Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	25796
Gene name	6-phosphogluconolactonase
Gene symbol	PGLS
Synonyms (NCBI Gene)	6PGLHEL-S-304
Chromosome	19
Chromosome location	19p13.11

Show/Hide all (31)

miRTarBase ID	miRNA	Experiments	Reference
MIRT450535	hsa-miR-5002-5p	PAR-CLIP	22100165
MIRT450534	hsa-miR-143-3p	PAR-CLIP	22100165
MIRT450533	hsa-miR-4770	PAR-CLIP	22100165
MIRT450532	hsa-miR-6088	PAR-CLIP	22100165
MIRT450531	hsa-miR-4708-5p	PAR-CLIP	22100165
MIRT450530	hsa-miR-1273f	PAR-CLIP	22100165
MIRT450529	hsa-miR-579-3p	PAR-CLIP	22100165
MIRT450528	hsa-miR-664b-3p	PAR-CLIP	22100165
MIRT450527	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450535	hsa-miR-5002-5p	PAR-CLIP	22100165
MIRT450534	hsa-miR-143-3p	PAR-CLIP	22100165
MIRT450533	hsa-miR-4770	PAR-CLIP	22100165
MIRT450532	hsa-miR-6088	PAR-CLIP	22100165
MIRT450531	hsa-miR-4708-5p	PAR-CLIP	22100165
MIRT450530	hsa-miR-1273f	PAR-CLIP	22100165
MIRT450529	hsa-miR-579-3p	PAR-CLIP	22100165
MIRT450528	hsa-miR-664b-3p	PAR-CLIP	22100165
MIRT450527	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT2066636	hsa-miR-15a	CLIP-seq
MIRT2066637	hsa-miR-15b	CLIP-seq
MIRT2066638	hsa-miR-16	CLIP-seq
MIRT2066639	hsa-miR-195	CLIP-seq
MIRT2066640	hsa-miR-2115	CLIP-seq
MIRT2066641	hsa-miR-338-3p	CLIP-seq
MIRT2066642	hsa-miR-424	CLIP-seq
MIRT2066643	hsa-miR-4530	CLIP-seq
MIRT2066644	hsa-miR-497	CLIP-seq
MIRT2294171	hsa-miR-198	CLIP-seq
MIRT2294172	hsa-miR-2964a-5p	CLIP-seq
MIRT2294173	hsa-miR-520a-5p	CLIP-seq
MIRT2294174	hsa-miR-525-5p	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21044950, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006098	Process	Pentose-phosphate shunt	IDA	10518023
GO:0006098	Process	Pentose-phosphate shunt	IEA
GO:0006098	Process	Pentose-phosphate shunt	TAS
GO:0009051	Process	Pentose-phosphate shunt, oxidative branch	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0017057	Function	6-phosphogluconolactonase activity	EXP	10518023
GO:0017057	Function	6-phosphogluconolactonase activity	IBA
GO:0017057	Function	6-phosphogluconolactonase activity	IDA	10518023, 11457850
GO:0017057	Function	6-phosphogluconolactonase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
604951	8903	ENSG00000130313

O95336

Protein name

6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)

Protein function

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01182	Glucosamine_iso	13 → 238	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	Domain

Sequence

MAAPAPGLISVFSSSQELGAALAQLVAQRAACCLAGARARFALGLSGGSLVSMLARELPA
AVAPAGPASLARWTLGFCDERLVPFDHAESTYGLYRTHLLSRLPIPESQVITINPELPVE
EAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQEREKIVAPISDSPK
PPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTGKLCWFL
DEAAARLLTVPFEKHSTL

Sequence length

258

Interactions

View interactions

	KEGG		Reactome
	Pentose phosphate pathway Metabolic pathways Carbon metabolism		Pentose phosphate pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OSTEOPOROSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	29682102		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28260828, 29682102	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	34953081	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18318472, 29682102		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	CTD_human_DG	18924182		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteoporosis, Age-Related	Osteoporosis	CTD_human_DG	18924182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis, Senile	Osteoporosis	CTD_human_DG	18924182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Post-Traumatic Osteoporosis	Osteoporosis	CTD_human_DG	18924182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	34953081	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PGLS (6-phosphogluconolactonase)