HYPK (huntingtin interacting protein K)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 25764
• Gene name: Huntingtin interacting protein K
• Gene symbol: HYPK
• Synonyms (NCBI Gene): C15orf63, HSPC136
• Chromosome: 15
• Chromosome location: 15q15.3

miRNA Show/Hide all (174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043856	hsa-miR-340-3p	CLASH	23622248
MIRT036313	hsa-miR-1229-3p	CLASH	23622248
MIRT667939	hsa-miR-5693	HITS-CLIP	23824327
MIRT667938	hsa-miR-194-3p	HITS-CLIP	23824327
MIRT640415	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT640414	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT640413	hsa-miR-4775	HITS-CLIP	23824327
MIRT667937	hsa-miR-4276	HITS-CLIP	23824327
MIRT640412	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT640411	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT640410	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT640409	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT640408	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT638585	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT638584	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT638583	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT643195	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT638582	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT638581	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT638580	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT638579	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT643194	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT643193	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT643192	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT643191	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT643190	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT643189	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT643188	hsa-miR-4770	HITS-CLIP	23824327
MIRT643187	hsa-miR-6088	HITS-CLIP	23824327
MIRT643186	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT643185	hsa-miR-1273f	HITS-CLIP	23824327
MIRT643184	hsa-miR-4534	HITS-CLIP	23824327
MIRT643183	hsa-miR-8082	HITS-CLIP	23824327
MIRT643181	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT643182	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT643180	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT643179	hsa-miR-8055	HITS-CLIP	23824327
MIRT643178	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT192609	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT640416	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT640415	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT640414	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT640413	hsa-miR-4775	HITS-CLIP	23824327
MIRT640412	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT640411	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT640410	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT640409	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT640408	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT638585	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT638584	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT638583	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT638582	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT638581	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT638580	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT638579	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT638578	hsa-miR-498	HITS-CLIP	23824327
MIRT523086	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT523085	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT523084	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT523083	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT523082	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT523081	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT523080	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT523079	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT523078	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT523077	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT523076	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT523075	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT523074	hsa-miR-302e	PAR-CLIP	23446348
MIRT523073	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT523072	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT523071	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT523070	hsa-miR-520b	PAR-CLIP	23446348
MIRT523069	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT523068	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT523067	hsa-miR-520e	PAR-CLIP	23446348
MIRT523066	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT523065	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT523064	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT523063	hsa-miR-520h	PAR-CLIP	23446348
MIRT523062	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT523061	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT523060	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT523059	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT523058	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT523057	hsa-miR-877-5p	PAR-CLIP	23446348
MIRT523056	hsa-miR-6866-5p	PAR-CLIP	23446348
MIRT523055	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT667939	hsa-miR-5693	HITS-CLIP	23824327
MIRT667938	hsa-miR-194-3p	HITS-CLIP	23824327
MIRT640415	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT640414	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT640413	hsa-miR-4775	HITS-CLIP	23824327
MIRT667937	hsa-miR-4276	HITS-CLIP	23824327
MIRT640412	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT640411	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT640410	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT640409	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT640408	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT638585	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT638584	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT638583	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT643195	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT638582	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT638581	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT638580	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT638579	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT643194	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT643193	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT643192	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT643191	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT643190	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT643189	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT643188	hsa-miR-4770	HITS-CLIP	23824327
MIRT643187	hsa-miR-6088	HITS-CLIP	23824327
MIRT643186	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT643185	hsa-miR-1273f	HITS-CLIP	23824327
MIRT643184	hsa-miR-4534	HITS-CLIP	23824327
MIRT643183	hsa-miR-8082	HITS-CLIP	23824327
MIRT643181	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT643182	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT643180	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT643179	hsa-miR-8055	HITS-CLIP	23824327
MIRT643178	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT192609	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT640416	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT640415	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT640414	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT640413	hsa-miR-4775	HITS-CLIP	23824327
MIRT640412	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT640411	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT640410	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT640409	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT640408	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT638585	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT638584	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT638583	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT638582	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT638581	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT638580	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT638579	hsa-miR-3160-5p	HITS-CLIP	23824327
MIRT638578	hsa-miR-498	HITS-CLIP	23824327
MIRT523086	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT523085	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT523084	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT523083	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT523082	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT523081	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT523080	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT523079	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT523078	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT523077	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT523076	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT523075	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT523074	hsa-miR-302e	PAR-CLIP	23446348
MIRT523073	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT523072	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT523071	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT523070	hsa-miR-520b	PAR-CLIP	23446348
MIRT523069	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT523068	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT523067	hsa-miR-520e	PAR-CLIP	23446348
MIRT523066	hsa-miR-449b-3p	PAR-CLIP	23446348
MIRT523065	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT523064	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT523063	hsa-miR-520h	PAR-CLIP	23446348
MIRT523062	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT523061	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT523060	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT523059	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT523058	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT523057	hsa-miR-877-5p	PAR-CLIP	23446348
MIRT523056	hsa-miR-6866-5p	PAR-CLIP	23446348
MIRT523055	hsa-miR-5089-5p	PAR-CLIP	23446348

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17500595, 17947297, 24981860, 25416956, 28514442, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	17947297
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	17947297
GO:0005737	Component	Cytoplasm	IEA
GO:0006457	Process	Protein folding	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0032991	Component	Protein-containing complex	IDA	17947297
GO:0043066	Process	Negative regulation of apoptotic process	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IDA	17947297
GO:0044183	Function	Protein folding chaperone	EXP	18076027
GO:0044183	Function	Protein folding chaperone	IDA	18076027
GO:0050821	Process	Protein stabilization	IBA
GO:0050821	Process	Protein stabilization	IDA	17947297

Other IDs

• MIM: 612784
• HGNC: 18418
• e!Ensembl: ENSG00000242028

Protein

• UniProt ID: Q9NX55
• Protein name: Huntingtin-interacting protein K (Huntingtin yeast partner K)
• Protein function: Component of several N-terminal acetyltransferase complexes (PubMed:20154145, PubMed:29754825, PubMed:32042062). Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex)
• PDB: 6C95 , 6PW9 , 9F1D
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF19026	HYPK_UBA	88 → 128	HYPK UBA domain	Domain

• Sequence:

  MRRRGEIDMATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNL
  ETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNV
  VEALIALTN

• Sequence length: 129

Related Genes

No strongly related genes found yet for HYPK.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to HYPK.