seq
MIRT2182511	hsa-miR-1207-3p	CLIP-seq
MIRT1556040	hsa-miR-1224-3p	CLIP-seq
MIRT1556041	hsa-miR-1260	CLIP-seq
MIRT1556042	hsa-miR-1260b	CLIP-seq
MIRT824644	hsa-miR-127-5p	CLIP-seq
MIRT1556043	hsa-miR-1280	CLIP-seq
MIRT1943793	hsa-miR-132	CLIP-seq
MIRT1943794	hsa-miR-1910	CLIP-seq
MIRT1943795	hsa-miR-212	CLIP-seq
MIRT2182513	hsa-miR-3064-3p	CLIP-seq
MIRT1943797	hsa-miR-3140-5p	CLIP-seq
MIRT824645	hsa-miR-3163	CLIP-seq
MIRT824647	hsa-miR-3671	CLIP-seq
MIRT824648	hsa-miR-4282	CLIP-seq
MIRT1556044	hsa-miR-4315	CLIP-seq
MIRT2182514	hsa-miR-4497	CLIP-seq
MIRT2182515	hsa-miR-4746-5p	CLIP-seq
MIRT1556045	hsa-miR-4790-5p	CLIP-seq
MIRT1556046	hsa-miR-520d-5p	CLIP-seq
MIRT1556047	hsa-miR-524-5p	CLIP-seq
MIRT824653	hsa-miR-944	CLIP-seq
MIRT1556040	hsa-miR-1224-3p	CLIP-seq
MIRT1556041	hsa-miR-1260	CLIP-seq
MIRT1556042	hsa-miR-1260b	CLIP-seq
MIRT824644	hsa-miR-127-5p	CLIP-seq
MIRT1556043	hsa-miR-1280	CLIP-seq
MIRT1943793	hsa-miR-132	CLIP-seq
MIRT1943794	hsa-miR-1910	CLIP-seq
MIRT1943795	hsa-miR-212	CLIP-seq
MIRT2182513	hsa-miR-3064-3p	CLIP-seq
MIRT1943797	hsa-miR-3140-5p	CLIP-seq
MIRT824647	hsa-miR-3671	CLIP-seq
MIRT1556044	hsa-miR-4315	CLIP-seq
MIRT2182514	hsa-miR-4497	CLIP-seq
MIRT2182515	hsa-miR-4746-5p	CLIP-seq
MIRT1556045	hsa-miR-4790-5p	CLIP-seq
MIRT1556046	hsa-miR-520d-5p	CLIP-seq
MIRT1556047	hsa-miR-524-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11860200, 30983867, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0042802	Function	Identical protein binding	IDA	15606899
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

MIM	HGNC	e!Ensembl
615628	1109	ENSG00000164713

O95415

Protein name

Membrane protein BRI3 (Brain protein I3) (pRGR2)

Protein function

Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10164	DUF2367	28 → 124	Uncharacterized conserved protein (DUF2367)	Family

Sequence

MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPYLVTGIPTHHPRVYNIH
SRTVTRYPANSIVVVGGCPVCRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNC
GATFA

Sequence length

125

Interactions

View interactions

	Reactome
			Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

BRI3 (brain protein I3)